Optimal design with variable cost and precision requirements

1989 ◽  
Vol 19 (12) ◽  
pp. 1591-1597
Author(s):  
Margaret Penner
Keyword(s):  
Biological Sciences ◽  
Optimal Design ◽  
Sample Size ◽  
Design Theory ◽  
Sampling Design ◽  
Unit Cost ◽  
Evaluation Process ◽  
Variable Cost ◽  
Design Flexibility ◽  
The Cost

A method for incorporating variable costs and differing precision requirements into optimal design theory is developed and discussed. In many studies and experiments, particularly in the biological sciences, the cost of each observation can vary considerably depending on the attributes of the sample. Ignoring observation costs leads to designs that maximize precision for a given sample size. However, by incorporating costs, efficiency is maximized by optimizing precision per unit cost. An example is presented that demonstrates the efficiency of a weighted optimal design in comparison with several alternatives. The weighted optimal design is most efficient at meeting the experimenter's precision objectives. Comparing designs allows the introduction of additional criteria such as design flexibility into the evaluation process. Explicitly incorporating both cost and precision in the search for a sampling design ensures time is wisely spent considering study objectives, including precision requirements.

A method for analyzing the typical structure of direct costs in the cost of a laboratory test

2021 ◽  
Vol 66 (3) ◽  
pp. 187-192
Author(s):  
O. O. Ivoylov ◽  
A. G. Kochetov
Keyword(s):  
Laboratory Test ◽  
Laboratory Tests ◽  
Unit Cost ◽  
Direct Costs ◽  
Medical Laboratory ◽  
Variable Cost ◽  
Fixed Costs ◽  
Typical Structure ◽  
Component Structure ◽  
The Cost

The basis for calculating the cost price of any product, including laboratory tests, is based on an estimate of direct costs of the production. At present, there are no systematic ideas about the structure of such costs, and approaches to their analysis have not been defined, in the management practice of medical laboratories. The purpose of this work was developing and testing a method for analyzing the structure of direct costs and their allocation bases when calculating the cost of a laboratory test. We analyzed data on the volume of laboratory tests performed in the clinical diagnostic laboratory of the National Medical Research Center of Cardiology, prices for purchased reagents and consumables, depreciation and maintenance costs of equipment, staff salaries. As a result, we proposed a typical component structure of direct costs, established the allocation bases of fixed costs, and determined the ratio of some variable cost components to onе product unit cost. On the basis of these concepts, an algorithm for calculating the total direct laboratory (technological) cost per test has been developed, which makes it possible to simulate the cost structure under conditions of arbitrarily specified variables. During the testing of the algorithm, the values of direct costs and the technological cost per test were calculated for billable (ordered) laboratory tests. Comparison of the economic efficiency of various methods, as well as modeling of changes in the cost depending on the volume of testing and the turn-around time (TAT) has been performed. It can be concluded that the approach to creating the tables of the technological cost per test based on dividing direct costs into variable and fixed costs and structuring them by components and allocation bases is an effective tool for medical laboratory management.

Studies on the Design of Reverse Osmosis Water Desalination Systems for Cost and Energy Efficiency

2010 ◽  
Author(s):  
Karim Hamza ◽  
Mohammed Shalaby ◽  
Ashraf O. Nassef ◽  
Mohamed F. Aly ◽  
Kazuhiro Saitou
Keyword(s):  
Optimal Design ◽  
Reverse Osmosis ◽  
Fresh Water ◽  
Unit Cost ◽  
Minimum Cost ◽  
Water Desalination ◽  
Salt Ions ◽  
Cost Of Energy ◽  
Flow Through ◽  
The Cost

This paper explores optimal design of reverse osmosis (RO) systems for water desalination. In these systems, salty water flows at high pressure through vessels containing semi-permeable membrane modules. The membranes can allow water to flow through, but prohibit the passage of salt ions. When the pressure is sufficiently high, water molecules will flow through the membranes leaving the salt ions behind, and are collected in a fresh water stream. Typical system design variables include the number and layout of the vessels and membrane modules, as well as the operating pressure and flow rate. This paper presents models for single and two-stage pressure vessel configurations. The models are used to explore the various design scenarios in order to minimize the cost and energy required per unit volume of produced fresh water. Multi-objective genetic algorithm (GA) is used to generate the Pareto-optimal design scenarios for the systems. Case studies are considered for four different water salinity concentration levels. Results of the studies indicate that even though the energy required to drive the RO system is a major contributor to the cost of fresh water production, there exists a tradeoff between minimum energy and minimum cost. An additional parametric study on the unit cost of energy is performed in order to explore future trends. The parametric study demonstrates how an increase in the unit cost of energy may shift the minimum cost designs to shift to more energy-efficient design scenarios.

scholarly journals Economic Design of X̅ Control Chart under Double EWMA

2020 ◽  
Vol 18 (2) ◽  
pp. 2-12
Author(s):  
Manzoor A. Khanday ◽  
J. R. Singh
Keyword(s):  
Optimal Design ◽  
Sample Size ◽  
Control Chart ◽  
Control Charts ◽  
Moving Average ◽  
Sampling Interval ◽  
Economic Design ◽  
Exponentially Weighted Moving Average ◽  
The Cost ◽  
Weighted Moving Average

Designing of parameters plays an important role in economic design of control charts for lowering the cost and time. Manipulating sample size (n) and sampling interval (h), the effect of double exponentially weighted moving average (DEWMA) model was studied for the Economic Design (ED) of X̅ control chart. Optimum sizes and level were obtained when the characteristics of an item possesses DEWMA model. When shifts are uncertain the optimal design for DEWMA chart should be more conservative and should be implemented for benefiting the consumers as well as producers.

Marginal assessment of the cost and benefits of aphasia treatment: Evidence from community-based telerehabilitation treatment for aphasia

2021 ◽  
pp. 1357633X2098277
Author(s):  
Molly Jacobs ◽  
Patrick M Briley ◽  
Heather Harris Wright ◽  
Charles Ellis
Keyword(s):  
Cost Effectiveness ◽  
Economies Of Scale ◽  
Reference Group ◽  
Unit Cost ◽  
Community Based ◽  
Face To Face ◽  
Conduction Aphasia ◽  
Aphasia Treatment ◽  
The Cost ◽  
The Relationship

Introduction Few studies have reported information related to the cost-effectiveness of traditional face-to-face treatments for aphasia. The emergence and demand for telepractice approaches to aphasia treatment has resulted in an urgent need to understand the costs and cost-benefits of this approach. Methods Eighteen stroke survivors with aphasia completed community-based aphasia telerehabilitation treatment, utilizing the Language-Oriented Treatment (LOT) delivered via Webex videoconferencing program. Marginal benefits to treatment were calculated as the change in Western Aphasia Battery-Revised (WAB-R) score pre- and post-treatment and marginal cost of treatment was calculated as the relationship between change in WAB-R aphasia quotient (AQ) and the average cost per treatment. Controlling for demographic variables, Bayesian estimation evaluated the primary contributors to WAB-R change and assessed cost-effectiveness of treatment by aphasia type. Results Thirteen out of 18 participants experienced significant improvement in WAB-R AQ following telerehabilitation delivered therapy. Compared to anomic aphasia (reference group), those with conduction aphasia had relatively similar levels of improvement whereas those with Broca’s aphasia had smaller improvement. Those with global aphasia had the largest improvement. Each one-point of improvement cost between US$89 and US$864 for those who improved (mean = US$200) depending on aphasia type/severity. Discussion Individuals with severe aphasia may have the greatest gains per unit cost from treatment. Both improvement magnitude and the cost per unit of improvement were driven by aphasia type, severity and race. Economies of scale to aphasia treatment–cost may be minimized by treating a variety of types of aphasia at various levels of severity.

scholarly journals Estimating the programmatic cost of targeted mass drug administration for malaria in Myanmar

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shwe Sin Kyaw ◽  
Gilles Delmas ◽  
Tom L. Drake ◽  
Olivier Celhay ◽  
Wirichada Pan-ngum ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Malaria Elimination ◽  
Unit Cost ◽  
Financial Data ◽  
Research Activities ◽  
High Incidence ◽  
Implementation Costs ◽  
The Cost ◽  
Greater Mekong Subregion

Abstract Background Mass drug administration (MDA) has received growing interest to accelerate the elimination of multi-drug resistant malaria in the Greater Mekong Subregion. Targeted MDA, sometimes referred to as focal MDA, is the practice of delivering MDA to high incidence subpopulations only, rather than the entire population. The potential effectiveness of delivering targeted MDA was demonstrated in a recent intervention in Kayin State, Myanmar. Policymakers and funders need to know what resources are required if MDA, targeted or otherwise, is to be included in elimination packages beyond existing malaria interventions. This study aims to estimate the programmatic cost and the unit cost of targeted MDA in Kayin State, Myanmar. Methods We used financial data from a malaria elimination initiative, conducted in Kayin State, to estimate the programmatic costs of the targeted MDA component using a micro-costing approach. Three activities (community engagement, identification of villages for targeted MDA, and conducting mass treatment in target villages) were evaluated. We then estimated the programmatic costs of implementing targeted MDA to support P. falciparum malaria elimination in Kayin State. A costing tool was developed to aid future analyses. Results The cost of delivering targeted MDA within an integrated malaria elimination initiative in eastern Kayin State was approximately US$ 910,000. The cost per person reached, distributed among those in targeted and non-targeted villages, for the MDA component was US$ 2.5. Conclusion This cost analysis can assist policymakers in determining the resources required to clear malaria parasite reservoirs. The analysis demonstrated the value of using financial data from research activities to predict programmatic implementation costs of targeting MDA to different numbers of target villages.

Application and Research of Digital Technology in Optimal Design of CNC Floor Boring and Milling Machine

2012 ◽  
Vol 429 ◽  
pp. 111-115
Author(s):  
Zhen Long Leng ◽  
Jin Feng Yang ◽  
Qun Ping Liu ◽  
Xun Deng
Keyword(s):  
Numerical Simulation ◽  
Optimal Design ◽  
Digital Technology ◽  
Three Dimensional ◽  
Milling Machine ◽  
Machine Model ◽  
Digital Modeling ◽  
Key Technologies ◽  
The Cost ◽  
Interference Checking

This paper focuses on application of the three-dimensional digital modeling, numerical analysis and optimization, digital control and other key technologies which provide technical support for the design and development in CNC floor boring and milling machine manufactruing. The three-dimensional digital modeling, digital assembly, interference checking help to eliminate some hidden trouble before processing and assembly. Numerical simulation reduces the cost and shortens the cycle of designand manufactruing in the optimal design of the machine. This technique has been successfully applied to a CNC Floor Boring and Milling Machine Model, which has been running for three years and achieved satisfactary economic result.

Penetapan Tarif Ambulans Untuk Evakuasi Medis Berbasis Unit Cost

2021 ◽  
Vol 7 (1) ◽  
pp. 167-173
Author(s):  
Kelvin Riupassa ◽  
Narizma Nova ◽  
Endah Lestari ◽  
Sri Juniarti Azis ◽  
Wahyu Sulistiadi
Keyword(s):  
Recovery Rate ◽  
Unit Cost ◽  
Cost Recovery ◽  
Maintenance Costs ◽  
Total Cost ◽  
Medical Evacuation ◽  
Operational Costs ◽  
Emergency Ambulance ◽  
The Cost ◽  
Cost Components

Background: An ambulance is a vehicle designed to be able to handle emergency patients, provide first aid and carry out intensive care while on the way to a referral hospital. Ambulance operations require a large amount of funds obtained from APBD funds through tariffs that were passed through the DKI Jakarta Governor Regulation five years ago. For this reason, a new tariff is required to adjust to current conditions. Objectives: The purpose of this study is to calculate the unit cost of ambulance services in DKI Jakarta to be a consideration in the tariff setting policy in DKI Jakarta province. Research Metodes: This study uses a quantitative descriptive approach to obtain information about the unit cost of the Jakarta ambulance production unit. The method used is the calculation of real cost using the basis of the causes of costs. This research was conducted at the DKI Jakarta Emergency Ambulance using secondary data on investment costs, operational costs and maintenance costs in 2018. Results: The total cost of emergency ambulance in 2018 is known that the proportion of three cost components, namely operational costs, is 76%, followed by investment costs of 20% and maintenance costs of 3%. The calculation of the total cost of medical evacuation using the double distribution method is Rp. 98,915,016,805.00 divided by the number of medical evacuations in 2018 of 37,564 activities, the unit cost of medical evacuation for the AGD of DKI Jakarta Health Office is Rp. 2,633,215.00 without subsidies. APBD costs, while if the subsidy component is included in the calculation, the unit cost for one trip to the AGD of the Health Office is Rp. 604,071.00. This is still far above the current tariff of Rp. 450.00, so the cost recovery rate (CRR) is still below. 100%. Conclusion: From the three cost components consisting of investment, operational and maintenance costs,the largest proportion was operational costs at 76%. The Cost Recovery Rate has not reached 100% so that the existing rates have not covered the costs incurred.   Keywords: ambulance; price fixing; unit cost

scholarly journals Direct cost of connecting, maintaining and disconnecting patient-controlled analgesia pump

2014 ◽  
Vol 48 (1) ◽  
pp. 104-109 ◽  
Author(s):  
Áquila Lopes Gouvêa ◽  
Antônio Fernandes Costa Lima
Keyword(s):  
Quantitative Research ◽  
Unit Cost ◽  
Patient Controlled Analgesia ◽  
Unified Health System ◽  
Effective Decision ◽  
The Mean ◽  
Effective Decision Making ◽  
Cost Of Materials ◽  
The Cost ◽  
Probabilistic Sample

Quantitative research that aimed to identify the mean total cost (MTC) of connecting, maintaining and disconnecting patient-controlled analgesia pump (PCA) in the management of pain. The non-probabilistic sample corresponded to the observation of 81 procedures in 17 units of the Central Institute of the Clinics Hospital, Faculty of Medicine, University of Sao Paulo. We calculated the MTC multiplying by the time spent by nurses at a unit cost of direct labor, adding the cost of materials and medications/solutions. The MTC of connecting was R$ 107.91; maintenance R$ 110.55 and disconnecting R$ 4.94. The results found will subsidize discussions about the need to transfer money from the Unified Health System to hospitals units that perform this technique of analgesic therapy and it will contribute to the cost management aimed at making efficient and effective decision-making in the allocation of available resources.

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