RELATIONSHIPS BETWEEN STRUCTURE AND ACTIVITY OF MALEIC HYDRAZIDE ANALOGUES AND RELATED COMPOUNDS

1962 ◽  
Vol 40 (9) ◽  
pp. 1159-1165 ◽  
Author(s):  
E. V. Parups ◽  
I. Hoffman ◽  
H. V. Morley
Keyword(s):  
Analytical Procedure ◽  
Maleic Hydrazide ◽  
Parent Compound ◽  
Ring Closure ◽  
Straight Chain ◽  
Bud Growth ◽  
Related Compounds ◽  
Structure And Activity ◽  
Growth Inhibiting

The growth inhibiting activities of a number of compounds structurally related to maleic hydrazide have been examined using the technique of bud growth inhibition. The degree of inhibitory activity of maleic hydrazide derivatives depended on the ease with which the plant can split off substituents. Straight-chain compounds which partially resemble maleic hydrazide were not as active as the parent compound and ring closure was necessary for full activity. Residue data for some of the tested compounds showed that activity failure was not due to lack of uptake and translocation. The analytical procedure for maleic hydrazide is shown to be valid for the quantitative determination of N-hydroxymethyl-MH and N-benzoyl-MH.

RELATIONSHIPS BETWEEN STRUCTURE AND ACTIVITY OF MALEIC HYDRAZIDE ANALOGUES AND RELATED COMPOUNDS

1962 ◽  
Vol 40 (1) ◽  
pp. 1159-1165 ◽  
Author(s):  
E. V. Parups ◽  
I. Hoffman ◽  
H. V. Morley
Keyword(s):  
Analytical Procedure ◽  
Maleic Hydrazide ◽  
Parent Compound ◽  
Ring Closure ◽  
Straight Chain ◽  
Bud Growth ◽  
Related Compounds ◽  
Structure And Activity ◽  
Growth Inhibiting

The growth inhibiting activities of a number of compounds structurally related to maleic hydrazide have been examined using the technique of bud growth inhibition. The degree of inhibitory activity of maleic hydrazide derivatives depended on the ease with which the plant can split off substituents. Straight-chain compounds which partially resemble maleic hydrazide were not as active as the parent compound and ring closure was necessary for full activity. Residue data for some of the tested compounds showed that activity failure was not due to lack of uptake and translocation. The analytical procedure for maleic hydrazide is shown to be valid for the quantitative determination of N-hydroxymethyl-MH and N-benzoyl-MH.

scholarly journals Use of Nanomaterial-Based (Micro)Extraction Techniques for the Determination of Cosmetic-Related Compounds

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2586
Author(s):  
José Grau ◽  
Juan L. Benedé ◽  
Alberto Chisvert
Keyword(s):  
Parent Compound ◽  
Environmental Surveillance ◽  
Extraction Techniques ◽  
Trace Level ◽  
Adverse Health Effects ◽  
Cosmetic Ingredients ◽  
Absorption Studies ◽  
Related Compounds ◽  
Harmful Effects

The high consumer demand for cosmetic products has caused the authorities and the industry to require rigorous analytical controls to assure their safety and efficacy. Thus, the determination of prohibited compounds that could be present at trace level due to unintended causes is increasingly important. Furthermore, some cosmetic ingredients can be percutaneously absorbed, further metabolized and eventually excreted or bioaccumulated. Either the parent compound and/or their metabolites can cause adverse health effects even at trace level. Moreover, due to the increasing use of cosmetics, some of their ingredients have reached the environment, where they are accumulated causing harmful effects in the flora and fauna at trace levels. To this regard, the development of sensitive analytical methods to determine these cosmetic-related compounds either for cosmetic control, for percutaneous absorption studies or for environmental surveillance monitoring is of high interest. In this sense, (micro)extraction techniques based on nanomaterials as extraction phase have attracted attention during the last years, since they allow to reach the desired selectivity. The aim of this review is to provide a compilation of those nanomaterial-based (micro)extraction techniques for the determination of cosmetic-related compounds in cosmetic, biological and/or environmental samples spanning from the first attempt in 2010 to the present.

Liquid Chromatographic Determination of Amiodarone Hydrochloride and Related Compounds in Raw Materials and Tablets

1994 ◽  
Vol 77 (6) ◽  
pp. 1447-1453 ◽  
Author(s):  
Pauline M Lacrok ◽  
Norman M Curran ◽  
Wing-Wah Sy ◽  
Dennis K J Goreck ◽  
Pierre Thibault ◽  
...  
Keyword(s):  
Raw Materials ◽  
Chromatographic Determination ◽  
Raw Material ◽  
Liquid Chromatographic Method ◽  
Limit Of Quantitation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Amiodarone Hydrochloride ◽  
Related Compounds

Abstract A liquid chromatographic method for the determination of amiodarone hydrochloride and 10 related compounds in drug raw material and for assay of drug in tablets was developed. The method specifies a 3 jxm Hypersil nitrile column (150 × 4.6 mm), a mobile phase of 1 + 1 acetonitrile–ammonium acetate buffer (0.1 M adjusted to pH 6.0 with 0.1 M acetic acid), a flow rate of 1 mL/min, and detection at 240 nm. The lower limit of quantitation of the related compounds is 0.02% or less. Drug contents in 2 raw material samples were 100.1 and 99.9% and ranged from 98.2 to 99.4% in 3 tablet formulations. Impurity levels in 2 samples of raw material from different manufacturers were ca 0.4%. The presence of 3 of the known related compounds in these samples was confirmed by liquid chromatographymass spectrometry. The method applied to raw materials was evaluated by a second laboratory and found to be satisfactory.

scholarly journals A CHEMICAL METHOD FOR THE DETERMINATION OF PTEROYLGLUTAMIC ACID AND RELATED COMPOUNDS

1947 ◽  
Vol 168 (2) ◽  
pp. 705-710
Author(s):  
B.L. Hutchings ◽  
E.L.R. Stokstad ◽  
J.H. Boothe ◽  
J.H. Mowat ◽  
C.W. Waller ◽  
...  
Keyword(s):  
Chemical Method ◽  
Pteroylglutamic Acid ◽  
Related Compounds

Improved Method for the Determination of Ethylenebisdithiocarbamate Residues in Plants, Fruits, and Vegetables

1967 ◽  
Vol 50 (5) ◽  
pp. 1102-1108
Author(s):  
Charles F Gordon ◽  
Richard J Schuckert ◽  
William E Bornak
Keyword(s):  
Sulfuric Acid ◽  
Fruits And Vegetables ◽  
Analytical Procedure ◽  
Improved Method ◽  
Modified Method ◽  
Fungicide Residues ◽  
Crop Types ◽  
Large Representative

Abstract A modified method for the determination of dithiocarbamate fungicide residues on crops is presented. A large representative subsample of the frozen crop is blended in ice-cold deaerated water and an aliquot of the homogenate is added to the analytical apparatus containing hot 5 0% sulfuric acid. Dithiocarbamates are decomposed to evolve CS2 which is removed by a continuous gentle air-sweep from the digestion flask. Variations in technique allow the analysis of dithiocarbamate fungicide residues in several ranges, 1-10, 10-200, and 200-1000 /ig maneb. Recoveries from a wide variety of crops averaged 70 to 103%. Certain crop types present low recoveries and/or high apparent control values, but modifications in the analytical procedure are successful in solving these problems.

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