Comparison of the pathogenicity of three species of coagulase-negative Staphylococcus in a mouse model with and without a foreign body

1991 ◽  
Vol 37 (9) ◽  
pp. 722-724 ◽  
Author(s):  
K. P. Ferguson ◽  
D. W. Lambe Jr. ◽  
J. L. Keplinger ◽  
J. H. Kalbfleisch
Keyword(s):  
Foreign Body ◽  
Mouse Model ◽  
Staphylococcus Epidermidis ◽  
Foreign Bodies ◽  
Abscess Formation ◽  
Coagulase Negative Staphylococcus ◽  
Staphylococcus Lugdunensis ◽  
Key Words Foreign Body ◽  
High Incidence ◽  
Culture Positive

Staphylococcus schleiferi, Staphylococcus lugdunensis, and Staphylococcus epidermidis produce a high incidence of abscesses in a mouse model with an implanted foreign body. We investigated the significance of the foreign body in this process. Fourteen strains of S. schleiferi, S. epidermidis, and S. lugdunensis were tested in our model. A preadhered foreign body was implanted into one mouse group, followed by injection of a test strain. Another group received injection without implant. Abscesses were assessed at 7 days; foreign bodies and infected tissues were cultured. The percent of samples that developed abscesses or were culture positive was compared for each strain. Nearly all mice infected with S. schleiferi developed abscesses and were culture positive. The foreign body made no difference in abscess formation for three of four S. schleiferi but increased the incidence of both organism recovery and abscess for three of five S. epidermidis. The foreign body enhanced abscess formation for four of five S. lugdunensis, with all five strains yielding significantly more culture recovery. Although the pathogenicity of nine strains was increased by the foreign body, five strains yielded high abscess and culture recovery rates that were not enhanced by its presence. Key words: foreign body, Staphylococcus lugdunensis, Staphylococcus schleiferi.

Pathogenicity of Staphylococcus lugdunensis, Staphylococcus schleiferi, and three other coagulase-negative staphylococci in a mouse model and possible virulence factors

1990 ◽  
Vol 36 (7) ◽  
pp. 455-463 ◽  
Author(s):  
D. W. Lambe Jr. ◽  
K. P. Ferguson ◽  
J. L. Keplinger ◽  
C. G. Gemmell ◽  
J. H. Kalbfleisch
Keyword(s):  
Mouse Model ◽  
Virulence Factors ◽  
Staphylococcus Epidermidis ◽  
Abscess Formation ◽  
Test Strain ◽  
Coagulase Negative Staphylococci ◽  
Staphylococcus Lugdunensis ◽  
Pure Cultures ◽  
Staphylococcus Hominis ◽  
Culture Positive

Staphylococcus lugdunensis and Staphylococcus schleiferi, two newly described species, have been isolated from numerous types of human infections. We compared the pathogenicity of 30 strains of S. lugdunensis, S. schleiferi, Staphylococcus epidermidis, Staphylococcus warneri, and Staphylococcus hominis, using a mouse model in which a foreign body preadhered with the test strain was implanted subcutaneously, followed by injection of the test strain. All five species of staphylococci produced abscesses. Staphylococcus epidermidis, S. schleiferi, and S. lugdunensis yielded species means of 76–91% abscess formation; 80–100% of the infected foreign bodies and tissues were culture positive. These three species were more virulent than S. warneri or S. hominis, which produced abscesses in 54 and 65% of mice, respectively; only 10–48% of the infected samples were culture positive. Transmission electron microscopy of pure cultures of selected strains showed that all species possessed glycocalyx. All species produced a variety of possible virulence factors, such as α and δ hemolysins, as well as the aggressins lipase and esterase. The production of exoenzymes did not always correlate with virulence as demonstrated by abscess formation in mice. Key words: coagulase-negative staphylococci, Staphylococcus lugdunensis, Staphylococcus schleiferi.

Natural History of Chronic Staphylococcus epidermidis Foreign Body Infection in a Mouse Model

1991 ◽  
Vol 164 (6) ◽  
pp. 1220-1223 ◽  
Author(s):  
B. Gallimore ◽  
R. F. Gagnon ◽  
R. Subang ◽  
G. K. Richards
Keyword(s):  
Foreign Body ◽  
Natural History ◽  
Mouse Model ◽  
Staphylococcus Epidermidis ◽  
History Of

scholarly journals A novel rat model of foreign body osteomyelitis for evaluation of antimicrobial efficacy

2019 ◽  
Vol 3 (1) ◽  
pp. 7-14
Author(s):  
Cassandra L. Brinkman ◽  
Suzannah M. Schmidt-Malan ◽  
Melissa J. Karau ◽  
Robin Patel
Keyword(s):  
Foreign Body ◽  
Animal Models ◽  
Rat Model ◽  
Staphylococcus Epidermidis ◽  
Foreign Bodies ◽  
Infected Animal ◽  
Infection Site ◽  
Aureus Infection ◽  
Novel Model ◽  
A Current

The most common organism-type causing orthopedic foreign body infection is the staphylococci, of which Staphylococcus aureus and Staphylococcus epidermidis are especially common. These organisms form biofilms on orthopedic foreign body surfaces, rendering such infections challenging and time consuming to treat. Our group evaluates novel therapeutics for orthopedic foreign body infection in animal models. A current limitation of most animal models is that that they only allow for the removal of one sample per animal, at the time of sacrifice. Herein, we describe a novel rat model of foreign body osteomyelitis that allows removal of foreign bodies at different time points, from the same infected animal. We demonstrate that this model can be used for both S. aureus and S. epidermidis orthopedic foreign body infection, with 3.56, 3.60 and 5.51 log10 cfu/cm2 S. aureus recovered at four, five and six weeks, respectively, after infection, and 2.08, 2.17 and 2.62 log10 cfu/cm2 S. epidermidis recovered at four, five and six weeks, respectively, after infection. We evaluated the model with S. aureus infection treated with rifampin 25 mg/kg twice daily for 21 days. Using quantitative cultures, we were no longer able to detect bacteria as of the 14th day of treatment with bacteria becoming detectable again 7 days following the discontinuation of rifampin a period. This novel model allows monitoring of evolution of infection at the infection site in the same animal.

scholarly journals A unique foreign body in bronchus: surgical challenge

1970 ◽  
Vol 17 (2) ◽  
pp. 132-134
Author(s):  
Bharti Solanki ◽  
Govind Narayan Purohit
Keyword(s):  
Foreign Body ◽  
Key Words ◽  
Present Article ◽  
Gold Standard ◽  
Foreign Bodies ◽  
Main Bronchus ◽  
Bronchial Tree ◽  
Key Words Foreign Body ◽  
Glass Bulb

Exogenous foreign bodies in tracheo bronchial tree are not uncommon, particularly in children. The gold standard principal of foreign body management is bronchoscopic removal and this procedure becomes difficult and challenging in cases of large and smooth foreign body as occur in our case. The present article reports a case of unique and large foreign body i.e. intact glass bulb in right main bronchus. Key words: Foreign body; Bronchus.DOI: http://dx.doi.org/10.3329/bjo.v17i2.8854 BJO 2011; 17(2): 132-134

A foreign body (a fish bone) in the esophagus translocating into soft tissues of the neck – a case report

2019 ◽  
Vol 8 (1) ◽  
pp. 56-59
Author(s):  
Magda Licznerska-Kreczko ◽  
Jerzy Kuczkowski ◽  
Tomasz Nowicki ◽  
Maciej Świerblewski ◽  
Andrzej Skorek
Keyword(s):  
Case Report ◽  
Foreign Body ◽  
Antibiotic Prophylaxis ◽  
Digestive Tract ◽  
Foreign Bodies ◽  
Soft Tissues ◽  
Atlantic Cod ◽  
Fish Bone ◽  
Endoscopic Removal ◽  
Key Words Foreign Body

Background: Patients with foreign bodies in upper digestive tract not infrequently trigger many diagnostic and treatment challenges, especially when foreign bodies translocate and are lodged outside the esophagus. Case report: We present a case of a foreign body in esophagus 56-years old woman who had developed persistent sensation of an obstacle in her throat after eating fish (Atlantic cod). She has initially dismissed her symptoms and refused medical treatment. Subsequently, a neck CT done one week later showed a 20-milimeter long fish bone in the soft tissues on the left side of her neck (between pharynx and vertebral column). Few attempts of endoscopic removal were unsuccessful. Despite antibiotic prophylaxis and due to the fish bone translocation into soft tissues of the neck and its location close to a common carotid artery and an internal jugular vein a decision was made to remove it from the external approach. The foreign body was successfully removed without any esophageal damages. Conclusions: Foreign bodies in digestive tract may result in many life-threatening complications. The fundamental management is based on the endoscopic removal of a foreign body and the antibiotic prophylaxis. In case of foreign bodies lodged in soft tissues open surgery is recommended. Key words: foreign body in the esophagus; fish bone; paraesophageal abscess ; treatment

scholarly journals A vaginal fornix foreign body in a bitch: a case report

2014 ◽  
Vol 59 (No. 9) ◽  
pp. 457-460 ◽  
Author(s):  
M. Fabbi ◽  
S. Manfredi ◽  
F. Di Ianni ◽  
C. Bresciani ◽  
AM Cantoni ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Foreign Body ◽  
Staphylococcus Epidermidis ◽  
Foreign Bodies ◽  
Clinical Signs ◽  
Abdominal Ultrasound ◽  
Intact Female ◽  
History Of ◽  
Grass Awn

A six-year-old intact female Lagotto Romagnolo was referred with a two-day history of purulent vulvar discharge associated with fever, lethargy, polyuria, polydipsia and signs of abdominal pain. Abdominal ultrasound revealed a grass awn foreign body in the vaginal fornix. Culture swabs obtained from the vagina revealed the presence of Staphylococcus epidermidis as the preponderant organism. Ovariohysterectomy was performed, and the presence of the grass awn was confirmed. A chronic-active vaginitis was found at histological examination. The dog recovered with resolution of all clinical signs.  Differential diagnoses for acute vulvar discharge in bitches should include retention of vaginal foreign bodies. To the authors’ knowledge, this is the first reported case of a grass awn foreign body in the vaginal fornix of a dog.  

scholarly journals Chronic retained esophageal foreign body: a case report

2021 ◽  
Vol 8 (2) ◽  
pp. 383
Author(s):  
Gurpreet Singh Chhabra ◽  
Anumeet Singh Grover ◽  
Gagandeep Kaur
Keyword(s):  
Case Report ◽  
Foreign Body ◽  
Respiratory Symptoms ◽  
Foreign Bodies ◽  
Gastrointestinal Symptoms ◽  
Esophageal Foreign Body ◽  
High Incidence ◽  
History Of ◽  
Foreign Body Impaction ◽  
Esophageal Foreign Bodies

Chronic esophageal foreign bodies (CEFB) are associated with a high incidence of morbidity and mortality in adults. However, the presentation, management and outcome of chronic esophageal foreign bodies in children are not well described. Seventy-six percent of patients presented with a primary complaint of respiratory symptoms, with respiratory distress being the most common followed by asthmatic symptoms and cough. Twenty-two percent of patients had primarily gastrointestinal symptoms including nausea, vomiting and dysphagia. We present a case report of 2year 6month old male with 3 months history of cough and vomiting later diagnosed to be a case of upper esophageal foreign body impaction.

A Large Bullet in the Bladder

Swiss Surgery ◽  
2001 ◽  
Vol 7 (3) ◽  
pp. 139-140 ◽  
Author(s):  
Halkic ◽  
Wisard ◽  
Abdelmoumene ◽  
Vuilleumier
Keyword(s):  
Foreign Body ◽  
Foreign Bodies ◽  
Gross Hematuria ◽  
Suprapubic Cystostomy ◽  
Laparoscopic Port ◽  
Urethral Trauma ◽  
Bullet Injury

All manner of foreign bodies have been extracted from the bladder. Introduction into the bladder may be through self-insertion, iatrogenic means or migration from adjacent organs. Extraction should be tailored according to the nature of the foreign body and should minimise bladder and urethral trauma. We report a case of a bullet injury to the bladder, which finally presented as a gross hematuria after remaining asymptomatic for four years. We present here an alternative to suprapubic cystostomy with a large bladder foreign body treated via a combined transurethral unroofing followed by removal using a grasper passed through a suprapubic laparoscopic port.

CLINICAL AND PARACLINICAL CHARACTERISTICS AND RESULTS FROM TREATMENT OF FOREIGN BODIES INGESTION

2016 ◽  
pp. 63-69
Author(s):  
Hoang Cuong Vo ◽  
Thanh Dang ◽  
Phuong Nam Tran ◽  
Thanh Thai Le
Keyword(s):  
Foreign Body ◽  
Clinical Characteristics ◽  
Foreign Bodies ◽  
University Hospital ◽  
Age Group ◽  
Central Hospital ◽  
Results Of Treatment ◽  
Rigid Esophagoscopy ◽  
Flexible Esophagoscopy ◽  
Esophageal Foreign Bodies

Background: Foreign bodies ingestion is a emergency in otology, knowledge of people about foreign bodies ingestion is not enough. Objective: To study the clinical characteristics, paraclinical characteristics and results of treatment from foreign bodies ingestion in Hue Central Hospital and Hue University Hospital. Methods and patiens: A cross descriptive and prospective study over the period from 6/2014 to 5/2016, total are 137 patients come to be diagnosised and treatmented. Results: the average age is 35 years old. Gender: male (51.8%) and women (48.2%). Adults (84.7%) having more than children (15.3%). Age group from 16-30 years is highest (32.8%). There are 95.7% of organic foreign bodies, 4.3% are inorganic foreign bodies. There are 90.5% of patients on diagnosis and treatment in stages less inflammation, arthritis 8.0% in the period and 1.5% in the period complications. Foreign body in the throat problems (73.7%), esophageal foreign bodies (26.3%). Pick up directly foreign bodies 54%, indirectly by the mirror 11.7% and endoscopy 8%, rigid esophagoscopy is 17.5%, flexible esophagoscopy is 7.3%, cervicotomy is 1.5%. Conclusion: Practing direction with in the oropharynx foreign body, using the larynx mirror or endoscopy with in the laryngopharynx for the esophagus foreign bodies, rigid esophagoscopy is better. Key words: Foreign bodies ingestion

How we do it: impacted oesophageal foreign body removal using a dilatation balloon

2021 ◽  
pp. 1-3
Author(s):  
P D Chakravarty ◽  
T Kunanandam ◽  
G Walker
Keyword(s):  
Foreign Body ◽  
Granulation Tissue ◽  
Foreign Bodies ◽  
Fluoroscopic Guidance ◽  
Tertiary Referral ◽  
Foreign Body Removal ◽  
Novel Technique ◽  
Common Presentation ◽  
Reproducible Technique ◽  
Rigid Oesophagoscopy

Abstract Background Ingested foreign bodies are a common presentation to paediatric ENT services. Depending on the site, these are usually managed with flexible or rigid oesophagoscopy and retrieval. This paper presents a novel technique for removing a hollow foreign body that could not be removed using conventional means. Method and results After rigid and flexible approaches failed, a guidewire was passed through the foreign body under fluoroscopic guidance and a dilatation balloon passed through the lumen of the object. Inflating the balloon allowed dilatation of the inflamed mucosa above and below the object, facilitating straightforward removal under traction. Conclusion This is a novel and reproducible technique that uses equipment readily available in tertiary referral centres. Employed in this context, the technique enabled removal of an impacted object surrounded by granulation tissue, and would be appropriate for other objects with a lumen.

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