The Darzens glycidic ester condensation of indan-1-ones. A reinvestigation of the reaction

1978 ◽  
Vol 56 (5) ◽  
pp. 730-732 ◽  
Author(s):  
Gerry Kavadias ◽  
Stephan Velkof
Keyword(s):  
Carboxylic Acid ◽  
High Yield ◽  
Ethyl Chloroacetate ◽  
Inflammatory Agent ◽  
Ester Condensation ◽  
Anti Inflammatory

The Darzens glycidic ester condensation of indan-1-one (1a) with ethyl chloroacetate was reinvestigated. Contrary to previous reports, the reaction proceeded normally yielding the glycidic ester 2a in high yield. Similarly, 5-cyclohexylindan-1-one (1b) produced the glycidic ester 2b. The glycidic esters 2a,b were converted to the corresponding aldehydes 4a,b by hydrolysis and decarboxylation. Oxidation of 4b yielded (±)-5-cyclohexylindan-1-carboxylic acid (3), a potent anti-inflammatory agent.

Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review

2020 ◽  
Vol 16 (8) ◽  
pp. 1134-1146
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve ◽  
Uttam S. Baghel
Keyword(s):  
Rheumatoid Arthritis ◽  
Adverse Effects ◽  
Chronic Conditions ◽  
Review Article ◽  
Google Scholar ◽  
Medical Community ◽  
Inflammatory Agent ◽  
Skin Cancers ◽  
Medicinal Properties ◽  
Anti Inflammatory

Objective: Helenalin is a natural anti-inflammatory agent that is proving its efficacy to treat various medical conditions. Though many plants are proving their effectiveness but their mechanisms are still not well understood. The objective of the review is to summarize various mechanisms of helenalin to treat inflammatory disorders and cancers, adverse effects, and avenues of further research. Methods: Structured research was carried out including Pub med, Science direct Medline, Research Gate and Google Scholar to find all articles published on helenalin. Various keywords used were “helenalin”, “Arnica”, “cancer”, “anti-inflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc. The aim of the review was to find out the problem prevailing in the data published to date which will help the researchers to investigate the molecule clinically. Results: Seventy articles are included in the review. Helenalin is found to cure chronic conditions like rheumatoid arthritis, ulcers and malignancies like stomach, colon, breast, larynx, lung and skin cancers via multiple mechanisms. These diseases do not proceed via a unilateral pathway. So, it can be a useful molecule to treat numerous diseases. Conclusion: This review article will help us to systemically analyze the wealth of information concerning the medicinal properties of helenalin and to recognize the gaps which have vetoed its pervasive application in the medical community.

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