Microwave-assisted N-nitroarylation of some pyrimidine and purine nucleobases

2006 ◽  
Vol 84 (7) ◽  
pp. 979-985 ◽  
Author(s):  
Ali Khalafi-Nezhad ◽  
Abdolkarim Zare ◽  
Abolfath Parhami ◽  
Mohammad Navid Soltani Rad ◽  
Gholam Reza Nejabat
Keyword(s):  
Efficient Procedure ◽  
Microwave Assisted ◽  
High Yields ◽  
Derivatives Of

An efficient procedure for the synthesis of some N-nitroaryl derivatives of nucleobases via microwave-assisted N-nitroarylation of nucleobases in the presence of SiO2 and Cs2CO3 in DMSO, as the homogenizing solvent, is described. In this method, some pyrimidine and purine nucleobases are nitroarylated regioselectively in moderate to high yields and short reaction times.Key words: microwave, N-nitroarylation, pyrimidine, purine, SNAr.

Zinc oxide as a new, highly efficient, green, and reusable catalyst for microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters in ionic liquids

2007 ◽  
Vol 85 (6) ◽  
pp. 438-444 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Ahmad Reza Moosavi Zare ◽  
Abolfath Parhami ◽  
Hashem Sharghi ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Michael Addition ◽  
Catalytic Amount ◽  
Reusable Catalyst ◽  
Efficient Procedure ◽  
Unsaturated Esters ◽  
Microwave Assisted ◽  
Alkyl Derivatives ◽  
High Yields ◽  
Derivatives Of

A simple, clean, and efficient procedure for the green synthesis of some N-alkyl derivatives of sulfonamides is described. Microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters, in the presence of catalytic amount of zinc oxide (ZnO) in 1-butyl-3-methylimidazolium bromide ([bmim]Br), affords the title compounds in high yields and short reaction times.Key words: zinc oxide, green chemistry, microwave, Michael addition, sulfonamide, ionic liquid.

Solid-state regioselective nitration of activated hydroxyaromatics and hydroxycoumarins with cerium (IV) ammonium nitrate

2005 ◽  
Vol 2005 (11) ◽  
pp. 733-735 ◽  
Author(s):  
Nemai C. Ganguly ◽  
Sanjoy Dutta ◽  
Mrityunjoy Datta ◽  
Prithwiraj De
Keyword(s):  
Solid State ◽  
Ammonium Nitrate ◽  
High Efficiency ◽  
Solvent Free ◽  
High Melting ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Regioselective Nitration ◽  
Cerium Iv Ammonium Nitrate

Predominant ortho-selective mononitration of low-melting and liquid phenols and hydroxycoumarins in moderate to high yields has been accomplished upon grinding with solid cerium (IV) ammonium nitrate (CAN). Microwave-assisted expeditious CAN-mediated nitration of relatively high melting phenols and hydroxycoumarins with high efficiency and selectively under solvent-free conditions has been also developed to address the problems of sluggishness and low yield for these reluctant substrates.

scholarly journals Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization

Pharmacia ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 141-146
Author(s):  
Hanna Severina ◽  
Olga O. Skupa ◽  
Natalya I. Voloshchuk ◽  
Marharyta M. Suleiman ◽  
Victoriya A. Georgiyants
Keyword(s):  
Sulphuric Acid ◽  
Anticonvulsant Activity ◽  
Sodium Methoxide ◽  
Structure Activity ◽  
Phenacyl Bromides ◽  
Pharmacological Screening ◽  
High Yields ◽  
Derivatives Of

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3 a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylated derivatives – 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one - were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacological screening of synthesized compounds for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “structure-activity” was established.

scholarly journals Microwave Assisted Synthesis of 1,5-Benzothiazepines Using Greener Reaction Medium

2019 ◽  
Vol 31 (5) ◽  
pp. 993-996 ◽  
Author(s):  
Sanjay S. Kotalwar ◽  
Amol D. Kale ◽  
Ram B. Kohire ◽  
Vasant B. Jagrut
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Reaction Medium ◽  
Microwave Assisted Synthesis ◽  
Reaction Conditions ◽  
Renewable Sources ◽  
Microwave Assisted ◽  
High Yields

An efficient and eco-friendly synthesis of 1,5-benzothiazepines has been developed by the reaction of various 2-propen-1-ones with 2-aminothiophenol using microwave irradiation in greener reaction medium, glycerol. The clean reaction conditions, shorter reaction time, high yields and non-toxic, biodegradable reaction medium manufactured from renewable sources are unique features of this method.

scholarly journals Microwave assisted synthesis of five membered nitrogen heterocycles

RSC Advances ◽  
2020 ◽  
Vol 10 (59) ◽  
pp. 36031-36041
Author(s):  
Gopinadh Meera ◽  
K. R. Rohit ◽  
Salim Saranya ◽  
Gopinathan Anilkumar
Keyword(s):  
Reaction Time ◽  
Nitrogen Heterocycles ◽  
Product Formation ◽  
Microwave Assisted Synthesis ◽  
Short Reaction Time ◽  
Microwave Assisted ◽  
High Yields

Microwave assisted synthesis of N-heterocycles with short reaction time, high yields and high product purities along with a decrease in the rate of by-product formation.

Photochemical syntheses. III. The synthesis and photo-isomerization of 1,2-Diphenyl-2a,8b-dihydrocyclobuta[a]naphthalene and some derivatives

1971 ◽  
Vol 24 (11) ◽  
pp. 2325 ◽  
Author(s):  
PJ Collin ◽  
WHF Sasse
Keyword(s):  
Methoxy Derivative ◽  
High Yields ◽  
Derivatives Of

Fourteen derivatives of the naphthalene-diphenylacetylene photo-adduct (1a) have been thermally isomerized to give high yields of derivatives of 1,2-diphenyl-2a,8b-dihydrocyclobuta[a]naphthalene (1b). Of these only the 4-methoxy derivative (13b) could be rearranged to the isomeric benzocyclooctatetraene (13c). Five alkyl and one methoxy derivative of (1b) were quantitatively isomerized to derivatives of (1a) but the isomerization of the esters (10b) and (11b) gave mixtures. Photo-iso- merization of the methoxybenzocyclooctatetraene (13c) gave exclusively (13b) and (13a). ��� Mechanistic aspects of these reactions are discussed.

scholarly journals The first in situ synthesis of 1,3-dioxan-5-one derivatives and their direct use in Claisen-Schmidt reactions

2019 ◽  
Vol 25 (1) ◽  
pp. 85-90 ◽  
Author(s):  
M. Javad Poursharifi ◽  
Mohammad M. Mojtahedi ◽  
M. Saeed Abaee ◽  
Mohammad M. Hashemi
Keyword(s):  
Acetic Acid ◽  
Aromatic Aldehydes ◽  
In Situ Synthesis ◽  
Stepwise Procedures ◽  
Time Periods ◽  
High Yields ◽  
Short Time ◽  
Direct Use ◽  
Derivatives Of

AbstractA method is developed for in situ generation of 1,3-dioxan-5-one derivatives 2. These compounds are simple precursors for accessing carbohydrate structures and previously had to be produced via stepwise procedures using excessive amounts of reagents. In the present work, three different derivatives of 2 were synthesized via the reaction of trialkoxyalkanes with dihydroxyacetone dimer 1 in the presence of acetic acid as the catalyst. In the same pot, derivatives of 2 were reacted with aromatic aldehydes and 30 mol% of pyrrolidine to obtain high yields of the respective bischalcones 3 within short time periods.

scholarly journals Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3277
Author(s):  
Panagiotis Theodosis-Nobelos ◽  
Georgios Papagiouvannis ◽  
Panos N. Kourounakis ◽  
Eleni A. Rekka
Keyword(s):  
Acute Inflammation ◽  
Current Knowledge ◽  
Rat Plasma ◽  
Straightforward Method ◽  
Inflammatory Drugs ◽  
Multifunctional Agents ◽  
Anti Inflammatory ◽  
High Yields ◽  
Derivatives Of ◽  
And Oxidative Stress

Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress.

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