ORGANO ARSENIC COMPOUNDS: II. N,N-DIALKYL AMIDODIFLUOROARSENITES AND N-ALKYL IMIDOFLUOROARSENITES

1960 ◽  
Vol 38 (9) ◽  
pp. 1431-1433 ◽  
Author(s):  
George A. Olah ◽  
Alexis A. Oswald
Keyword(s):  
Aliphatic Amines ◽  
Secondary Amines ◽  
Primary Amines ◽  
Arsenic Compounds

The reaction of arsenic fluoride with aliphatic amines was studied. Secondary amines gave N,N-dialkyl amidodifluoroarsenites. Primary amines while reacting similarly lose HF subsequently and yield N-alkyl imidofluoroarsenites.

ORGANO ARSENIC COMPOUNDS: I. N,N-DIALKYL AMIDODICHLOROARSENITES AND N-ALKYL IMIDOCHLOROARSENITES

1960 ◽  
Vol 38 (9) ◽  
pp. 1428-1430 ◽  
Author(s):  
G. A. Olah ◽  
A. A. Oswald
Keyword(s):  
Secondary Amines ◽  
Primary Amines ◽  
Arsenic Compounds ◽  
Arsenic Trichloride

N,N-Dialkyl amidodichloroarsenites were prepared by the reaction of arsenic trichloride with aliphatic secondary amines. Arsenic trichloride and primary amines react similarly, but the N-alkyl amidodichloroarsenites formed usually lose HCl and give N-alkyl imidoarsenites on distillation.

Reactions of Quinolizine- and Pyridino[1,2–a]pyrimidine-3-diazonium Tetrafluoroborates with Aliphatic Amines

2004 ◽  
Vol 59 (4) ◽  
pp. 380-385 ◽  
Author(s):  
Simon Rečnik ◽  
Jurij Svete ◽  
Branko Stanovnik
Keyword(s):  
Picolinic Acid ◽  
The Other ◽  
Aliphatic Amines ◽  
Secondary Amines ◽  
Primary Amines ◽  
Other Hand ◽  
High Yields

KeywordsReactions of 1-cyano-4-oxo-4H-quinolizine-3-diazonium tetrafluoroborate (1a) and 4-oxo-4Hpyridino[ 1,2-a]pyrimidine-3-diazonium tetrafluoroborate (1b) with aliphatic amines 2a - g were studied. Treatment of heteroaryldiazonium salts 1 with secondary amines 2a - d afforded the corresponding N-alkyl-N’-heteroaryltriazenes 3a - h in high yields. On the other hand, reactions of 1a with aliphatic primary amines 2e - g resulted in an unexpected rearrangements into the corresponding picolinic acid N-alkylcarboxamides 4a - c.

Reaction of 2,3-dihydro-1,3-6H-oxazine-2,6-dione with aliphatic amines and amino acids

1982 ◽  
Vol 47 (11) ◽  
pp. 2932-2945 ◽  
Author(s):  
Jiří Farkaš ◽  
Jaroslav Hapala ◽  
Olga Jindrová ◽  
Jan Škoda
Keyword(s):  
Amino Acids ◽  
Aqueous Medium ◽  
Aliphatic Amines ◽  
Secondary Amines ◽  
Primary Amines ◽  
Kinetic Measurements ◽  
Propenoic Acid ◽  
Tert Butylamine ◽  
By Products

Reaction of 2,3-dihydro-1,3-6H-oxazine-2,6-dione (I) with amines in aqueous medium leads predominantly to N-substituted amides of (Z)-3-carboxylamino-2-propenoic acid. Isomeric 3-(N'-alkylureido)-2-propenoic acids are formed as by-products in the reaction of compound I with ammonia or methylamine; tert-butylamine affords ureido derivative as the sole reaction product. Secondary amines react with compound I substantially more rapidly than primary amines. In both cases the branching on the α-carbon decreases the reactivity distinctly while the branching on the β-carbon does not have a significant effect on the rate of aminolysis. The results of kinetic measurements of the reaction of compound I with amino acids are discussed n connection with the possible interaction of compound I with enzymes.

Acceptorless amine dehydrogenation and transamination using Pd-doped layered double hydroxides

2018 ◽  
Author(s):  
Diana Ainembabazi ◽  
Nan An ◽  
Jinesh Manayil ◽  
Kare Wilson ◽  
Adam Lee ◽  
...  
Keyword(s):  
Layered Double Hydroxides ◽  
Oxidation States ◽  
Secondary Amines ◽  
Primary Amines ◽  
Acid Dissolution ◽  
Oxidative Amination ◽  
Strong Function ◽  
Excellent Activity ◽  
High Yields ◽  
Double Hydroxides

<div> <p>The synthesis, characterization, and activity of Pd-doped layered double hydroxides (Pd-LDHs) for for acceptorless amine dehydrogenation is reported. These multifunctional catalysts comprise Brønsted basic and Lewis acidic surface sites that stabilize Pd species in 0, 2+, and 4+ oxidation states. Pd speciation and corresponding cataytic performance is a strong function of metal loading. Excellent activity is observed for the oxidative transamination of primary amines and acceptorless dehydrogenation of secondary amines to secondary imines using a low Pd loading (0.5 mol%), without the need for oxidants. N-heterocycles, such as indoline, 1,2,3,4-tetrahydroquinoline, and piperidine, are dehydrogenated to the corresponding aromatics with high yields. The relative yields of secondary imines are proportional to the calculated free energy of reaction, while yields for oxidative amination correlate with the electrophilicity of primary imine intermediates. Reversible amine dehydrogenation and imine hydrogenation determine the relative imine:amine selectivity. Poisoning tests evidence that Pd-LDHs operate heterogeneously, with negligible metal leaching; catalysts can be regenerated by acid dissolution and re-precipitation.</p> </div> <br>

Efficient Copper-Catalysed Synthesis of Carbazoles by Double N-Arylation of Primary Amines with 2,2′-Dibromobiphenyl in the Presence of Air

Synlett ◽  
2021 ◽  
Author(s):  
Tran Quang Hung ◽  
Tuan Thanh Dang ◽  
Peter Langer ◽  
Ha Nam Do ◽  
Nguyen Minh Quan ◽  
...  
Keyword(s):  
Aromatic Amines ◽  
Aliphatic Amines ◽  
Primary Amines ◽  
Coupling Reactions ◽  
Carbazole Derivatives ◽  
High Yields

AbstractAn efficient Cu-catalyzed synthesis of carbazole derivatives is reported, which proceeds by double C–N coupling reactions of 2,2′-dibromobiphenyl and amines in the presence of air. The reaction is robust, proceeds in high yields, and tolerates a series of amines including neutral, electron-rich, electron-deficient aromatic amines and aliphatic amines.

Cyclic amidines derived from benz[c,d]indole and 4,5-dihydro-3H-1-benzazepine including some related compounds: Synthesis and pharmacological screening

1985 ◽  
Vol 50 (8) ◽  
pp. 1888-1898 ◽  
Author(s):  
Miroslav Protiva ◽  
Zdeněk Šedivý ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Jiří Němec
Keyword(s):  
Titanium Tetrachloride ◽  
Aqueous Sodium Hydroxide ◽  
Secondary Amines ◽  
Primary Amines ◽  
Open Chain ◽  
Lithium Aluminium ◽  
Pharmacological Screening ◽  
Antiinflammatory Effects ◽  
Related Compounds ◽  
Sodium Amide

Reactions of naphthostyril (I) with primary and secondary amines and titanium tetrachloride afforded cyclic amidines III-IX. Hydrogenation of I on Pd-C resulted in the 6,7,8,8a-tetrahydro derivative X which gave by treatment with sodium amide and 3-dimethylaminopropyl chloride the N-(aminoalkyl) compound XI. Reduction of I and its N-methyl derivative II with sodium amalgam in aqueous sodium hydroxide gave the 2a,3,4,5-tetrahydro derivatives XII and XIII. Reaction of XIII with sodium amide and 3-dimethylaminopropyl chloride afforded the 2a-(aminoalkyl) compound XIV. 1,3,4,5-Tetrahydro-1-benzazepin-2-one (XV) treated with primary amines and titanium tetrachloride gave the amidines XVI-XVIII. 3-Methyl-7,8,9,9a-tetrahydro-1H-benz[d,e]isoquinoline (XIX) was reduced with sodium borohydride to compound XX which was alkylated with propargyl bromide to 1-methyl-2-propargyl-2,3,3a,4,5,6-hexahydro-1H-benz[d,e]isoquinoline (XXI). An attempt to prepare the 2-(2-phenylethyl) analogue by treatment of compound XX with phenylacetyl chloride and by the following reduction with lithium aluminium hydride resulted in the open-chain amine XXII. The lactams I, II, X, and XIII showed some discoordinating, hypothermic, peripheral vasodilating, hyperglycaemic, diuretic and antiinflammatory effects. The amidines III-IX and XVI-XVIII had local anaesthetic, slight hypotensive, antiarrhythmic, peripheral myorelaxant, papaverine-like spasmolytic and thiopental potentiating effects.

Titration syntheses of polyaminosubstituted phthalocyanines via nucleophilic aromatic substitutions on zinc(II) 1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25-hexadecafluorophthalocyanine

2007 ◽  
Vol 11 (07) ◽  
pp. 537-546 ◽  
Author(s):  
Clifford C. Leznoff ◽  
Annette Hiebert ◽  
Sibel Ok
Keyword(s):  
Amino Acids ◽  
Chain Length ◽  
Secondary Amines ◽  
Primary Amines ◽  
Tertiary Butyl ◽  
Butyl Esters ◽  
Mild Conditions ◽  
Nucleophilic Aromatic Substitutions

Primary amines, secondary amines and tertiary butyl esters of amino acids are used as nucleophiles with zinc(II) hexadecafluorophthalocyanine to provide mixtures of mono and disubstituted fluorinated phthalocyanines under mild conditions, or polyaminosubstituted phthalocyanines when using the amines as solvents. Diamines give cyclic substituted phthalocyanines, binuclear or trinuclear phthalocyanines or mixtures of both types, depending on the chain length or structure of the diamine.

ChemInform Abstract: The “Benzostabase” Protecting Group for Primary Amines. Application to Aliphatic Amines.

ChemInform ◽  
2010 ◽  
Vol 23 (15) ◽  
pp. no-no
Author(s):  
R. P. BONAR-LAW ◽  
A. P. DAVIS ◽  
B. J. DORGAN ◽  
M. T. REETZ ◽  
A. WEHRSIG
Keyword(s):  
Aliphatic Amines ◽  
Primary Amines ◽  
Protecting Group
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