Sulfametopyrazine: blood levels in neonatal piglets after a single oral dose

1973 ◽  
Vol 92 (10) ◽  
pp. 263-263
Author(s):  
R. Medd ◽  
I. Burrows ◽  
D. Ross
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Blood Levels ◽  
Neonatal Piglets

scholarly journals Vitamin B12absorption in the neonatal piglet

1985 ◽  
Vol 54 (1) ◽  
pp. 245-255 ◽  
Author(s):  
N. M. F. Trugo ◽  
J. E. Ford ◽  
B. F. Sansom
Keyword(s):  
Oral Dose ◽  
Blood Plasma ◽  
Single Oral Dose ◽  
The Body ◽  
Whole Body ◽  
Vitamin B ◽  
Weaned Piglets ◽  
High Concentration ◽  
Neonatal Piglets ◽  
Natural Analogues

1. The vitamin B12in sows' milk is strongly attached to a specific ‘binder’ protein, which is present in excess. The influence of this ‘binder’ on the uptake and retention of cyanocobalamin and two natural analogues(cobinamide and Co-α-[2-methyladenyl]cobamide) was investigated with neonatal piglets.2. Retention of a single oral dose of cyano[58Co]cobalamin given before 7 d of age was consistently higher with suckled than with early-weaned piglets, as determined by measurement of whole-body radioactivity.3. Efficiency of retention declined with age, more rapidly in early-weaned than in suckled animals; when the dose was given at 14 d approximately 30% was retained by both groups.4. Distribution of the retained cyano[58Co]cobalamin within the body of the piglets was the same in both groups; about half was present in the liver.5. Foraging piglets may ingest adventitious vitamin B12and its analogues, which are present in the sow's faeces and in contaminated litter. The influence of the vitamin B12-binder in sows' milk on the uptake and retention of two non-cobalamin analogues, and the effects of the analogues on the uptake and retention of vitamin B12from 2 to 14 d after parturition, were investigated with early-weaned piglets.6. The analogues were detected in the liver but not in the body organs. They were also present in blood plasma, urine and bile, in high concentration relative to that of vitamin B12. The content of analogues in the liver was very small in relation to the amounts ingested, and much less than that of vitamin B12. There was no indication that the vitamin B12-binder in sows' milk influenced uptake and retention of the analogues, or that ingestion of analogues affected the content of vitamin B12in the body organs and fluids examined.

EFFECTS OF INHIBITORS OF SULFANILAMIDE ACETYLATION ON SULPHONAMIDE BLOOD CONCENTRATIONS

1955 ◽  
Vol 33 (1) ◽  
pp. 523-529 ◽  
Author(s):  
Willard Johnson
Keyword(s):  
Oral Dose ◽  
Benzoic Acid ◽  
Single Oral Dose ◽  
Blood Level ◽  
Acid Hydrazide ◽  
Blood Levels ◽  
Aminosalicylic Acid ◽  
Blood Concentrations ◽  
Twofold Increase ◽  
Effect Of Inhibitors

The effect of inhibitors of sulphanilamide acetylation on free and total sulphonamide blood levels has been investigated. p-Aminosalicylic acid hydrazide, administered to rabbits in combination with sulphanilamide, produced a twofold increase in the blood level of free sulphanilamide six hours after a single oral dose. Similarly, p-aminosalicylate and p-(dipropylsulphamyl)-benzoic acid together were responsible for a twofold increase in free-sulphonamide blood level six hours after a single oral dose of a triple sulphonamide mixture. Salicylamide and 5-bromosalicylamide were ineffective. The significance of these results is discussed.

EFFECTS OF INHIBITORS OF SULFANILAMIDE ACETYLATION ON SULPHONAMIDE BLOOD CONCENTRATIONS

1955 ◽  
Vol 33 (4) ◽  
pp. 523-529 ◽  
Author(s):  
Willard Johnson
Keyword(s):  
Oral Dose ◽  
Benzoic Acid ◽  
Single Oral Dose ◽  
Blood Level ◽  
Acid Hydrazide ◽  
Blood Levels ◽  
Aminosalicylic Acid ◽  
Blood Concentrations ◽  
Twofold Increase ◽  
Effect Of Inhibitors

The effect of inhibitors of sulphanilamide acetylation on free and total sulphonamide blood levels has been investigated. p-Aminosalicylic acid hydrazide, administered to rabbits in combination with sulphanilamide, produced a twofold increase in the blood level of free sulphanilamide six hours after a single oral dose. Similarly, p-aminosalicylate and p-(dipropylsulphamyl)-benzoic acid together were responsible for a twofold increase in free-sulphonamide blood level six hours after a single oral dose of a triple sulphonamide mixture. Salicylamide and 5-bromosalicylamide were ineffective. The significance of these results is discussed.

A Rapid (48 hours) Thyroid Suppression Test using a Single Oral Dose of 100 of Triiodothyronine

1973 ◽  
Vol 12 (03) ◽  
pp. 218-224
Author(s):  
Elli Lakka - Papadodima ◽  
Constantin Ntalles ◽  
Denis Ikkos
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Suppression Test

Des mesurages répétés de la fixation thyroïdienne de 10 minutes du 132I injecté intraveineusement on été effectués sur 55 malades euthyroïdiens sans et avec goitre et sur 16 malades hyperthyreoïdiens par 4 jours consécutifs. Immédiatement après le premier mesurage tous les malades recevaient une dose unique oral de 100 μg de Triiodothyronine (T3). Les valeurs de fixation 24, 48 et 72 heures après le T3 (moyen ± déviation standard) étaient de 75 ± 1,7, 64 ± 1,8, et 67 ± 1,9 dans le groupe euthyroïdien et le 106 ± 2,6, 104 ± 2,2 et 108 ± 4,0 dans le groupe hyperthyroïdien, exprimés en pourcentage du groupe controle. 48 heures après T3 tous les personnes euthyroïdiens, sauf une, avaient des valeurs en dessous de 88% tandis que la valeur la plus basse des personnes hyperthyroïdiens ce jour était de 93%. La séparation des valeurs 48 heures des deux groupes était complète après avoir respecté l’influence de la première fixation sur la valeur 48 heures. On peut donc supposer q’un test thyroïdien de suppression utilisable en clinique peut-être effectué en 48 heures après une administration oral de 100 μg de T3 et mesurage de la fixation 10 minutes après l’injection du radioisotope.

Effect of Aspirin on the Thrombelastogram of Human Blood

1973 ◽  
Vol 30 (03) ◽  
pp. 494-498 ◽  
Author(s):  
G de Gaetano ◽  
J Vermylen
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Platelet Function ◽  
Human Blood ◽  
Platelet Rich Plasma ◽  
Plasma Samples ◽  
Release Reaction ◽  
Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

Serum Enzyme, Corticosterone and Tissue Changes in Rats Following a Single Oral Dose of Ethanol

1970 ◽  
Vol 31 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Paul D. Altland ◽  
Benjamin Highman ◽  
Milton G. Parker ◽  
Michael P. Dieter
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Serum Enzyme ◽  
Tissue Changes

Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women

1983 ◽  
Vol 103 (3) ◽  
pp. 309-314 ◽  
Author(s):  
G. Rosadini ◽  
P. Masturzo ◽  
G. Rodriguez ◽  
G. Murialdo ◽  
V. Montano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Power Analysis ◽  
Sleep Pattern ◽  
Absolute Power ◽  
Normal Women

Abstract. The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.

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