SOME REACTIONS OF ORGANOALUMINUM COMPOUNDS WITH NITROGEN-CONTAINING BASES

1963 ◽  
Vol 41 (5) ◽  
pp. 1359-1367 ◽  
Author(s):  
Neil R. Fetter ◽  
Bodo Bartocha ◽  
Frederick E. Brinckman Jr. ◽  
Donald W. Moore
Keyword(s):  
Linear Structure ◽  
Structural Formula ◽  
Organoaluminum Compounds

The reactions of Me3Al with Me2NNMe2 and Me2NCH2NMe2 have yielded complexes whose n.m.r. spectra suggest cyclic structures. They have the formulas Me3Al:Me2NNMe2 and Me3Al:Me2NCH2NMe2 respectively. Me3Al reacts with Me2NCH2CH2NMe2 to form a complex with a linear structure and the formula Me3Al:Me2NCH2CH2NMe2:AlMe3.The reactions of H3Al:NMe3 with several methyl hydrazines have yielded the following compounds: [—Al(HNNHMe)NHNMe—]n, [—HAlNNMe2—]n, H2Al—NHNEt2, [(—HAlNNEt2—):NMe3]n, and H2Al—NMe2. No reaction occurred between H3Al·(Et2O)n and tetramethylhydrazine and the reaction of 3 moles of H2NNMe2 with 1 mole of H3Al:NMe3 yielded a compound for which no structural formula could be assigned, but which had emperical formula C4H15N5Al.

Exploring the Active Compounds of Traditional Mongolian Medicine Agsirga in Intervention of Novel Coronavirus (2019-nCoV) Based on HPLC-Q-Exactive-MS/MS and Molecular Docking Method

2020 ◽  
Author(s):  
Jie Cheng ◽  
Yuchen Tang ◽  
Baoquan Bao ◽  
Ping Zhang
Keyword(s):  
Mass Spectrometry ◽  
Molecular Docking ◽  
High Resolution ◽  
Mass Spectra ◽  
High Resolution Mass Spectrometry ◽  
Structural Formula ◽  
Active Compounds ◽  
High Resolution Mass ◽  
Q Exactive ◽  
Resolution Mass

<p><a></a><a></a><a></a><a><b>Objective</b></a>: To screen all compounds of Agsirga based on the HPLC-Q-Exactive high-resolution mass spectrometry and find potential inhibitors that can respond to 2019-nCoV from active compounds of Agsirga by molecular docking technology.</p> <p><b>Methods</b>: HPLC-Q-Exactive high-resolution mass spectrometry was adopted to identify the complex components of Mongolian medicine Agsirga, and separated by the high-resolution mass spectrometry Q-Exactive detector. Then the Orbitrap detector was used in tandem high-resolution mass spectrometry, and the related molecular and structural formula were found by using the chemsipider database and related literature, combined with precise molecular formulas (errors ≤ 5 × 10<sup>−6</sup>) , retention time, primary mass spectra, and secondary mass spectra information, The fragmentation regularities of mass spectra of these compounds were deduced. Taking ACE2 as the receptor and deduced compounds as the ligand, all of them were pretreated by discover studio, autodock and Chem3D. The molecular docking between the active ingredients and the target protein was studied by using AutoDock molecular docking software. The interaction between ligand and receptor is applied to provide a choice for screening anti-2019-nCoV drugs.</p> <p><b>Result</b>: Based on the fragmentation patterns of the reference compounds and consulting literature, a total of 96 major alkaloids and stilbenes were screened and identified in Agsirga by the HPLC-Q-Exactive-MS/MS method. Combining with molecular docking, a conclusion was got that there are potential active substances in Mongolian medicine Agsirga which can block the binding of ACE2 and 2019-nCoV at the molecular level.</p>

Glucan isolated from leaves of Althaea officinalis L.

1983 ◽  
Vol 48 (7) ◽  
pp. 2082-2087 ◽  
Author(s):  
Alžbeta Kardošová ◽  
Jozef Rosík ◽  
Rudolf Toman ◽  
Peter Capek
Keyword(s):  
Medicinal Plant ◽  
Periodate Oxidation ◽  
Linear Structure ◽  
Water Soluble ◽  
Partial Hydrolysis ◽  
Methylation Analysis ◽  
Glycosidic Bonds ◽  
Nmr Data ◽  
Althaea Officinalis ◽  
C Nmr

A water-soluble low-molecular D-glucan was isolated from leaves of the medicinal plant marsh-mallow (Althaea officinalis L.). The results of methylation analysis, partial hydrolysis, periodate oxidation, and 13C NMR data indicated a virtually linear structure with α-(1→6) glycosidic bonds.

Polysaccharides from the Flowers of Malva silvestris L., ssp. mauritiana (L.) THELL.: The Structure of D-Glucan

1992 ◽  
Vol 57 (11) ◽  
pp. 2400-2406 ◽  
Author(s):  
Peter Capek
Keyword(s):  
Molecular Weight ◽  
Ion Exchange ◽  
Average Molecular Weight ◽  
Linear Structure ◽  
Gel Chromatography ◽  
Spectroscopic Investigations ◽  
Glycosidic Bonds

The neutral polysaccharide α-D-glucan was isolated from the flowers of Malva silvestris L., ssp. mauritiana (L.) THELL. using a combination of ion exchange and gel chromatography. It was homogeneous under the conditions of free electrophoresis of average molecular weight Mn 25260. The chemical and spectroscopic investigations indicated a linear structure of the polysaccharide in which the α-D-glucopyranose units were linked predominantly by 1→6 glycosidic bonds, while some saccharides were the place of branching in position C-3.

scholarly journals Catalytic Systems Based on Cp2ZrX2 (X = Cl, H), Organoaluminum Compounds and Perfluorophenylboranes: Role of Zr,Zr- and Zr,Al-Hydride Intermediates in Alkene Dimerization and Oligomerization

Catalysts ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 39
Author(s):  
Lyudmila V. Parfenova ◽  
Pavel V. Kovyazin ◽  
Almira Kh. Bikmeeva ◽  
Eldar R. Palatov
Keyword(s):  
Diffusion Coefficients ◽  
Organoaluminum Compounds ◽  
Zirconium Hydride ◽  
Nmr Studies ◽  
Catalytic Systems ◽  
Selective Formation

The activity and chemoselectivity of the Cp2ZrCl2-XAlBui2 (X = H, Bui) and [Cp2ZrH2]2-ClAlEt2 catalytic systems activated by (Ph3C)[B(C6F5)4] or B(C6F5)3 were studied in reactions with 1-hexene. The activation of the systems by B(C6F5)3 resulted in the selective formation of head-to-tail alkene dimers in up to 93% yields. NMR studies of the reactions of Zr complexes with organoaluminum compounds (OACs) and boron activators showed the formation of Zr,Zr- and Zr,Al-hydride intermediates, for which diffusion coefficients, hydrodynamic radii, and volumes were estimated using the diffusion ordered spectroscopy DOSY. Bis-zirconium hydride clusters of type x[Cp2ZrH2∙Cp2ZrHCl∙ClAlR2]∙yRnAl(C6F5)3−n were found to be the key intermediates of alkene dimerization, whereas cationic Zr,Al-hydrides led to the formation of oligomers.

scholarly journals A very persistent chicken bone: two separate perforations from the same foreign object 2 months apart

2019 ◽  
Vol 12 (5) ◽  
pp. e228050
Author(s):  
Andrew James Brown ◽  
Thomas Whitehead-Clarke ◽  
Vera Tudyka
Keyword(s):  
Small Bowel ◽  
Bowel Perforation ◽  
Linear Structure ◽  
Small Bowel Resection ◽  
Emergency Laparotomy ◽  
Small Bowel Perforation ◽  
Chicken Bone ◽  
Abdomen Ct ◽  
Distal Migration ◽  
The Right

A 56-year-old man presented acutely with abdominal pain and raised inflammatory markers. Initial CT images demonstrated acute inflammation in the right upper quadrant surrounding a high-density linear structure. The appearance was of a chicken bone causing a contained small bowel perforation. This was managed conservatively with intravenous antibiotics and the patient was discharged 10 days later. The same patient returned to the hospital 2 months later, once again with an acute abdomen. CT imaging on this occasion showed distal migration of the chicken bone as well as free gas and fluid indicative of a new small bowel perforation. The patient underwent an emergency laparotomy, washout and small bowel resection. No foreign body was found at laparotomy or in the histopathology specimen. The postoperative course was complicated by an anastomotic leak. A further CT on that admission demonstrated that the chicken bone had migrated to the rectum!

scholarly journals The radio-loud narrow-line Seyfert 1 galaxy 1H 0323+342 in a galaxy merger

2020 ◽  
Vol 496 (2) ◽  
pp. 1757-1765 ◽  
Author(s):  
Akihiro Doi ◽  
Motoki Kino ◽  
Nozomu Kawakatu ◽  
Kazuhiro Hada
Keyword(s):  
Black Holes ◽  
Near Infrared ◽  
Gamma Ray ◽  
Linear Structure ◽  
Seyfert Galaxies ◽  
Mass Function ◽  
High Mass ◽  
Host Galaxy ◽  
Supporting Evidence ◽  
Narrow Line

ABSTRACT The supermassive black holes (SMBHs) of narrow-line Seyfert 1 galaxies (NLS1s) are at the lower end of the mass function of active galactic nuclei (AGNs) and reside preferentially in late-type host galaxies with pseudobulges, which are thought to be formed by internal secular evolution. On the other hand, the population of radio-loud NLS1s presents a challenge for the relativistic jet paradigm, which states that powerful radio jets are associated exclusively with very high mass SMBHs in elliptical hosts, which are built up through galaxy mergers. We investigated distorted radio structures associated with the nearest gamma-ray-emitting, radio-loud NLS1, 1H 0323+342. This provides supporting evidence for the merger hypothesis based on past optical/near-infrared observations of its host galaxy. The anomalous radio morphology consists of two different structures: the inner curved structure of the currently active jet and an outer linear structure of low-brightness relics. Such coexistence might be indicative of the stage of an established black hole binary with precession before the black holes coalesce in the galaxy merger process. 1H 0323+342 and other radio-loud NLS1s under galaxy interactions may be extreme objects on the evolutionary path from radio-quiet NLS1s to normal Seyfert galaxies with larger SMBHs in classical bulges through mergers and merger-induced jet phases.

Exploring genomes with a game engine

2014 ◽  
Vol 169 ◽  
pp. 443-453 ◽  
Author(s):  
Jeremiah J. Shepherd ◽  
Lingxi Zhou ◽  
William Arndt ◽  
Yan Zhang ◽  
W. Jim Zheng ◽  
...  
Keyword(s):  
Real Time ◽  
Video Game ◽  
Linear Structure ◽  
Structural Data ◽  
Game Engine ◽  
3D Genome ◽  
Genome Viewer ◽  
A Genome ◽  
Visualization Techniques ◽  
Insight Into

More and more evidence indicates that the 3D conformation of eukaryotic genomes is a critical part of genome function. However, due to the lack of accurate and reliable 3D genome structural data, this information is largely ignored and most of these studies have to use information systems that view the DNA in a linear structure. Visualizing genomes in real time 3D can give researchers more insight, but this is fraught with hardware limitations since each element contains vast amounts of information that cannot be processed on the fly. Using a game engine and sophisticated video game visualization techniques enables us to construct a multi-platform real-time 3D genome viewer. The game engine-based viewer achieves much better rendering speed and can handle much larger amounts of data compared to our previous implementation using OpenGL. Combining this viewer with 3D genome models from experimental data could provide unprecedented opportunities to gain insight into the conformation–function relationships of a genome.

Miniature UWB Filter Using Three-Quarters Wavelength Resonator with Direct-Connected Feed Method

2012 ◽  
Vol 571 ◽  
pp. 721-724
Author(s):  
Cai Peng
Keyword(s):  
Transmission Lines ◽  
Linear Structure ◽  
Ultra Wideband ◽  
Input Output ◽  
Transmission Zeros ◽  
Full Wave ◽  
Quarter Wavelength ◽  
Ring Structures ◽  
Loss Characteristic ◽  
Better Than

A miniature ultra-wideband (UWB) bandpass filter using three-quarters wavelength resonators is presented in this paper. Direct-connected feed method is employed between the input/output ports and the resonators in order to overcome the shortcomings due to the gap-coupled feed method and produce two transmission zeros in the lower and upper stopbands. On the other hand, two quarter-wavelength matching transmission lines are introduced to the input/output ports to improve the reflection loss characteristic in the passband of the filter. In addition, the resonators are folded to be open ring structures, which are more miniaturized than the conventional linear structure. As a consequence, the filter is compact in size and exhibits good performance. The filter is successfully realized in theory and verified by full wave EM simulation, and simulated frequency response results show that the fabricated filter has an insertion loss of better than 1dB in the passband and two rejections of greater than 25dB in most of the stopbands.

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