The Cys-loop pentameric ligand-gated ion channel receptors: 50 years on

2012 ◽  
Vol 90 (6) ◽  
pp. 771-782 ◽  
Author(s):  
Janna L. Kozuska ◽  
Isabelle M. Paulsen

This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understanding of pLGICs, and highlight the contributions made by members of our department. The individual at the center of our story is Susan Dunn; her passing earlier this year has robbed the Department of Pharmacology and the research community of a most insightful colleague. Her dissection of ligand interactions with the nAChR, together with their interpretation, was the hallmark of her extensive collaborations with Michael Raftery. Here, we highlight some electrophysiological studies from her laboratory over the last few years, using the technique that she introduced to the department in Edmonton, the 2-electrode voltage-clamp of Xenopus oocytes. Finally, we discuss some single-channel studies of the anionic GlyR and GABAAR that prefaced the introduction of this technique to her laboratory.

Botany ◽  
2016 ◽  
Vol 94 (9) ◽  
pp. 661-681 ◽  
Author(s):  
Kathleen B. Pigg ◽  
Melanie L. DeVore

The Princeton chert is one of the most completely studied permineralized floras of the Paleogene. Remains of over 30 plant taxa have been described in detail, along with a diverse assemblage of fungi that document a variety of ecological interactions with plants. As a flora of the Okanagan Highlands, the Princeton chert plants are an assemblage of higher elevation taxa of the latest early to earliest middle Eocene, with some components similar to those in the related compression floras. However, like the well-known floras of Clarno, Appian Way, the London Clay, and Messel, the Princeton chert provides an additional dimension of internal structure. In the present study, we outline the history of Princeton chert plant research, starting with Boneham and others, and extending into studies by Stockey and her students and colleagues. These studies were undertaken primarily at the University of Alberta, Edmonton. We then re-examine the individual elements of the Princeton chert flora, using the framework of the currently recognized Angiosperm Phylogeny Group (APG III) phylogeny and in light of recent fossil discoveries. We hope that this update will bring to mind new aspects of the significance of the Princeton chert flora to Paleogene paleobiology, biogeography, and plant evolution.


Author(s):  
Brianne H. Roos ◽  
Carey C. Borkoski

Purpose The purpose of this review article is to examine the well-being of faculty in higher education. Success in academia depends on productivity in research, teaching, and service to the university, and the workload model that excludes attention to the welfare of faculty members themselves contributes to stress and burnout. Importantly, student success and well-being is influenced largely by their faculty members, whose ability to inspire and lead depends on their own well-being. This review article underscores the importance of attending to the well-being of the people behind the productivity in higher education. Method This study is a narrative review of the literature about faculty well-being in higher education. The history of well-being in the workplace and academia, concepts of stress and well-being in higher education faculty, and evidence-based strategies to promote and cultivate faculty well-being were explored in the literature using electronic sources. Conclusions Faculty feel overburdened and pressured to work constantly to meet the demands of academia, and they strive for work–life balance. Faculty report stress and burnout related to excessively high expectations, financial pressures to obtain research funding, limited time to manage their workload, and a belief that individual progress is never sufficient. Faculty well-being is important for the individual and in support of scholarship and student outcomes. This article concludes with strategies to improve faculty well-being that incorporate an intentional focus on faculty members themselves, prioritize a community of well-being, and implement continuous high-quality professional learning.


2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Sean Luyk

Batten, Jack. Oscar Peterson: The Man and His Jazz. Toronto: Tundra Books, 2012. Print. This young adult non-fiction novel explores the life of the legendary Canadian jazz pianist and composer Oscar Peterson. Beginning with an account of Peterson’s 1949 breakthrough performance at Carnegie Hall as part of the influential Jazz at the Philharmonic (JATP) concert series, Batten traces the seventy year musical career of Oscar Peterson in an engaging and insightful style. This book seamlessly combines a personal and musical biography of Peterson with a history of the development of jazz from the 1920s to the time of Peterson’s death in 2007. True to the title of the book, Batten’s is indeed one about both the man and his music. From Peterson’s humble upbringing as the son of immigrants from the West Indies living in poverty in Montréal, the influence of his family on his personal and musical development is a consistent theme throughout the book. Batten does not hold back when describing the social conditions Peterson was operating under throughout his career. The racism Peterson encountered both at home and abroad, as well as the drug use prominent among jazz musicians is honestly explored, as are the personal tragedies Peterson faced, including his failed marriages and consistently poor health. Peterson’s many longtime musical collaborations are explored in great detail, with Batten highlighting the influential performing and recording achievements of his career. From his longtime relationship with the jazz promoter Norman Granz, through the many iterations of Peterson’s famous trio, Batten doesn’t leave out the details at any point. The addition of multiple photographs, quotes from Peterson’s teachers and collaborators, and a selected bibliography and discography add to the historical richness of this title. This book is recommended to the young adult reader with an interest in jazz history, and the life and accomplishments of one of Canada’s most cherished musicians.Recommended: 3 out of 4 starsReviewer: Sean LuykSean is the Music Librarian for the Rutherford Humanities and Social Sciences Library at the University of Alberta. Sean holds an MA in Music Criticism and B.Mus from McMaster University, as well as an MLIS from the University of Western Ontario.


2012 ◽  
Vol 2 (1) ◽  
Author(s):  
Allison Sivak

Lewis, J. P. Black Cat Bone: the Life of Blues Legend Robert Johnson. Illus. Gary Kelley. Mankato: Creative Editions, 2006. Print.Although this book is designed as a large-format picture book, Black Cat Bone is more likely to appeal to older children (middle school and adolescents) as a poetic text, with its rich illustrations and unusual narrative flow. The foreword of the book addresses a reader who knows some about blues musicians, as well as has some hint of the history of blues music in the United States. The language of the text is not trying to tell a linear story, but to be more evocative of a time, and of some of the historical context. The book actually has several texts: the address of the historical context that bookends the work, the bluesy poems which make up the majority of the text, excerpts from Johnson's own lyrics, and a footer running throughout the book, which provides aphoristic summaries of Johnson's story: “He was destined for legend not a field hand's work.” Each text tells a part of the interpretation of Johnson's story. With the images, it adds up to a faceted narrative of the man and his musical legacy. The illustrations alternate between impressionistic pastels in deep dark colours, reinforcing the air of mystery around Johnson's life as understood by popular culture. Kelley's other illustrative style is reminiscent of Indonesian shadow-puppets, dramatic and exaggerated in their execution. A particularly lovely example is show in full on the cover, a depiction of Johnson and the devil facing each other, each with a hand on the guitar. This image is reproduced in the text, split by the page turn in a clever design turn. Recommended: 3 stars out of 4Reviewer: Allison SivakAllison Sivak is the Assessment Librarian at the University of Alberta Libraries. She is currently pursuing her PhD in Library and Information Studies and Elementary Education, focusing on how the aesthetics of information design influence young people’s trust in the credibility of information content.


1996 ◽  
Vol 39 (1) ◽  
pp. 1-41 ◽  
Author(s):  
Mario Liverani

AbstractThe reconstruction of ancient Near Eastern history has mainly concentrated on urban (and especially palace) environments, leaving the rural landscape outside these analyses. Recent advances in archaeological and palaeobotanical fields greatly help in the recovery of the general outlines of rural exploitation in Mesopotamia and the surrounding regions; yet they cannot but miss the details of the individual exploitation units (fields and orchards), whose size and shape can be reconstructed on the basis of textual data such as cadastral texts (and other administrative recordings) and legal texts (related to the transfer of landed properties). Continuing the author's earlier work on the shape of fields in Ur III (ca. 2100-2000 B.C.), based on cadastral documents from Lagash province in lower Mesopotamia, this article examines, by way of ‘gross’ generalization and occasional exemplification, the entire history of the Mesopotamian landscape from the first administrative landscape in “late-Uruk” documents (ca. 3000 B.C.), down to the Neo-Babylonian documents of the Archaemenid period (ca. 500 B.C.).


2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Sandy Campbell

Qitsualik-Tinsley, Rachel and Sean Qitsualik-Tinsley.  Skraelings. Illus. Andrew Trabbold. Iqaluit, NU:  Inhabit Media, 2014. Print.This volume is the first in the Arctic Moon Magick series.  In it writing duo, Rachael and Sean Qitsualik-Tinsley, have recreated an Inuit world at the time of Viking contact, presented through the eyes of a young Inuit hunter, Kannujaq.  In his travels, he comes across people of the Tuniit culture, of whom he has only heard legends.  He meets Siku, a boy-shaman, whose name means “ice” and is named for his blue eyes.  The Tuniit have been attacked in the past by Vikings from Greenland.  They return each spring and Kannujaq finds himself in the middle of a battle, where he becomes a reluctant warrior. The title Skraelings, which means “Weaklings”, is a Viking taunt to the Tuniit.This is a well written chapter book for ages 12 and older and the language is age-appropriate. There are a few black and white drawings that complement the text.   While much of the story proceeds logically along the plot line,  occasionally, the authors break in, not as narrators, but simply to give the reader additional information.  For example:  "Oh, we forgot to tell you:  Shamans were pretty clever when it came to the things that plants and other natural materials could do" (p. 26). While this is unusual in a novel and breaks the flow of the story, it is completely in keeping with oral storytelling and is rather endearing.  However, this book should not be mistaken for simple story.  It is an engaging read, culminating in a final plot twist that demonstrates the authors’ broad and compassionate understanding of the regional history of the Eastern Arctic. This is an excellent work and unique in young adult Arctic literature.  It should definitely be included in junior high and middle school libraries and public libraries everywhere.Recommendation:  4 stars out of 4Reviewer:  Sandy CampbellSandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines.  Sandy thinks that sharing books with children is one of the greatest gifts anyone can give. 


2012 ◽  
Vol 1 (3) ◽  
Author(s):  
Sandy Campbell

Marsden, Carolyn.  Starfields.  Sommerville, MA.:  Candlewick Press, 2011. Print. This book makes me sad, not for the content, but for the unrealized potential.  The central premise, parallel stories of a modern-day girl in rural Mexico and an ancient Mayan boy-priest, is an interesting one. However, there are several problems with the execution of this work.  When writers fictionalize the culture, religion and history of a group of people, they have a duty to know that group well enough to speak for them.  In addition to thinking carefully about ethical issues that surround cultural appropriation and telling stories that are not theirs to tell, writers must respect their subjects by representing the depth and complexity of their world. California writer Marsden states in her notes that she “gathered information from the photographs and accounts of those who’ve spent time among the contemporary Mayans.”  She also indicates that she has “spent time in Mexico and Belize and … also called upon [her] own personal experience of Mayan culture”. However, many passages read as though they are descriptions of photographs.  The presentation of the people and their relationships also lacks depth. The crisis in this story is the rather clichéd building of a road to the remote village, which is causing environmental damage and threatening traditional ways of life.  It seems absurd, in a land-based society, that a young girl is the only person who could notice that there is an environmental crisis going on. Further she only knows this because a new friend, Alicia, visiting from the city with a research team, points it out to her.  Rosalba is too frightened to speak to the elders until an ancestral boy-priest tells her in a dream to weave images of dead corn fields into her work.  This causes the elders to recognize that there is something wrong with her and then, she has the courage and opportunity to alert them to the crisis. One expects less reality of the story of the boy-priest, because it must, of course, be imaginary.  However, when Rosalba thinks that he has made physical contact with her, and he confirms this in his story line, the plot unexpectedly moves temporarily out of modern day reality into fantasy. There are undeveloped themes throughout the book.  For example Rosalba’s parents were Zapatista revolutionaries, but we learn very little about them. We just know that they would fight for their land.  The title, “Starfields”, refers to the night sky, which both the boy-priest and Rosalba can see.  The starfields are important in Mayan mythology and religion, however, the theme is not developed.  These, combined with the presence of a number of Mayan and Spanish words, which have to be looked up in a glossary and the parallel stories, which do not intersect until close to the end of the book, make for a choppy, disconnected and frustrating read. While sophisticated young adult readers may make their way through it, it would not be a first choice for libraries with limited budgets.Recommended with reservations: 2 out of 4 starsReviewer: Sandy CampbellSandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines.  Sandy thinks that sharing books with children is one of the greatest gifts anyone can give.


2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Sandy Campbell

Evic, Vera.  Trip to the Moon.  Iqaluit, NV:  Inhabit Media, 2013. Print.This simple story manages to be simultaneously local and universal.  Most children can relate to dreaming about flying to the moon, having the sensation of falling while they are dreaming and actually  falling out of bed during a dream.  That’s what happens in this story.  However, the characters in this story live in Pangnirtung on Baffin Island in Nunavut, and the story reflects things local to that place.  In many “flying to the moon” stories, children fly on a magic carpet, boat or a rocket, but these children find a dented and dirty oil drum rusting on the beach and that becomes their enchanted conveyance. This book is the result of a contest, designed to encourage literacy in the community.  Vera Evic’s story was selected from those submitted.  The illustrations are done by five youths who are members of the Pangnirtung-Uqqurmiut Inuit Artist Organization.  Every other page is a full-page brightly-coloured illustration, each showing the individual illustrator’s style.  All of the illustrations depict local things – kids on bikes, houses on stilts, tundra landscape.  Even the little people they meet on the moon are dressed in Inuit style clothing.  While the level of skill varies among the illustrators the differences are charming rather than jarring.The text is printed in English and Inuktitut syllabics. The story is easy to read and appropriate for the intended pre-school and early elementary school audience.   This book deserves stars for the creative involvement of community, the support of literacy and Indigenous language retention in young children and also for the quality of the end product.  Highly recommended for public and elementary school libraries.Highly recommended: 4 stars out of 4 Reviewer:  Sandy CampbellSandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines.  Sandy thinks that sharing books with children is one of the greatest gifts anyone can give.


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