Glycerol as an inhibitor of cholesterol synthesis

1968 ◽  
Vol 46 (8) ◽  
pp. 859-863 ◽  
Author(s):  
B. B. Migicovsky
Keyword(s):  
Total Cholesterol ◽  
Rat Liver ◽  
Serum Cholesterol ◽  
Cholesterol Synthesis ◽  
Specific Radioactivity ◽  
Cholesterol Concentration ◽  
Liver Cholesterol ◽  
Water Control ◽  
Glycerol Water ◽  
Serum Cholesterol Concentration

The supernatant from a homogenate of rat liver was incubated in a system containing 14C-acetate. The mixture was then saponified, the cholesterol isolated as the digitonide, and its radioactivity determined. When glycerol (water control) was a constituent of the incubation mixture, less radioactivity appeared in the digitonide. Under the same conditions, glycerol did not apparently inhibit the incorporation of 14C-mevalonate into liver cholesterol. When rats were given glycerol or glucose by mouth then 14C-acetate intraperitoneally, the total cholesterol radioactivity, specific radioactivity, and in most cases the serum cholesterol concentration, were all lower in those rats that had been given the glycerol.

Effect of Nicotinic Acid on Cholesterol Metabolism in Monkeys

1974 ◽  
Vol 46 (4) ◽  
pp. 527-538
Author(s):  
Amany A. Magide ◽  
N. B. Myant
Keyword(s):  
Nicotinic Acid ◽  
Serum Cholesterol ◽  
Cholesterol Metabolism ◽  
Specific Radioactivity ◽  
Cholesterol Concentration ◽  
Moderate Degree ◽  
Serum Free Fatty Acid ◽  
Faecal Excretion ◽  
Serum Cholesterol Concentration ◽  
Endogenous Steroids

1. Single subcutaneous injections of nicotinic acid lowered the serum free fatty acid and triglyceride concentration in two non-fasting Rhesus monkeys. 2. Injections of nicotinic acid repeated daily for 2–4 weeks led to a substantial fall in serum cholesterol concentration, comparable with that obtained in humans given therapeutic doses of nicotinic acid by mouth. 3. The fall in serum cholesterol concentration was accompanied by a decrease in hepatic synthesis of cholesterol but there was no change in the faecal excretion of endogenous steroids. 4. The rate of synthesis of cholesterol, estimated from the faecal excretion of endogenous steroids and from the serum specific radioactivity curve, was such that a moderate degree of inhibition would have accounted for the observed decrease in the amount of circulating cholesterol during nicotinic acid treatment.

scholarly journals Effect of modification of thyroid function on cholesterol 7α-hydroxylation in rat liver

1975 ◽  
Vol 148 (3) ◽  
pp. 499-503 ◽  
Author(s):  
N Takeuchi ◽  
M Ito ◽  
K Uchida ◽  
Y Yamamura
Keyword(s):  
Thyroid Function ◽  
Serum Cholesterol ◽  
Cholesterol Synthesis ◽  
Low Dose ◽  
Cholesterol Concentration ◽  
Hydroxylase Activity ◽  
Synthetic Enzymes ◽  
Glucose Administration ◽  
Serum Cholesterol Concentration ◽  
High Doses

Hepatic activities of cholesterol synthesis and cholesterol 7 alpha-hydroxylation were determined in hyper- and hypo-thyroid rats after oral administration of glucose or cholesterol. Increases in activities of both cholesterol synthesis and cholesterol 7 alpha-hydroxylation induced by glucose administration were enhanced by pretreatment with thyroid powder but suppressed by pretreatment with thiouracil. The enhancement of 7 alpha-hydroxylation was produced by a relatively small amount of thyroid powder, but high doses were required to increase cholesterol synthesis. On the other hand, the suppression of 7 alpha-hydroxylation was brought about by a low dose of thiouracil, but high doses were required to decrease cholesterol synthesis. Although cholesterol synthesis increased similarly in both hypo- and hyper-thyroid rats after glucose administration, hydroxylase activity in hypothyroid rats began to increase more slowly and was always lower than that in hyperthyroid rats. Thus it is concluded that cholesterol 7 alpha-hydroxylase activity is more sensitive to thyroid function than are activities of cholesterol-synthetic enzymes. When exogenous cholesterol was given, hypothyroid rats showed a larger increase in serum cholesterol concentration than hyperthyroid rats, and there was an inverse relationship between serum cholesterol concentrations and hepatic cholesterol 7 alpha-hydroxylase activities.

Effect of ß-sitosterol on serum cholesterol concentration in the rat

1959 ◽  
Vol 197 (1) ◽  
pp. 102-104 ◽  
Author(s):  
Narindar Nath ◽  
A. E. Harper
Keyword(s):  
Cholic Acid ◽  
Serum Cholesterol ◽  
Corn Oil ◽  
Cholesterol Concentration ◽  
Liver Cholesterol ◽  
Serum Cholesterol Concentration

ß-Sitosterol added to a diet containing cholesterol alone or with cholic acid, diminished the accumulation of serum and liver cholesterol in the rat. This effect depended upon the quantity of ß-sitosterol added. Addition of ß-sitosterol to a diet containing corn oil enhanced the hypocholesteremic effect of corn oil. Calciferol and Q275 when fed to rats had no significant effect on serum cholesterol concentration, but calciferol caused an increase in the deposition of cholesterol in the liver.

scholarly journals THE EFFECTS OF CHOLESTEROL DOSAGE, CORTISONE, AND DCA ON TOTAL SERUM CHOLESTEROL, LIPOPROTEINS, AND ATHEROSCLEROSIS IN THE RABBIT

1952 ◽  
Vol 96 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Donald L. Cook ◽  
Roger Ray ◽  
Edwin Davisson ◽  
Lois M. Feldstein ◽  
Lyle D. Calvin ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Cholesterol Concentration ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Cholesterol Diet ◽  
Serum Lipoproteins ◽  
Cholesterol Feeding ◽  
Serum Cholesterol Concentration ◽  
Desoxycorticosterone Acetate

The effects of cholesterol dosage, cortisone, and desoxycorticosterone acetate on total serum cholesterol, lipoproteins, and atherosclerosis were studied over a period of 112 days in thirty-two rabbits. Cholesterol was administered by feeding the rabbits diets containing 0.063, 0.25, and 1.0 per cent cholesterol At intervals measurements were made of total serum cholesterol and of low density lipid and lipoprotein components of three classes, Sf, 5–9, Sf 10–15, and Sf 16–30. All three classes of lipoproteins increased with cholesterol feeding. The total serum cholesterol concentration was linearly related to both the quantity of cholesterol consumed and its concentration in the diet. Lipoprotein and total serum cholesterol concentrations were significantly and equally well correlated with the severity of atherosclerosis. Cortisone administration in the normal rabbit increased the concentrations of total cholesterol and of lipoprotein components of the Sf 10–15 and Sf 16–30 classes, but did not produce atherosclerosis. Cortisone treatment in cholesterol-fed rabbits did not significantly affect the levels of serum lipoproteins, cholesterol concentration, or atherosclerosis produced by a 1.0 per cent cholesterol diet alone. Values for total cholesterol and Sf 5–9 class of lipoproteins in DCA-treated animals were lower than those in controls but the degree of atherosclerosis was not significantly less.

scholarly journals Low serum cholesterol concentration and serotonin metabolism in men

BMJ ◽  
1996 ◽  
Vol 312 (7025) ◽  
pp. 221-221 ◽  
Author(s):  
P. H A Steegmans ◽  
D. Fekkes ◽  
A. W Hoes ◽  
A. A A Bak ◽  
E. van der Does ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Cholesterol Concentration ◽  
Serotonin Metabolism ◽  
Serum Cholesterol Concentration ◽  
Low Serum
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