Anthropogenic sound and marine mammal health: measures of the nervous and immune systems before and after intense sound exposure

2004 ◽  
Vol 61 (7) ◽  
pp. 1124-1134 ◽  
Author(s):  
T A Romano ◽  
M J Keogh ◽  
C Kelly ◽  
P Feng ◽  
L Berk ◽  
...  
Keyword(s):  
Marine Mammals ◽  
Experimental Period ◽  
Delphinapterus Leucas ◽  
White Whale ◽  
Sound Exposure ◽  
Immune Parameters ◽  
Sound Levels ◽  
Before And After ◽  
High Level ◽  
Immune Changes

Anthropogenic sound is a potential stressor for marine mammals that may affect health, as has been demonstrated in other mammals. Therefore, we have initiated investigations on the effects of intense underwater sounds on nervous system activation and immune function in marine mammals. Blood samples were obtained before and after sound exposures (single underwater impulsive sounds (up to 200 kPa) produced from a seismic water gun and (or) single pure tones (up to 201 dB re 1 μPa) resembling sonar “pings” from a white whale, Delphinapterus leucas, and a bottlenose dolphin, Tursiops truncatus, to measure neural-immune parameters. Norepinephrine, epinephrine, and dopamine levels increased with increasing sound levels and were significantly higher after high-level sound exposures (>100 kPa) compared with low-level sound exposures (<100 kPa) or controls (P = 0.003, 0.006, and 0.020) for the white whale. Alkaline phosphatase decreased over the experimental period (P < 0.001), while γ-glutamyltransferase increased over the experimental period (P < 0.001). Significant neural-immune measurements for the dolphin after exposure to impulsive sounds included an increase in aldosterone (P = 0.003) and a decrease in monocytes (P = 0.006). Neural-immune changes to tonal sound exposures were minimal, although changes were observed in multiple neural-immune measures over time.

scholarly journals Simulated seal scarer sounds scare porpoises, but not seals: species-specific responses to 12 kHz deterrence sounds

2017 ◽  
Vol 4 (7) ◽  
pp. 170286 ◽  
Author(s):  
Lonnie Mikkelsen ◽  
Line Hermannsen ◽  
Kristian Beedholm ◽  
Peter Teglberg Madsen ◽  
Jakob Tougaard
Keyword(s):  
Marine Mammals ◽  
Peak Level ◽  
Sensitive Species ◽  
Sound Sources ◽  
Sound Exposure ◽  
Sound Levels ◽  
Harbour Seals ◽  
Key Species ◽  
Species Specific ◽  
Avoidance Reactions

Acoustic harassment devices (AHD) or ‘seal scarers’ are used extensively, not only to deter seals from fisheries, but also as mitigation tools to deter marine mammals from potentially harmful sound sources, such as offshore pile driving. To test the effectiveness of AHDs, we conducted two studies with similar experimental set-ups on two key species: harbour porpoises and harbour seals. We exposed animals to 500 ms tone bursts at 12 kHz simulating that of an AHD (Lofitech), but with reduced output levels (source peak-to-peak level of 165 dB re 1 µPa). Animals were localized with a theodolite before, during and after sound exposures. In total, 12 sound exposures were conducted to porpoises and 13 exposures to seals. Porpoises were found to exhibit avoidance reactions out to ranges of 525 m from the sound source. Contrary to this, seal observations increased during sound exposure within 100 m of the loudspeaker. We thereby demonstrate that porpoises and seals respond very differently to AHD sounds. This has important implications for application of AHDs in multi-species habitats, as sound levels required to deter less sensitive species (seals) can lead to excessive and unwanted large deterrence ranges on more sensitive species (porpoises).

scholarly journals Benefit of a pharmacist-led intervention for medication management of renal transplant patients: a controlled before-and-after study

2021 ◽  
Vol 12 ◽  
pp. 204062232110052
Author(s):  
Jeremy Chambord ◽  
Lionel Couzi ◽  
Pierre Merville ◽  
Karine Moreau ◽  
Fabien Xuereb ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Immunosuppressive Therapy ◽  
Medication Management ◽  
Intervention Group ◽  
Knowledge Score ◽  
Control Group ◽  
Patient Knowledge ◽  
Transplant Patients ◽  
Before And After ◽  
High Level

Aims: To assess the effect of a pharmacist-led intervention, using Barrows cards method, during the first year after renal transplantation, on patient knowledge about their treatment, medication adherence and exposure to treatment in a French cohort. Methods: We conducted a before-and-after comparative study between two groups of patients: those who benefited from a complementary pharmacist-led intervention [intervention group (IG), n = 44] versus those who did not [control group (CG), n = 48]. The pharmacist-led intervention consisted of a behavioral and educational interview at the first visit (visit 1). The intervention was assessed 4 months later at the second visit (visit 2), using the following endpoints: treatment knowledge, medication adherence [proportion of days covered (PDC) by immunosuppressive therapy] and tacrolimus exposure. Results: At visit 2, IG patients achieved a significantly higher knowledge score than CG patients (83.3% versus 72.2%, p = 0.001). We did not find any differences in treatment exposure or medication adherence; however, the intervention tended to reduce the proportion of non-adherent patients with low knowledge scores. Using the PDC by immunosuppressive therapy, we identified 10 non-adherent patients (10.9%) at visit 1 and six at visit 2. Conclusions: Our intervention showed a positive effect on patient knowledge about their treatment. However, our results did not show any improvement in overall medication adherence, which was likely to be because of the initially high level of adherence in our study population. Nevertheless, the intervention appears to have improved adherence in non-adherent patients with low knowledge scores.

scholarly journals Gender Differences in Neuromuscular, Haematological and Urinary Responses during Padel Matches

2021 ◽  
Vol 18 (11) ◽  
pp. 5864
Author(s):  
Francisco Pradas ◽  
Alejandro García-Giménez ◽  
Víctor Toro-Román ◽  
Nicolae Ochiana ◽  
Carlos Castellar
Keyword(s):  
Gender Differences ◽  
Red Blood Cells ◽  
Grip Strength ◽  
Blood Cells ◽  
Temporal Structure ◽  
Hand Grip Strength ◽  
Squat Jump ◽  
Hand Grip ◽  
Before And After ◽  
High Level

Research on the acute physiological response to a padel match is limited. The present study aimed to: (a) evaluate neuromuscular, urinary, and hematological responses after simulated padel competition (SC) and (b) analyze possible gender differences. In this study, 28 high-level padel players participated (men = 13, age = 26.83 ± 6.57 years; women = 15, age = 30.07 ± 4.36 years). The following parameters were analyzed before and after SC: neuromuscular (hand grip strength, squat jump (SJ), countermovement jump (CMJ), and Abalakov jump (ABK)), hematological (red blood cells, hemoglobin, and hematocrit), and urinary (pH, specific gravity, microalbuminuria, and red blood cells). Significant gender differences were found in neuromuscular and hematological responses, with men obtaining higher values (p < 0.05). For the SC influence, changes were noted in ABK and microalbuminuria (p < 0.05). The percentages of change in hand grip strength, SJ (height and watts), CMJ (height), and ABK (height) were higher for men than women (p < 0.05). SC negatively influenced the neuromuscular parameters to a greater extent in women. Our results could be related to gender differences in game actions, the temporal structure, and anthropometric and physiological characteristics. Game dynamics and a different organic response between male and female padel playing were confirmed.

scholarly journals Real-Time High-Level Acute Pain Detection Using a Smartphone and a Wrist-Worn Electrodermal Activity Sensor

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 3956
Author(s):  
Youngsun Kong ◽  
Hugo F. Posada-Quintero ◽  
Ki H. Chon
Keyword(s):  
Real Time ◽  
Electrodermal Activity ◽  
Smartphone Application ◽  
Real Time Processing ◽  
Pain Stimulation ◽  
Significant Difference ◽  
Before And After ◽  
Electrical Pulses ◽  
Pain Detection ◽  
High Level

The subjectiveness of pain can lead to inaccurate prescribing of pain medication, which can exacerbate drug addiction and overdose. Given that pain is often experienced in patients’ homes, there is an urgent need for ambulatory devices that can quantify pain in real-time. We implemented three time- and frequency-domain electrodermal activity (EDA) indices in our smartphone application that collects EDA signals using a wrist-worn device. We then evaluated our computational algorithms using thermal grill data from ten subjects. The thermal grill delivered a level of pain that was calibrated for each subject to be 8 out of 10 on a visual analog scale (VAS). Furthermore, we simulated the real-time processing of the smartphone application using a dataset pre-collected from another group of fifteen subjects who underwent pain stimulation using electrical pulses, which elicited a VAS pain score level 7 out of 10. All EDA features showed significant difference between painless and pain segments, termed for the 5-s segments before and after each pain stimulus. Random forest showed the highest accuracy in detecting pain, 81.5%, with 78.9% sensitivity and 84.2% specificity with leave-one-subject-out cross-validation approach. Our results show the potential of a smartphone application to provide near real-time objective pain detection.

scholarly journals Transfer and generalization of learned manipulation between unimanual and bimanual tasks

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Trevor Lee-Miller ◽  
Marco Santello ◽  
Andrew M. Gordon
Keyword(s):  
Learning Transfer ◽  
Center Of Pressure ◽  
Center Of Mass ◽  
Pressure Point ◽  
Torque Generation ◽  
Before And After ◽  
Object Center ◽  
High Level ◽  
Bimanual Grasping ◽  
Partial Learning

AbstractSuccessful object manipulation, such as preventing object roll, relies on the modulation of forces and centers of pressure (point of application of digits on each grasp surface) prior to lift onset to generate a compensatory torque. Whether or not generalization of learned manipulation can occur after adding or removing effectors is not known. We examined this by recruiting participants to perform lifts in unimanual and bimanual grasps and analyzed results before and after transfer. Our results show partial generalization of learned manipulation occurred when switching from a (1) unimanual to bimanual grasp regardless of object center of mass, and (2) bimanual to unimanual grasp when the center of mass was on the thumb side. Partial generalization was driven by the modulation of effectors’ center of pressure, in the appropriate direction but of insufficient magnitude, while load forces did not contribute to torque generation after transfer. In addition, we show that the combination of effector forces and centers of pressure in the generation of compensatory torque differ between unimanual and bimanual grasping. These findings highlight that (1) high-level representations of learned manipulation enable only partial learning transfer when adding or removing effectors, and (2) such partial generalization is mainly driven by modulation of effectors’ center of pressure.

scholarly journals Quality of colostral passive immunity and pattern of serum protein fluctuation in newborn calves

2003 ◽  
Vol 60 (3) ◽  
pp. 453-456 ◽  
Author(s):  
Patricia Pauletti ◽  
Raul Machado Neto ◽  
Irineu Umberto Packer ◽  
Raul Dantas D'Arce ◽  
Rosana Bessi
Keyword(s):  
Total Protein ◽  
Statistical Design ◽  
Extended Period ◽  
Experimental Period ◽  
Passive Immunity ◽  
Serum Total Protein ◽  
Non Linear ◽  
Medium Level ◽  
Group 2 ◽  
High Level

Immunity acquired by newborn animals is known as passive immunity, and for ruminants, antibody acquisition depends on the ingestion and absorption of adequate amounts of immunoglobulins from colostrum. This study relates different initial levels of acquired passive protection and serum total protein (TP) and immunoglobulin G (IgG). Serum immunoglobulin concentration and total protein were evaluated for female Holstein calves in the first sixty days of life. Animals were separated into three groups according to their initial level of passive immunity: group 1- animals with a low level of passive immunity (below 20 mg mL-1); group 2- animals with a medium level (between 20 and 30 mg mL-1), and group 3- animals with a high level (above 30 mg mL-1). Serum total protein was determined through the biuret method and IgG was determined by radial immunodiffusion. Data were analyzed as a completely randomized, split-plot statistical design. Fluctuation of the variables along the experimental period was determined through non-linear regression by the DUD method (PROC NLIN - Non Linear SAS). Animals with low antibody acquisition started to produce antibodies earlier, reflecting a compensatory synthesis. On the other hand, animals having adequate levels exhibited an extended period of immunoglobulin catabolism and the beginning of the endogenous phase was delayed. Regardless initial levels, the fluctuations in IgG contents occurred around adequate physiological concentrations, ranging from 20 to 25 mg mL-1.

scholarly journals Analysis of the resistance mediated by several R-factors to Tetracycline and Minocycline

1972 ◽  
Vol 20 (2) ◽  
pp. 239-252 ◽  
Author(s):  
J. M. Robertson ◽  
E. C. R. Reeve
Keyword(s):  
Tetracycline Resistance ◽  
Klebsiella Aerogenes ◽  
R Factor ◽  
Before And After ◽  
Challenge Tests ◽  
Simple Growth ◽  
High Level ◽  
K 12 ◽  
R Factors ◽  
Level Group

SUMMARYThe resistance levels conferred by the T-determinants in four R-factors to Tetracycline and Minocycline in cells ofEscherichia coliK 12, before and after induction of maximum resistance by treatment with sub-inhibitory concentrations of the drugs, are measured by simple growth-and-challenge tests. The effect of a plasmid TKwhich confers tetracycline resistance on its hostKlebsiella aerogenesis tested in the same way. The five T-determinants fall into a high-level and a low-level group for resistance, the former giving 3- to 4-fold higher resistance in both induced and uninduced cells than the latter. The T-determinants all confer much lower resistance to Minocycline (a tetracycline molecule modified at the C-6 and C-7 positions) than to Tetracycline. The main cause of this difference is that cells carrying a T-determinant exclude Minocycline much less efficiently than Tetracycline, but in addition Minocycline is less effective than Tetracycline in inducing increased resistance. These results are discussed in the light of a model put forward to explain the inducible nature of R-factor resistance to the tetracyclines.

scholarly journals Evaluation of nutritional values of smoke cured riverine and marine hilsa (Tenualosa ilisha; Hamilton, 1882)

2018 ◽  
Vol 46 (2) ◽  
pp. 177-184
Author(s):  
Sumon Debnath ◽  
Gulshan Ara Latifa ◽  
Mohajira Begum ◽  
Md Abu Obaida
Keyword(s):  
Head Region ◽  
Nutritional Values ◽  
Caudal Region ◽  
Abdominal Region ◽  
Before And After ◽  
Tenualosa Ilisha ◽  
High Level

Present study was conducted to evaluate nutritional values of smoked hilsa fish (Tenualosa ilisha; Hamilton, 1882) in relation to its raw condition. Smoking is one of the processes of fish preservation from ancient period of our country. The nutrients values of the hilsa from two different regions were significantly (p < 0.05) varied. The nutritional values were different before and after processing of hilsa. Riverine hilsa contains relatively more moisture (56.45 ± 0.51%) and protein (15.98 ± 0.50%) than marine hilsa. Fat (16.18 ± 0.45%) and salt (1.92 ± 0.18%) contents are higher in marine hilsa; whereas ash (8.34 ± 0.35%) content was higher in riverine hilsa. Minerals like iron (4.72 ± 0.08 mg/100 g) and calcium (481.77 ± 6.20 mg/100g) remain in large amount on marine hilsa but phosphorus (115.73 ± 4.36 mg/100 g) content remain high level in riverine hilsa. In addition, the protein (raw condition, 19.54 ± 0.47%, riverine; 17.12 ± 0.42%, marine and smoked condition, 29.64 ± 0.41%, riverine; 28.51 ± 0.51%, marine) and fat (raw condition, 16.41 ± 0.46%, riverine; 20.07 ± 0.39%, marine and smoked condition, 20.71 ± 0.47%, riverine; 23.31 ± 0.47%, marine) content were higher in abdominal region of riverine and marine hilsa both raw and smoked condition than head region (protein in raw condition, 11.21 ± 0.51%, riverine; 10.51 ± 0.53%, marine and smoked condition, 17.14 ± 0.42%, riverine; 15.69 ± 0.4%, marine; fat in raw condition, 9.04 ± 0.45%, riverine; 11.21 ± 0.51%, marine and smoked condition, 12.32 ± 0.44%, riverine; 14.56 ± 0.47%, marine) and caudal region (protein in raw condition17.21 ± 0.52%, riverine; 15.22 ± 0.66%, marine and smoked condition, 27.68 ± 0.44%, riverine; 26.73 ± 0.46%, marine; fat in raw condition, 14.05 ± 0.5%, riverine; 17.28 ± 0.47%, marine and smoked condition, 17.35 ± 0.43%, riverine; 19.18 ± 0.51%, marine). Bangladesh J. Zool. 46(2): 177-184, 2018

Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen

2000 ◽  
Vol 279 (1) ◽  
pp. G157-G162 ◽  
Author(s):  
Esther Staunton ◽  
Scott D. Smid ◽  
John Dent ◽  
L. Ashley Blackshaw
Keyword(s):  
Gastroesophageal Reflux ◽  
Lower Esophageal Sphincter ◽  
Glucose Infusion ◽  
Gastric Distention ◽  
Low Level ◽  
Before And After ◽  
Esophageal Sphincter ◽  
Splanchnic Mechanoreceptors ◽  
High Level

Activation of gastric vagal mechanoreceptors by distention is thought to be the trigger for transient lower esophageal sphincter relaxations (TLESR), which lead to gastroesophageal reflux. The contribution of higher-threshold gastric splanchnic mechanoreceptors is uninvestigated. GABABreceptor agonists, including baclofen, potently reduce triggering of TLESR by low-level gastric distention. We aimed to determine first whether this effect of baclofen is maintained at high-level distention and second the role of splanchnic pathways in triggering TLESR. Micromanometric/pH studies in conscious ferrets showed that intragastric glucose infusion (25 ml) increased triggering of TLESR and reflux. Both were significantly reduced by baclofen (7 μmol/kg ip) ( P < 0.05). When 40 ml of air was added to the glucose infusion, more TLESR occurred than with glucose alone ( P < 0.01). These were also reduced by baclofen ( P < 0.001). TLESR after glucose/air infusion were assessed before and after splanchnectomy (2–4, 9–11, and 23–25 days), which revealed no change. Baclofen inhibits TLESR after both low- and high-level gastric distention. Splanchnic pathways do not contribute to increased triggering of TLESR by high-level gastric distention.

scholarly journals Contribuições do cuidado de enfermagem na redução da dor em clientes com dermatoses imunobolhosas: avaliação pela lógica fuzzi

2016 ◽  
Vol 15 (4) ◽  
pp. 675 ◽  
Author(s):  
Euzeli Da Silva Brandão ◽  
Iraci Dos Santos ◽  
Regina Serrão Lanzillotti
Keyword(s):  
Fuzzy Logic ◽  
Pain Intensity ◽  
Nursing Care ◽  
Pain Reduction ◽  
Low Level ◽  
Before And After ◽  
Reduction Of Pain ◽  
High Level

Aim: to evaluate the intensity of the client’s pain with autoimmune bullous  dermatoses,  before  and  after the  protocol  of  nursing  care  is  applied to  a  client with autoimmune bullous dermatoses. Method: the data were treated using fuzzy logic. Results: when associating the implementation of the protocol with pain reduction in the 14 study subjects the following stand out: in T0, seven subjects presented high levels of pain, with a pertinence of 1.0; in T1, 24 hours after intervention, eight presented a low level of pain, with pertinences ranging from 1.0 and 0.75, and only one with high level of pain;  in  T2,  only  one  remained  with  a  high  level  of  pain.  Discussion:  the  use  of analgesics prior to application of the protocol demonstrates that change in pain intensity was  not  influenced  by  use  of  medication,  but  rather  by  the  implemented  care. Conclusion: based on the classifications of fuzzy logic, there was a significant reduction of pain levels, especially in the first 24 hours.

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