Novel Regioselective Hydroxyl-Alkylation of 4,5-Diphenylimidazole-2-thione and a Competitive Intramolecular Ring Closure of the S-Hydroxyalkyl-imidazoles to Imidazo[2,1-b]thiazines and Thiazoles. Role of Catalyst, Microwave Irradiation, and Solid Support.

ChemInform ◽  
2007 ◽  
Vol 38 (47) ◽  
Author(s):  
E. S. H. El Ashry ◽  
N. Rashed ◽  
L. F. Awad ◽  
E. Ramadan ◽  
S. M. Abdel-Maggeed ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solid Support ◽  
Ring Closure ◽  
Intramolecular Ring

scholarly journals An expedient route to heterocycles through α-arylation of ketones and arylamides by microwave induced thermal SRN1 reactions

RSC Advances ◽  
2014 ◽  
Vol 4 (34) ◽  
pp. 17490-17497 ◽  
Author(s):  
Silvia M. Soria-Castro ◽  
Daniel A. Caminos ◽  
Alicia B. Peñéñory
Keyword(s):  
Electron Transfer ◽  
Microwave Irradiation ◽  
Nucleophilic Substitution ◽  
Transfer Mechanism ◽  
Ring Closure ◽  
Electron Transfer Mechanism ◽  
Thermally Induced ◽  
Intramolecular Ring

Quick reaction by microwave irradiation promotes nucleophilic substitution by thermally induced electron transfer mechanism and allows to synthesize deoxibenzoin and indol heterocycles derivates by inter or intramolecular ring closure.

Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

2015 ◽  
Vol 17 (5) ◽  
pp. 3157-3163 ◽  
Author(s):  
Andrea Ojeda-Porras ◽  
Alejandra Hernández-Santana ◽  
Diego Gamba-Sánchez
Keyword(s):  
Fatty Acids ◽  
Microwave Irradiation ◽  
Carboxylic Acids ◽  
Silica Gel ◽  
Solid Support ◽  
Secondary Amines ◽  
Primary And Secondary Amines ◽  
Direct Amidation

A highly improved methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. Several examples using aliphatic, aromatic, unsaturated and fatty acids combined with primary and secondary amines are shown.

scholarly journals TfOH-Promoted Reaction of 2,4-Diaryl-1,1,1-Trifluorobut-3-yn-2-oles with Arenes: Synthesis of 1,3-Diaryl-1-CF3-Indenes and Versatility of the Reaction Mechanisms

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3079 ◽  
Author(s):  
Aleksey V. Zerov ◽  
Anna N. Kazakova ◽  
Irina A. Boyarskaya ◽  
Taras L. Panikorovskii ◽  
Vitalii V. Suslonov ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Reaction Mechanisms ◽  
Room Temperature ◽  
Ring Closure ◽  
Nucleophilic Attack ◽  
New Process ◽  
Intramolecular Ring ◽  
Propargyl Alcohols

The TfOH-mediated reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-oles (CF3-substituted diaryl propargyl alcohols) with arenes in CH2Cl2 afford 1,3-diaryl-1-CF3-indenes in yields up to 84%. This new process for synthesis of such CF3-indenes is complete at room temperature within one hour. The synthetic potential, scope, and limitations of this reaction were illustrated by more than 70 examples. The proposed reaction mechanism invokes the formation of highly reactive CF3-propargyl cation intermediates that can be trapped at the two mesomeric positions by the intermolecular nucleophilic attack of an arene partner with a subsequent intramolecular ring closure.

An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation

2016 ◽  
Vol 147 (9) ◽  
pp. 1605-1614 ◽  
Author(s):  
Dawei Zhang ◽  
Xiaodong Chen ◽  
Xue Guo ◽  
Yumin Zhang ◽  
Yaya Hou ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solid Support ◽  
Solvent Free ◽  
Solvent Free Synthesis
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