scholarly journals Neuronal Networks with Gap Junctions: A Study of Piecewise Linear Planar Neuron Models

2008 ◽  
Vol 7 (3) ◽  
pp. 1101-1129 ◽  
Author(s):  
S. Coombes
Keyword(s):  
Gap Junctions ◽  
Neuronal Networks ◽  
Piecewise Linear ◽  
Neuron Models

scholarly journals Gap Junctions in Developing Thalamic and Neocortical Neuronal Networks

2013 ◽  
Vol 24 (12) ◽  
pp. 3097-3106 ◽  
Author(s):  
D. Niculescu ◽  
C. Lohmann
Keyword(s):  
Gap Junctions ◽  
Neuronal Networks

scholarly journals LFPy – multimodal modeling of extracellular neuronal recordings in Python

2019 ◽  
Author(s):  
Espen Hagen ◽  
Solveig Næss ◽  
Torbjørn V. Ness ◽  
Gaute T. Einevoll
Keyword(s):  
Open Source ◽  
Neuronal Networks ◽  
Single Cells ◽  
Simulation Environment ◽  
Neuron Models ◽  
Open Source Tool ◽  
Brain Signals ◽  
Python Package ◽  
Extracellular Potentials ◽  
Neuron Simulation

1.AbstractLFPy is an open-source tool for calculating brain signals such as extracellular potentials and magnetic signals from simulated activity in multicompartment neuron models, ranging from single cells to large neuronal networks. The tool is provided as a Python package, and relies on the NEURON simulation environment.

A generalized analog implementation of piecewise linear neuron models using CCII building blocks

2014 ◽  
Vol 51 ◽  
pp. 26-38 ◽  
Author(s):  
Hamid Soleimani ◽  
Arash Ahmadi ◽  
Mohammad Bavandpour ◽  
Ozra Sharifipoor
Keyword(s):  
Piecewise Linear ◽  
Building Blocks ◽  
Neuron Models ◽  
Analog Implementation

scholarly journals Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum

2014 ◽  
Vol 111 (4) ◽  
pp. 836-848 ◽  
Author(s):  
Sriraman Damodaran ◽  
Rebekah C. Evans ◽  
Kim T. Blackwell
Keyword(s):  
Gap Junctions ◽  
Motor Deficits ◽  
Inhibitory Input ◽  
Dopamine Depletion ◽  
Indirect Pathway ◽  
Neuron Models ◽  
Cortical Input ◽  
Inhibitory Circuits ◽  
Excitatory Synaptic Input ◽  
Fast Spiking

The inhibitory circuits of the striatum are known to be critical for motor function, yet their contributions to Parkinsonian motor deficits are not clear. Altered firing in the globus pallidus suggests that striatal medium spiny neurons (MSN) of the direct (D1 MSN) and indirect pathway (D2 MSN) are imbalanced during dopamine depletion. Both MSN classes receive inhibitory input from each other and from inhibitory interneurons within the striatum, specifically the fast-spiking interneurons (FSI). To investigate the role of inhibition in maintaining striatal balance, we developed a biologically-realistic striatal network model consisting of multicompartmental neuron models: 500 D1 MSNs, 500 D2 MSNs and 49 FSIs. The D1 and D2 MSN models are differentiated based on published experiments of individual channel modulations by dopamine, with D2 MSNs being more excitable than D1 MSNs. Despite this difference in response to current injection, in the network D1 and D2 MSNs fire at similar frequencies in response to excitatory synaptic input. Simulations further reveal that inhibition from FSIs connected by gap junctions is critical to produce balanced firing. Although gap junctions produce only a small increase in synchronization between FSIs, removing these connections resulted in significant firing differences between D1 and D2 MSNs, and balanced firing was restored by providing synchronized cortical input to the FSIs. Together these findings suggest that desynchronization of FSI firing is sufficient to alter balanced firing between D1 and D2 MSNs.

scholarly journals The effect of rectifying gap junctions on phase-locking in neuronal networks

2008 ◽  
Vol 9 (Suppl 1) ◽  
pp. P132
Author(s):  
Donald French ◽  
Tamara J Schlichter ◽  
Timothy J Lewis
Keyword(s):  
Gap Junctions ◽  
Neuronal Networks ◽  
Phase Locking

Quantitative EM of gap junction distribution in mutant drosophila wing discs

1983 ◽  
Vol 41 ◽  
pp. 720-721
Author(s):  
J.S. Ryerse
Keyword(s):  
Gap Junctions ◽  
Growth Control ◽  
Intercellular Junctions ◽  
Wing Disc ◽  
En Bloc ◽  
Metabolic Cooperation ◽  
Drosophila Wing ◽  
Adult Wing ◽  
Wing Discs ◽  
Wing Pouch

Gap junctions are intercellular junctions found in both vertebrates and invertebrates through which ions and small molecules can pass. Their distribution in tissues could be of critical importance for ionic coupling or metabolic cooperation between cells or for regulating the intracellular movement of growth control and pattern formation factors. Studies of the distribution of gap junctions in mutants which develop abnormally may shed light upon their role in normal development. I report here the distribution of gap junctions in the wing pouch of 3 Drosophila wing disc mutants, vg (vestigial) a cell death mutant, 1(2)gd (lethal giant disc) a pattern abnormality mutant and 1(2)gl (lethal giant larva) a neoplastic mutant and compare these with wildtype wing discs.The wing pouch (the anlagen of the adult wing blade) of a wild-type wing disc is shown in Fig. 1 and consists of columnar cells (Fig. 5) joined by gap junctions (Fig. 6). 14000x EMs of conventionally processed, UA en bloc stained, longitudinally sectioned wing pouches were enlarged to 45000x with a projector and tracings were made on which the lateral plasma membrane (LPM) and gap junctions were marked.

Structural modifications of intercellular junctions.

1978 ◽  
Vol 36 (2) ◽  
pp. 330-331
Author(s):  
J. Metz ◽  
M. Merlo ◽  
W. G. Forssmann
Keyword(s):  
Gap Junctions ◽  
Intercellular Junctions ◽  
Cell Isolation ◽  
Extrahepatic Cholestasis ◽  
Structural Modifications ◽  
Pancreatic Duct Ligation ◽  
Pancreatic Cells ◽  
Duct Ligation ◽  
Thin Sectioning ◽  
And Function

Structure and function of intercellular junctions were studied under the electronmicroscope using conventional thin sectioning and freeze-etch replicas. Alterations of tight and gap junctions were analyzed 1. of exocrine pancreatic cells under cell isolation conditions and pancreatic duct ligation and 2. of hepatocytes during extrahepatic cholestasis.During the different steps of cell isolation of exocrine pancreatic cells, gradual changes of tight and gap junctions were observed. Tight junctions, which formed belt-like structures around the apex of control acinar cells in situ, subsequently diminished, became interrupted and were concentrated into macular areas (Fig. 1). Aggregations of membrane associated particles, which looked similar to gap junctions, were intermixed within tight junctional areas (Fig. 1). These structures continously disappeared in the last stages of the isolation procedure. The intercellular junctions were finally separated without destroying the integrity of the cell membrane, which was confirmed with porcion yellow, lanthanum chloride and horse radish peroxidase.

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