A RECESSIVE GENE WITH MAJOR PLEIOTROPIC EFFECTS IN SWEETCLOVER, MELILOTUS ALBA L

1962 ◽  
Vol 4 (2) ◽  
pp. 141-146 ◽  
Author(s):  
B. P. Goplen
Keyword(s):  
Recessive Gene ◽  
Pleiotropic Effects ◽  
Melilotus Alba

A recessive gene for white sepal colour in sweetclover, Melilotus alba L.

1992 ◽  
Vol 72 (4) ◽  
pp. 1259-1262 ◽  
Author(s):  
B. P. Goplen
Keyword(s):  
Genetic Analysis ◽  
Recessive Gene ◽  
Pleiotropic Effects ◽  
Single Recessive Gene ◽  
Green Colour ◽  
Melilotus Alba ◽  
Mature Flower ◽  
Entire Plant ◽  
Regressive Effects

A genetic analysis involving P, F1, F2 and F3 in sweetclover (Melilotus alba L.) revealed that the white sepal trait was controlled by a single recessive gene, designated ws. This trait is characterized by chlorophyll-deficient white sepals and several associated pleiotropic effects including: lighter green colour of stems and foliage and a general greenish-red colour of the entire plant, lax and wilted appearance of the white sepal racemes, reduced opening of the mature flower, and a much reduced fertility as measured by percent pod set. Because of these regressive effects associated with the white sepal trait, it has limited use as a plant marker.Key words: Melilotus alba, white sepal, chimera, pleiotropy

scholarly journals Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse

1978 ◽  
Vol 32 (2) ◽  
pp. 135-149 ◽  
Author(s):  
Margaret E. Wallace ◽  
P. J. Knights ◽  
Janice R. Anderson
Keyword(s):  
House Mouse ◽  
Neural Tube ◽  
Strong Evidence ◽  
Recessive Gene ◽  
Dorsal Surface ◽  
Pleiotropic Effects ◽  
Genetic Evidence ◽  
Chromosomal Anomalies ◽  
Single Recessive Gene ◽  
The Brain

SUMMARYAn inherited exencephaly in the mouse is described, using embryos at 11–17 days gestation. The cephalic portion of the neural tube remains open on the dorsal surface, the bony vault of the brain fails to develop, and the tissues of the brain are exposed; the development of these tissues, which is somewhat variable, is described. There is strong evidence that the condition is due to a single recessive gene, xn, with full viability until birth. Penetrance is twice as high in females as in males, and it varies overall according to the genetic milieu studied, from 33% to 84%. These features, and the absence of pleiotropic effects and of genetic evidence of associated chromosomal anomalies, make its inheritance different from that of exencephalies so far described.

INHERITANCE OF PALE COTYLEDON (PC) IN SWEETCLOVER

1969 ◽  
Vol 11 (1) ◽  
pp. 30-33
Author(s):  
B. P. Goplen
Keyword(s):  
Genetic Analysis ◽  
Seedling Survival ◽  
Recessive Gene ◽  
Single Recessive Gene ◽  
Melilotus Alba ◽  
Normal Green

A genetic analysis of P1, F1, F2 and BC1 in Melilotus alba revealed that the pale cotyledon trait was controlled by a single recessive gene, designated pc. This trait is characterized by chlorophyll-deficient cotyledons and normal green unifoliolate and subsequent trifoliolate leaves. Mature plants are indistinguishable from normal green sibs. The consistent deficiency of recessive F2 segregates was attributed to reduced vigor and differential seedling survival of the pale cotyledon segregates.

scholarly journals Spontaneous mutation for a quantitative trait in Drosophila melanogaster. II. Distribution of mutant effects on the trait and fitness

1993 ◽  
Vol 61 (2) ◽  
pp. 117-126 ◽  
Author(s):  
Marí A. López ◽  
Carlos López-Fanjul
Keyword(s):  
Drosophila Melanogaster ◽  
Large Fraction ◽  
Spontaneous Mutation ◽  
Natural Populations ◽  
Recessive Gene ◽  
Considerable Effect ◽  
Pleiotropic Effects ◽  
Standing Variation ◽  
Bristle Number ◽  
B Lines

SummaryStarting from a completely homozygous population of Drosophila melanogaster, lines have been derived and subjected to 47 generations of divergent selection for abdominal bristle number (20 lines selected in each direction) or to 60–67 generations of inbreeding (100 B lines maintained by a single brother-sister mating, 100 C lines maintained by two double first cousin ma tings). In the selected lines, 25 were identified carrying at least 30 mutations affecting bristle number. A large fraction of these mutations (42 %) were lethals. Non-lethal mutations had smaller effects on the trait, were predominantly additive and had no detectable pleiotropic effects on fitness. In the inbred lines, 21 mutations affecting bristles were individually analysed. Deleterious mutations had the largest effects on the trait (irrespective of sign) and showed recessive gene action (complete or incomplete). The rest were predominantly additive and had smaller effects. Thus, both procedures identify a quasi-neutral class of additive mutations which should be close to that responsible for standing variation in natural populations. Moreover, the results indicate a leptokurtic distribution of mutant effects, consistent with a model of natural selection acting on bristles through pleiotropic effects of pertinent loci on fitness. Consequently, neutral additive alleles of considerable effect can be found segregating at intermediate frequencies in natural populations.

Pleiotropic Effects of Totum-63—Simultaneous Targeting of Multiple Diabetes Mediators

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2312-PUB ◽  
Author(s):  
VIVIEN CHAVANELLE ◽  
YOLANDA F. OTERO ◽  
PASCAL SIRVENT ◽  
PATRICE D. CANI ◽  
SEBASTIEN PELTIER
Keyword(s):  
Pleiotropic Effects
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