Effects of two mutations on production of a red plasmodial pigment in the myxomycete Didymium iridis

1969 ◽  
Vol 15 (10) ◽  
pp. 1245-1247 ◽  
Author(s):  
O'Neil Ray Collins ◽  
Beverly A. Erlebacher
Keyword(s):  
Didymium Iridis ◽  
Mutant Genes

Spectrophotometric and chromatographic studies reveal that two unlinked mutant genes, b1 and b2, partially block production of a red plasmodial pigment. As a result, mutant Plasmodia are cream-colored instead of brown.

scholarly journals Remodeling Alzheimer-amyloidosis models by seeding

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Brittany S. Ulm ◽  
David R. Borchelt ◽  
Brenda D. Moore
Keyword(s):  
Amyloid Precursor Protein ◽  
Neurodegenerative Diseases ◽  
Amyloid Beta ◽  
Precursor Protein ◽  
Time Interval ◽  
Murine Models ◽  
Brain Pathology ◽  
Amyloid Deposits ◽  
Transgenic Murine Models ◽  
Mutant Genes

AbstractAlzheimer’s disease (AD) is among the most prevalent neurodegenerative diseases, with brain pathology defined by extracellular amyloid beta deposits and intracellular tau aggregates. To aid in research efforts to improve understanding of this disease, transgenic murine models have been developed that replicate aspects of AD pathology. Familial AD is associated with mutations in the amyloid precursor protein and in the presenilins (associated with amyloidosis); transgenic amyloid models feature one or more of these mutant genes. Recent advances in seeding methods provide a means to alter the morphology of resultant amyloid deposits and the age that pathology develops. In this review, we discuss the variety of factors that influence the seeding of amyloid beta pathology, including the source of seed, the time interval after seeding, the nature of the transgenic host, and the preparation of the seeding inoculum.

scholarly journals The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment

2020 ◽  
Vol 19 ◽  
pp. 153303382092096
Author(s):  
Hongzhi Sun ◽  
Bo Zhang ◽  
Haijun Li
Keyword(s):  
Tumor Microenvironment ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Stromal Cells ◽  
Genomic Analysis ◽  
Ductal Adenocarcinoma ◽  
Genetic Mutations ◽  
Cellular Processes ◽  
Dismal Prognosis ◽  
Mutant Genes

Pancreatic ductal adenocarcinoma has extremely high malignancy and patients with pancreatic ductal adenocarcinoma have dismal prognosis. The failure of pancreatic ductal adenocarcinoma treatment is largely due to the tumor microenvironment, which is featured by ample stromal cells and complicated extracellular matrix. Recent genomic analysis revealed that pancreatic ductal adenocarcinoma harbors frequently mutated genes including KRAS, TP53, CDKN2A, and SMAD4, which can widely alter cellular processes and behaviors. As shown by accumulating studies, these mutant genes may also change tumor microenvironment, which in turn affects pancreatic ductal adenocarcinoma progression. In this review, we summarize the role of such genetic mutations in tumor microenvironment regulation and potential mechanisms.

scholarly journals Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Fangqi He ◽  
Hongfeng Wang ◽  
Xiaoyu Zhang ◽  
Qingping Gao ◽  
Feng Guo ◽  
...  
Keyword(s):  
Conservation Analysis ◽  
Pathogenicity Prediction ◽  
Mutant Genes

INHERITANCE AND LINKAGE STUDIES WITH THE GRANDPA GENE IN BARLEY, HORDEUM VULGARE L.

1971 ◽  
Vol 13 (3) ◽  
pp. 489-498
Author(s):  
R. W. Matchett ◽  
H. G. Nass ◽  
D. W. Robertson
Keyword(s):  
Hordeum Vulgare ◽  
Chromosomal Location ◽  
Gene Interactions ◽  
Chromosome 2 ◽  
Linkage Studies ◽  
Hordeum Vulgare L ◽  
Barley Genome ◽  
Chlorophyll Mutants ◽  
Mutant Genes ◽  
Linkage Association

This study was initiated to determine the chromosomal location of the grandpa (gp) gene within the barley genome. The gp gene was placed on the long arm of chromosome 2 as indicated by linkage association with liguleless (li).Tests of allelism showed the gp gene to the allelic with the gp-2 gene. Seven sources of "yellow" chlorophyll mutants when crossed to grandpa plants gave albino double recessive seedlings. Three other sources of "yellow" chlorophyll mutants in the double recessive combination with grandpa exhibited yellow and white bands on the leaves. Double recessive individuals carrying the mottled (mt2) and grandpa genes were also albino. This is evidence of gene interactions between chlorophyll mutant genes.

scholarly journals Accumulation of mutations in sexual and asexual populations

1987 ◽  
Vol 49 (2) ◽  
pp. 135-146 ◽  
Author(s):  
Pekka Pamilo ◽  
Masatoshi Nei ◽  
Wen-Hsiung Li
Keyword(s):  
Weak Selection ◽  
Population Variance ◽  
Asexual Population ◽  
Term Evolution ◽  
A Genome ◽  
Analytical Formulae ◽  
The Mean ◽  
Asexual Populations ◽  
Mutant Genes

SummaryThe accumulation of beneficial and harmful mutations in a genome is studied by using analytical methods as well as computer simulation for different modes of reproduction. The modes of reproduction examined are biparental (bisexual, hermaphroditic), uniparental (selfing, automictic, asexual) and mixed (partial selfing, mixture of hermaphroditism and parthenogenesis). It is shown that the rates of accumulation of both beneficial and harmful mutations with weak selection depend on the within-population variance of the number of mutant genes per genome. Analytical formulae for this variance are derived for neutral mutant genes for hermaphroditic, selfing and asexual populations; the neutral variance is largest in a selfing population and smallest in an asexual population. Directional selection reduces the population variance in most cases, whereas recombination partially restores the reduced variance. Therefore, biparental organisms accumulate beneficial mutations at the highest rate and harmful mutations at the lowest rate. Selfing organisms are intermediate between biparental and asexual organisms. Even a limited amount of outcrossing in largely selfing and parthenogenetic organisms markedly affects the accumulation rates. The accumulation of mutations is likely to affect the mean population fitness only in long-term evolution.

scholarly journals SURVIVAL PROCESS OF LINKED MUTANT GENES

Evolution ◽  
1967 ◽  
Vol 21 (3) ◽  
pp. 518-531 ◽  
Author(s):  
Ken-ichi Kojima ◽  
Henry E. Schaffer
Keyword(s):  
Mutant Genes

Production of Hybrids between Physiological Races of the True Slime Mould Didymium iridis

Nature ◽  
1962 ◽  
Vol 193 (4815) ◽  
pp. 598-599 ◽  
Author(s):  
CONSTANTINE J. ALEXOPOULOS ◽  
GEORGE G. ZABKA
Keyword(s):  
Slime Mould ◽  
Physiological Races ◽  
Didymium Iridis

MUTANT GENES IN WILMS' TUMOUR

The Lancet ◽  
1984 ◽  
Vol 324 (8394) ◽  
pp. 97
Author(s):  
M.D'A. Crawfurd ◽  
P.J. Smith ◽  
F.P. Imray
Keyword(s):  
Wilms Tumour ◽  
Mutant Genes
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