THE GASTRIC ENDOCRINE AND EXOCRINE RESPONSE TO HISTAMINE IN DOGS AND EFFECT OF PASSAGE OF BLOOD THROUGH THE GASTRIC AND HEPATIC VESSELS ON ITS PEPSINOGEN CONTENT

1956 ◽  
Vol 34 (2) ◽  
pp. 244-252 ◽  
Author(s):  
K. Kowalewski ◽  
S. T. Norvell Jr. ◽  
Walter C. MacKenzie
Keyword(s):  
Body Weight ◽  
Experimental Period ◽  
Enzyme Concentration ◽  
Pepsin Secretion ◽  
Gastric Artery ◽  
Before And After ◽  
Gastric Pepsin ◽  
Hepatic Vessels ◽  
Endocrine Secretion ◽  
Gastric Pepsin Secretion

Subcutaneous histamine in dogs in a dose of 5 mgm. per kgm. of body weight provoked a significant increase in gastric pepsin secretion over a four-hour period. The increased pepsin production was accompanied by increased secretion of free HCl, increased volume of gastric juice, and elevation of plasma pepsinogen in the same experimental period. Plasma pepsinogen levels, before and after histamine, were investigated in a gastric artery, a gastric vein, the portal vein, a hepatic vein, and a cephalic vein. The enzyme concentration was significantly higher in the gastric vein than in the gastric artery and this difference was accentuated following histamine administration. These findings were attributed to endocrine secretion of pepsinogen by the zymogenic cells of the gastric mucosa. There was no evidence that pepsinogen concentration is altered as the blood traverses the liver.

THE GASTRIC ENDOCRINE AND EXOCRINE RESPONSE TO HISTAMINE IN DOGS AND EFFECT OF PASSAGE OF BLOOD THROUGH THE GASTRIC AND HEPATIC VESSELS ON ITS PEPSINOGEN CONTENT

1956 ◽  
Vol 34 (1) ◽  
pp. 244-252
Author(s):  
K. Kowalewski ◽  
S. T. Norvell Jr. ◽  
Walter C. MacKenzie
Keyword(s):  
Body Weight ◽  
Experimental Period ◽  
Enzyme Concentration ◽  
Pepsin Secretion ◽  
Gastric Artery ◽  
Before And After ◽  
Gastric Pepsin ◽  
Hepatic Vessels ◽  
Endocrine Secretion ◽  
Gastric Pepsin Secretion

Subcutaneous histamine in dogs in a dose of 5 mgm. per kgm. of body weight provoked a significant increase in gastric pepsin secretion over a four-hour period. The increased pepsin production was accompanied by increased secretion of free HCl, increased volume of gastric juice, and elevation of plasma pepsinogen in the same experimental period. Plasma pepsinogen levels, before and after histamine, were investigated in a gastric artery, a gastric vein, the portal vein, a hepatic vein, and a cephalic vein. The enzyme concentration was significantly higher in the gastric vein than in the gastric artery and this difference was accentuated following histamine administration. These findings were attributed to endocrine secretion of pepsinogen by the zymogenic cells of the gastric mucosa. There was no evidence that pepsinogen concentration is altered as the blood traverses the liver.

Effect of topical application of amino acids on gastric pepsin secretion in the rat

1981 ◽  
Vol 16 (2) ◽  
pp. 100-109 ◽  
Author(s):  
Mitsuru Aono ◽  
Motoyuki Moriga ◽  
Haruto Uchino
Keyword(s):  
Amino Acids ◽  
Topical Application ◽  
Pepsin Secretion ◽  
Gastric Pepsin ◽  
Gastric Pepsin Secretion

Effect of high dose omeprazole on gastric pepsin secretion and serum pepsinogen levels in man

1988 ◽  
Vol 35 (2) ◽  
pp. 173-176 ◽  
Author(s):  
R. W. Ten Kate ◽  
H. A. R. E. Tuynman ◽  
H. P. M. Festen ◽  
G. Pals ◽  
S. G. M. Meuwissen
Keyword(s):  
High Dose ◽  
Serum Pepsinogen ◽  
Pepsin Secretion ◽  
Gastric Pepsin ◽  
Gastric Pepsin Secretion

Inhibition of gastric pepsin secretion by glucagon 20–23 region

1983 ◽  
Vol 7 (3) ◽  
pp. 287
Author(s):  
A.S. Gilroy ◽  
D.J. Sanders ◽  
B.H. Hirst ◽  
A.P. Marr ◽  
S. Zahedi-Asl
Keyword(s):  
Pepsin Secretion ◽  
Gastric Pepsin ◽  
Gastric Pepsin Secretion

Effect of nickel toxicity on growth parameters and hepatic enzymes in major carp

2015 ◽  
Author(s):  
Husna Malik ◽  
Sumera Sajjad ◽  
Sobia Akhtar ◽  
Sana Bilal
Keyword(s):  
Body Weight ◽  
Growth Parameters ◽  
Experimental Period ◽  
Total Proteins ◽  
Nickel Toxicity ◽  
Experimental Fish ◽  
Before And After ◽  
Experimental Group ◽  
Group 1

Labeo rohita were used to investigate effect of nickel induced toxicity. For this two groups, control groups (N=50) and experimental groups (N=50) were further divided into group 1-4, on the basis of dosage of nickel and blood sampling. Body weight of animals was noted before and after dose treatment. It was found that body length in the experimental group did not show marked increase throughout experimental period while the effect of nickel toxicity was observed on body weight. The weight of experimental fish decreased in experimental group significantly (p<0.05) from first dose to the last dose. Blood plasma was analyzed for biochemical parameters (Total proteins, AST, ALT, and ALP). AST, ALT and ALP levels increased remarkably in experimental fish as compared to the control one, while the levels of total proteins decreased significantly from group 1-4. Results of the present study suggest hepatotoxicity caused by metal and role of nickel as endocrine disrupter in fish body. Nickel also causes changes in growth parameters of animal by affecting their body weight with increased dosage of metal.

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