Neat reaction microwave technology for the synthesis of N-substituted-1,4-dihydropyridines

2004 ◽  
Vol 82 (3) ◽  
pp. 427-429 ◽  
Author(s):  
Mazaahir Kidwai ◽  
Richa Mohan
Keyword(s):  
Microwave Irradiation ◽  
Good Yield ◽  
Solid Support ◽  
Environmentally Benign ◽  
Heating Effect ◽  
Uniform Heating ◽  
Hantzsch Synthesis ◽  
Microwave Technology ◽  
Rate Enhancement ◽  
Excellent Yield

Hantzsch synthesis of N-substituted-1,4-dihydropyridines (1,4-DHP) was carried out using an environmentally benign procedure. Neat reactants were subjected to microwave irradiation (MWI) to give the required products in excellent yield. Appreciable results were not obtained when conventional synthesis using neat reactants was carried out. The good yield and rate enhancement observed in the case of microwave irradiation is attributed to the uniform heating effect of microwaves.Key words: 1,4-dihydropyridines (1,4-DHP), microwave irradiation (MWI), neat reaction, solid support.

Trimethylsilyl Chloride Catalyzed Highly Efficient Synthesis of Schiff Bases of Thiazole in Glycerol under Microwave Irradiation

2019 ◽  
Vol 4 (2) ◽  
pp. 109-112
Author(s):  
Mujahed Shaikh ◽  
Ashvini Sonone ◽  
Mazahar Farooqui ◽  
Ayesha Durrani
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Schiff Bases ◽  
Room Temperature ◽  
Environmentally Benign ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
Acidic Catalyst ◽  
Excellent Yield ◽  
Work Up

A green and environmentally benign protocol is developed for the synthesis of Schiff bases of sulphur containing compound by irradiating thiazole and pyrazole aldehyde in glycerol under microwave irradiation at 70 ºC with trimethylsilyl chloride (TMSCl) as a catalyst. The method has advantages such as excellent yield, use of green solvent, easy work-up and most important the reaction completed within 2.5 min by using TMSCl catalyst. The TMSCl is an acidic catalyst, which enhances the yield of product, reaction time (with microwave, with reflux at 75 ºC and with stirring at room temperature) which can be easily removed from reaction mask.

Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

2015 ◽  
Vol 17 (5) ◽  
pp. 3157-3163 ◽  
Author(s):  
Andrea Ojeda-Porras ◽  
Alejandra Hernández-Santana ◽  
Diego Gamba-Sánchez
Keyword(s):  
Fatty Acids ◽  
Microwave Irradiation ◽  
Carboxylic Acids ◽  
Silica Gel ◽  
Solid Support ◽  
Secondary Amines ◽  
Primary And Secondary Amines ◽  
Direct Amidation

A highly improved methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. Several examples using aliphatic, aromatic, unsaturated and fatty acids combined with primary and secondary amines are shown.

An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation

2016 ◽  
Vol 147 (9) ◽  
pp. 1605-1614 ◽  
Author(s):  
Dawei Zhang ◽  
Xiaodong Chen ◽  
Xue Guo ◽  
Yumin Zhang ◽  
Yaya Hou ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solid Support ◽  
Solvent Free ◽  
Solvent Free Synthesis

Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety

2010 ◽  
Vol 75 (3) ◽  
pp. 275-287 ◽  
Author(s):  
Mithlesh ◽  
Pawan K. Pareek ◽  
Hemraj Chippa ◽  
Ravikant ◽  
Krishan G. Ojha
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Aldehyde ◽  
Microwave Synthesis ◽  
Solid Support ◽  
Solvent Free ◽  
Microwave Irradiation Method ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Active Methylene

2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

Microwave Enhanced Acetylation of Alcohols

2002 ◽  
Vol 2002 (6) ◽  
pp. 301-302 ◽  
Author(s):  
Ramesh Patnam ◽  
Fang-Rong Chang ◽  
Reen-Yen Kuo ◽  
Wen-Bin Pan ◽  
Yang-Chang Wu
Keyword(s):  
Acetic Anhydride ◽  
Microwave Irradiation ◽  
Catalytic Amount ◽  
Excellent Yield

Microwave irradiation of alcohols with acetic anhydride in the presence of a catalytic amount of NaOH for a few minutes yielded the corresponding acetylated products in excellent yield.

ChemInform Abstract: Selective Oxidation of Allylic Methyl Groups over a Solid Support under Microwave Irradiation.

ChemInform ◽  
2010 ◽  
Vol 28 (48) ◽  
pp. no-no
Author(s):  
J. SINGH ◽  
M. SHARMA ◽  
G. L. KAD ◽  
B. R. CHHABRA
Keyword(s):  
Microwave Irradiation ◽  
Selective Oxidation ◽  
Solid Support ◽  
Methyl Groups

scholarly journals Facile Condensation of Aromatic Aldehydes with Chroman-4-ones and 1-Thiochroman-4-ones Catalysed by Amberlyst-15 under Microwave Irradiation Condition

2011 ◽  
Vol 8 (2) ◽  
pp. 863-869 ◽  
Author(s):  
Tapas K. Mandal ◽  
Rammohan Pal ◽  
Rina Mondal ◽  
Asok K. Mallik
Keyword(s):  
Microwave Irradiation ◽  
Aldol Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Environmentally Benign ◽  
High Yield ◽  
Irradiation Condition ◽  
Free Condition ◽  
Amberlyst 15 ◽  
Solvent Free Condition

Different aromatic aldehydes and cinnamaldehyde undergo cross-aldol condensation with chroman-4-ones and1-thiochroman-4-ones in the presence of amberlyst-15 under microwave irradiation in solvent free condition to afford rapidly the correspondingE-3-arylidene andE-3-cinnamylidene derivatives, respectively, in high yield. This process is simple, efficient and environmentally benign.

The effect of microwave irradiation on carbodiimide-mediated esterifications on solid support

Tetrahedron ◽  
2001 ◽  
Vol 57 (18) ◽  
pp. 3915-3920 ◽  
Author(s):  
Alexander Stadler ◽  
C.Oliver Kappe
Keyword(s):  
Microwave Irradiation ◽  
Solid Support

DRY MEDIA SYNTHESIS OF 4H-1, 4-BENZOTHIAZINES UNDER MICROWAVE IRRADIATION USING BASIC ALUMINA AS SOLID SUPPORT

2001 ◽  
Vol 31 (5) ◽  
pp. 711-717 ◽  
Author(s):  
Satya Paul ◽  
Rajive Gupta ◽  
André Loupy ◽  
Babita Rani ◽  
Anshu Dandia
Keyword(s):  
Microwave Irradiation ◽  
Solid Support ◽  
Basic Alumina
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