scholarly journals Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities

RSC Advances ◽  
2020 ◽  
Vol 10 (69) ◽  
pp. 42287-42296
Author(s):  
Diego R. Merchán-Arenas ◽  
Felipe Sojo ◽  
Francisco Arvelo ◽  
Vladimir V. Kouznetsov
Keyword(s):  
In Silico ◽  
Biological Properties ◽  
Alder Reaction ◽  
Diels Alder ◽  
Antitumor Activities ◽  
Diels Alder Reaction ◽  
In Silico Admet

We synthesized a series of dihydroisoindolo[2,1-a]quinolin-11-ones using the imino Diels–Alder reaction and evaluated their biological properties, finding a new hit in anticancer research.

scholarly journals Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction andin vitroanticancer studies

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16802-16814 ◽  
Author(s):  
Pravati Panda ◽  
Sabita Nayak ◽  
Susanta Ku. Sahoo ◽  
Seetaram Mohapatra ◽  
Deepika Nayak ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Diels Alder Reaction

Synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction has been demonstrated and evaluated for theirin vitroanticancer activity.

scholarly journals A synthetic and in silico study on the highly regioselective Diels–Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin

2010 ◽  
Vol 51 (38) ◽  
pp. 4968-4971
Author(s):  
Zsolt Fejes ◽  
Attila Mándi ◽  
István Komáromi ◽  
László Majoros ◽  
Gyula Batta ◽  
...  
Keyword(s):  
In Silico ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Antifungal Antibiotics ◽  
In Silico Study

Synthesis and in vitro activity of several new carbapenems

1986 ◽  
Vol 64 (11) ◽  
pp. 2184-2191 ◽  
Author(s):  
Yasutsugu Ueda ◽  
Viviane Vinet
Keyword(s):  
Carboxylic Acids ◽  
Alder Reaction ◽  
Diels Alder ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Diels Alder Reaction

The synthesis and in vitro activity of several new carbapenems, 2-(3-cis-substituted cyclopentylthio)- and 2-(4-cis-substituted cyclohexylthio)-(6S)-[(1′R)-hydroxyethyl]-(5R)-carbapen-2-em-3-carboxylic acids 7 and 8, are described. The synthesis involves the stereospecific preparation of cis-substituted cyclopentyl- and cyclohexylthiols 2 and 3 by the hetero Diels–Alder reaction followed by some chemical manipulations.

scholarly journals A New Family of Rigid Dienone Musks Challenges the Perceptive Range of the Human Olfactory Receptor OR5AN1

Synlett ◽  
2020 ◽  
Vol 31 (10) ◽  
pp. 972-976
Author(s):  
Quanrui Wang ◽  
Sereina Riniker ◽  
Philip Kraft ◽  
Jie Liu ◽  
Vera Hürlimann ◽  
...  
Keyword(s):  
Claisen Rearrangement ◽  
Alder Reaction ◽  
Diels Alder ◽  
Domino Reaction ◽  
Vitro Assay ◽  
New Family ◽  
Diels Alder Reaction ◽  
Nitro Musks ◽  
Acid Catalyzed

A new family of dienone musks was discovered by alkylation of different aldehydes with but-3-en-1-yn-1-yllithium and subsequent domino reaction of a Saucy–Marbet transfer vinylation–Claisen rearrangement with an intramolecular Diels–Alder reaction, and concluding Lewis acid catalyzed double-bond isomerization. The newly synthesized dienone structures possess pleasant musk odors displaying fatty, slightly fruity and green facets. Although the dienone musks were predicted in silico to bind to the OR5AN1 receptor based on QM/MM calculations, they were found to be inactive in the in vitro assay. The latter results suggest that the OR5AN1 receptor is not the prime musk receptor but primarily responsible for the animalic character of certain macrocyclic ketones and nitro musks.

scholarly journals Synthesis and Antifungal in Vitro Evaluation of Pyrazolo[3,4-b]pyridines Derivatives Obtained by Aza-Diels–Alder Reaction and Microwave Irradiation

2017 ◽  
Vol 65 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Jairo Quiroga ◽  
Yazmín Villarreal ◽  
Jaime Gálvez ◽  
Alejandro Ortíz ◽  
Braulio Insuasty ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction
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