scholarly journals Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates?

Thorax ◽  
1998 ◽  
Vol 53 (2) ◽  
pp. 152-153 ◽  
Author(s):  
C Leroyer ◽  
L Perfetti ◽  
A Cartier ◽  
J L Malo
Keyword(s):  
Case History ◽  
Occupational Asthma ◽  
Challenge Test ◽  
Diphenylmethane Diisocyanate ◽  
Specific Inhalation Challenge ◽  
Inhalation Challenge ◽  
High Level ◽  
Reactive Airways

The case history is described of a worker who presented with a history suggestive of reactive airways dysfunction syndrome which occurred after an acute high level inhalation of diphenylmethane diisocyanate. Further exposure at work, at a time when concentrations of isocyanates were no longer "irritant", suggested occupational asthma; this diagnosis was confirmed by a specific inhalation challenge test.

Occupational asthma caused by peracetic acid-hydrogen peroxide mixture

2019 ◽  
Vol 69 (4) ◽  
pp. 294-297 ◽  
Author(s):  
G I Walters ◽  
P S Burge ◽  
V C Moore ◽  
M O Thomas ◽  
A S Robertson
Keyword(s):  
Hydrogen Peroxide ◽  
Peracetic Acid ◽  
Occupational Asthma ◽  
Challenge Test ◽  
City Hospital ◽  
Flow Measurements ◽  
Occupational Lung Disease ◽  
Specific Inhalation Challenge ◽  
Inhalation Challenge ◽  
The Uk

Abstract Background Healthcare practice in the UK has moved away from using aldehyde disinfectants for the decontamination of endoscopes, in part due to the risk of respiratory sensitization. Peracetic acid (PAA) in combination with hydrogen peroxide (HP) is a commonly used alternative. Aim We describe a case of occupational asthma (OA) diagnosed at our specialist occupational lung disease clinic and caused by occupational exposure to PAA-HP mixture, used as a disinfectant in an endoscope washer-disinfector machine. Case report A 48-year-old man employed as a mycologist and environmental microbiologist at a Birmingham city hospital, UK, presented following an acute exposure to PAA-HP mixture causing lacrimation, burning optic pain and headache. He had also experienced symptoms suggestive of OA for the preceding 10 months, and the diagnosis was confirmed through OASYS analysis of serial peak expiratory flow measurements. He had been exposed to PAA-HP mixture whilst working in the endoscopy department for 12 months prior to the acute episode, and a subsequent specific inhalation challenge test was positive with a late asthmatic response to PAA-HP mixture. Conclusion This case provides evidence for a sensitization mechanism in OA caused by PAA-HP mixture.

Can persulfates cause hypersensitivity pneumonitis? A report of specific inhalation challenge test in 42 hairdressers

2020 ◽  
Author(s):  
Jens-Tore Granslo ◽  
Jorunn Kirkeleit ◽  
Stein Håkon Låstad Lygre ◽  
William Horsnell ◽  
Thomas Blix Grydeland ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Challenge Test ◽  
Specific Inhalation Challenge ◽  
Inhalation Challenge

Diagnosing of bakers' respiratory allergy: Is specific inhalation challenge test essential?

2011 ◽  
Vol 32 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Marta Wiszniewska ◽  
Ewa Nowakowska-Świrta ◽  
Cezary Pałczyński ◽  
Jolanta Walusiak-Skorupa
Keyword(s):  
Challenge Test ◽  
Respiratory Allergy ◽  
Specific Inhalation Challenge ◽  
Inhalation Challenge
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