Abstracts from the symposium on the 50th anniversary of the Department of Pharmacology at the University of Alberta

2012 ◽  
Vol 90 (6) ◽  
pp. 669-679
Keyword(s):  
50Th Anniversary ◽  
University Of Alberta ◽  
The University

The Cys-loop pentameric ligand-gated ion channel receptors: 50 years on

2012 ◽  
Vol 90 (6) ◽  
pp. 771-782 ◽  
Author(s):  
Janna L. Kozuska ◽  
Isabelle M. Paulsen
Keyword(s):  
Ion Channel ◽  
Single Channel ◽  
50Th Anniversary ◽  
University Of Alberta ◽  
Electrophysiological Studies ◽  
Ligand Interactions ◽  
History Of ◽  
Entire History ◽  
The Individual ◽  
The University

This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understanding of pLGICs, and highlight the contributions made by members of our department. The individual at the center of our story is Susan Dunn; her passing earlier this year has robbed the Department of Pharmacology and the research community of a most insightful colleague. Her dissection of ligand interactions with the nAChR, together with their interpretation, was the hallmark of her extensive collaborations with Michael Raftery. Here, we highlight some electrophysiological studies from her laboratory over the last few years, using the technique that she introduced to the department in Edmonton, the 2-electrode voltage-clamp of Xenopus oocytes. Finally, we discuss some single-channel studies of the anionic GlyR and GABAAR that prefaced the introduction of this technique to her laboratory.

Centres for Health Evidence Demonstration Project

2013 ◽  
Author(s):  
Tracy Stewart ◽  
Denise Koufogiannakis ◽  
Robert S.A. Hayward ◽  
Ellen Crumley ◽  
Michael E. Moffatt
Keyword(s):  
Evidence Based Practice ◽  
Demonstration Project ◽  
Evidence Based ◽  
Research Opportunities ◽  
University Of Alberta ◽  
Information Usage ◽  
University Of Manitoba ◽  
The University ◽  
Hospital Wards ◽  
Support Evidence

This paper will report on the establishment of the Centres for Health Evidence (CHE) Demonstration Project in both Edmonton at the University of Alberta and in Winnipeg at the University of Manitoba. The CHE Project brings together a variety of partners to support evidence-based practice using Internet-based desktops on hospital wards. There is a discussion of the CHE's cultural and political experiences. An overview of the research opportunities emanating from the CHE Project is presented as well as some early observations about information usage.

scholarly journals Is the Letter ‘t’ in the Word ‘gourmet’? Disruption in Task-Evoked Connectivity Networks in Adults with Impaired Literacy Skills

NeuroSci ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 75-94
Author(s):  
Kulpreet Cheema ◽  
William E. Hodgetts ◽  
Jacqueline Cummine
Keyword(s):  
Developmental Disorders ◽  
Brain Networks ◽  
Literacy Skills ◽  
Resting State Networks ◽  
Skilled Readers ◽  
University Of Alberta ◽  
Domain Specific ◽  
Probe Task ◽  
The University ◽  
General Networks

Much work has been done to characterize domain-specific brain networks associated with reading, but very little work has been done with respect to spelling. Our aim was to characterize domain-specific spelling networks (SpNs) and domain-general resting state networks (RSNs) in adults with and without literacy impairments. Skilled and impaired adults were recruited from the University of Alberta. Participants completed three conditions of an in-scanner spelling task called a letter probe task (LPT). We found highly connected SpNs for both groups of individuals, albeit comparatively more connections for skilled (50) vs. impaired (43) readers. Notably, the SpNs did not correlate with spelling behaviour for either group. We also found relationships between SpNs and RSNs for both groups of individuals, this time with comparatively fewer connections for skilled (36) vs. impaired (53) readers. Finally, the RSNs did predict spelling performance in a limited manner for the skilled readers. These results advance our understanding of brain networks associated with spelling and add to the growing body of literature that describes the important and intricate connections between domain-specific networks and domain-general networks (i.e., resting states) in individuals with and without developmental disorders.

scholarly journals Access to Healthcare for Immigrant Children in Canada

2020 ◽  
Vol 17 (9) ◽  
pp. 3320
Author(s):  
Bukola Salami ◽  
Alleson Mason ◽  
Jordana Salma ◽  
Sophie Yohani ◽  
Maryam Amin ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Service Providers ◽  
Social Determinant ◽  
Immigrant Children ◽  
Access To Healthcare ◽  
Cultural Barriers ◽  
Immigrant Parents ◽  
Financial Barriers ◽  
University Of Alberta ◽  
The University

Immigrants experience poorer health outcomes than nonimmigrants in Canada for several reasons. A central contributing factor to poor health outcomes for immigrants is access to healthcare. Previous research on access to healthcare for immigrants has largely focused on the experience of immigrant adults. The purpose of this study was to investigate how immigrants access health services for their children in Alberta, Canada. Our study involved a descriptive qualitative design. Upon receiving ethics approval from the University of Alberta Research Ethics Board, we invited immigrant parents to participate in this study. We interviewed 50 immigrant parents, including 17 fathers and 33 mothers. Interviews were audio recorded, transcribed, and analyzed according to the themes that emerged. Findings reveal that systemic barriers contributed to challenges in accessing healthcare for immigrant children. Participants identified several of these barriers—namely, system barriers, language and cultural barriers, relationship with health professionals, and financial barriers. These barriers can be addressed by policymakers and service providers by strengthening the diversity of the workforce, addressing income as a social determinant of health, and improving access to language interpretation services.

scholarly journals Success factors in the realization of large ice projects in education

2021 ◽  
Vol 36 (1) ◽  
pp. 4-12
Author(s):  
Arno Pronk ◽  
Peng Luo ◽  
Qingpeng Li ◽  
Fred Sanders ◽  
Marjolein overtoom ◽  
...  
Keyword(s):  
Success Factors ◽  
Learning Experience ◽  
Learning By Doing ◽  
University Of Alberta ◽  
The North ◽  
3D Printed ◽  
Good Learning ◽  
The University ◽  
Ice Shell ◽  
Motivation And Learning

There has been a long tradition in making ice structures, but the development of technical improvements for making ice buildings is a new field with just a handful of researchers. Most of the projects were realized by professors in cooperation with their students as part of their education in architecture and civil engineering. The following professors have realized ice projects in this setting: Heinz Isler realized some experiments since the 1950s; Tsutomu Kokawa created in the past three decades several ice domes in the north of Japan with a span up to 25 m; Lancelot Coar realized a number of fabric formed ice shell structures including fiberglass bars and hanging fabric as a mold for an ice shell in 2011 and in 2015 he produced an fabric-formed ice origami structure in cooperation with MIT (Caitlin Mueller) and VUB (Lars de Laet). Arno Pronk realized several ice projects such as the 2004 artificially cooled igloo, in 2014 and 2015 dome structures with an inflatable mold in Finland and in 2016–2019, an ice dome, several ice towers and a 3D printed gridshell of ice in Harbin (China) as a cooperation between the Universities of Eindhoven & Leuven (Pronk) and Harbin (Wu and Luo). In cooperation between the University of Alberta and Eindhoven two ice beams were realized during a workshop in 2020. In this paper we will present the motivation and learning experiences of students involved in learning-by-doing by realizing one large project in ice. The 2014–2016 projects were evaluated by Sanders and Overtoom; using questionnaires among the participants by mixed cultural teams under extreme conditions. By comparing the results in different situations and cultures we have found common rules for the success of those kinds of educational projects. In this paper we suggest that the synergy among students participating in one main project without a clear individual goal can be very large. The paper will present the success factors for projects to be perceived as a good learning experience.

James Bertram Collip, 1892-1965

1973 ◽  
Vol 19 ◽  
pp. 234-267 ◽  
Keyword(s):  
Family Life ◽  
Clinical Medicine ◽  
National Research Council ◽  
Pituitary Hormones ◽  
University Of Alberta ◽  
University Of Toronto ◽  
Mcgill University ◽  
Medical Importance ◽  
The University ◽  
Happy Family

James Bertram Collip was a pioneer in endocrine research, especially in its biochemical aspects. Following an excellent training in biochemistry under Professor A. B. Macallum, F.R.S., at the University of Toronto, he spent thirteen years at the University of Alberta in Edmonton. There was a momentous year at the University of Toronto about midway through the Edmonton period; this coincided with the discovery of insulin by Sir Frederick G. Banting, F.R.S., and Professor Charles S. Best, F.R.S., and the experience altered the course of his career. Henceforth, Professor Collip’s life was dominated by an urge to discover hormones that would be useful in clinical medicine. Success attended these efforts, first in the isolation of the parthyroid hormone, called parathormone, while he was at the University of Alberta and later in the identification of placental and pituitary hormones during particularly fruitful years at McGill University. There were other important facets to Professor Collip’s career. These included the training of young scientists, many of whom subsequently came to occupy positions of responsibility, work with the National Research Council of Canada, and in his latter years an important contribution as Dean of the Faculty of Medicine, University of Western Ontario. In addition to a life of fulfilment through accomplishments of scientific and medical importance, Professor Collip’s career was enriched by a happy family life and by the friendship of a host of individuals who were attracted to his brilliance as a scientist and his warm personality.

Development of an agronomically superior blackleg resistant canola cultivar in Brassica napus L. using doubled haploidy

1995 ◽  
Vol 75 (2) ◽  
pp. 437-439 ◽  
Author(s):  
G. R. Stringam ◽  
V. K. Bansal ◽  
M. R. Thiagarajah ◽  
D. F. Degenhardt ◽  
J. P. Tewari
Keyword(s):  
Brassica Napus ◽  
Doubled Haploid ◽  
Leptosphaeria Maculans ◽  
Resistance Breeding ◽  
Breeding Method ◽  
Brassica Napus L ◽  
Breeding Lines ◽  
University Of Alberta ◽  
Blackleg Resistance ◽  
The University

The doubled haploid breeding method and greenhouse screening using cotyledon bio-assay were successfully applied to transfer blackleg resistance from the Australian cultivar Maluka (Brassicas napus), into susceptible advanced B. napus lines from the University of Alberta. This approach for blackleg resistance breeding was effective and efficient as several superior blackleg resistant breeding lines were identified within 4 yr from the initial cross. One of these lines (91–21864NA) was entered in the 1993 trials of the Western Canada Canola/Rapeseed Recommending Committee. Key words: Blackleg resistance, Leptosphaeria maculans, doubled haploid, Brassica napus

Clinical quality improvement project: finding a repeatable approach for improving STAT lab testing

2003 ◽  
Vol 16 (2) ◽  
pp. 1-5
Author(s):  
Lynette Lutes ◽  
Sarvesh Logsetty ◽  
Jan McGuinness ◽  
Joan M. Carlson
Keyword(s):  
Quality Improvement ◽  
Pilot Project ◽  
Improvement Project ◽  
Clinical Quality ◽  
University Of Alberta ◽  
Improved Performance ◽  
The University ◽  
Culture Of Quality ◽  
Quality Process ◽  
Clinical Quality Improvement

Explores the development of a clinical quality improvement pilot project at the University of Alberta Hospital and Stollery Children’s Hospital which aimed to establish a team of individuals that could disseminate a culture of quality improvement and develop a framework for a quality process that could be replicated and repeated. Outcomes of the clinical pilot project included improved performance as well as opportunities to learn some key lessons around team membership and involvement.

The effects of burning on Festuca hallii in the parklands of central Alberta

1995 ◽  
Vol 73 (6) ◽  
pp. 937-942 ◽  
Author(s):  
Heather Sinton Gerling ◽  
Arthur W. Bailey ◽  
Walter D. Willms
Keyword(s):  
Standing Crop ◽  
Growing Season ◽  
Early Spring ◽  
Leaf Length ◽  
Tiller Number ◽  
Phenological Stages ◽  
University Of Alberta ◽  
Festuca Hallii ◽  
Tiller Density ◽  
The University

The response of Festuca hallii (Vassey) Piper to time of burning was examined on the Festuca–Stipa grasslands of the Aspen Parklands at the University of Alberta Ranch located 150 km southeast of Edmonton, Alberta. Two defoliation treatments (burning and mowing) were examined on five dates in 1978 (8 April, 27 April, 1 June, 31 July, and 18 October), corresponding to different phenological stages of F. hallii. Burning and mowing reduced the standing crop of F. hallii produced in the first growing season after treatment, but tiller densities increased. Defoliation in early spring (8 April) had little effect on the standing crop; apparently the increase in tiller density compensated for the reduction in tiller length. Inflorescence density also increased following burning or mowing from 8 April to 1 June. Soil temperature (3 cm deep) on previously burned or mown sites was greater than on the control the year after treatment. Festuca hallii tolerates single burns at any time of the year, but early spring fires have the greatest benefits by increased tillering and standing crop. Key words: standing crop, tiller number, leaf length, litter, defoliation, mowing.

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