Analogs and derivatives of tenoxicam. 1. Synthesis and antiinflammatory activities of analogs with different residues on the ring nitrogen and the amide nitrogen

1987 ◽  
Vol 30 (4) ◽  
pp. 678-682 ◽  
Author(s):  
Dieter Binder ◽  
Otto Hromatka ◽  
Franz Geissler ◽  
Karl Schmied ◽  
Christian R. Noe ◽  
...  
Keyword(s):  
Amide Nitrogen ◽  
Ring Nitrogen ◽  
Derivatives Of

Übergangsmetallkomplexe mit Nitroxidradikalen: Palladium-, Platin-, Pentamethylcyclopentadienyl-rhodium- und -iridium-Komplexe sowie α-Aminocarboxylatkomplexe mit Donor-haltigen Derivaten des 2,5-Dihydroimidazol-l-oxyls / Transition Metal Complexes of Nitroxide Radicals, Palladium, Platinum, Pentamethylcyclopentadienyl Rhodium and Iridium Complexes, and α-Aminocarboxylate Complexes with Derivatives of 2,5-Dihydroimidazole-l-oxyls

1998 ◽  
Vol 53 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Frank Hintermaier ◽  
Sylvia Helding ◽  
Leonid B. Volodarsky ◽  
Karlheinz Sünkel ◽  
Kurt Polbom ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Molecular Structures ◽  
Iridium Complexes ◽  
X Ray Diffraction ◽  
Chelate Complexes ◽  
X Ray ◽  
Ring Nitrogen ◽  
Derivatives Of ◽  
Ring Nitrogen Atom ◽  
Palladium Platinum

2,5-Dihydroimidazoline-l-oxyl radicals I, II with imino substituents coordinate to Pd(II) and Pt(II) complexes with formation of the N,N chelate complexes 1-6. With oxygen containing substituents either monodentate N-coordination to give 8 or N ,O chelate formation to give 9 takes place, depending on the position of the oxygen atom relative to the ring nitrogen atom. With radicals III that also have the second ring nitrogen atom oxidized and the Rh(III) or Ir(III) complexes [Cp*MCl2]2 the O , O chelates 11 -13 could be obtained, while with Na2PdCl4 the heterocycle was destroyed with formation of a N,N chelate complex 10 of an α-nitrosooxime ligand. The orthopalladated 2,2,5,5 tetramethyl-4-phenyl-2,5-dihydroimidazoline-l-oxyl complex 7a reacts with several a-amino acidates under splitting of the dichloro bridge with formation of the C,N/N,O-bis-chelate complexes 7b-f. The molecular structures of 2 and 10 were determined by X-ray diffraction.

scholarly journals Exploring the Isomer Dependent SERS Spectra of (diphenylphosphoryl)(pyridin-2, -3, and -4-yl)methanol Adsorbed on Gold Nanocolloids

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Pięta ◽  
Edyta Proniewicz ◽  
Bogdan Boduszek ◽  
Tomasz K. Olszewski ◽  
Younkyoo Kim ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Adsorption Process ◽  
Gold Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Ring Nitrogen ◽  
Derivatives Of ◽  
Ring Nitrogen Atom ◽  
Surface Changes

The surface-enhanced Raman scattering (SERS) spectra of three aminophosphonate derivatives of pyridine: (diphenylphosphoryl)(pyridin-2-yl)methanol (α-Pyr), (diphenylphosphoryl)(pyridin-3-yl)methanol (β-Pyr), and (diphenylphosphoryl)(pyridin-4-yl)methanol (γ-Pyr) were measured after immobilization onto colloidal gold surface. Changes in the wavenumber, broadness, and enhancement between the corresponding Raman and SERS bands allowed to deduce orientation of theα-,β-, andγ-isomers (α-,β-, andγ-refer to the position of the substituent relative to the ring nitrogen atom) of aminophosphonate derivatives of pyridine on the gold surface. Briefly, it was demonstrated that theα-Pyr andβ-Pyr show the same mode of adsorption, whereas the adsorption process of theγ-Pyr isomer differs in this regard that pyridine assists in the interaction with the gold surface.

Partition coefficients and ultraviolet absorption maxima for the cinnamoyl derivatives of some long-chain and large-ring amines

1970 ◽  
Vol 48 (8) ◽  
pp. 1340-1343 ◽  
Author(s):  
D. J. Currie ◽  
H. L. Holmes
Keyword(s):  
Nitrogen Atom ◽  
Chain Length ◽  
Partition Coefficients ◽  
The Other ◽  
Ring Size ◽  
Amide Nitrogen ◽  
Derivatives Of ◽  
Limiting Value ◽  
Long Chain ◽  
Amide Nitrogen Atom

Partition coefficients of the title compounds in the system cyclohexane–water do not increase steadily with increasing chain length or ring size but level off to a limiting value. Reasons are advanced to account for this observation. Absorption maxima, on the other hand, are not influenced by the size of the ring or the length of the chain but are dependent only upon the degree of substitution on the amide nitrogen atom.

The mass spectra of Schiff bases. I. Simple fissions and rearrangements

1966 ◽  
Vol 19 (2) ◽  
pp. 251 ◽  
Author(s):  
DJ Elias ◽  
RG Gillis
Keyword(s):  
Double Bond ◽  
Electron Impact ◽  
Schiff Bases ◽  
Mass Spectra ◽  
Hydrogen Transfer ◽  
Molecular Ion ◽  
Ring Carbon ◽  
Carbon Bonds ◽  
Ring Nitrogen ◽  
Derivatives Of

Under electron impact, Schiff bases give a stable molecular ion which undergoes simple fission at the ring-nitrogen and ring-carbon bonds. Ortho substitution leads to ions derived from five-membered heterocycles. Derivatives of o-methoxy-benzaldehyde exhibit a two-hydrogen transfer with fission of the azomethine double bond to give the amine radical-ion.

Sulphonamides. IV. The Reaction of N-Heterocyclic Amines with Sulphonyl Halides

1952 ◽  
Vol 5 (2) ◽  
pp. 374
Author(s):  
SJ Angyal
Keyword(s):  
Heterocyclic Amines ◽  
Amino Group ◽  
Ring Nitrogen ◽  
Amino Derivatives ◽  
Cyclic Compounds ◽  
Derivatives Of

The hypothesis is advanced that the reaction of sulphonyl halides with amino-derivatives of nitrogen-containing cyclic compounds occurs on the ring-nitrogen (which is the more basic), followed either by reaction of the amino-group with another molecule of sulphonyl halide, or by migration of the sulphonyl group from the ring to the ammo-nitrogen. Several apparently anomalous cases of this reaction are explained.

Mechanisms for the Benzoylation of 2-Aminopyridine

1979 ◽  
Vol 32 (2) ◽  
pp. 381 ◽  
Author(s):  
LW Deady ◽  
DC Stillman
Keyword(s):  
Acetic Anhydride ◽  
Benzoyl Chloride ◽  
Relative Rate ◽  
Direct Reaction ◽  
Ring Nitrogen ◽  
Derivatives Of

Relative rate studies on ring methyl-substituted derivatives of 2-aminopyridine in pyridine solvent show that reaction with benzoyl chloride gives monobenzoyl derivatives by direct reaction on the exocyclic nitrogen (N'). The reaction is analogous to acetylation with acetic anhydride. Reaction in acetone, however, gives, except for the 6-methyl compound, N',N?-dibenzoylamino compounds, even in the presence of excess of amine. The results are shown to be consistent with ring nitrogen benzoylation (N1), followed by rapid N'-benzoylation and intramolecular benzoyl rearrangement from N1 to N'.

THE SPECIFICITY OF HYDROGEN BOND FORMATION BETWEEN DERIVATIVES OF NUCLEIC ACID BASES AND SOME ANALOGUES

1966 ◽  
Vol 44 (9) ◽  
pp. 1045-1050 ◽  
Author(s):  
J. Pitha ◽  
R. Norman Jones ◽  
P. Pithova
Keyword(s):  
Chloroform Solution ◽  
Infrared Spectrophotometry ◽  
Nucleic Acid Bases ◽  
Desoxyribonucleic Acid ◽  
Hydrogen Bond Formation ◽  
Naturally Occurring ◽  
Ring Nitrogen ◽  
Pharmacologically Active ◽  
Derivatives Of ◽  
Ring Nitrogen Atom

Hydrogen bonding between pairs of derivatives of the base constituents of nucleic acids and their analogues has been studied in chloroform solution by infrared spectrophotometry. The strongest interactions occur between derivatives of guanine and cytosine. The introduction of the additional ring nitrogen atom in the pharmacologically active 5-azacytosine and 6-azacytosine derivatives does not change the complexing behavior. The positions of the N—H stretching bands in the infared spectra indicate that these complexes have a structure similar to that of the complexes formed between the corresponding pairs of bases in the naturally occurring desoxyribonucleic acid chain.

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