AN ANTIBIOTIC PRODUCED BY THE MYCORRHIZAL FUNGUS CENOCOCCUM GRANIFORME

1964 ◽  
Vol 10 (3) ◽  
pp. 365-370 ◽  
Author(s):  
George N. Krywolap ◽  
L. E. Casida Jr.

An antibiotic active against representatives of the bacteria, yeasts, and actinomycetes has been extracted from the mycelium, produced in vitro, of several strains of the mycorrhizal fungus, Cenococcum graniforme. No activity was observed in culture fluids of this organism. The antibiotic differed from that found in Boletus luteus mycelium by its microbial inhibition and ultraviolet absorption spectra.

1964 ◽  
Vol 10 (3) ◽  
pp. 323-328 ◽  
Author(s):  
George N. Krywolap ◽  
Larry F. Grand ◽  
L. E. Casida Jr.

Antibiotic activity chromatographically resembling that produced in vitro by Cenococcum graniforme has been demonstrated in extracts from C. graniforme mycorrhizae and from roots and needles of three species of conifers. In trembling aspen (Populus tremuloides Michx.), activity was observed only in mycorrhizal roots and not in leaves. Seedlings of conifers, presumably devoid of C. graniforme mycorrhizae, also contained antibiotic resembling that of C. graniforme. However, the surrounding soil, which contained C. graniforme sclerotia, also exhibited the antibiotic on extraction with acetone but not on extraction with saline.


1960 ◽  
Vol XXXIII (III) ◽  
pp. 444-450 ◽  
Author(s):  
Maria de la Luz Suarez Soto ◽  
Jean Legault Démare

ABSTRACT Serum gonadotrophin (PMS) when added to the incubation medium of rat ovary slices increases the amount of Δ4-3-ketosteroids produced. This enhancement is proportional to the logarithm of dose. The ketosteroids were determined by their ultraviolet absorption; paper chromatography has shown that only androst-4-en-3,17-dione is present.


2013 ◽  
Vol 779 (1) ◽  
pp. 40 ◽  
Author(s):  
Yu-Jong Wu ◽  
Hui-Fen Chen ◽  
Shiang-Jiun Chuang ◽  
Tzu-Ping Huang

Chemistry ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 238-255
Author(s):  
Esther M. Sánchez-Carnerero ◽  
Marina Russo ◽  
Andreas Jakob ◽  
Lucie Muchová ◽  
Libor Vítek ◽  
...  

Carbon monoxide (CO) is an endogenously produced signaling molecule involved in the control of a vast array of physiological processes. One of the strategies to administer therapeutic amounts of CO is the precise spatial and temporal control over its release from photoactivatable CO-releasing molecules (photoCORMs). Here we present the synthesis and photophysical and photochemical properties of a small library of meso-carboxy BODIPY derivatives bearing different substituents at positions 2 and 6. We show that the nature of substituents has a major impact on both their photophysics and the efficiency of CO photorelease. CO was found to be efficiently released from π-extended 2,6-arylethynyl BODIPY derivatives possessing absorption spectra shifted to a more biologically desirable wavelength range. Selected photoCORMs were subjected to in vitro experiments that did not reveal any serious toxic effects, suggesting their potential for further biological research.


1950 ◽  
Vol 187 (1) ◽  
pp. 299-312
Author(s):  
R.L. Sinsheimer ◽  
J.F. Scott ◽  
J.R. Loofbourow

1959 ◽  
Vol 37 (3) ◽  
pp. 563-574 ◽  
Author(s):  
Eugene Lieber ◽  
J. Ramachandran ◽  
C. N. R. Rao ◽  
C. N. Pillai

The ultraviolet absorption spectra of 5-(substituted)amino-1,2,3,4-thiatriazoles and the corresponding isomeric 1-substituted-tetrazoline-5-thiones have been studied. The spectra and the dipole moments of the 5-(substituted)amino-1,2,3,4-thiatriazoles eliminate the possibility of meso-ionic structures for these compounds. The dipole moments of 5-amino-, 5-methylamino-, and 5-dimethylamino-1,2,3,4-thiatriazole were all high but approximately of the same value (5.77 to 5.84 D). This suggests that the amino thiatriazoles are best represented by conventional covalent structures with significant ionic resonance contributions. The thiatriazole ring system exhibits a characteristic absorption maximum at 250–255 mμ and an electron-withdrawing effect approximately equal to the tetrazolyl ring system. The tetrazolinethionolyl ring system is similarly electron-withdrawing. The relative acidities of the 1-substituted-tetrazoline-5-thiones and the 5-alkylmercaptotetrazoles have also been studied and the results support the observations made on the basis of their ultraviolet absorption spectra.


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