Beyond the walls of the nucleus: the role of histones in cellular signaling and innate immunityThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

2006 ◽  
Vol 84 (4) ◽  
pp. 589-595 ◽  
Author(s):  
Missag H. Parseghian ◽  
Keith A. Luhrs
Keyword(s):  
Antimicrobial Agents ◽  
Peer Review Process ◽  
Vital Role ◽  
Surface Acting ◽  
Microbial Infection ◽  
Post Translational Modifications ◽  
Linker Histones ◽  
The Past ◽  
Critical Components

Although they are one of the oldest family of proteins known (first described in 1884 by Kossel), histones continue to surprise researchers with their ever expanding roles in biology. In the past 25 years, the view of core histone octamers as a simple spool around which DNA in the nucleus is wound and linker histones as mere fasteners clipping it all together has transformed into the realization that histones play a vital role in transcriptional regulation. Through post-translational modifications, histones control the accessibility of transcription factors and a host of other proteins to multiple, conceivably thousands of, genes at once. While researchers have spent decades deciphering the role of histones in the overall structure of chromatin, it might surprise some to find that an entirely separate faction of scientists have focused on the role of histones beyond the confines of the nuclear envelope. In the past decade, there has been an accumulation of observations that suggest that histones can be found at the mitochondrion during the onset of apoptotic signaling and even at the cell surface, acting as a receptor for bacterial and viral proteins. More provocatively, immunologists are becoming convinced that they can also be found in the lumen of several tissues, acting as antimicrobial agents—critical components of an ancient innate immune system. Perhaps nowhere is this observation as dramatic as in the ability of neutrophils to entrap bacterial pathogens by casting out "nets" of DNA and histones that not only act as a physical barrier, but also display bactericidal activity. As our views regarding the role of histones inside and outside the cell evolve, some have begun to develop therapies that either utilize or target histones in the fight against cancer, microbial infection, and autoimmune disease. It is our goal here to begin the process of merging the dichotomous lives of histones both within and without the nuclear membrane.

scholarly journals “Here are the Women”

1970 ◽  
pp. 63-69
Author(s):  
Farah Kobaissy
Keyword(s):  
Women Leaders ◽  
Labor Movement ◽  
Vital Role ◽  
Female Worker ◽  
Assembly Lines ◽  
Sexual Discrimination ◽  
The Past ◽  
Active Contribution

This article sheds light on the labor movement in Egypt, examines the vital role of the Egyptian female worker within it and tries to analyze how her active contribution in the past few years has led to the emergence of women leaders who played a prominent role in strikes and protests in a number of factories and assembly lines. It also examines how much women are capable, in the midst of the said movement, of breaking the barrier of sexual discrimination.

Reaching the New Tourist Through Creativity

2022 ◽  
pp. 231-245
Author(s):  
Christian Stipanović ◽  
Elena Rudan ◽  
Vedran Zubović
Keyword(s):  
Economic Development ◽  
Cultural Heritage ◽  
Social Status ◽  
Vital Role ◽  
Modern World ◽  
Economic Activities ◽  
Tourist Destinations ◽  
The Past ◽  
Opening Up

In today's modern world, creative expression is opening up new dimensions of business and new opportunities for economic development. One field of economic activities in which this is evident is tourism. Creativity in tourist destinations can be viewed in different ways, for example, through creative action (undertaken by destination management, residents, entrepreneurs, and tourists) and through creative spaces and creative events. Creativity plays a vital role in all elements involved in the creation of a destination's offering, regardless of which form of tourism is the focus of development efforts. Given the growing role of self-actualisation of individuals in society and the displaying of social status, creativity has in the past 20 years begun to positively impact on economy activities taking place in tourist destinations. Creativity is especially important in developing cultural tourism in all its sub-types, where it is seen as a means of animating and adding value to cultural heritage locations.

scholarly journals Aeromedical evacuation: experiences from the UK military level 2 hospital in Bentiu, South Sudan, during Op TRENTON

2020 ◽  
pp. bmjmilitary-2020-001448 ◽  
Author(s):  
Leanne Jane Eveson ◽  
W Nevin ◽  
N Cordingley ◽  
M Almond
Keyword(s):  
South Sudan ◽  
Febrile Illness ◽  
Vital Role ◽  
Diagnostic Group ◽  
Aeromedical Evacuation ◽  
The Past ◽  
The Uk ◽  
To Receive ◽  
Level 2

IntroductionAeromedical Evacuation (AE) is a vital role of the Defence Medical Services (DMS). With a far-reaching defence global footprint, an AE capability is crucial to enable movement of patients in the fastest, safest and least stressful way that meets or exceeds the level of care an injured or ill person may expect to receive in the UK. Operation (Op) TRENTON is a UK military humanitarian operation in support of the United Nations (UN) Mission in South Sudan.MethodsA retrospective analysis was carried out of all patients who underwent AE from the UK level 2 hospital at Bentiu during Op TRENTON over a 17-month period from June 2017 to October 2018.Results14 patients underwent AE. The median age was 36 (22–64) years and all patients were male. 21% of AEs were for UK personnel and 79% were for UN personnel. 29% of AEs were due to non-battle injury with the remainder due to disease. Musculoskeletal was the largest diagnostic group (n=4) followed by respiratory (n=3), cardiovascular (n=2), undifferentiated febrile illness (n=2), neurology (n=1), renal medicine (n=1) and psychiatry (n=1).ConclusionsPatients requiring AE from the level 2 hospital at Bentiu mostly had musculoskeletal and medical pathology, a stark contrast to the trauma patient cohort from operations in the past. The majority of patients had definitive care under the medical team highlighting the requirement for DMS physicians and the AE team, to be trained in acute, general and aviation medicine. The majority of AE moves were for UN personnel and on UN airframes, highlighting the importance of a sound understanding of the nations we are working with.

The End of Art and the Non-End of Religion: Hegel on Aesthetics and Religion

2019 ◽  
Vol 26 (2) ◽  
pp. 1-25
Author(s):  
David Lê
Keyword(s):  
Social Life ◽  
Vital Role ◽  
Modern Life ◽  
The Past ◽  
Per Se ◽  
End Of Art ◽  
Role Of Religion

Abstract While Hegel’s infamous “end of art” thesis states that art is “for us, a thing of the past” he insists that philosophy and, to a degree that is often underestimated by contemporary readers, religion endure within the structure of modern life. In this paper I aim to demonstrate how by focusing on Hegel’s claim that religion meets no end, we can come to a better understanding of how and why he thinks art does end. This will lead us away from common, but false, picture of Hegel as being indifferent (or even hostile) to art’s sensuous mode of intelligibility. Inasmuch as religion remains both necessarily sensuous and a component of social life that realizes freedom and divinity within modernity, the “problem” with art cannot be its sensuousness per se. What art ultimately finds itself unable to do, and what religion can do, is find a way to reconcile the destabilizing force of individual, subjective freedom with a jointly-held representation of who and what we are and what we value most, what Hegel calls “divinity” (das Göttliche). By countenancing the vital role of religion in Hegel’s thought, we can therefore better understand one of his most famous, and least understood philosophical claims.

A compendium of the histone H1 family of somatic subtypes: An elusive cast of characters and their characteristics

2001 ◽  
Vol 79 (3) ◽  
pp. 289-304 ◽  
Author(s):  
Missag H Parseghian ◽  
Barbara A Hamkalo
Keyword(s):  
Historical Context ◽  
Histone H1 ◽  
General Function ◽  
Linker Histones ◽  
Chromatin Compaction ◽  
The Core ◽  
The Past ◽  
Current State ◽  
Core Histones

The last 35 years has seen a substantial amount of information collected about the somatic H1 subtypes, yet much of this work has been overshadowed by research into highly divergent isoforms of H1, such as H5. Reports from several laboratories in the past few years have begun to call into question some of the traditional views regarding the general function of linker histones and their heterogeneity. Hence, the impression in some circles is that less is known about these ubiquitous nuclear proteins as compared with the core histones. The goal of the following review is to acquaint the reader with the ubiquitous somatic H1s by categorizing them and their characteristics into several classes. The reasons for our current state of misunderstanding is put into a historical context along with recent controversies centering on the role of H1 in the nucleus. Finally, we propose a model that may explain the functional role of H1 heterogeneity in chromatin compaction.Key words: histone H1, linker histones, chromatin organization, chromatin compaction, heat shock.

Policy Implications

2021 ◽  
pp. 433-436
Author(s):  
Mark Knights
Keyword(s):  
Vital Role ◽  
Public Deliberation ◽  
Cultural Dimensions ◽  
Policy Implications ◽  
Historical Research ◽  
Top Down ◽  
Public Discussion ◽  
The Past ◽  
Rule Change

This chapter offers a short summary of policy implications raised by the book’s historical research. It comments on the speed and nature of change; the importance of context and state formation; the vital role of public deliberation as well as official compliance; the politics of anti-corruption; and the socio-cultural dimensions that frame what constitutes corruption in office. It is argued that policies should be bottom-up and deliberative as well as top-down and formal; that anti-corruption is a protracted, political and contested process which involves personal, institutional and systemic issues as well as extensive public discussion of ethical questions; that rule-change is easier to achieve than culture-change but reform requires both; that the art of governance is a balance between trust and distrust of office-holders, and between formal and informal modes of accountability; and that history is useful in offering data about the process of anti-corruption and influence of the past.

scholarly journals Serum Therapy for Tuberculosis Revisited: Reappraisal of the Role of Antibody-Mediated Immunity againstMycobacterium tuberculosis

1998 ◽  
Vol 11 (3) ◽  
pp. 514-532 ◽  
Author(s):  
Aharona Glatman-Freedman ◽  
Arturo Casadevall
Keyword(s):  
Antimicrobial Agents ◽  
Public Health Problem ◽  
Advanced Technology ◽  
Sufficient Evidence ◽  
The Past ◽  
History Of ◽  
Potential Vaccine ◽  
Resistant Strains ◽  
Serum Therapy

SUMMARY Fifty years after the introduction of the first effective antimicrobial agents against Mycobacterium tuberculosis, this pathogen continues to be a tremendous public health problem. The rise in the number of resistant strains and the difficulties involved in the therapy of tuberculosis in immunocompromised AIDS patients have renewed the interest in the development of effective vaccines. To evaluate whether a potential vaccine against tuberculosis could prevent infection by eliciting a protective antibody response, we reviewed the history of antibody-mediated immunity against tuberculosis. Review of the literature of the past 100 years demonstrates that there is sufficient evidence to conclude that antibody-mediated immunity can modify the course of infection in certain situations. Based on our findings and on what is known in other systems, we propose that the role of antibody-mediated immunity to M. tuberculosis be reexamined, using advanced technology.

scholarly journals An Insight into the Factors Influencing Specificity of the SUMO System in Plants

Plants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1788
Author(s):  
Moumita Srivastava ◽  
Ari Sadanandom
Keyword(s):  
Current Knowledge ◽  
Protein A ◽  
Vital Role ◽  
Target Protein ◽  
Plant Responses ◽  
Adaptive Responses ◽  
Post Translational Modifications ◽  
Sumo Proteases ◽  
Small Set

Due to their sessile nature, plants are constantly subjected to various environmental stresses such as drought, salinity, and pathogen infections. Post-translational modifications (PTMs), like SUMOylation, play a vital role in the regulation of plant responses to their environment. The process of SUMOylation typically involves an enzymatic cascade containing the activation, (E1), conjugation (E2), and ligation (E3) of SUMO to a target protein. Additionally, it also requires a class of SUMO proteases that generate mature SUMO from its precursor and cleave it off the target protein, a process termed deSUMOylation. It is now clear that SUMOylation in plants is key to a plethora of adaptive responses. How this is achieved with an extremely limited set of machinery components is still unclear. One possibility is that novel SUMO components are yet to be discovered. However, current knowledge indicates that only a small set of enzymes seem to be responsible for the modification of a large number of SUMO substrates. It is yet unknown where the specificity lies within the SUMO system. Although this seems to be a crucial question in the field of SUMOylation studies, not much is known about the factors that provide specificity. In this review, we highlight the role of the localisation of SUMO components as an important factor that can play a vital role in contributing to the specificity within the process. This will introduce a new facet to our understanding of the mechanisms underlying such a dynamic process.

scholarly journals The Role of Visual Inspection in the 21st Century

2017 ◽  
Vol 61 (1) ◽  
pp. 262-266 ◽  
Author(s):  
Judi E. See ◽  
Colin G. Drury ◽  
Ann Speed ◽  
Allison Williams ◽  
Negar Khalandi
Keyword(s):  
21St Century ◽  
Visual Inspection ◽  
Past Research ◽  
Vital Role ◽  
Automated Detection ◽  
Lessons Learned ◽  
The Past ◽  
Different Types ◽  
Inspection Process

Visual inspection research has a long history spanning the 20th century and continuing to the present day. Current efforts in multiple venues demonstrate that visual inspection continues to have a vital role for many different types of tasks in the 21st century. The nature of this role spans the range from traditional human visual inspection to fully automated detection of defects. Consequently, today’s practitioners must not only successfully identify and apply lessons learned from the past, but also explore new areas of research in order to derive solutions for modern day issues such as those presented by introducing automation during inspection. A key lesson from past research indicates that the factors that can degrade performance will persist today, unless care is taken to design the inspection process appropriately.

scholarly journals INCREASING EFFECTIVENESS WAQF ROLE IN EDUCATION IN INDUSTRI REVOLUTION 4.0 ERA

2020 ◽  
Vol 3 (12) ◽  
pp. 53-63
Author(s):  
Cecep Soleh Kurniawan ◽  
Mas Nooraini Mohiddin
Keyword(s):  
Human Resources ◽  
Secondary Data ◽  
Vital Role ◽  
Muslim Community ◽  
Descriptive Research ◽  
The Core ◽  
The Past ◽  
History Of ◽  
Individual Style

The vital role of waqf institution and its contribution in many sectors becomes the core of the strongest economy in the Muslim community in the past at present. Waqf is the main sponsorship for the Muslim community when its function is to eliminate ignorance through education. Education is the most important thing in this era which can change an individual style of life. The success of education can become a medium in developing the country through the success of producing a quality, potential, creative and innovative product. This research tends to explore the history of waqf and education in order to identify the way of improving the waqf role in this era. A descriptive research methodology will be used. Analyzing information from secondary data such as journals, paper works, and relevant articles will be done. Waqf Management and administration should be done in order to prepare for the Industry Revolution 4.0 which robotic has replaced human resources. The effectiveness of waqf in education will enable to produce quality human resources and provide a better education for the community.

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