Androgenic hormones in anaemia

1964 ◽  
Vol 2 (19) ◽  
pp. 75-76
Keyword(s):  
Breast Cancer ◽  
Aplastic Anaemia ◽  
Anabolic Steroids ◽  
Male Hypogonadism ◽  
Medical Letter ◽  
The Many

Despite the many claims made (see Medical Letter, Brit. ed. 1962, 1, 38), androgens and the anabolic steroids related to them have been shown to be of value only in male hypogonadism, in breast cancer in women after the menopause and in some patients with myelofibrosis and aplastic anaemia.

scholarly journals Expression analisis of the ITSN2 and TKS5 mRNA isoforms in human malignant breast tumors

2018 ◽  
Vol 16 (1) ◽  
pp. 20-27
Author(s):  
S. V. Kropyvko ◽  
L. O. Tsyba ◽  
O. V. Novokhatska ◽  
L. A. Syvak ◽  
T. Ye. Tarasenko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Expression Analysis ◽  
Rna Isolation ◽  
Breast Tumors ◽  
Quantitative Real Time Pcr ◽  
Mrna Isoforms ◽  
Extensive Experience ◽  
Great Progress ◽  
Malignant Breast ◽  
The Many

Aim. Despite the great progress in cancer treating, the breast cancer remains lethal in 15 % cases. Regardless of the many years of research and extensive experience in the treatment of this type of cancer, one of the main problems in diagnosis and therapy is its high clinical and genetic heterogeneity. Thereby the identification of markers for personalized treatment of patients is still an actual issue. Methods. Collection of clinical material, RNA isolation, and expression analysis of ITSN2 and TKS5 isoforms using quantitative real time PCR with fluorescence-labeled probes. Results. We have found that ITSN2-S expression is reliably reduced in HER2/neu-positive tumors with poor prognosis. There were no significant differences in the expression of ITSN2-L and TKS5-L in the analyzed samples. Conclusions. These studies have demonstrated the possible use of ITSN2 short isoform (ITSN2-S) as a prognostic marker for breast cancer. Keywords: breast cancer, ITSN2, TKS5, expression analysis.

New insights in the interaction of FGF/FGFR and steroid receptor signaling in breast cancer

Endocrinology ◽  
2022 ◽  
Author(s):  
Cecilia Pérez Piñero ◽  
Sebastián Giulianelli ◽  
Caroline A Lamb ◽  
Claudia Lanari
Keyword(s):  
Breast Cancer ◽  
Hormone Receptors ◽  
Endocrine Resistance ◽  
Short Review ◽  
Experimental Models ◽  
Luminal Breast Cancer ◽  
Tumor Subtypes ◽  
Stromal Tissue ◽  
The Many

Abstract Luminal breast cancer (BrCa) has a favorable prognosis compared to other tumor subtypes. However, with time tumors may evolve and lead to disease progression. Thus, there is a great interest in unraveling the mechanisms that drive tumor metastasis and endocrine resistance. In this review we focused in one of the many pathways that have been involved in tumor progression, the FGF/FGFR axis. We emphasized in data obtained from in vivo experimental models since we believe that in luminal BrCa, tumor growth relies in a crosstalk with the stromal tissue. We revisited the studies that illustrate the interaction between hormone receptors and FGFR. We also highlighted the most frequent alterations found in BrCa cell lines and we provide a short review on the trials that use FGFR inhibitors in combination with endocrine therapies. The analysis of this data suggests that there are many players involved in this pathway that might be also targeted to decrease FGF signaling in addition to specific FGFR inhibitors that may be exploited to increase their efficacy.

scholarly journals Potential risks related to anabolic steroids use on nervous, cardiovascular and reproductive systems disorders in men

2018 ◽  
Vol 31 (3) ◽  
pp. 135-159 ◽  
Author(s):  
Agnieszka Kujawska ◽  
Joanna Androsiuk-Perkowska ◽  
Jakub Husejko ◽  
Marcin Kozuchowski ◽  
Daria Bieniek ◽  
...  
Keyword(s):  
Health Risks ◽  
Anabolic Steroids ◽  
Biochemical Mechanism ◽  
Negative Effects ◽  
Potential Health ◽  
Amateur Sport ◽  
Thrombotic Complications ◽  
Potential Risks ◽  
The Many ◽  
The Relationship

AbstractAnabolic steroids (AS) have been a subject of intensive research for the last several decades. Due to wide use of AS in pharmacological treatment and in professional and amateur sport, it is, hence, worthwhile to describe the biochemical mechanism of the effects of AS usage in humans and its potential health risks. In this work, the relationship between diet and its effect on the level of testosterone in blood is described. Testosterone affects the nervous system, however, there is need for further researches to examine the influence of AS therapy on emotional and cognitive functioning. AS therapy has known negative effects on the cardiovascular system: cardiac hypertrophy can occur, blood pressure can vastly increased, thrombotic complications can come about. These effects are observed not only in patients who are treated with AS, but also in athletes. The paper also describes the relationship between AS and reproductive system diseases. Decreased libido and erectile dysfunction are only some of the many side effects of an incorrect AS treatment.

scholarly journals Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

2020 ◽  
Vol 21 (20) ◽  
pp. 7475
Author(s):  
Salvador Harguindey ◽  
Khalid Alfarouk ◽  
Julián Polo Orozco ◽  
Stefano Fais ◽  
Jesús Devesa
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Hydrogen Ion ◽  
Ion Dynamics ◽  
Hallmarks Of Cancer ◽  
New Approach ◽  
Therapeutic Protocol ◽  
New Knowledge ◽  
The Many ◽  
Ranging Model

A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced.

scholarly journals Breast cancer and long-term hormonal treatment of male hypogonadism

2007 ◽  
Vol 102 (2) ◽  
pp. 251-251 ◽  
Author(s):  
Marek Medras ◽  
Alicja Filus ◽  
Paweł Jozkow ◽  
Jacek Winowski ◽  
Teresa Sicinska-Werner
Keyword(s):  
Breast Cancer ◽  
Hormonal Treatment ◽  
Male Hypogonadism

APLASTIC ANAEMIA TREATED WITH ANABOLIC STEROIDS

1979 ◽  
Vol 43 (3) ◽  
pp. 483-484 ◽  
Author(s):  
Robert Peter Gale ◽  
C. Haanen
Keyword(s):  
Aplastic Anaemia ◽  
Anabolic Steroids

scholarly journals Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy

2004 ◽  
Vol 11 (4) ◽  
pp. 623-641 ◽  
Author(s):  
R I Nicholson ◽  
C Staka ◽  
F Boyns ◽  
I R Hutcheson ◽  
J M W Gee
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Cells ◽  
Endocrine Resistance ◽  
Signaling Networks ◽  
Growth Factor Signaling ◽  
Independent Manner ◽  
Estrogen Withdrawal ◽  
Current Article ◽  
The Many

There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.

scholarly journals A Perspective on Tongue Diagnosis in Patients with Breast Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Po-Chi Hsu ◽  
Han-Kuei Wu ◽  
Hen-Hong Chang ◽  
Jia-Ming Chen ◽  
John Y. Chiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Blood Stasis ◽  
Cross Sectional ◽  
Tongue Diagnosis ◽  
Yin Deficiency ◽  
Lung Area ◽  
Integrated Medical Care ◽  
Fur Color ◽  
The Many ◽  
Tongue Color

Introduction. Breast cancer (BC) is the most common cancer in women and patients with BC often undergo complex treatment. In Taiwan, nearly 80% of patients with BC seek traditional Chinese medicine (TCM) during adjuvant chemotherapy to relieve discomfort and side effects. This study investigated tongue features and pattern differentiation through noninvasive TCM tongue diagnosis in patients with BC. Materials and Methods. This cross-sectional, case-controlled, retrospective observational study collected patient data through a chart review. The tongue features were extracted using the automatic tongue diagnosis system (ATDS). Nine tongue features, including tongue shape, tongue color, fur thickness, fur color, saliva, tongue fissures, ecchymoses, teeth marks, and red dots, were analyzed. Results and Discussion. Objective image analysis techniques were used to identify significant differences in the many tongue features between BC patients and non-BC individuals. A significantly larger proportion of patients with BC had a small tongue ( p < 0.001 ), pale tongue ( p < 0.001 ), thick fur ( p < 0.001 ), yellow fur ( p < 0.001 ), wet saliva ( p < 0.001 ), thick tongue fur ( p < 0.001 ), fissures ( p = 0.040 ), and ecchymoses in the heart-lung area ( p = 0.013 ). According to logistic regression, small tongue shape, pale tongue color, yellow fur color, wet saliva, and the amounts of fissures were associated with a significantly increased odds ratio for BC. Conclusions. This study showed significant differences in tongue features, such as small tongue shape, pale tongue color, thick fur, yellow fur color, wet saliva, fissure, and ecchymoses in the heart-lung area in patients with BC. These tongue features would imply yin deficiency, deficiencies of blood, stagnation of heat, and phlegm/blood stasis in TCM theory. There is a need to investigate effective and safe treatment to enhance the role of TCM in integrated medical care for patients with BC.

scholarly journals Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer

2020 ◽  
Vol 21 (23) ◽  
pp. 9139
Author(s):  
Louisane Eve ◽  
Béatrice Fervers ◽  
Muriel Le Romancer ◽  
Nelly Etienne-Selloum
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Disease Incidence ◽  
Endocrine Disrupting Chemicals ◽  
Epidemiological Studies ◽  
Environmental Chemicals ◽  
Endocrine Disrupting ◽  
Carcinogenic Effects ◽  
The Many

Breast cancer (BC) is the second most common cancer and the fifth deadliest in the world. Exposure to endocrine disrupting pollutants has been suggested to contribute to the increase in disease incidence. Indeed, a growing number of researchershave investigated the effects of widely used environmental chemicals with endocrine disrupting properties on BC development in experimental (in vitro and animal models) and epidemiological studies. The complex effects of endocrine disrupting chemicals (EDCs) on hormonal pathways, involving carcinogenic effects and an increase in mammary gland susceptibility to carcinogenesis—together with the specific characteristics of the mammary gland evolving over the course of life and the multifactorial etiology of BC—make the evaluation of these compounds a complex issue. Among the many EDCs suspected of increasing the risk of BC, strong evidence has only been provided for few EDCs including diethylstilbestrol, dichlorodiphenyltrichloroethane, dioxins and bisphenol A. However, given the ubiquitous nature and massive use of EDCs, it is essential to continue to assess their long-term health effects, particularly on carcinogenesis, to eradicate the worst of them and to sensitize the population to minimize their use.

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