Synthesis of and allergic contact dermatitis to bicyclo-[2,2,1]-heptyl-α-methylene-γ-butyrolactones derived from norbornene and camphene

1978 ◽  
Vol 56 (3) ◽  
pp. 153-157 ◽  
Author(s):  
Gilbert Schlewer ◽  
Jean-Luc Stampf ◽  
Claude Benezra
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Guinea Pigs ◽  
Human Volunteer ◽  
Allergic Contact

Three new lactones, 2-oxo-3-methylene-4,7-methanobenzofuran and two α-methylene spirolactones, 3′,3′-dimethylspiro(2-oxo-3-methylenefuran-5,2′-norbornane), were synthesized and their skin activity was tested on one human volunteer and on guinea pigs. The man, sensitized to Frullania, was found sensitive to the above lactones and also reacted to frullanolide and alantolactone. The guinea pigs, experimentally sensitized to alantolactone, cross-reacted to 2-oxo-3-methylene-4,7-methanobenzofuran and the two α-methylene spirolactones, and also to isolantolactone and frullanolide.

scholarly journals Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by DNFB.

Ensho ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 571-574
Author(s):  
Yoko Shoji ◽  
Tadashi Fukumura ◽  
Toshitaka Kudo ◽  
Akira Yanagawa ◽  
Jingoro Shimada ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Mycophenolic Acid ◽  
Guinea Pigs ◽  
Topical Preparation ◽  
Allergic Contact ◽  
Experimental Allergic

scholarly journals Synthese von seitenkettenmodifizierten Analogen des Allergens Primin / Synthesis of Side-Chain-Modified Analogues of the Allergen Primin

1993 ◽  
Vol 48 (3) ◽  
pp. 387-393 ◽  
Author(s):  
Wilfried A. König. ◽  
Holger Faasch ◽  
Holger Heitsch ◽  
Cornelia Colberg ◽  
Björn M. Hausen
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Chain Length ◽  
Guinea Pigs ◽  
Chemical Structure ◽  
Alkyl Chain ◽  
Maximum Activity ◽  
Side Chain ◽  
Allergic Contact ◽  
The Relationship

Benzoquinones such as primin (2-methoxy-6-pentyl-1,4-benzoquinone) from Primula obconica HANCE (Primulaceae) are known to be strong sensitizers and thus the source of severe allergic contact dermatitis (cell-mediated type of allergy). In order to determine the relationship between sensitizing capacity and chemical structure the synthesis of 19 side-chain-modified analogues of primin was carried out. With each of these primin derivatives 10 guinea pigs were sensitized using a modified FCA-method (FCA = Freund’s complete adjuvant). Elicitation was done open epicutaneously with 0.001 molar concentrations. In these sensitization experiments 2-methoxy-6-alkyl-1,4-benzoquinones (chain length C1-C15) showed ascending sensitizing potency with increasing number of the side chain carbon atoms reaching maximum activity at an alkyl chain of 10 to 11 carbons. Beyond this point a decrease of the sensitizing potency in correlation with a further prolongation of the side chain was observed.

Topical cyclosporine: effects on allergic contact dermatitis in guinea pigs *

1989 ◽  
Vol 20 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Catherine A. Biren ◽  
Ronald J. Barr ◽  
Grace S. Ganderup ◽  
Lucille L. Emus ◽  
Jerry L. McCullough
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Guinea Pigs ◽  
Allergic Contact
Sign in / Sign up

Export Citation Format

Share Document