THE SPECIFICITY OF HYDROGEN BOND FORMATION BETWEEN DERIVATIVES OF NUCLEIC ACID BASES AND SOME ANALOGUES

1966 ◽  
Vol 44 (9) ◽  
pp. 1045-1050 ◽  
Author(s):  
J. Pitha ◽  
R. Norman Jones ◽  
P. Pithova
Keyword(s):  
Chloroform Solution ◽  
Infrared Spectrophotometry ◽  
Nucleic Acid Bases ◽  
Desoxyribonucleic Acid ◽  
Hydrogen Bond Formation ◽  
Naturally Occurring ◽  
Ring Nitrogen ◽  
Pharmacologically Active ◽  
Derivatives Of ◽  
Ring Nitrogen Atom

Hydrogen bonding between pairs of derivatives of the base constituents of nucleic acids and their analogues has been studied in chloroform solution by infrared spectrophotometry. The strongest interactions occur between derivatives of guanine and cytosine. The introduction of the additional ring nitrogen atom in the pharmacologically active 5-azacytosine and 6-azacytosine derivatives does not change the complexing behavior. The positions of the N—H stretching bands in the infared spectra indicate that these complexes have a structure similar to that of the complexes formed between the corresponding pairs of bases in the naturally occurring desoxyribonucleic acid chain.

Übergangsmetallkomplexe mit Nitroxidradikalen: Palladium-, Platin-, Pentamethylcyclopentadienyl-rhodium- und -iridium-Komplexe sowie α-Aminocarboxylatkomplexe mit Donor-haltigen Derivaten des 2,5-Dihydroimidazol-l-oxyls / Transition Metal Complexes of Nitroxide Radicals, Palladium, Platinum, Pentamethylcyclopentadienyl Rhodium and Iridium Complexes, and α-Aminocarboxylate Complexes with Derivatives of 2,5-Dihydroimidazole-l-oxyls

1998 ◽  
Vol 53 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Frank Hintermaier ◽  
Sylvia Helding ◽  
Leonid B. Volodarsky ◽  
Karlheinz Sünkel ◽  
Kurt Polbom ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Molecular Structures ◽  
Iridium Complexes ◽  
X Ray Diffraction ◽  
Chelate Complexes ◽  
X Ray ◽  
Ring Nitrogen ◽  
Derivatives Of ◽  
Ring Nitrogen Atom ◽  
Palladium Platinum

2,5-Dihydroimidazoline-l-oxyl radicals I, II with imino substituents coordinate to Pd(II) and Pt(II) complexes with formation of the N,N chelate complexes 1-6. With oxygen containing substituents either monodentate N-coordination to give 8 or N ,O chelate formation to give 9 takes place, depending on the position of the oxygen atom relative to the ring nitrogen atom. With radicals III that also have the second ring nitrogen atom oxidized and the Rh(III) or Ir(III) complexes [Cp*MCl2]2 the O , O chelates 11 -13 could be obtained, while with Na2PdCl4 the heterocycle was destroyed with formation of a N,N chelate complex 10 of an α-nitrosooxime ligand. The orthopalladated 2,2,5,5 tetramethyl-4-phenyl-2,5-dihydroimidazoline-l-oxyl complex 7a reacts with several a-amino acidates under splitting of the dichloro bridge with formation of the C,N/N,O-bis-chelate complexes 7b-f. The molecular structures of 2 and 10 were determined by X-ray diffraction.

scholarly journals Exploring the Isomer Dependent SERS Spectra of (diphenylphosphoryl)(pyridin-2, -3, and -4-yl)methanol Adsorbed on Gold Nanocolloids

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Pięta ◽  
Edyta Proniewicz ◽  
Bogdan Boduszek ◽  
Tomasz K. Olszewski ◽  
Younkyoo Kim ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Adsorption Process ◽  
Gold Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Ring Nitrogen ◽  
Derivatives Of ◽  
Ring Nitrogen Atom ◽  
Surface Changes

The surface-enhanced Raman scattering (SERS) spectra of three aminophosphonate derivatives of pyridine: (diphenylphosphoryl)(pyridin-2-yl)methanol (α-Pyr), (diphenylphosphoryl)(pyridin-3-yl)methanol (β-Pyr), and (diphenylphosphoryl)(pyridin-4-yl)methanol (γ-Pyr) were measured after immobilization onto colloidal gold surface. Changes in the wavenumber, broadness, and enhancement between the corresponding Raman and SERS bands allowed to deduce orientation of theα-,β-, andγ-isomers (α-,β-, andγ-refer to the position of the substituent relative to the ring nitrogen atom) of aminophosphonate derivatives of pyridine on the gold surface. Briefly, it was demonstrated that theα-Pyr andβ-Pyr show the same mode of adsorption, whereas the adsorption process of theγ-Pyr isomer differs in this regard that pyridine assists in the interaction with the gold surface.

scholarly journals Podophyllotoxin: History, Recent Advances and Future Prospects

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 603
Author(s):  
Zinnia Shah ◽  
Umar Farooq Gohar ◽  
Iffat Jamshed ◽  
Aamir Mushtaq ◽  
Hamid Mukhtar ◽  
...  
Keyword(s):  
Structure Optimization ◽  
Cytokine Storm ◽  
Chemotherapeutic Drug ◽  
Future Prospects ◽  
Naturally Occurring ◽  
Pharmacologically Active ◽  
Almost All ◽  
Pharmacologically Active Compounds ◽  
Synthetic Derivatives ◽  
Related Compounds

Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior anticancer activity. It has recently been redeveloped for the purpose of treating cytokine storm in COVID-19 patients. Podophyllotoxin and its naturally occurring congeners have low bioavailability and almost all these initially discovered compounds cause systemic toxicity and development of drug resistance. Moreover, the production of synthetic derivatives that could suffice for the clinical limitations of these naturally occurring compounds is not economically feasible. These challenges demanded continuous devotions towards improving the druggability of these drugs and continue to seek structure-optimization strategies. The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This review focuses on the exigency of innovation and research required in the global R&D and pharmaceutical industry for podophyllotoxin and related compounds based on recent scientific findings and market predictions.

scholarly journals Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid

2015 ◽  
Vol 71 (4) ◽  
pp. 262-265 ◽  
Author(s):  
Subramanya Pingali ◽  
James P. Donahue ◽  
Florastina Payton-Stewart
Keyword(s):  
Hydrogen Bonds ◽  
Crystal Packing ◽  
Racemic Mixture ◽  
Inversion Center ◽  
Intermolecular Hydrogen Bonds ◽  
Naturally Occurring ◽  
Pharmacologically Active

Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72 (5)° between the arene rings at the two ends of the reduced quinolizinium core. The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benzodioxole –CH2...OCH3and –OCH3...OCH3interactions between neighboring molecules.

Analogs and derivatives of tenoxicam. 1. Synthesis and antiinflammatory activities of analogs with different residues on the ring nitrogen and the amide nitrogen

1987 ◽  
Vol 30 (4) ◽  
pp. 678-682 ◽  
Author(s):  
Dieter Binder ◽  
Otto Hromatka ◽  
Franz Geissler ◽  
Karl Schmied ◽  
Christian R. Noe ◽  
...  
Keyword(s):  
Amide Nitrogen ◽  
Ring Nitrogen ◽  
Derivatives Of

ChemInform Abstract: SEARCH FOR PHARMACOLOGICALLY ACTIVE COMPOUNDS IN A SERIES OF AMINOMETHYL DERIVATIVES OF 5-HYDROXYBENZOFURAN

1979 ◽  
Vol 10 (29) ◽  
Author(s):  
A. N. GRINEV ◽  
N. V. ARKHANGEL'SKAYA ◽  
G. YA. URETSKAYA ◽  
A. A. STOLYARCHUK ◽  
P. A. GALENKO-YAROSHEVSKII
Keyword(s):  
Active Compounds ◽  
Aminomethyl Derivatives ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds ◽  
Derivatives Of
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