scholarly journals Leukotriene receptor antagonist therapy and Churg-Strauss syndrome: culprit or innocent bystander?

Thorax ◽  
2008 ◽  
Vol 63 (10) ◽  
pp. 847-849 ◽  
Author(s):  
R. Beasley ◽  
S. Bibby ◽  
M. Weatherall
Keyword(s):  
Receptor Antagonist ◽  
Innocent Bystander ◽  
Leukotriene Receptor Antagonist ◽  
Antagonist Therapy ◽  
Churg Strauss Syndrome ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
Churg Strauss

Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast

2004 ◽  
Vol 24 (6) ◽  
pp. 661-662 ◽  
Author(s):  
Junsuke Shimbo ◽  
Osamu Onodera ◽  
Keiko Tanaka ◽  
Shoji Tsuji
Keyword(s):  
Receptor Antagonist ◽  
Leukotriene Receptor Antagonist ◽  
Churg Strauss Syndrome ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
Churg Strauss

scholarly journals A Case of Montelukast-Induced Churg-Strauss Syndrome Associated with Liver Dysfunction

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Keiji Matsui ◽  
Kosuke Nishijima
Keyword(s):  
Liver Dysfunction ◽  
Carnitine Deficiency ◽  
Acid Oxidation ◽  
Fatty Change ◽  
Churg Strauss Syndrome ◽  
History Of ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
The Relationship ◽  
Churg Strauss

A 64-year-old woman was admitted to hospital due to protracted diarrhea and liver dysfunction. The patient was diagnosed as Churg-Strauss syndrome (CSS) due to asthma, paranasal sinusitis, hypereosinophilia, and polyneuropathy. There was a history of taking montelukast, a leukotriene receptor antagonist (LTRA), which is thought to have some relationship with CSS. The liver biopsy specimen showed eosinophilic infiltration and centrolobular fatty change. In this paper, we review the relationship between LTRA and CSS. Several lines of evidence suggest that leukotriene plays an important role in maintaining neural tissues. We also review the potential relationship between centrolobular fatty change and pivoxil-containing antibiotics, which was prescribed for sinusitis before admission. Carnitine deficiency induced by pivoxil-containing agents may cause impaired fatty acid oxidation in mitochondria.

scholarly journals Churg-Strauss vasculitis in patient who received montelukas

2018 ◽  
Vol 75 (4) ◽  
pp. 428-431 ◽  
Author(s):  
Vojislav Cupurdija ◽  
Ivan Cekerevac ◽  
Marina Petrovic ◽  
Gordana Kostic ◽  
Romana Susa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Left Lung ◽  
Leukotriene Receptor Antagonist ◽  
Sputum Production ◽  
Eosinophilic Granulocytes ◽  
Strauss Syndrome ◽  
Leukotriene Receptor ◽  
High Doses ◽  
The Right ◽  
Churg Strauss

Introduction. Montelukast is a selective leukotriene receptor antagonist. One of side effects of this drug class is the Churg-Strauss syndrome (CSS). There is still no reliable evidence whether the expression of this syndrome could be masked by high doses of corticosteroids and become expressed by termination of corticosteroid use, or whether it could be a consequence of leukotriene receptor antagonists use. Case report. Female patient, aged 49 years, was hospitalized with symptoms of fever, dyspnea, cough and increased sputum production with occasional hemoptysis. She was treated for asthma during the previous year. Leukocyte differential formula registered 44% of eosinophils. IgE value was extremely elevated, with value measured to 580 kU/L and eosinophile cation protein value was 15.1 ?g/L. Computed tomography of the chest described changes in the form of ground glass located in all lobes of the right lung and in the upper lobe of the left lung. Computed tomography of paranasal sinuses described changes that could resemble to polyposis, chronic sinusitis, and possible granulomatosis. Mononeuritis of peroneal nerve of the right leg was proven by electromyographic examination. Bone marrow biopsy indicated hypercellularity with domination of eosinophilic granulocytes (30%). Five out of six criteria were noted in patient?s clinical presentation, after which the diagnosis of CSS was set. The patient began treatment with high doses of corticosteroids while montelukast was discontinued which resulted in disease remission. Conclusion. Although there is no evidence that leukotriene modifiers cause the CSS in all patients with asthma, in case of frequent exacerbations with the appearance of pulmonary infiltrates, eosinophilia and paranasal sinus abnormalities make one think of this form of vasculitis.

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