Histone Hl° expression during developmental growth of rat liver

1983 ◽  
Vol 61 (11) ◽  
pp. 1197-1200 ◽  
Author(s):  
Hélène Larue ◽  
Elyse Bissonnette ◽  
Luc Bélanger
Keyword(s):  
Dna Synthesis ◽  
Rat Liver ◽  
Cytosine Arabinoside ◽  
Proliferative Activity ◽  
Neonatal Rats ◽  
Developmental Event ◽  
Rat Liver Nuclei ◽  
Developmental Growth ◽  
Liver Nuclei

Histone Hl° appears in rat liver nuclei around the time of birth; it increases to near-adult levels by 30 days of age, in waves which correlate with distinct phases of liver developmental growth. Hl° emerges as the liver terminates the bulk of its proliferative activity, but it accumulates mainly during the terminal cytodifferentiation phases leading to polyploidization. Premature interruption of liver DNA synthesis in neonatal rats, with cytosine arabinoside or dexamethasone, induces some accumulation of Hl° in the liver. Our data suggest that DNA synthesis arrest conditions in part, but is not the main developmental event underlying Hl° expression during differentiation of rat liver.

Effect of benzo[a]pyrene on DNA synthesis and DNA polymerase activity of rat liver nuclei

1985 ◽  
Vol 34 (6) ◽  
pp. 755-762 ◽  
Author(s):  
Inés Salazar ◽  
Laura Tarragó-Litvak ◽  
Simón Litvak ◽  
Lionel Gil
Keyword(s):  
Dna Synthesis ◽  
Dna Polymerase ◽  
Rat Liver ◽  
Polymerase Activity ◽  
Rat Liver Nuclei ◽  
Liver Nuclei

scholarly journals STRUCTURAL ALTERATION IN ISOLATED RAT LIVER NUCLEI AFTER REMOVAL OF TEMPLATE RESTRICTION BY POLYANIONS

1972 ◽  
Vol 53 (3) ◽  
pp. 737-757 ◽  
Author(s):  
Eugene A. Arnold ◽  
David H. Yawn ◽  
David G. Brown ◽  
Robert C. Wyllie ◽  
Donald S. Coffey
Keyword(s):  
Dna Synthesis ◽  
Rat Liver ◽  
Nuclear Dna ◽  
Nuclear Ultrastructure ◽  
Isolated Rat Liver ◽  
Rat Liver Nuclei ◽  
Dna Release ◽  
Liver Nuclei ◽  
Dna Template ◽  
Isolated Rat

Specific polyanions release DNA template restrictions for DNA synthesis in isolated rat liver nuclei. The degree to which DNA synthesis is enhanced can be correlated with a spectrum of changes in nuclear structure Each polyanion which is effective in the release of template restriction produces a characteristic alteration in nuclear ultrastructure. Polyanions which have no effect on DNA synthesis do not appear to cause any change in nuclear organization or ultrastructure. Parallel measurements of nuclear DNA release and nuclear volume changes also indicate that template-activating polyanions cause remarkable changes in the structural organization of the treated nuclei. These results indicate that DNA template activation involves direct interactions between polyanions and nuclear constituents and suggest the possibility that naturally occurring polyanions might have a role in the control of gene activity

scholarly journals The synthesis of nicotinamide–adenine dinucleotide and poly(adenosine diphosphate ribose) in various classes of rat liver nuclei

1969 ◽  
Vol 115 (5) ◽  
pp. 881-887 ◽  
Author(s):  
M E Haines ◽  
I R Johnston ◽  
A P Mathias ◽  
D. Ridge
Keyword(s):  
Dna Synthesis ◽  
Rat Liver ◽  
Nicotinamide Adenine Dinucleotide ◽  
Adenosine Diphosphate ◽  
Nicotinamide Adenine ◽  
Nad Metabolism ◽  
Rat Liver Nuclei ◽  
Liver Nuclei ◽  
Specific Activities

1. The activities of NMN adenylyltransferase and an enzyme that synthesizes poly (ADP-ribose) from NAD were investigated in the various classes of rat liver nuclei fractionated by zonal centrifugation. 2. The highest specific activities of these two nuclear enzymes occur in different classes of nuclei. In very young and in mature rats it was shown that a correlation exists between DNA synthesis and NMN adenylyltransferase activity, but in rats of intermediate age this correlation is less evident. The highest activities of the enzyme that catalyses formation of poly (ADP-ribose) are in the nuclei involved in the synthesis of RNA. 3. The significance of these results in relation to NAD metabolism is discussed.

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