Discussing prognosis for canine diabetes mellitus: do we have relevant data?

2019 ◽  
Vol 185 (22) ◽  
pp. 689-691 ◽  
Author(s):  
Chen Gilor
Keyword(s):  
Diabetes Mellitus ◽  
Canine Diabetes Mellitus

Canine diabetes mellitus: from phenotype to genotype

2007 ◽  
Vol 0 (0) ◽  
pp. 070706190648004-??? ◽  
Author(s):  
B. Catchpole ◽  
L. J. Kennedy ◽  
L. J. Davison ◽  
W. E. R. Ollier
Keyword(s):  
Diabetes Mellitus ◽  
Canine Diabetes Mellitus

Canine diabetes mellitus: what is new?

2015 ◽  
Vol 20 (8) ◽  
pp. 442-446 ◽  
Author(s):  
Stijn Niessen
Keyword(s):  
Diabetes Mellitus ◽  
Canine Diabetes Mellitus

scholarly journals Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches

2019 ◽  
Vol 8 (5) ◽  
pp. 450-455 ◽  
Author(s):  
Maryam Moshref ◽  
Bonnie Tangey ◽  
Chen Gilor ◽  
Klearchos K. Papas ◽  
Peter Williamson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regenerative Medicine ◽  
Translational Model ◽  
Concise Review ◽  
Canine Diabetes Mellitus

Feeding, Exercise, and Weight Identified as Risk Factors in Canine Diabetes Mellitus

2006 ◽  
Vol 136 (7) ◽  
pp. 1985S-1987S ◽  
Author(s):  
Hanna Klinkenberg ◽  
Marie H. Sallander ◽  
Åke Hedhammar
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Canine Diabetes Mellitus

scholarly journals The Serum and Saliva Proteome of Dogs with Diabetes Mellitus

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2261
Author(s):  
Lorena Franco-Martínez ◽  
Andrea Gelemanović ◽  
Anita Horvatić ◽  
María Dolores Contreras-Aguilar ◽  
Vladimir Mrljak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Healthy Controls ◽  
Serum Samples ◽  
Proteomic Data ◽  
Proteomic Approach ◽  
Paired Serum ◽  
Canine Diabetes Mellitus ◽  
Type 1 Dm ◽  
First Time

This study aims to evaluate the changes in salivary and serum proteomes that occur in canine diabetes mellitus type-1 (DM) through a high-throughput quantitative proteomic analysis. The proteomes of 10 paired serum and saliva samples from healthy controls (HC group, n = 5) and dogs with untreated DM (DM group, n = 5) were analyzed using Tandem Mass Tags (TMT)-based proteomic approach. Additionally, 24 serum samples from healthy controls and untreated DM were used to validate haptoglobin in serum. The TMT analysis quantified 767 and 389 proteins in saliva and serum, respectively. Of those, 16 unique proteins in serum and 26 in saliva were differently represented between DM and HC groups. The verification of haptoglobin in serum was in concordance with the proteomic data. Our results pointed out changes in both saliva and serum proteomes that reflect different physiopathological changes in dogs with DM. Although some of the proteins identified here, such as malate dehydrogenase or glyceraldehyde-3-phosphate dehydrogenase, were previously related with DM in dogs, most of the proteins modulated in serum and saliva are described in canine DM for the first time and could be a source of potential biomarkers of the disease. Additionally, the molecular function, biological process, pathways and protein class of the differential proteins were revealed, which could improve the understanding of the disease’s pathological mechanisms.

Sign in / Sign up

Export Citation Format

Share Document