Photoreactivation in Halobacterium cutirubrum

1972 ◽  
Vol 18 (7) ◽  
pp. 981-985 ◽  
Author(s):  
M. A. Hescox ◽  
D. M. Carlberg
Keyword(s):  
Energy Transfer ◽  
Natural Environment ◽  
Ultraviolet Irradiation ◽  
Halophilic Bacteria ◽  
Complete Recovery ◽  
Carotenoid Pigments ◽  
Original Population ◽  
High Doses ◽  
Ultraviolet Damage

Extremely halophilic bacteria are able to survive in a natural environment exposed to high doses of ultraviolet irradiation. One such organism, Halobacterium cutirubrum, has been characterized to possess an extremely efficient photoreactivation from ultraviolet damage. A population irradiated to 1% survivors can photoreactivate to complete recovery of the original population in less than 1 h of illumination. Inhibition of carotenoid pigments by 10−6 M diphenylamine decreased photoreactivation efficiency. The carotene pigments have been implicated in an energy-transfer role to augment the photoreactivation mechanism

The influence of acridine dyes and caffeine on recovery from ultraviolet damage in Eudorina elegans

1975 ◽  
Vol 21 (11) ◽  
pp. 1849-1854 ◽  
Author(s):  
C. L. Kemp ◽  
K. M. Malloy
Keyword(s):  
Dna Synthesis ◽  
Acridine Orange ◽  
Ultraviolet Light ◽  
Ultraviolet Irradiation ◽  
Repair Process ◽  
Repair System ◽  
Acridine Dyes ◽  
Dark Survival ◽  
High Doses ◽  
Ultraviolet Damage

Caffeine and the acridine dyes, acridine orange and acriflavine, were used to examine the repair potential in Eudorina elegans following ultraviolet irradiation. Acridines blocked photoreactivation primarily as a result of absorption of photoreactivating wavelengths, but acridines did not influence dark survival. Therefore, an acridine-sensitive excision–resynthesis–repair process is absent in Eudorina.Caffeine decreased both dark and light survival, the latter only after relatively high doses of ultraviolet light were used for inactivation. The caffeine-sensitive repair process appears to function most actively when the organisms are engaged in DNA synthesis, indicating that a postreplication–repair system exists in Eudorina. However, the data suggest that a repair system not associated with the DNA synthetic phases may also exist.

scholarly journals Neuroleptic malignant syndrome

2011 ◽  
Vol 69 (5) ◽  
pp. 751-755 ◽  
Author(s):  
Mariana Moscovich ◽  
Felipe T.M. Nóvak ◽  
Artur F. Fernandes ◽  
Tatiana Bruch ◽  
Tabita Tomelin ◽  
...  
Keyword(s):  
Adverse Event ◽  
Neuroleptic Malignant Syndrome ◽  
Fatal Outcome ◽  
Signs And Symptoms ◽  
Complete Recovery ◽  
Past Medical History ◽  
History Of ◽  
High Doses ◽  
Symptoms And Signs ◽  
Gathering Data

Neuroleptic malignant syndrome (NMS) is a potentially fatal adverse event associated with the use of antipsychotics (AP). The objective of this study was to investigate the profile of cases of NMS and to compare our findings with those published in similar settings. A series of 18 consecutive patients with an established diagnosis of NMS was analyzed, gathering data on demography, symptoms and signs. Two thirds of all cases involved woman with a past medical history of psychiatric disorder receiving relatively high doses of AP. The signs and symptoms of NMS episodes were similar to those reported in other series and only one case had a fatal outcome, the remaining presenting complete recovery. As expected, more than two thirds of our cases were using classic AP (68%), however the clinical profile of these in comparison with those taking newer agent was similar. Newer AP also carry the potential for NMS.

scholarly journals Bisphosphonate-Related Osteonecrosis of the Jaws. A Severe Side Effect of Bisphosphonate Therapy

2012 ◽  
Vol 55 (3) ◽  
pp. 111-115 ◽  
Author(s):  
Zuzana Janovská
Keyword(s):  
High Risk ◽  
Bone Resorption ◽  
Secondary Infection ◽  
Complete Recovery ◽  
Bisphosphonate Therapy ◽  
Severe Side Effect ◽  
Main Role ◽  
Osteonecrosis Of The Jaws ◽  
Oncologic Patients ◽  
High Doses

Bisphosphonates (BP) are potent inhibitors of bone resorption used mainly in the treatment of metastatic bone disease and osteoporosis. By inhibiting bone resorption, they prevent complications as pathological fracture, pain, tumor-induced hypercalcemia. Even though patient’s benefit of BP therapy is huge, various side effects may develop. Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is among the most serious ones. Oncologic patients receiving high doses of BP intravenously are at high risk of BRONJ development. BPs impair bone turnover leading to compromised bone healing which may result in the exposure of necrotic bone in the oral cavity frequently following tooth extraction or trauma of the oral mucosa. Frank bone exposure may be complicated by secondary infection leading to osteomyelitis development with various symptoms and radiological findings. In the management of BRONJ, conservative therapy aiming to reduce the symptoms plays the main role. In patients with extensive bone involvement resective surgery may lead to complete recovery, provided that the procedure is correctly indicated. Since the treatment of BRONJ is difficult, prevention is the main goal. Therefore in high risk patients dental preventive measures should be taken prior to bisphosphonate administration. This requires adequate communication between the prescribing physician, the patient and the dentist.

scholarly journals Chemotherapy-Induced Leukoencephalopathy: A Case Series

2021 ◽  
Vol 5 (1) ◽  
pp. 658-663
Author(s):  
Paula Bianca E Nuqui ◽  
Flerida G Hernandez
Keyword(s):  
Lymphoblastic Leukemia ◽  
Case Series ◽  
Complete Recovery ◽  
Mri Findings ◽  
Adequate Hydration ◽  
A Cell ◽  
Tetrahydrofolic Acid ◽  
High Doses ◽  
Neuro Imaging ◽  
Specific Agent

Rationale: Leukoencephalopathy, a complication associated with chemotherapy has been reported after giving high doses of methotrexate and cytarabine with no specific risk factors to date.  Objectives: To review the prevalence of chemotherapy-induced leukoencephalopathy in children with acute lymphoblastic leukemia (ALL). To present the clinical course, pathogenesis and neuro-imaging findings of chemotherapy-induced leukoencephalopathy in children with ALL. Case: We reported three cases of adolescent ALL precursor B-cell patients who received high doses of methotrexate and presented with neurologic and MRI findings consistent with leukoencephalopathy. Our patients were only placed on supportive measures with adequate hydration, without providing any special intervention. Yet, all of them had complete neurological recovery.  Discussion and Summary: Methotrexate is a cell cycle-specific agent that inhibits the enzyme dihydrofolate reductase, preventing the conversion of folic acid to tetrahydrofolic acid and inhibiting cell replication. It is one of the most commonly implicated drug causing leukoencephalopathy.[3] On MRI T2-weighted images, all of them had hyperintensities on the posterior frontal/parietal corona radiata and centrum semiovale consistent with leukoencephalopathy. Complete recovery happened spontaneously in all of the cases. There is no standard treatment for acute and subacute toxicities from methotrexate.  Keywords: Leukoencephalopathy, Chemotherapeutic drugs, Neurotoxicity, Case series

Intestinal microbiota in patients with acute leukemia (AL) and allogeneic hematopoietics stem cell transplantation (allo-HSCT).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19518-e19518
Author(s):  
Brenda Lizeth Acosta-Maldonado ◽  
Fernando Vallejo-Leucona ◽  
Felipe Vaca-Paniagua ◽  
Liliana Rivera-Fong ◽  
Elizabeth Hernández-Urzúa ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Bacterial Resistance ◽  
Complete Recovery ◽  
Shannon Index ◽  
Intestinal Microbiome ◽  
Control Group ◽  
Rrna Gene ◽  
Poor Overall Survival ◽  
High Doses ◽  
Multiple Drugs

e19518 Background: Microbiome is a challenging study area due to its influence on the multiple host functions. The majority of human-associated microbes reside within the colon. Our understanding about the complex interplay between host and environmental factors to shaping the microbiota is evolving rapidly AL is an unfavorable prognosis disease whose only cure possibility is the allo-HSCT. This procedure uses high doses of chemotherapy and multiple drugs such as antibiotics, antiviral, antifungals, and immunosuppressants that damage the mucous membranes and alter the intestinal microbiome balance. These events have been linked to bacterial resistance, relapse risk, Graft Versus Host Disease (GVHD), and poor Overall Survival (OS). The present study’s objective was to identify the intestinal microbiome bacteria groups during allo-HSCT and to evaluate their impact on patients outcome. Methods: Observational and prospective study was performed. Eleven patients with acute leukemia under alloHSCT and 11 health control (relatives) were enrolled. Gut faecal samples were collected in both groups; three for patients (at income day (ID), neutropenic period (N) and 30 days after discharge (+30D) and one in healthy donor (HD) at income day of their relatives. Bacterial 16S rRNA gene sequences were characterized by illumina and QUIIME 2. Biodiversity of microbiome was evaluated by OTUS, Shannon index and dominance. This proyect was supported by CONACyT. Results: We analyze 11 patients, 55% were male, with a median of 25 years-old at allo-HSCT. 7/10 received a HLA-identical and 4/10 an haploidentical HSCT. 82% had GVHD (I-IV), 1/11 died (two due to infections-GVHD and one of disease relapse). We analyzed 44 samples. There are no difference between healthy control group and income day patients’ samples. Statistical differences in the patients’ microbiome were identified among HSCT moments. According OTUS and Shannon Index the biodiversity decrease at neutropenia, and increase at day +30 outcome but it doesn’t represent a complete recovery. Greater bacterial dominance was observed in neutropenia period. (Table). 3/10 patients who died didn’t recovery biodiversity at day +30. Conclusions: Our results suggest that poor microbiome biodiversity recovery could be a worst prognostic [Table: see text]

Cluster Headache: Clinical Efficacy of Lithium Salts in a Haemodialysis Treated Patient

Cephalalgia ◽  
1985 ◽  
Vol 5 (2) ◽  
pp. 95-98 ◽  
Author(s):  
A Zuddas ◽  
S Mulas ◽  
M Del Zompo ◽  
GU Corsini
Keyword(s):  
Cluster Headache ◽  
Treated Patient ◽  
Lithium Treatment ◽  
Lithium Carbonate ◽  
Complete Recovery ◽  
Serum Levels ◽  
Lithium Salts ◽  
Headache Therapy ◽  
High Doses ◽  
Haemodialysis Treatment

Over the last ten years the efficacy of lithium salts in cluster headache has been well demonstrated. Our patient, who had been suffering from cluster headache for approximately 30 years, had been in haemodialysis treatment for the last ten years for chronic renal failure. Moreover, he was affected by heart failure and peptic ulcer. The patient was currently under therapy with Digitalis, Isorbide dinitrate, and ranitidine and was dialyzed three times a week for a total of five hours each time. Neither prophylactic headache therapy nor high doses of analgesic drugs had proved effective. Although this patient was in haemodialysis, lithium treatment was indicated. The administration of lithium carbonate 300 mg during dialysis days and 150 mg during non-dialysis days improved the attacks. Complete recovery from the attacks was obtained when the serum levels of lithium reached the therapeutic range. No side effects were noted.

CAROTENOID PIGMENTS OF HALOPHILIC BACTERIA

1960 ◽  
Vol 6 (4) ◽  
pp. 417-424 ◽  
Author(s):  
R. M. Baxter
Keyword(s):  
Growth Medium ◽  
Rhodospirillum Rubrum ◽  
Halophilic Bacteria ◽  
Carotenoid Biosynthesis ◽  
The Other ◽  
Carotenoid Content ◽  
Carotenoid Pigments ◽  
Halobacterium Salinarium ◽  
Physical Conditions

The carotenoids of two yellow and four red halophilic bacteria were studied by chromatography on alumina. One yellow organism contained predominantly one pigment, or a group of closely related pigments similar to neurosporene, while the other contained the neurosporene-like pigments and appreciable amounts of an unknown pigment with absorption maxima at about 420, 450, and 485 mμ.The red organisms, three species of Halobacterium and one Sarcina, contained α- and β-bacterioruberin, and at least six minor pigments. All except two of these were very similar to carotenoids previously reported in Rhodospirillum rubrum. Methoxyl could not be detected in α-bacterioruberin, supporting the suggestion of others that it is demethylated spirilloxanthin. It is suggested that the pathway of carotenoid biosynthesis in red halophiles is very similar to that in Rhodospirillum rubrum, except that the pigments are not methylated.The carotenoid content of Halobacterium salinarium was not influenced by addition of various precursors to the growth medium, or by altering the physical conditions of growth, but increased with the age of the culture.

Effects of Intravenous High Doses of Ketoprofen on Blood Clotting, Bleeding Time and Platelet Aggregation in Man

1983 ◽  
Vol 11 (4) ◽  
pp. 243-246 ◽  
Author(s):  
R Gandini ◽  
E Cunietti ◽  
V Pappalepore ◽  
M Ferrari ◽  
B Deleo ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Blood Clotting ◽  
Bleeding Time ◽  
Day Treatment ◽  
Complete Recovery ◽  
Single Intravenous Dose ◽  
Prothrombin Activity ◽  
Baseline Values ◽  
High Doses

The effect of ketoprofen (Orudis, Farmitalia) on ADP, epinephrine (EPI) and collagen (COLL) induced platelet aggregation (PIA), simplate bleeding time (SBT), partial thromboplastin time (PTT) and per cent prothrombin activity (PrA) was studied in eleven patients, four males and seven females (median age 59 years) with rheumatoid arthritis (six cases), cancer (four cases) and osteoarthrosis (one case). Tests were performed before and 1, 8 and 24 hours after a single intravenous dose (600 mg) of ketoprofen and on Days 4 and 8 during a 7-day treatment (200 mg i.v. every 8 hours) and 1 day after withdrawal of the drug. PTT and PrA were not affected by the drug. Bleeding time was not significantly modified by the acute treatment, but was prolonged during the subacute course, though it was not different from baseline values at the end of the trial. Significant reduction of platelet aggregation was seen in both acute and subacute conditions with complete or almost complete recovery 36 hours after the last dose. It is concluded that ketoprofen affects platelets with readily reversible inhibition of in vitro aggregation and a slight increase of bleeding time.

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