Rates of Gastric Emptying in Young Cod

1970 ◽  
Vol 27 (7) ◽  
pp. 1177-1189 ◽  
Author(s):  
A. V. Tyler
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Intestinal Absorption ◽  
Gastric Volume ◽  
Acclimation Temperature ◽  
Rate Data ◽  
Time Intervals ◽  
Digestion Rate ◽  
Straight Line ◽  
Depletion Rate

Stomachs of young cod were opened at various time intervals after they had voluntarily eaten measured meals. More digested food left the stomach in the first few hours after the meal was given than towards the end of digestion. Instantaneous depletion rate increased rapidly with increase in acclimation temperature from 2 to 15 C. The rate was not increased at 19 C and was possibly depressed. Fish would not feed at 21 C. When meal size was varied, a straight-line relation was found between rate of gastric emptying and quantity of food in the stomach. This implies that in young cod intestinal absorption is coupled to food intake by regulation of the gastric volume. It is likely that digestion rate data could be used to estimate daily rations for fish in their own environment by measuring quantity of food in the stomach.

scholarly journals Gastric Sensory and Motor Functions and Energy Intake in Health and Obesity—Therapeutic Implications

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1158
Author(s):  
Lizeth Cifuentes ◽  
Michael Camilleri ◽  
Andres Acosta
Keyword(s):  
Energy Consumption ◽  
Gastric Emptying ◽  
Food Intake ◽  
Gastric Volume ◽  
Obesity Management ◽  
Bariatric Endoscopy ◽  
Motor Functions ◽  
Therapeutic Implications ◽  
Intestinal Functions

Sensory and motor functions of the stomach, including gastric emptying and accommodation, have significant effects on energy consumption and appetite. Obesity is characterized by energy imbalance; altered gastric functions, such as rapid gastric emptying and large fasting gastric volume in obesity, may result in increased food intake prior to reaching usual fullness and increased appetite. Thus, many different interventions for obesity, including different diets, anti-obesity medications, bariatric endoscopy, and surgery, alter gastric functions and gastrointestinal motility. In this review, we focus on the role of the gastric and intestinal functions in food intake, pathophysiology of obesity, and obesity management.

Evidence for the Assumption of Independence between Gastric Emptying Rate and Swimming Activity Using Atlantic Cod, Gadus morhua

1977 ◽  
Vol 34 (12) ◽  
pp. 2411-2413 ◽  
Author(s):  
A. V. Tyler
Keyword(s):  
Gastric Emptying ◽  
Key Words ◽  
Swimming Speed ◽  
Gadus Morhua ◽  
Atlantic Cod ◽  
Swimming Activity ◽  
Rate Data ◽  
Gastric Emptying Rate ◽  
Digestion Rate ◽  
Sufficient Magnitude

Juvenile Atlantic cod, Gadus morhua, were forced to swim at speeds of 0.07, 0.6, and 1.2 body lengths/s after eating measured quantities of food. Higher speeds could not be maintained for more than 2 days. Only the highest speed caused a decrease in gastric emptying rate, but the decrease was not of sufficient magnitude to interfere with ration estimates based on digestion rate data. Key words: feeding, swimming speed, digestion rate

The rôle of the gastrointestinal tract in the control of voluntary food intake

1989 ◽  
Vol 13 ◽  
pp. 27-39 ◽  
Author(s):  
D. V. Rayner ◽  
P. C. Gregory
Keyword(s):  
Gastrointestinal Tract ◽  
Gastric Emptying ◽  
Food Intake ◽  
Protein Hydrolysate ◽  
Gastric Volume ◽  
Normal Diet ◽  
Constant Rate ◽  
Stomach Volume ◽  
Fat Diets

AbstractThe short-term regulation of intake is thought to be achieved at least in part by signals from the gastrointestinal tract. Infusions of glucose, protein hydrolysate or emulsified fat into the stomach, and of glucose or protein hydrolysate into the duodenum, jejunum or ileum caused pigs to reduce their intake to compensate approximately for the energy infused, probably through the regulation of gastric emptying. Protein or protein hydrolysate infusions also caused a long-term inhibition of intake for 30 h by up to three times the energy infused. During feeding gastric emptying occurred at a constant rate of calories, the rate increasing linearly with body weight; duodenal infusion of glucose slowed gastric emptying to compensate for the infused energy and satiety occurred at a reduced food intake but at the same stomach volume. Duodenal infusion of emulsified fat caused a greater than caloric inhibition of intake, which was blocked by the cholecystokinin (CCK) antagonist L-364,718 and appeared to be mediated through a mono-glyceride-induced CCK release. Emulsified fat infused into the duodenum slowed gastric emptying by more than the energy infused and the gastric volume at satiety was decreased suggesting that the effects of fats on intake are possibly independent of gastric emptying. Since L-364,718 did not increase intake on a normal diet (186 g protein, 20 g fat per kg), CCK may only contribute to satiety in pigs eating high-fat diets.

scholarly journals GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility

2012 ◽  
Vol 303 (7) ◽  
pp. E853-E864 ◽  
Author(s):  
Xinfu Guan ◽  
Xuemei Shi ◽  
Xiaojie Li ◽  
Benny Chang ◽  
Yi Wang ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Feeding Behavior ◽  
Gastric Motility ◽  
Late Onset ◽  
Physiological Role ◽  
Immune Defense ◽  
Melanocortin Receptor ◽  
Melanocortin System ◽  
Dorsomedial Nucleus

Glucagon-like peptides (GLP-1/2) are cosecreted from endocrine L cells in the gut and preproglucagonergic neurons in the brain. Peripheral GLP-2 action is essential for maintaining intestinal homeostasis, improving absorption efficiency and blood flow, promoting immune defense, and producing efficacy in treatment of gastrointestinal diseases. However, it is unknown if CNS GLP-2 plays a physiological role in the control of energy homeostasis. Since GLP-1/2 are cotranslated from preproglucagongene and coproduced by prohormone convertase-1, it is challenging to knockout GLP-2 only. Instead, our laboratory has generated a Glp2r-floxed mouse line to dissect cell-specific GLP-2 receptor GLP-2R) action in the regulation of energy balance. Our objective was to determine if GLP-2R in the hypothalamus modulates feeding behavior and gastric emptying. We show that Glp2r mRNA and protein are highly expressed in the arcuate nucleus and dorsomedial nucleus of the mouse hypothalamus. Using the Cre-LoxP system, we generated mice that lack Glp2r expression in POMC neurons (KO; mainly in the hypothalamus). The KO mice showed hyperphagic behavior (such as increases in food intake and meal frequency), accelerated gastric emptying (assessed by [13C]octanoic acid breath test), and late-onset obesity, yet there was no decrease in basal metabolic rate. Infusion of GLP-2 (2.5 nmol into the 4th ventricle) suppressed food intake and gastric emptying, while GLP-2-mediated effects were abolished in the melanocortin receptor-4 (MC4R) KO mice. We conclude that Glp2r deletion in POMC neurons enhances feeding behavior and gastric motility, whereas icv GLP-2R activation suppresses food intake and gastric emptying through the MC4R signaling pathway. This study indicates that CNS GLP-2R plays a physiological role in the control of feeding behavior and gastric emptying and that this is mediated probably through the melanocortin system.

LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications

2006 ◽  
Vol 291 (4) ◽  
pp. G611-G620 ◽  
Author(s):  
Lixin Wang ◽  
Nicole R. Basa ◽  
Almaas Shaikh ◽  
Andrew Luckey ◽  
David Heber ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Food Intake ◽  
Intravenous Injection ◽  
Plasma Levels ◽  
Inhibitory Action ◽  
Functional Implications ◽  
Urocortin 1 ◽  
Fasted Rats

LPS injected intraperitoneally decreases fasted plasma levels of ghrelin at 3 h postinjection in rats. We characterized the inhibitory action of LPS on plasma ghrelin and whether exogenous ghrelin restores LPS-induced suppression of food intake and gastric emptying in fasted rats. Plasma ghrelin and insulin and blood glucose were measured after intraperitoneal injection of LPS, intravenous injection of IL-1β and urocortin 1, and in response to LPS under conditions of blockade of IL-1 or CRF receptors by subcutaneous injection of IL-1 receptor antagonist (IL-1Ra) or astressin B, respectively, and prostaglandin (PG) synthesis by intraperitoneal indomethacin. Food intake and gastric emptying were measured after intravenous injection of ghrelin at 5 h postintraperitoneal LPS injection. LPS inhibited the elevated fasted plasma ghrelin levels by 47.6 ± 4.9%, 58.9 ± 3.3%, 74.4 ± 2.7%, and 48.9 ± 8.7% at 2, 3, 5, and 7 h postinjection, respectively, and values returned to preinjection levels at 24 h. Insulin levels were negatively correlated to those of ghrelin, whereas there was no significant correlation between glucose and ghrelin. IL-1Ra and indomethacin prevented the first 3-h decline in ghrelin levels induced by LPS, whereas astressin B did not. IL-1β inhibited plasma ghrelin levels, whereas urocortin 1 had no influence. Ghrelin injected intravenously prevented an LPS-induced 87% reduction of gastric emptying and 61% reduction of food intake. These data showed that IL-1 and PG pathways are part of the early mechanisms by which LPS suppresses fasted plasma ghrelin and that exogenous ghrelin can normalize LPS-induced-altered digestive functions.

Relative contributions of “pressure pump” and “peristaltic pump” to gastric emptying

2000 ◽  
Vol 278 (4) ◽  
pp. G604-G616 ◽  
Author(s):  
K. Indireshkumar ◽  
James G. Brasseur ◽  
Henryk Faas ◽  
Geoffrey S. Hebbard ◽  
Patrik Kunz ◽  
...  
Keyword(s):  
High Pressure ◽  
Gastric Emptying ◽  
Muscle Tone ◽  
Contractile Activity ◽  
Average Rate ◽  
Gastric Volume ◽  
Peristaltic Pump ◽  
Pressure Pump ◽  
Significant Difference ◽  
Common Cavity

The relative contributions to gastric emptying from common cavity antroduodenal pressure difference (“pressure pump”) vs. propagating high-pressure waves in the distal antrum (“peristaltic pump”) were analyzed in humans by high-resolution manometry concurrently with time-resolved three-dimensional magnetic resonance imaging during intraduodenal nutrient infusion at 2 kcal/min. Gastric volume, space-time pressure, and contraction wave histories in the antropyloroduodenal region were measured in seven healthy subjects. The subjects fell into two distinct groups with an order of magnitude difference in levels of antral pressure activity. However, there was no significant difference in average rate of gastric emptying between the two groups. Antral pressure history was separated into “propagating high-pressure events” (HPE), “nonpropagating HPEs,” and “quiescent periods.” Quiescent periods dominated, and average pressure during quiescent periods remained unchanged with decreasing gastric volume, suggesting that common cavity pressure levels were maintained by increasing wall muscle tone with decreasing volume. When propagating HPEs moved to within 2–3 cm of the pylorus, pyloric resistance was found statistically to increase with decreasing distance between peristaltic waves and the pylorus. We conclude that transpyloric flow tends to be blocked when antral contraction waves are within a “zone of influence” proximal to the pylorus, suggesting physiological coordination between pyloric and antral contractile activity. We further conclude that gastric emptying of nutrient liquids is primarily through the “pressure pump” mechanism controlled by pyloric opening during periods of relative quiescence in antral contractile wave activity.

scholarly journals Gfral-expressing Neurons Suppress Food Intake via Aversive Pathways

2020 ◽  
Author(s):  
Paul V. Sabatini ◽  
Henriette Frikke-Schmidt ◽  
Joe Arthurs ◽  
Desiree Gordian ◽  
Anita Patel ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Taste Aversion ◽  
Conditioned Taste Aversion ◽  
Mechanisms Of Action ◽  
Parabrachial Nucleus ◽  
Gastric Physiology ◽  
Anorexigenic Peptide ◽  
Artificial Activation ◽  
Meal Ingestion

AbstractTo determine the function and mechanisms of action for hindbrain neurons that express GFRAL, the receptor for the anorexigenic peptide, GDF-15, we generated Gfralcre and conditional GfralCreERT mice. While signals of infection or pathophysiologic states (rather than meal ingestion) stimulate GFRAL neurons, the artificial activation of GfralCre- expressing neurons inhibited feeding, decreased gastric emptying, and promoted a conditioned taste aversion (CTA). Additionally, activation of the smaller population of GFRAL neurons captured by the GfralCreERT allele decreased gastric emptying and produced a CTA without suppressing food intake, suggesting that GFRAL neurons primarily modulate gastric physiology and stimulate aversive responses. GFRAL neurons most strongly innervated the parabrachial nucleus (PBN), where they targeted CGRP-expressing (CGRPPBN) neurons. Silencing CGRPPBN neurons abrogated the aversive and anorexic effects of GDF-15. These findings suggest that GFRAL neurons link non-meal-associated, pathophysiologic signals to the aversive suppression of nutrient uptake and absorption.

Food intake and gastric emptying in rats with streptozotocin-induced diabetes

1984 ◽  
Vol 247 (6) ◽  
pp. R1054-R1061 ◽  
Author(s):  
J. G. Granneman ◽  
E. M. Stricker
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Glucose Absorption ◽  
Diabetic Rats ◽  
High Carbohydrate Diet ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
High Carbohydrate ◽  
Low Carbohydrate ◽  
Streptozotocin Induced Diabetes

Recent studies suggest that the rate of nutrient transit through the upper gastrointestract may provide cues that are important to the control of food intake. We examined gastrointestinal function in rats with streptozotocin-induced diabetes and related these findings to concomitant changes in food intake. Control and diabetic rats were adapted to one of two isocaloric diets either high in carbohydrate or fat. Control rats ate similar amounts of each diet. In contrast, diabetic animals fed high-carbohydrate diet were hyperphagic, whereas those fed low-carbohydrate diet ate normal amounts of food. Gastric emptying, intestinal mass, disaccharidase activity, and glucose absorption were increased in normophagic diabetic rats fed a low-carbohydrate diet. Feeding diabetic rats high-carbohydrate diet potentiated each of these effects, and food intake was highly correlated with rate of gastric emptying. These and other results indicate that diabetes enhances gastric emptying and intestinal carbohydrate digestion and absorption, even in the absence of hyperphagia. Consequently, the hyperphagia of diabetic rats may be in part a behavioral response to a greatly accelerated clearance of nutrients from the upper gastrointestinal tract that occurs when these animals are fed diets rich in carbohydrate.

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