scholarly journals Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products

2004 ◽  
Vol 61 (8) ◽  
pp. 715-716 ◽  
Author(s):  
E L Bader
Keyword(s):  
Drinking Water ◽  
Urinary Excretion ◽  
Half Life ◽  
Trichloroacetic Acid ◽  
Water Disinfection ◽  
Biomarker Of Exposure ◽  
Chlorinated Drinking Water ◽  
Drinking Water Disinfection ◽  
By Products

scholarly journals Validation of urinary trichloroacetic acid as a biomarker of exposure to drinking water disinfection by-products

2009 ◽  
Vol 7 (3) ◽  
pp. 359-371 ◽  
Author(s):  
Weiping Zhang ◽  
Stephan Gabos ◽  
Donald Schopflocher ◽  
Xing-Fang Li ◽  
Wendy P. Gati ◽  
...  
Keyword(s):  
Drinking Water ◽  
Trichloroacetic Acid ◽  
Tap Water ◽  
Water Disinfection ◽  
Public Health Issue ◽  
Experimental Exposure ◽  
Biomarker Of Exposure ◽  
Drinking Water Disinfection ◽  
Study Participants ◽  
By Products

Disinfection by-products (DBPs) in drinking water represent a public health issue and a challenge for epidemiology to provide evidence towards the causation of various hypothesized health effects. Validation of a biomarker of exposure to DBPs is a strategy to achieve progress which has been advocated. The objective of this study was to validate urinary trichloroacetic acid (TCAA) excretion as a biomarker of exposure to DBPs in an experimental exposure cohort. A total of 52 healthy women participated in the study. Participants consumed supplied tap water for 15 d and provided urine and blood samples for TCAA measurements. The findings revealed that (1) background levels of TCAA in urine and blood were readily detectable, (2) TCAA levels in blood and urine increased with increased amounts of TCAA ingested, (3) the correlations between measurements of TCAA ingestion and urinary excretion were modest (r=0.66, p<0.001) based on one days' sampling and high (r=0.77–0.83, p<0.001) based on two to four days' sampling, (4) the correlations between measurements of TCAA ingestion and blood TCAA concentration were high (r=0.80, p<0.001) and (5) multiple days' urinary TCAA measures improved the prediction of TCAA ingestion through urinary TCAA excretion. TCAA can be a valid biomarker of exposure for DBPs in drinking water.

Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-products

2002 ◽  
Vol 40 (2) ◽  
pp. 134-142 ◽  
Author(s):  
Michael J. Plewa ◽  
Yahya Kargalioglu ◽  
Danielle Vankerk ◽  
Roger A. Minear ◽  
Elizabeth D. Wagner
Keyword(s):  
Drinking Water ◽  
Mammalian Cell ◽  
Water Disinfection ◽  
Cell Cytotoxicity ◽  
Drinking Water Disinfection ◽  
By Products

Detection of genotoxic effects of drinking water disinfection by-products using Vicia faba bioassay

2016 ◽  
Vol 24 (2) ◽  
pp. 1509-1517 ◽  
Author(s):  
Yu Hu ◽  
Li Tan ◽  
Shao-Hui Zhang ◽  
Yu-Ting Zuo ◽  
Xue Han ◽  
...  
Keyword(s):  
Drinking Water ◽  
Vicia Faba ◽  
Water Disinfection ◽  
Genotoxic Effects ◽  
Drinking Water Disinfection ◽  
By Products
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