Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets challenged with lipopolysaccharide

2017 ◽  
Author(s):  
Shen Xing ◽  
Bo-Lin Zhang ◽  
Meng Lin ◽  
Jiaolong Li ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Glutamine Supplementation ◽  
Small Intestinal Mucosa ◽  
Weaned Piglets ◽  
Small Intestinal

scholarly journals Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets

2016 ◽  
Vol 30 (2) ◽  
pp. 236-245 ◽  
Author(s):  
Shen Xing ◽  
Bolin Zhang ◽  
Meng Lin ◽  
Ping Zhou ◽  
Jiaolong Li ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Glutamine Supplementation ◽  
Small Intestinal Mucosa ◽  
Weaned Piglets ◽  
Small Intestinal

Effect of grapeseed procyanidins on small intestinal mucosa morphology and small intestinal development in weaned piglets

2020 ◽  
Vol 60 (16) ◽  
pp. 1894
Author(s):  
Huishi Yan ◽  
Wenwei Gao ◽  
Qinghong Li ◽  
Hongquan Li ◽  
Ruirong Hao
Keyword(s):  
Intestinal Mucosa ◽  
Dietary Supplementation ◽  
Control Group ◽  
Small Intestinal Mucosa ◽  
Intestinal Development ◽  
Weaned Piglets ◽  
Villus Height ◽  
Crypt Depth ◽  
Expression Of Genes ◽  
Small Intestinal

Context Grapeseed procyanidins (GSP) are widely recognised to have potential biological properties, and dietary supplementation with GSP could reduce diarrhoea incidence in weaned piglets. Aims This trial was conducted to investigate the effect of GSP on small intestinal mucosa morphology and small intestinal development in weaned piglets. Methods Seventy-two weaned piglets were randomly allocated into four dietary groups with three replicate pens per group and six piglets per pen. Each group received one of the following diets: a basal maize–soybean meal diet; or basal diet supplemented with 50, 100 or 150 mg GSP/kg. Small intestinal mucosa morphology and the expression of genes involved in improving small intestinal development were determined. Key results Morphological observations obtained by optical microscopy showed that the villus height of the duodenum and ileum increased in all groups receiving GSP, significantly (P < 0.05) so in the group receiving 100 mg GSP/kg compared with the control group. Crypt depth of the duodenum and ileum in the groups receiving 100 and 150 mg GSP/kg decreased compared with the control group. Similarly, the crypt depth of the jejunum in the group receiving 100 mg GSP/kg was significantly (P < 0.05) lowered. Moreover, the villus height/crypt depth ratio of each small intestinal segment in the group receiving 100 mg GSP/kg increased significantly (P < 0.01). Morphological observations obtained by scanning electron microscopy indicated that dietary supplementation with GSP was favourable for growth of small intestinal villi. Specifically, the villi of the small intestine in the group receiving 100 mg GSP/kg were most closely aligned, most uniform in size and clearest in structure. Furthermore, dietary supplementation with GSP increased the expression of genes encoding epidermal growth factor receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor in the duodenum, the group receiving 100 mg GSP/kg showing a significant (P < 0.05) increase. Conclusions Dietary supplementation with GSP could improve small intestinal mucosa morphology and promote small intestinal development. Dietary supplementation of 100 mg GSP/kg could be recommended for weaned piglets. Implications Dietary supplementation with GSP generated a beneficial role in small intestinal health in weaned piglets.

scholarly journals Dietary Tryptophan Levels Impact Growth Performance and Intestinal Microbial Ecology in Weaned Piglets via Tryptophan Metabolites and Intestinal Antimicrobial Peptides

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 817
Author(s):  
Zebin Rao ◽  
Jinlong Li ◽  
Baoshi Shi ◽  
Yan Zeng ◽  
Yubo Liu ◽  
...  
Keyword(s):  
Growth Performance ◽  
Microbial Ecology ◽  
Intestinal Mucosa ◽  
Soybean Meal ◽  
Body Weight Gain ◽  
Mucosal Barrier ◽  
Small Intestinal Mucosa ◽  
Dependent Manner ◽  
Weaned Piglets ◽  
Small Intestinal

Tryptophan (Trp) plays an important role in piglet growth. However, the effect of dietary Trp on microbial flora is still poorly understood. A total of 40 28-d weaned piglets were allocated to four groups with 10 barrows per group and one pig per replicate. Piglets were fed a corn and soybean meal-based diet with 0.14%, 0.21%, 0.28%, or 0.35% Trp for four weeks. Five piglets from each diet group were euthanized, and blood and tissue samples were collected. The average daily body weight gain, average daily feed intake, feed conversion ratio, spleen index, pancreas index, longissimus dorsi muscle index, plasma insulin, 5-hydroxytryptamine, kynurenine, and Trp concentrations of weaned piglets increased in a dose-dependent manner (p < 0.05). Compared with the 0.14% Trp diet, the adequate-Trp diets (0.21%, 0.28%, or 0.35%) down-regulated the relative abundances of 12 genera including Turicibacter, Prevotella, Mitsuokella, Anaerovibrio, Megasphaera, Succinivibrio, Sutterella, Desulfovibrio, and Methanobrevibacter (p < 0.05); up-regulated the abundances of Ruminococcaceae, Lactobacillus, and Muribaculaceae in the colon (p < 0.05); and augmented the mRNA level and concentration of porcine β-defensin 2 in the small intestinal mucosa (p < 0.05). Moreover, Trp-adequate diets increased the abundances of Trp hydroxylase, indoleamine 2,3-dioxygenase, porcine β-defensin 2, phosphorylated mammalian target of rapamycin, and phosphorylated protein kinase B in the small intestinal mucosa (p < 0.05). We noted that a corn and soybean meal-based diet with 0.35% Trp may be a nutritional strategy to improve growth performance, intestinal mucosal barrier integrity, and intestinal microbial ecology in weaned piglets.

scholarly journals Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets

2009 ◽  
Vol 102 (9) ◽  
pp. 1285-1296 ◽  
Author(s):  
Maud Le Gall ◽  
Mélanie Gallois ◽  
Bernard Sève ◽  
Isabelle Louveau ◽  
Jens J. Holst ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Sodium Butyrate ◽  
Feed Intake ◽  
Body Growth ◽  
Small Intestinal Mucosa ◽  
Anatomy And Physiology ◽  
Feed Digestibility ◽  
Before And After ◽  
Villous Height ◽  
Small Intestinal

Sodium butyrate (SB) provided orally favours body growth and maturation of the gastrointestinal tract (GIT) in milk-fed pigs. In weaned pigs, conflicting results have been obtained. Therefore, we hypothesised that the effects of SB (3 g/kg DM intake) depend on the period (before v. after weaning) of its oral administration. From the age of 5 d, thirty-two pigs, blocked in quadruplicates within litters, were assigned to one of four treatments: no SB (control), SB before (for 24 d), or after (for 11–12 d) weaning and SB before and after weaning (for 35–36 d). Growth performance, feed intake and various end-point indices of GIT anatomy and physiology were investigated at slaughter. The pigs supplemented with SB before weaning grew faster after weaning than the controls (P < 0·05). The feed intake was higher in pigs supplemented with SB before or after weaning (P < 0·05). SB provided before weaning improved post-weaning faecal digestibility (P < 0·05) while SB after weaning decreased ileal and faecal digestibilities (P < 0·05). Gastric digesta retention was higher when SB was provided before weaning (P < 0·05). Post-weaning administration of SB decreased the activity of three pancreatic enzymes and five intestinal enzymes (P < 0·05). IL-18 gene expression tended to be lower in the mid-jejunum in SB-supplemented pigs. The small-intestinal mucosa was thinner and jejunal villous height lower in all SB groups (P < 0·05). In conclusion, the pre-weaning SB supplementation was the most efficient to stimulate body growth and feed intake after weaning, by reducing gastric emptying and intestinal mucosa weight and by increasing feed digestibility.

scholarly journals Biosynthesis of apolipoprotein C-III in rat liver and small intestinal mucosa.

1984 ◽  
Vol 259 (4) ◽  
pp. 2452-2456 ◽  
Author(s):  
M C Blaufuss ◽  
J I Gordon ◽  
G Schonfeld ◽  
A W Strauss ◽  
D H Alpers
Keyword(s):  
Rat Liver ◽  
Intestinal Mucosa ◽  
Small Intestinal Mucosa ◽  
Apolipoprotein C ◽  
Small Intestinal

scholarly journals Contribution of Infectious Agents to the Development of Celiac Disease

2021 ◽  
Vol 9 (3) ◽  
pp. 547
Author(s):  
Daniel Sánchez ◽  
Iva Hoffmanová ◽  
Adéla Szczepanková ◽  
Věra Hábová ◽  
Helena Tlaskalová-Hogenová
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa ◽  
Wheat Gluten ◽  
Small Intestinal Mucosa ◽  
Beneficial Effects ◽  
Immune Mediated ◽  
Healthy State ◽  
Food Antigens ◽  
Small Intestinal ◽  
And Function

The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and related proteins induce, in genetically predisposed individuals, celiac disease (CD), which is characterized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intestinal mucosa to a fully healthy state. Recently, the participation of microbial components in pathogenetic mechanisms of celiac disease was suggested. The present review provides information on infectious diseases associated with CD and the putative role of infections in CD development. Moreover, the involvement of the microbiota as a factor contributing to pathological changes in the intestine is discussed. Attention is paid to the mechanisms by which microbes and their components affect mucosal immunity, including tolerance to food antigens. Modulation of microbiota composition and function and the potential beneficial effects of probiotics in celiac disease are discussed.

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