Article

1999 ◽  
Vol 77 (10) ◽  
pp. 1648-1654
Author(s):  
F Williot ◽  
M Bernard ◽  
D Lucas ◽  
Y Mugnier ◽  
J Lessard
Keyword(s):  
Mass Spectrometry ◽  
Key Words ◽  
Electrochemical Reduction ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Base Catalysis ◽  
Chain Reaction ◽  
Chain Reactions

The electrochemical reduction of nitrosobenzene (PhNO) in the presence of cyclopentadiene derivatives containing the indenyl group represented as In'H2 (10a, 10b, and 12b) gives the imine derivatives PhN=In'. The process requires only a catalytic amount of electricity. When the electrolysis of aromatic aldehydes (ArCHO), 2,6-dichlorobenzaldehyde (1a), benzaldehyde (1b) and terephthalaldehyde (2), is performed in the presence of the In'H2 derivatives, compounds ArCH=In' are obtained in low yields. These compounds have been characterized by mass spectrometry and microanalysis. The overall process involves two consecutive chain reactions with regeneration of the anion In'H-.Key words: electrochemical reduction, nitrosobenzene, aromatic aldehydes, base catalysis, chain reaction.

Electrochemically induced chain reactions: the addition of fluorene and indene to aromatic aldehydes initiated by electrochemical reduction

1996 ◽  
Vol 74 (1) ◽  
pp. 55-63 ◽  
Author(s):  
J. C. Gard ◽  
B. Hanquet ◽  
L. Roullier ◽  
Y. Mugnier ◽  
J. Lessard
Keyword(s):  
Electrochemical Reduction ◽  
Supporting Electrolyte ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Proton Donor ◽  
Base Catalysis ◽  
Tetrabutylammonium Perchlorate ◽  
Chain Reaction ◽  
Chain Reactions ◽  
Voltammetric Behavior

The electrochemical reduction at −30 °C of 2,6-dichlorobenzaldehyde (1a), benzaldehyde (1b), and terephthalaldehyde (2) in tetrahydrofuran with tetrabutylammonium perchlorate as supporting electrolyte, under an argon atmosphere and in the presence of fluorene or indene, gives carbinols resulting from the addition of fluorene or indene and requires only a catalytic amount of electricity. The chain reaction is initiated by proton abstraction from fluorene or indene by a base electrogenerated by reduction of the aldehyde and the propagation involves the addition of the carbanion to the aldehyde followed by regeneration of the nucleophile by proton transfer from the proton donor to the alkoxide anion (base-catalyzed addition). The voltammetric behavior of the aldehydes in the absence and in the presence of fluorene or indene is also presented. Key words: electrochemical reduction, aromatic aldehydes, addition of fluorene (indene), base catalysis, chain reaction.

Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents

2020 ◽  
Vol 23 ◽  
Author(s):  
Hadis Khodadad ◽  
Farhad Hatamjafari ◽  
Khalil Pourshamsian ◽  
Babak Sadeghi
Keyword(s):  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Biological Evaluation ◽  
Aureus Strain ◽  
Microwave Assisted Synthesis ◽  
Pyrazole Derivatives ◽  
Microwave Assisted

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.

Zinc Sulfamate Catalyzed Efficient Selective Synthesis of Benzimidazole Derivatives under Ambient Conditions

2019 ◽  
Vol 16 (9) ◽  
pp. 740-749
Author(s):  
Sushil R. Mathapati ◽  
Arvind H. Jadhav ◽  
Mantosh B. Swami ◽  
Jairaj K. Dawle
Keyword(s):  
Benzimidazole Derivative ◽  
Sulfamic Acid ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Product Yield ◽  
Lewis Acidity ◽  
Benzimidazole Derivatives ◽  
Ambient Conditions ◽  
Reaction Condition ◽  
Green Approach

Zinc sulfamate (Zn(NH2SO3)2 is a derivative of sulfamic acid (H3NSO3) which possesses “Lewis acidity” and finds well suited in a number of catalytic applications. The present paper describes an efficient, eco-friendly, and clean synthesis of 2-substituted benzimidazole derivatives by reacting diverse o-phenylenediamine with various substituted aromatic aldehydes using a catalytic amount of zinc sulfamate in ethanol at ambient temperature. As a result, 10 mol.% of Zinc sulfamate catalyst showed 92% of respective product yield with 100% conversion using short reaction period in ethanol. Meanwhile, effect of reaction parameters, such as amount of catalyst, different solvents, and reaction temperature on reaction product, was also studied. In addition, in the optimized reaction condition various substituted biological important benzimidazoles derivatives were prepared by using optimized reaction condition in good to efficient yield. In addition, possible reaction mechanism in the presence of zinc sulfamate for the preparation of benzimidazole derivative was sketched and discussed. The present green approach showed significances with faster reaction rate with inexpensive catalyst, which showed excellent and clean yield of benzimidazole in mild reaction condition with easy work-up procedure.

An ICR mass spectrometry study of ion/molecule reactions between ethyl chloride and alkylamines

1991 ◽  
Vol 69 (2) ◽  
pp. 363-367
Author(s):  
Guoying Xu ◽  
Jan A. Herman
Keyword(s):  
Mass Spectrometry ◽  
Key Words ◽  
Rate Constant ◽  
Rate Constants ◽  
Ethyl Chloride ◽  
Ion Molecule Reactions ◽  
Mass Spectrometry Study ◽  
Ethyl Cation

Ion/molecule reactions in mixtures of ethyl chloride with C1–C4 alkylamines were studied by ICR mass spectrometry. Ethyl cation transfer to C1–C4 alkylamines proceeds mainly through diethylchloronium ions with rate constants ~3 × 10−10cm3 s−1. In the case of s-butylamine the corresponding rate constant is 0.5 × 10−10 cm3 s−1. Key words: ICR mass spectrometry, ion/molecule reactions, ethylchloride, methylamine, ethylamine, propylamines, butylamines

Investigation of Mutations in Exon 12 Of MYH7, 16 Of β-MYBPC3 and 2 Of TCAP Gene in Dogs with Dilated Cardiomyopathy using PCR-SSCP Technique

2021 ◽  
Author(s):  
R.B. Vishnurahav ◽  
S. Ajithkumar ◽  
Usha Narayana Pillai ◽  
N. Madhvan Unny ◽  
K.D. John Martin ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Dilated Cardiomyopathy ◽  
Genetic Alterations ◽  
Chain Reaction ◽  
Multifunctional Protein ◽  
Chain Reactions ◽  
Polymerase Chain Reactions ◽  
Intron 1 ◽  
Cardiac Disorders ◽  
Polymerase Chain

Background: Dilated cardiomyopathy is the important myocardial disease and one of the most common cause of death in the medium to large size dog breeds worldwide. The disease is characterized by dilatation of cardiac chambers and thinning of walls leads to systolic failure. Mutations in some sarcomere genes leads to cardiomyopathy in humans. Sarcomere is an important multifunctional protein network involved in the signal reception and transduction. Mutations in β-MYH7, MYBPC3 and TCAP genes produce alterations in the morphology of heart (hypertrophy or dilatation).Methods: In this study twenty apparently healthy and twenty five dogs with dilated cardiomyopathy (DCM) were selected from patients reported or referred to University Veterinary Hospital and Teaching Veterinary Clinical Complex, Mannuthy (2015-2017) based on the clinical examination, radiographic, electrocardiographic, haematobiochemical and echocardiographic studies cardiac disorders (Dilated cardiomyopathy and hypertrophic cardiomyopathy) were confirmed.Result: In the present study we investigated genetic alterations of exon 12 of MYH7, 16 of β-MYBPC3 and 2 of TCAP gene in dogs by polymerase chain reaction -single stranded confirmation of polymorphism (PCR-SSCP). Polymerase chain reactions were analysed using acrylamide gel and samples with different pattern of bands were sequenced. Polymerase chain reaction-SSCP showed different migration of band pattern in the intron 1 of TCAP gene in one sample.

Electrochemically induced chain reactions. Reactions of aromatic aldehydes induced by electrogenerated bases

1999 ◽  
Vol 23 (10) ◽  
pp. 993-999 ◽  
Author(s):  
Michaël Bernard ◽  
Dominique Lucas ◽  
Bernard Hanquet ◽  
Yves Mugnier ◽  
Jean Lessard
Keyword(s):  
Aromatic Aldehydes ◽  
Chain Reactions

An efficient synthesis of 3-alkyl-2-diversity-substituted benzofuro[3,2-d]pyrimidin-4(3H)-one derivatives

2019 ◽  
Vol 43 (5-6) ◽  
pp. 201-204 ◽  
Author(s):  
Hong-Mei Wang ◽  
Tian-Shuai Wang ◽  
Sheng-Jie He ◽  
Zong-Yun Chen ◽  
Yang-Gen Hu
Keyword(s):  
Mass Spectrometry ◽  
Sodium Ethoxide ◽  
Catalytic Amount ◽  
Alkyl Halides ◽  
Efficient Synthesis ◽  
Pyrimidine Derivatives ◽  
Excess Carbon ◽  
H Nmr ◽  
Aliphatic Esters ◽  
C Nmr

Benzofuro[3,2- d]pyrimidine derivatives are prepared using aza-Wittig reactions of iminophosphoranes with n-butyl isocyanate at 40–50 °C to give carbodiimide intermediates, which are reacted with nitrogen-oxygen-containing nucleophiles to give 3-alkyl-2-amino (aryloxy/alkoxy)-benzofuro[3,2- d]pyrimidin-4(3 H)-ones in satisfactory yields in the presence of a catalytic amount of sodium ethoxide or K2CO3. The iminophosphorane also reacts directly with excess carbon disulfide, followed by n-propylamine; further reaction with alkyl halides or halogenated aliphatic esters in the presence of anhydrous K2CO3 produces the corresponding 2-alkylthio-3-n-propyl-benzofuro[3,2- d]pyrimidin-4(3 H)-ones in good yields. Their structures of the products are confirmed by 1H NMR, 13C NMR, mass spectrometry, infrared and elemental analysis.

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