HOMOZYGOUS PERICENTRIC INVERSIONS AND OTHER STUDIES OF INVERSIONS ON CHROMOSOME 3 IN THE MOSQUITO ANOPHELES ALBIMANUS

1981 ◽  
Vol 23 (1) ◽  
pp. 57-64 ◽  
Author(s):  
S. G. Suguna ◽  
J. A. Seawright ◽  
D. J. Joslyn ◽  
M. G. Rabbani
Keyword(s):  
Genetic Control ◽  
Pericentric Inversion ◽  
Chromosome 3 ◽  
Double Heterozygote ◽  
Anopheles Albimanus ◽  
Control Schemes ◽  
Pericentric Inversions ◽  
Partial Sterility ◽  
Radiation Induced ◽  
Experimental Crosses

Two radiation-induced pericentric inversions on chromosome 3 in Anopheles albimanus Wiedemann have been established in homozygous stocks. In(3)17 and In(3)22 cover about 82% and 42%, respectively, of chromosome 3 and should be very useful as crossover suppressors in genetic crosses. In addition, three double-heterozygote stocks were established by combining inversions that had similar breakpoints but were viable only as heterozygotes. These balanced-lethal double heterozygotes can serve as a source of inversion gametes for use in experimental crosses and can be used in surveying populations for lethal chromosomes. Assays of the partial sterility inherent in males heterozygous for a pericentric inversion and a male-linked translocation indicated that the combination of inversions and translocations could be used in genetic control schemes.

X-RAY INDUCED PERICENTRIC INVERSIONS IN ANOPHELES ALBIMANUS

1977 ◽  
Vol 19 (1) ◽  
pp. 67-74 ◽  
Author(s):  
M. G. Rabbani ◽  
J. A. Seawright ◽  
J. B. Kitzmiller
Keyword(s):  
Salivary Gland ◽  
Curvilinear Relationship ◽  
Chromosome 3 ◽  
Chromosome 2 ◽  
Anopheles Albimanus ◽  
X Ray ◽  
Pericentric Inversions ◽  
Partial Sterility ◽  
Break Points ◽  
Theoretical Considerations

Sixteen different pericentric inversions, ten on chromosome 2 and six on chromosome 3, have been isolated and characterized. The partial sterility in the inversion heterozygotes ranged from about 28 to 50%. Contrary to theoretical considerations, a curvilinear relationship exists between inversion length and partial sterility, whereby a reduction in sterility was noted for progressively longer inversions. The break-points are distributed randomly over the autosomes, but are observed more frequently in the areas of the salivary gland chromosomes where diffuse and broken bands of variable stainability are located.

RADIATION INDUCED RECIPROCAL TRANSLOCATIONS AND INVERSIONS IN ANOPHELES ALBIMANUS

1982 ◽  
Vol 24 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. E. Kaiser ◽  
J. A. Seawright ◽  
M. Q. Benedict ◽  
S. Narang ◽  
S. G. Suguna
Keyword(s):  
X Rays ◽  
Anopheles Albimanus ◽  
Reciprocal Translocations ◽  
Pericentric Inversions ◽  
Radiation Induced ◽  
Homozygous Translocation ◽  
Paracentric Inversions ◽  
Heterozygous Translocation

Reciprocal translocations and inversions were induced in Anopheles albimanus Wiedemann by irradiation of males with X rays. A total of 1669 sperm were assayed, and 175 new aberrations were identified as follows: 102 reciprocal translocations (67 autosomal and 35 sex-linked), 45 pericentric inversions, and 28 paracentric inversions. Eleven of the translocations were nearly whole-arm interchanges, and these were selected for the construction of "capture systems" for compound chromosomes. Two double-heterozygous translocation strains and four homozygous translocation strains were established. Anopheles albimanus females were irradiated, and a pseudolinkage scheme involving mutant markers was employed to identify reciprocal translocations. The irradiation of females was very inefficient: only one translocation was recovered from 1080 ova tested.

Inheritance of Radiation-Induced Partial Sterility in the Indian Meal Moth134

1972 ◽  
Vol 65 (5) ◽  
pp. 1265-1268 ◽  
Author(s):  
Shahid H. Ashrafi ◽  
Elvin W. Tilton ◽  
John H. Brower
Keyword(s):  
Partial Sterility ◽  
Indian Meal ◽  
Radiation Induced

Studies of the X chromosome of Anopheles albimanus

1985 ◽  
Vol 27 (1) ◽  
pp. 74-82
Author(s):  
J. A. Seawright ◽  
M. Q. Benedict ◽  
S. Narang
Keyword(s):  
X Chromosome ◽  
Organizer Region ◽  
Nucleolar Organizer Region ◽  
Nucleolar Organizer ◽  
Chromosome Analysis ◽  
Anopheles Albimanus ◽  
Eye Color ◽  
Colour Mutant ◽  
Translocation Breakpoints ◽  
Radiation Induced

Snow (sn) is a recessive, eye color mutant that is phenotypically indistinguishable from the previously described mutant, white eye (we). The loci for these mutants are over 30 map units apart on the X chromosome. Analysis of salivary gland chromosomes of radiation-induced X-autosome translocations were used to define the positions of sn and we on the distal euchromatic portion of the long arm of the X chromosome. A recessive lethal trait (bubble head) was also mapped relative to we and sn, and the gene order on the long arm of the X chromosome is as follows: centromere – ? – snow – bubble head – white eye. Translocation breakpoints in the euchromatic portion of the X chromosome caused sterility or lethality in males hemizygous for the translocations, but breaks in the heterochromatin had no effect. Crossing-over was greatly reduced when translocation breakpoints were located in the euchromatic part of the X chromosome. The translocations were used to determine that the nucleolar organizer region is probably on the short arm of the X chromosome.Key words: Anopheles albimanus, eye colour mutant, X chromosome.

scholarly journals GENETIC CONTROL OF RADIATION SENSITIVITY IN SCHIZOSACCHAROMYCES POMBE

Genetics ◽  
1975 ◽  
Vol 79 (4) ◽  
pp. 573-582
Author(s):  
A Nasim ◽  
B P Smith
Keyword(s):  
Ionizing Radiation ◽  
Genetic Analysis ◽  
Schizosaccharomyces Pombe ◽  
Genetic Control ◽  
Single Gene ◽  
Radiation Sensitivity ◽  
Cellular Repair ◽  
Repair Mechanisms ◽  
Radiation Induced

ABSTRACT Genetic analysis of a large number of radiation-sensitive mutants of S. pombe, isolated in different laboratories, showed that these isolates represent 22 non-allelic loci. The mutants were shown to fall into three distinct classes concerning response to UV and ionizing radiation, including two mutants which are primarily sensitive to ionizing radiation but not to UV. Single-gene mutants were crossed to obtain supersensitive double mutants. Such double mutants showed a marked increase in sensitivity to a variety of inactivating agents as compared to the parental strains. The isolation of three classes of radiation-sensitive mutants and the construction of double mutants implies the presence of multiple pathways in S. pombe for repair of radiation-induced damage. The bearing of these data on cellular repair mechanisms in eukaryotes is discussed.

Homozygous-viable pericentric inversions for genetic control of Lucilia Cuprina

1991 ◽  
Vol 82 (6) ◽  
pp. 681-689 ◽  
Author(s):  
G. G. Foster ◽  
G. L. Weller ◽  
D. G. Bedo
Keyword(s):  
Genetic Control ◽  
Lucilia Cuprina ◽  
Pericentric Inversions

PARACENTRIC INVERSIONS AND DETECTION OF SEX LINKED RECESSIVE LETHALS IN AEDES AEGYPTI

1970 ◽  
Vol 12 (3) ◽  
pp. 635-650 ◽  
Author(s):  
Satish C. Bhalla
Keyword(s):  
Aedes Aegypti ◽  
Genetic Control ◽  
Chromosomal Aberrations ◽  
The Other ◽  
Crossing Over ◽  
Partial Sterility ◽  
X Irradiation ◽  
Paracentric Inversions

Two sex linked paracentric inversions one on m chromosome, marked with bz (bronze body) and the other on M chromosome, marked with w (white eye), were artificially induced with X-irradiation and isolated. The inversions are designated as In. (1)1 and In. (1)2 respectively. The former is more than 23 units long and the later more than 16 units. Both suppress crossing over markedly and are associated with partial sterility. The two inversions are utilized as crossover suppressors in a technique designed for detecting sex linked recessive lethals. The technique works satisfactorily with certain limitations. The possibility of combining inversions with other chromosomal aberrations for genetic control of Aedes aegypti populations is suggested.

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