Global Dynamics of a General Class of Multistage Models for Infectious Diseases

2012 ◽  
Vol 72 (1) ◽  
pp. 261-279 ◽  
Author(s):  
Hongbin Guo ◽  
Michael Y. Li ◽  
Zhisheng Shuai
Author(s):  
Luana da S. M. Forezi ◽  
Acácio S. de Souza ◽  
Carolina G. S. Lima ◽  
Amanda A. Borges ◽  
Patricia G. Ferreira ◽  
...  

: Naphthoquinones are important molecules belonging to the general class of quinones, and many of these compounds have become drugs that are in the pharmaceutical market for the treatment of several diseases. A special subclass of compounds is that of the bis(naphthoquinones), which have two linked naphthoquinone units. In the last few years, several synthetic approaches toward such valuable compounds have been described, as well as their evaluation against numerous important biological targets. In this review, we provide a thorough discussion on the various synthetic methods reported for the synthesis of bis(naphthoquinone) analogues, also highlighting the biological activities of these substances.


2018 ◽  
Vol 2018 ◽  
pp. 1-21 ◽  
Author(s):  
Rodrigue Yves M’pika Massoukou ◽  
Suares Clovis Oukouomi Noutchie ◽  
Richard Guiem

Vaccine-induced protection is substantial to control, prevent, and reduce the spread of infectious diseases and to get rid of infectious diseases. In this paper, we propose an SVEIR epidemic model with age-dependent vaccination, latency, and infection. The model also considers that the waning vaccine-induced immunity depends on vaccination age and the vaccinated individuals fall back to the susceptible class after losing immunity. The model is a coupled system of (hyperbolic) partial differential equations with ordinary differential equations. The global dynamics of the model is established through construction of appropriate Lyapunov functionals and application of Lasalle’s invariance principle. As a result, the global stability of the infection-free equilibrium and endemic equilibrium is obtained and is fully determined by the basic reproduction number R0.


2014 ◽  
Vol 71 (1) ◽  
pp. 69-98 ◽  
Author(s):  
Alain Rapaport ◽  
Ihab Haidar ◽  
Jérôme Harmand

2016 ◽  
Vol 13 (4) ◽  
pp. 813-840 ◽  
Author(s):  
Martin Luther Mann Manyombe ◽  
Joseph Mbang ◽  
Jean Lubuma ◽  
Berge Tsanou

2020 ◽  
pp. paper48-1-paper48-12
Author(s):  
Eugene Eremchenko ◽  
Vladimir Tikunov ◽  
Sergey Vylegzhanin ◽  
Alexander Fetishev

The article is a brief overview of the results of the current stage of study of the dynamics of infectious processes in the modern urban environment in Protvino (Russia) with the help of 3D-model of the town, made in the paradigm of the Digital Earth. Data for the period 2011-2016 (38791 events) were used. Spatial and temporal resolution “building-day” was achieved. It is demonstrated that infectious diseases rates even in neighboring buildings can vary significantly from one to another. The presence of buildings with both significantly higher and significantly lower rates of infectious diseases is shown. Such significant discrepancies between rates are difficult to explain by local ecological factors like air and water pollutions because of the generalized nature of their impact on such a small area. The example of the global dynamics of COVID-19 demonstrates the need to study both specific and non-specific factors for the local epidemic process. Prospectives of the future researches are discussed briefly.


2015 ◽  
Vol 12 (1) ◽  
pp. 99-115 ◽  
Author(s):  
Xiaomei Feng ◽  
◽  
Zhidong Teng ◽  
Fengqin Zhang ◽  

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