MARINE STEROLS: IX. BIOSYNTHESIS OF 24-METHYLENECHOLESTEROL IN CLAMS

1961 ◽  
Vol 39 (9) ◽  
pp. 1347-1355 ◽  
Author(s):  
U. H. M. Fagerlund ◽  
D. R. Idler

Clams (Saxidomus giganteus) are able to transform injected cholesterol-4-C14 into radioactive 24-methylenecholesterol in vivo. The highest rate of conversion was observed when the radioactive sterol was injected into the digestive gland. The findings suggest a possible pathway in the biosynthesis of C28-sterols and throw some light on the question of the origin of C28-sterols in lamellibranchs.

1960 ◽  
Vol 38 (1) ◽  
pp. 997-1002 ◽  
Author(s):  
U. H. M. Fagerlund ◽  
D. R. Idler

The in vivo incorporation of 2-C14-acetate into digitonin-precipitable material has been demonstrated in two molluscs, mussel (Mytilus californianus) and clam (Saxidomus giganteus). Clams are able to convert 11,14-C14-squalene into digitonin-precipitable material. When the azoylester of the material isolated from clams is chromatographed, the major portion of the radioactivity follows the least polar zone, which has previously been found to contain mainly monounsaturated Δ5-sterols.A starfish (Pisaster ochraceus) has been shown in vivo to convert ingested 4-C14-cholesterol to 7-cholestenol.


1960 ◽  
Vol 38 (9) ◽  
pp. 997-1002 ◽  
Author(s):  
U. H. M. Fagerlund ◽  
D. R. Idler

The in vivo incorporation of 2-C14-acetate into digitonin-precipitable material has been demonstrated in two molluscs, mussel (Mytilus californianus) and clam (Saxidomus giganteus). Clams are able to convert 11,14-C14-squalene into digitonin-precipitable material. When the azoylester of the material isolated from clams is chromatographed, the major portion of the radioactivity follows the least polar zone, which has previously been found to contain mainly monounsaturated Δ5-sterols.A starfish (Pisaster ochraceus) has been shown in vivo to convert ingested 4-C14-cholesterol to 7-cholestenol.


1972 ◽  
Vol 29 (11) ◽  
pp. 1657-1658 ◽  
Author(s):  
R. J. Price ◽  
J. S. Lee

Frozen toxic butter clam (Saxidomus giganteus) siphons were fractionated and each fraction was bioassayed for paralytic shellfish poison (PSP) and chemically analyzed for melanin. Sonication removed over 50% of the melanin from the siphons and this fraction contained nearly 50% of the PSP initially present in the siphons. The data presented further implicate melanin as a PSP binding agent in vivo.


1961 ◽  
Vol 39 (3) ◽  
pp. 505-509 ◽  
Author(s):  
U. H. M. Fagerlund ◽  
D. R. Idler

Analysis of the ozonolysis products of a sterol fraction obtained from clams (Saxidomus giganteus) injected with cholesterol-26-C14 has demonstrated that these molluscs are able to introduce unsaturation into the cholesterol side chain at C-22 and C-25.


2001 ◽  
Vol 79 (5) ◽  
pp. 907-915 ◽  
Author(s):  
Steven C Greenway ◽  
Kenneth B Storey

The effects of seasonal change (July versus November) and prolonged anoxia (N2 atmosphere at 5 or 10°C for 6 days) exposure in vivo on the activities of 18 enzymes, as well as the kinetic properties of phosphofructokinase (PFK) and pyruvate kinase (PK), were investigated in foot muscle and digestive gland of the marine periwinkle Littorina littorea L. Seasonal differences in enzyme maximal activities were tissue-specific, with generally increased activities during the summer and changes in a greater number of enzymes in digestive gland than in foot muscle. Seasonal differences in the kinetic properties of PFK and PK were observed in both tissues. PK from digestive gland of winter animals showed a much higher S0.5 for phosphoenolpyruvate and stronger changes in enzyme kinetic properties in response to anoxia than did the enzyme in summer animals; this may suggest the presence of seasonal isozymes. The effects of anoxia were tissue- and season-specific. Anoxia exposure during the winter induced a greater number of changes in enzyme maximal activities in foot muscle than in digestive gland. Anoxia-induced changes in the kinetic properties of both PFK and PK were also seen in both organs. For PK, these changes were consistent with less active enzyme forms in the anoxic state. Hence, both seasonal and environmental (anoxia) factors influence enzyme maximal activities and kinetic properties in L. littorea.


RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 64147-64154 ◽  
Author(s):  
Meivelu Moovendhan ◽  
Palaniappan Seedevi ◽  
Annaian Shanmugam ◽  
Shanmugam Vairamani

The purpose of this study was to explore thein vivocardioprotective potency of liver (digestive gland) oil fromS. lessonianaon isoproterenol induced myocardial infracted wistar rats.


2013 ◽  
Vol 132-133 ◽  
pp. 9-18 ◽  
Author(s):  
Cristina Barmo ◽  
Caterina Ciacci ◽  
Barbara Canonico ◽  
Rita Fabbri ◽  
Katia Cortese ◽  
...  

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