Effect of Nicotinic Acid on Cholesterol Metabolism in Monkeys

1974 ◽  
Vol 46 (4) ◽  
pp. 527-538
Author(s):  
Amany A. Magide ◽  
N. B. Myant
Keyword(s):  
Nicotinic Acid ◽  
Serum Cholesterol ◽  
Cholesterol Metabolism ◽  
Specific Radioactivity ◽  
Cholesterol Concentration ◽  
Moderate Degree ◽  
Serum Free Fatty Acid ◽  
Faecal Excretion ◽  
Serum Cholesterol Concentration ◽  
Endogenous Steroids

1. Single subcutaneous injections of nicotinic acid lowered the serum free fatty acid and triglyceride concentration in two non-fasting Rhesus monkeys. 2. Injections of nicotinic acid repeated daily for 2–4 weeks led to a substantial fall in serum cholesterol concentration, comparable with that obtained in humans given therapeutic doses of nicotinic acid by mouth. 3. The fall in serum cholesterol concentration was accompanied by a decrease in hepatic synthesis of cholesterol but there was no change in the faecal excretion of endogenous steroids. 4. The rate of synthesis of cholesterol, estimated from the faecal excretion of endogenous steroids and from the serum specific radioactivity curve, was such that a moderate degree of inhibition would have accounted for the observed decrease in the amount of circulating cholesterol during nicotinic acid treatment.

A PROPOSED MECHANISM FOR THE EFFECT OF DIFFERENT DIETARY FATS ON SOME ASPECTS OF CHOLESTEROL METABOLISM

1962 ◽  
Vol 40 (1) ◽  
pp. 1091-1100 ◽  
Author(s):  
J. A. Wilkens ◽  
H. de Wit ◽  
B. Bronte-Stewart
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Cholesterol Metabolism ◽  
Dietary Cholesterol ◽  
Serum Levels ◽  
High Serum ◽  
Dietary Fats ◽  
Cholesterol Concentration ◽  
Serum Cholesterol Concentration ◽  
Endogenous Cholesterol

To explain the effect of dietary cholesterol and different fats on serum cholesterol concentration a hypothesis is proposed according to which the condition for the absorption of dietary cholesterol is its state of solution in dietary or endogenous fats. Dietary fats, free from cholesterol, exert their effect on serum cholesterol concentration by causing reabsorption of biliary or endogenous cholesterol. To test this hypothesis the solubility of cholesterol in a number of natural and modified triglyceride fats at 37 °C was determined and found to correlate with the effects of these fats on the serum cholesterol concentration of rats and man. Relatively high solubilities were associated with high serum levels and vice versa. Artificial modification of both unsaponifiable matter and fatty acids of triglyceride oils was found to alter the solubility of cholesterol in these oils. The solubility concept is discussed as a possible mechanism underlying the effect of different dietary fats on serum cholesterol concentration and other aspects of cholesterol metabolism such as absorption, excretion, and liver synthesis.

Glycerol as an inhibitor of cholesterol synthesis

1968 ◽  
Vol 46 (8) ◽  
pp. 859-863 ◽  
Author(s):  
B. B. Migicovsky
Keyword(s):  
Total Cholesterol ◽  
Rat Liver ◽  
Serum Cholesterol ◽  
Cholesterol Synthesis ◽  
Specific Radioactivity ◽  
Cholesterol Concentration ◽  
Liver Cholesterol ◽  
Water Control ◽  
Glycerol Water ◽  
Serum Cholesterol Concentration

The supernatant from a homogenate of rat liver was incubated in a system containing 14C-acetate. The mixture was then saponified, the cholesterol isolated as the digitonide, and its radioactivity determined. When glycerol (water control) was a constituent of the incubation mixture, less radioactivity appeared in the digitonide. Under the same conditions, glycerol did not apparently inhibit the incorporation of 14C-mevalonate into liver cholesterol. When rats were given glycerol or glucose by mouth then 14C-acetate intraperitoneally, the total cholesterol radioactivity, specific radioactivity, and in most cases the serum cholesterol concentration, were all lower in those rats that had been given the glycerol.

A PROPOSED MECHANISM FOR THE EFFECT OF DIFFERENT DIETARY FATS ON SOME ASPECTS OF CHOLESTEROL METABOLISM

1962 ◽  
Vol 40 (8) ◽  
pp. 1091-1100 ◽  
Author(s):  
J. A. Wilkens ◽  
H. de Wit ◽  
B. Bronte-Stewart
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Cholesterol Metabolism ◽  
Dietary Cholesterol ◽  
Serum Levels ◽  
High Serum ◽  
Dietary Fats ◽  
Cholesterol Concentration ◽  
Serum Cholesterol Concentration ◽  
Endogenous Cholesterol

To explain the effect of dietary cholesterol and different fats on serum cholesterol concentration a hypothesis is proposed according to which the condition for the absorption of dietary cholesterol is its state of solution in dietary or endogenous fats. Dietary fats, free from cholesterol, exert their effect on serum cholesterol concentration by causing reabsorption of biliary or endogenous cholesterol. To test this hypothesis the solubility of cholesterol in a number of natural and modified triglyceride fats at 37 °C was determined and found to correlate with the effects of these fats on the serum cholesterol concentration of rats and man. Relatively high solubilities were associated with high serum levels and vice versa. Artificial modification of both unsaponifiable matter and fatty acids of triglyceride oils was found to alter the solubility of cholesterol in these oils. The solubility concept is discussed as a possible mechanism underlying the effect of different dietary fats on serum cholesterol concentration and other aspects of cholesterol metabolism such as absorption, excretion, and liver synthesis.

scholarly journals Low serum cholesterol concentration and serotonin metabolism in men

BMJ ◽  
1996 ◽  
Vol 312 (7025) ◽  
pp. 221-221 ◽  
Author(s):  
P. H A Steegmans ◽  
D. Fekkes ◽  
A. W Hoes ◽  
A. A A Bak ◽  
E. van der Does ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Cholesterol Concentration ◽  
Serotonin Metabolism ◽  
Serum Cholesterol Concentration ◽  
Low Serum

Association of personal and familial suicide risk with low serum cholesterol concentration in male lithium patients

2001 ◽  
Vol 104 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Alberto Bocchetta ◽  
Caterina Chillotti ◽  
Gianfranco Carboni ◽  
Antonio Oi ◽  
Marco Ponti ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Suicide Risk ◽  
Cholesterol Concentration ◽  
Serum Cholesterol Concentration ◽  
Low Serum
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