scholarly journals Cold related mortality in England and Wales; influence of social class in working and retired age groups

2003 ◽  
Vol 57 (10) ◽  
pp. 790-791 ◽  
Author(s):  
G C Donaldson
Keyword(s):  
Social Class ◽  
Age Groups ◽  
England And Wales ◽  
Related Mortality

Infection is associated with one in five childhood deaths in England and Wales: analysis of national death registrations data, 2013–15

2020 ◽  
Vol 105 (9) ◽  
pp. 857-863 ◽  
Author(s):  
Laura Ferreras-Antolín ◽  
Godwin Oligbu ◽  
Ifeanyichukwu O Okike ◽  
Shamez Ladhani
Keyword(s):  
Neonatal Period ◽  
Age Groups ◽  
Childhood Mortality ◽  
Similar Data ◽  
Central Nervous System Infections ◽  
England And Wales ◽  
The Past ◽  
Registration Data ◽  
Rate Ratios ◽  
Related Mortality

ObjectiveTo estimate the contribution of infections to childhood deaths in England and Wales over a 3-year period.DesignRetrospective analysis of national electronic death registration data.SettingEngland and Wales.PatientsChildren aged 28 days to 15 years who died during 2013–15.Main outcome measuresThe proportion of children who died of infection compared with total deaths over 3 years; the main pathogens responsible for infection-related deaths in different age groups; comparison with similar data from 2003 to 2005.ResultsThere were 5088 death registrations recorded in children aged 28 days to <15 years in England and Wales during the three calendar years, 2013–2015 (17.6 deaths/100 000 children annually) compared with 6897 (23.9/100 000) during 2003–05 (incidence rate ratios (IRR) 0.74, 95% CI 0.71 to 0.77). During 2013–15, there were 951 (18.7%, 951/5088) infection-related deaths compared with 1368 (19.8%, 1368/6897) during 2003–05, equivalent to an infection-related mortality rate of 3.3/100 000 compared with 4.8/100 000 during the two periods (IRR 0.69, 95% CI 0.64 to 0.75), respectively. An underlying comorbidity was recorded in 55.0% (523/951) of death registrations during 2013–15 and increased with age. Where recorded, respiratory tract infection was the most commonly reported presentation (374/876, 42.7%) during 2013–15. Central nervous system infections accounted for only 4.8% (42/876). Overall, 63.1% (378/599) of infection-related deaths were associated with a bacterial, 34.2% (205/599) with a viral and 2.5% (15/599) with a fungal infection.ConclusionsBeyond the neonatal period, all-cause and infection-related childhood mortality rates have declined by 26% and 31%, respectively, over the past decade. However, infection continues to contribute to one in five childhood deaths.

scholarly journals Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis

2021 ◽  
Vol 18 (14) ◽  
pp. 7249
Author(s):  
Alessandro Marcon ◽  
Elena Schievano ◽  
Ugo Fedeli
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cause Of Death ◽  
Age Groups ◽  
Mortality Rates ◽  
Annual Percent Change ◽  
Northeastern Italy ◽  
Mortality Ratio ◽  
The Impact ◽  
Related Mortality

Mortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multiple cause of death analyses, and to describe the impact of the COVID-19 epidemic in 2020. We identified IPF (ICD-10 code J84.1) among the causes of death registered in 557,932 certificates in the Veneto region. We assessed time trends in annual age-standardized mortality rates by gender and age (40–74, 75–84, and ≥85 years). IPF was the underlying cause of 1310 deaths in the 2251 certificates mentioning IPF. For all age groups combined, the age-standardized mortality rate from IPF identified as the underlying cause of death was close to the European median (males and females: 3.1 and 1.3 per 100,000/year, respectively). During 2008–2019, mortality rates increased in men aged ≥85 years (annual percent change of 6.5%, 95% CI: 2.0, 11.2%), but not among women or for the younger age groups. A 72% excess of IPF-related deaths was registered in March–April 2020 (mortality ratio 1.72, 95% CI: 1.29, 2.24). IPF mortality was increasing among older men in northeastern Italy. The burden of IPF was heavier than assessed by routine statistics, since less than two out of three IPF-related deaths were directly attributed to this condition. COVID-19 was accompanied by a remarkable increase in IPF-related mortality.

scholarly journals Emerging trends in the epidemiology of invasive mycoses in England and Wales (1990–9)

2001 ◽  
Vol 126 (3) ◽  
pp. 397-414 ◽  
Author(s):  
T. L. LAMAGNI ◽  
B. G. EVANS ◽  
M. SHIGEMATSU ◽  
E. M. JOHNSON
Keyword(s):  
Disease Surveillance ◽  
Fungal Infections ◽  
Communicable Disease ◽  
Pneumocystis Carinii ◽  
Age Groups ◽  
Public Health Problem ◽  
Risk Groups ◽  
Older Age ◽  
England And Wales ◽  
Invasive Mycoses

Invasive fungal infections are becoming an increasing public health problem owing to the growth in numbers of susceptible individuals. Despite this, the profile of mycoses remains low and there is no surveillance system specific to fungal infections currently existing in England and Wales. We analysed laboratory reports of deep-seated mycoses made to the Communicable Disease Surveillance Centre between 1990 and 1999 from England and Wales. A substantial rise in candidosis was seen during this period (6·76–13·70 reports per million population/year), particularly in the older age groups. Rates of cryptococcosis in males fluctuated over the decade but fell overall (1·05–0·66 per million population/year), whereas rates of female cases gradually rose up until 1998 (0·04–0·41 per million population/year). Reports of Pneumocystis carinii in men reduced substantially between 1990 and 1999 (2·77–0·42 per million population/year) but showed little change in women. Reports of aspergillosis fluctuated up until 1996, after which reports of male and female cases rose substantially (from 0·08 for both in 1996 to 1·92 and 1·69 per million population/year in 1999 for males and females respectively), largely accounted for by changes in reporting practice from one laboratory. Rates of invasive mycoses were generally higher in males than females, with overall male-to-female rate ratios of 1·32 (95% CI 1·25–1·40) for candidosis, 1·30 (95% CI 1·05–1·60) for aspergillosis, 3·99 (95% CI 2·93–5·53) for cryptococcosis and 4·36 (95% CI 3·47–5·53) for Pneumocystis carinii. The higher male than female rates of reports is likely to be a partial reflection of HIV epidemiology in England and Wales, although this does not fully explain the ratio in infants and older age groups. Lack of information on underlying predisposition prevents further identification of risk groups affected. Whilst substantial under-reporting of Pneumocystis carinii and Cryptococcus species was apparent, considerable numbers of superficial mycoses were mis-reported indicating a need for clarification of reporting guidelines. Efforts to enhance comprehensive laboratory reporting should be undertaken to maximize the utility of this approach for surveillance of deep-seated fungal infections.

scholarly journals The spatial epidemiology of alcohol-related mortality among the Czech adult population

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
L Kazmer ◽  
I Kulhanova ◽  
M Lustigova
Keyword(s):  
Local Community ◽  
Spatial Epidemiology ◽  
Adult Population ◽  
Age Groups ◽  
Health Determinants ◽  
Mortality Data ◽  
Annual Data ◽  
Cross Sectional ◽  
Inequalities In Health ◽  
Related Mortality

Abstract Background In Czechia, alcohol-induced deaths account for a significant portion of preventable mortality. As inequalities in health are both socially and spatially determined, the paper aims at the detailed examination of socio-geographic inequalities of this phenomenon. Methods The 2011-2015 annual data on both ICD-10 cause-specific deaths (K70; F10; X45/64; Y15) and mid-year population were obtained from the official Czech registries - the data were cross-classified by gender, 5-year age-groups, and permanent residence (N = 6,302 small area spatial units). The selected socio-demographic indicators (education, unemployment, religious population) from the Czech 2011 Census were spatially merged to the mortality dataset. From the data on education and unemployment, composite deprivation index (DI) was derived. In the adult population aged 25+, the age-standardised mortality ratios (SMR) were computed for each of the spatial units, separately by genders. The SMRs were spatially modelled by the Besag-York-Mollié (BYM) autoregressive approach, applying a fully bayesian framework integrated within the INLA R-package. The study applied cross-sectional design and employed ecological regression conducted on observational data. Results Compared to the Czech average, the highest SMRs were located in the historical regions of Moravia [SMR=1.15; 95%CI: 1.11-1.19] and Silesia [SMR=1.59; 95%CI: 1.52-1.66]. The SMRs were significantly correlated with DI among males [Rel.Risk=1.15; 95%CI: 1.11-1.19], and with religiousness rate among females [Rel.Risk=0.83; 95%CI: 0.77-0.90]. Conclusions Significant socio-geographic inequalities were detected, particularly with respect to the Czech historical regions. Among males, higher mortality was associated with a structural deprivation. Among females, protective effect of religiousness rate was found to be significant. The results highlight an importance of both socially and spatially integrated efforts for public health promotion. Key messages The inequalities in health are both socially and spatially contextualised. The paper presents robust empirical evidence in favour of the proposition, as examined on alcohol-related mortality data. The health determinants may be gender sensitive. Males might be more responsive to a structural disadvantage. Among females, cultural factors related to a local community might be more relevant.

scholarly journals Epidemiological and clinical characteristics of the first 500 confirmed COVID-19 inpatients in a tertiary infectious disease referral hospital in Manila, Philippines

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Kristal An Agrupis ◽  
Chris Smith ◽  
Shuichi Suzuki ◽  
Annavi Marie Villanueva ◽  
Koya Ariyoshi ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Age Groups ◽  
The Elderly ◽  
Underlying Disease ◽  
The Philippines ◽  
Referral Hospital ◽  
Limited Data ◽  
Metro Manila ◽  
Related Mortality

Abstract Background The Philippines has been one of the most affected COVID-19 countries in the Western Pacific region, but there are limited data on COVID-19-related mortality and associated factors from this setting. We aimed to describe the epidemiological and clinical characteristics and associations with mortality among COVID-19-confirmed individuals admitted to an infectious diseases referral hospital in Metro Manila. Main text This was a single-centre retrospective analysis including the first 500 laboratory-confirmed COVID-19 individuals admitted to San Lazaro Hospital, Metro Manila, Philippines, from January to October 2020. We extracted clinical data and examined epidemiological and clinical characteristics and factors associated with in-hospital mortality. Of the 500 individuals, 133 (26.6%) were healthcare workers (HCW) and 367 (73.4%) were non-HCW, with HCW more likely presenting with milder symptoms. Non-HCW admissions were more likely to have at least one underlying disease (51.6% vs. 40.0%; p = 0.002), with hypertension (35.4%), diabetes (17.4%), and tuberculosis (8.2%) being the most common. Sixty-one (12.2%) died, comprising 1 HCW and 60 non-HCW (0.7% vs. 16.3%; p < 0.001). Among the non-HCW, no death occurred for the 0–10 years age group, but deaths were recorded across all other age groups. Compared to those who recovered, individuals who died were more likely to be older (p < 0.001), male (p = 0.015), report difficulty of breathing (p < 0.001), be HIV positive (p = 0.008), be intubated (p < 0.001), categorised as severe or critical (p < 0.001), have a shorter mean hospital stay (p < 0.001), or have an additional diagnosis of pneumonia (p < 0.001) or ARDS (p < 0.001). Conclusion Our analysis reflected significant differences in characteristics, symptomatology, and outcomes between healthcare and non-healthcare workers. Despite the unique mix of cohorts, our results support the country’s national guideline on COVID-19 vaccination which prioritises healthcare workers, the elderly, and people with comorbidities and immunodeficiency states.

Differential fertility among immigrants to England and Wales and some implications for population projections

1969 ◽  
Vol 1 (S1) ◽  
pp. 119-127 ◽  
Author(s):  
Jean Thompson
Keyword(s):  
Age Structure ◽  
Age Groups ◽  
Population Projections ◽  
Fertility Rates ◽  
Female Population ◽  
Differential Fertility ◽  
England And Wales ◽  
Adult Age ◽  
Completed Family Size ◽  
Socio Economic Factors

SummaryThe age structure of the immigrant female population as shown by the 1961 Census was heavily biased towards the young adult age groups, where fertility rates are highest. The birth rate for such a population could be expected considerably to exceed the average for this country as a whole, due to differences in age structure alone. The Census also showed marked differences betwen the fertility rates of different groups of immigrants but suggested that for the most important groups —from the Irish Republic, the Indian sub-continent and the Caribbean—they then amounted to a completed family size of roughly ½ child above the England and Wales average. There were also marked differences in 1961 between the socio-economic structure of immigrant groups; such evidence as there is points to socio-economic factors as playing an important part in explaining the fertility of immigrants, and its possible change over time.

Retrospective analysis of neonatal deaths secondary to infections in England and Wales, 2013–2015

2020 ◽  
pp. fetalneonatal-2020-319093
Author(s):  
Godwin Oligbu ◽  
Leila Ahmed ◽  
Laura Ferraras-Antolin ◽  
Shamez Ladhani
Keyword(s):  
Mortality Rate ◽  
Retrospective Analysis ◽  
Neonatal Mortality ◽  
Mortality Rates ◽  
Neonatal Mortality Rate ◽  
England And Wales ◽  
Neonatal Deaths ◽  
Live Births ◽  
Extremely Preterm ◽  
Related Mortality

ObjectiveTo estimate the overall and infection-related neonatal mortality rate and the pathogens responsible using electronic death registrations.DesignRetrospective analysis of national electronic death registrations data.SettingEngland and Wales.PatientsNeonates aged <28 days.Main outcome measuresOverall and infection-related mortality rate per 1000 live births in term, preterm (28–36 weeks) and extremely preterm (<28 weeks) neonates; the contribution of infections and specific pathogens; comparison with mortality rates in 2003–2005.ResultsThe neonatal mortality rate during 2013–2015 (2.4/1000 live births; 5095 deaths) was 31% lower than in 2003–2005 (3.5/1000; 6700 deaths). Infection-related neonatal mortality rate in 2013–2015 (0.32/1000; n=669) was 20% lower compared with 2003–2015 (0.40/1000; n=768), respectively. Infections were responsible for 13.1% (669/5095) of neonatal deaths during 2013–2015 and 11.5% (768/6700) during 2003–2005. Of the infection-related deaths, 44.2% (296/669) were in term, 19.9% (133/669) preterm and 35.9% (240/669) extremely preterm neonates. Compared with term infants (0.15/1000 live births), infection-related mortality rate was 5.9-fold (95% CI 4.7 to 7.2) higher in preterm (0.90/1000) and 188-fold (95% CI 157 to 223) higher in extremely preterm infants (28.7/1000) during 2013–2015. A pathogen was recorded in 448 (67%) registrations: 400 (89.3%) were bacterial, 37 (8.3%) viral and 11 (2.4%) fungal. Group B streptococcus (GBS) was reported in 30.4% (49/161) of records that specified a bacterial infection and 7.3% (49/669) of infection-related deaths.ConclusionsOverall and infection-related neonatal mortality rates have declined, but the contribution of infection and of specific pathogens has not changed. Further preventive measures, including antenatal GBS vaccine may be required to prevent the single most common cause of infection-related deaths in neonates.

scholarly journals Statistical Modelling of Temperature-Attributable Deaths in Portuguese Metropolitan Areas under Climate Change: Who Is at Risk?

Atmosphere ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 159
Author(s):  
Mónica Rodrigues ◽  
Paula Santana ◽  
Alfredo Rocha
Keyword(s):  
Climate Change ◽  
Metropolitan Area ◽  
Age Groups ◽  
Circulatory System ◽  
Statistical Modelling ◽  
Attributable Mortality ◽  
Historical Period ◽  
Age Group ◽  
Circulatory System Diseases ◽  
Related Mortality

Several studies emphasize that temperature-related mortality can be expected to have differential effects on different subpopulations, particularly in the context of climate change. This study aims to evaluate and quantify the future temperature-attributable mortality due to circulatory system diseases by age groups (under 65 and 65+ years), in Lisbon metropolitan area (LMA) and Porto metropolitan area (PMA), over the 2051–2065 and 2085–2099 time horizons, considering the greenhouse gas emissions scenario RCP8.5, in relation to a historical period (1991–2005). We found a decrease in extreme cold-related deaths of 0.55% and 0.45% in LMA, for 2051–2065 and 2085–2099, respectively. In PMA, there was a decrease in cold-related deaths of 0.31% and 0.49% for 2051–2065 and 2085–2099, respectively, compared to 1991–2005. In LMA, the burden of extreme heat-related mortality in age group 65+ years is slightly higher than in age group <65 years, at 2.22% vs. 1.38%, for 2085–2099. In PMA, only people aged 65+ years showed significant temperature-related burden of deaths that can be attributable to hot temperatures. The heat-related excess deaths increased from 0.23% for 2051–2065 to 1.37% for 2085–2099, compared to the historical period.

Variations in the Seasonal Distribution of Births of Psychotic Patients in England and Wales

1978 ◽  
Vol 132 (2) ◽  
pp. 155-158 ◽  
Author(s):  
E. H. Hare
Keyword(s):  
Personality Disorder ◽  
General Population ◽  
Older Patients ◽  
Age Groups ◽  
Seasonal Distribution ◽  
Fourth Quarter ◽  
Affective Psychosis ◽  
England And Wales ◽  
Live Births ◽  
Younger Age

SummaryThe quarterly distribution of births of patients born in England and Wales 1921–60 and first admitted in 1970–75 was examined by decade of birth and by age at year of admission. For patients with schizophrenia and affective psychosis, the distribution varied: in the early decade (1921–30), and for older patients (45–54 years) the proportion of births in the fourth quarter of the year was high, compared with expectation from live births in the general population; but it became lower in succeeding decades and for younger age groups. No comparable change occurred for births of patients with neurosis or personality disorder.

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