Synthesis and in vitro activity of several new carbapenems

1986 ◽  
Vol 64 (11) ◽  
pp. 2184-2191 ◽  
Author(s):  
Yasutsugu Ueda ◽  
Viviane Vinet
Keyword(s):  
Carboxylic Acids ◽  
Alder Reaction ◽  
Diels Alder ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Diels Alder Reaction

The synthesis and in vitro activity of several new carbapenems, 2-(3-cis-substituted cyclopentylthio)- and 2-(4-cis-substituted cyclohexylthio)-(6S)-[(1′R)-hydroxyethyl]-(5R)-carbapen-2-em-3-carboxylic acids 7 and 8, are described. The synthesis involves the stereospecific preparation of cis-substituted cyclopentyl- and cyclohexylthiols 2 and 3 by the hetero Diels–Alder reaction followed by some chemical manipulations.

scholarly journals Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction andin vitroanticancer studies

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16802-16814 ◽  
Author(s):  
Pravati Panda ◽  
Sabita Nayak ◽  
Susanta Ku. Sahoo ◽  
Seetaram Mohapatra ◽  
Deepika Nayak ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Diels Alder Reaction

Synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction has been demonstrated and evaluated for theirin vitroanticancer activity.

Asymmetric synthesis of 2-aminonorbornane-2-carboxylic acids by Diels-Alder reaction

1991 ◽  
Vol 2 (12) ◽  
pp. 1295-1304 ◽  
Author(s):  
Carlos Cativiela ◽  
Pilar López ◽  
José A. Mayoral
Keyword(s):  
Asymmetric Synthesis ◽  
Carboxylic Acids ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction

New synthetic approach to substituted isoindolo[2,1-a]quinoline carboxylic acids via intramolecular Diels–Alder reaction of 4-(N-furyl-2)-4-arylaminobutenes-1 with maleic anhydride

Tetrahedron ◽  
2005 ◽  
Vol 61 (16) ◽  
pp. 4099-4113 ◽  
Author(s):  
Fedor I. Zubkov ◽  
Ekaterina V. Boltukhina ◽  
Konstantin F. Turchin ◽  
Roman S. Borisov ◽  
Alexey V. Varlamov
Keyword(s):  
Maleic Anhydride ◽  
Carboxylic Acids ◽  
Alder Reaction ◽  
Diels Alder ◽  
Synthetic Approach ◽  
Diels Alder Reaction

scholarly journals Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities

RSC Advances ◽  
2020 ◽  
Vol 10 (69) ◽  
pp. 42287-42296
Author(s):  
Diego R. Merchán-Arenas ◽  
Felipe Sojo ◽  
Francisco Arvelo ◽  
Vladimir V. Kouznetsov
Keyword(s):  
In Silico ◽  
Biological Properties ◽  
Alder Reaction ◽  
Diels Alder ◽  
Antitumor Activities ◽  
Diels Alder Reaction ◽  
In Silico Admet

We synthesized a series of dihydroisoindolo[2,1-a]quinolin-11-ones using the imino Diels–Alder reaction and evaluated their biological properties, finding a new hit in anticancer research.

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