Health secretary makes U turn over service closure at London hospital

BMJ ◽  
2011 ◽  
Vol 343 (sep14 1) ◽  
pp. d5848-d5848
Author(s):  
Z. Kmietowicz
Keyword(s):  
London Hospital ◽  
Turn Over ◽  
Service Closure

The photoreceptor cytoskeleton visualized

1992 ◽  
Vol 50 (1) ◽  
pp. 480-481
Author(s):  
Beth Burnside
Keyword(s):  
Outer Segment ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Cell Polarization ◽  
Synaptic Proteins ◽  
Cell Functions ◽  
Vertebrate Photoreceptor ◽  
Numerous Cell ◽  
Turn Over

The vertebrate photoreceptor provides a drammatic example of cell polarization. Specialized to carry out phototransduction at its distal end and to synapse with retinal interneurons at its proximal end, this long slender cell has a uniquely polarized morphology which is reflected in a similarly polarized cytoskeleton. Membranes bearing photopigment are localized in the outer segment, a modified sensory cilium. Sodium pumps which maintain the dark current critical to photosensory transduction are anchored along the inner segment plasma membrane between the outer segment and the nucleus.Proximal to the nucleus is a slender axon terminating in specialized invaginating synapses with other neurons of the retina. Though photoreceptor diameter is only 3-8u, its length from the tip of the outer segment to the synapse may be as great as 200μ. This peculiar linear cell morphology poses special logistical problems and has evoked interesting solutions for numerous cell functions. For example, the outer segment membranes turn over by means of a unique mechanism in which new disks are continuously added at the proximal base of the outer segment, while effete disks are discarded at the tip and phagocytosed by the retinal pigment epithelium. Outer segment proteins are synthesized in the Golgi near the nucleus and must be transported north through the inner segment to their sites of assembly into the outer segment, while synaptic proteins must be transported south through the axon to the synapse.The role of the cytoskeleton in photoreceptor motile processes is being intensely investigated in several laboratories.

THE EFFECTS OF MORPHINE AND OTHER NARCOTICS ON THYROID FUNCTION IN MICE

1966 ◽  
Vol 51 (3) ◽  
pp. 391-399 ◽  
Author(s):  
Tommie W. Redding ◽  
Cyril Y. Bowers ◽  
Andrew V. Schally
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Direct Action ◽  
Control Level ◽  
Daily Administration ◽  
Pituitary Secretion ◽  
Turn Over

ABSTRACT Several drugs from the morphine, pethidine and morphinan series were evaluated with respect to their action on the pituitary secretion of thyrotrophin (TSH). This action was measured by the release and the uptake of 131I by the thyroid gland of mice. Daily administration of 500 μg of morphine, codeine, dihydromorphinone, levorphan, dextrorphan or meperidine significantly depressed the uptake of 131I by the thyroid gland within five days. Single injections of 500 μg of either dihydromorphinone or levorphan increased the thyroidal uptake of 131I The thyroids of hypophysectomized mice, pretreated with 131I and thyroxine, failed to respond to injections of these drugs. Daily administration of these drugs for five days failed to change pituitary content of TSH from the control level, or to effect a change in the turn-over rate of exogenous radiothyroxine. These results suggest that these drugs do not exert direct action on the thyroid but act on thyroid function through their effect on the hypothalamus-pituitary axis.

TURN-OVER GURU PADA MADRASAH ALIYAH NAHDLATUL ULAMA

1970 ◽  
Vol 13 (1) ◽  
Author(s):  
Mochamad Iskarim
Keyword(s):  
Data Collection ◽  
Negative Impact ◽  
Positive Impact ◽  
New Teacher ◽  
Qualitative Approach ◽  
Depth Interview ◽  
Nahdlatul Ulama ◽  
Turn Over ◽  
Interview Questionnaire ◽  
Collection Methods

Penelitian ini dimaksudkan untuk mengetahui dampak positif dan negatif dari adanya pergantian (turn-over) guru di Madrasah Aliyah Nahdlatul Ulama Banyuputih kabupaten Batang. Penelitian inimenggunakan pendekatan kualitatif deskriptif analitis dengan metode pengumpulan data berupa wawancara mendalam, angket, dan dokumentasi. Hasil penelitian menunjukkan adanya turn-over yang tinggi pada guru atau pendidik di madrasah tersebut; keuntungan yang bersifat positif justru didapatkan ketika adanya turn-over guru dibandingkan dampak negatifnya; dan kehadiran guru baru menjadi hal yang sangat disukai oleh siswa dalam hal kreativitas, inovasi pembelajaran, motivasi, dan lain sebagainya.The aims of this research were to know the positive and negative impact of teacher turn over at Madrasah Aliyah Nahdlatul Ulama Banyuputih Kabupaten Batang. This research was use analytical descriptive qualitative approach with depth interview, questionnaire and documentation as data collection methods. The results of this research shows that the positive impact occur more than the negative impact when there was teacher turn over; and the presence of a new teacher become student’s favourite on creativity, learning innovation, and motivation aspects.

ANALISIS KINERJA KEUANGAN KOPERASI DOSEN DAN KARYAWAN (KDK) SEKOLAH TINGGI ILMU EKONOMI INDRAGIRI (STIE-I) RENGAT TAHUN BUKU 2014 – 2018 DENGAN PENDEKATAN DU-PONT SYSTEM

2018 ◽  
Vol 7 (4) ◽  
pp. 67-80
Author(s):  
Suwaji Suwaji
Keyword(s):  
Profit Margin ◽  
Total Asset ◽  
Net Profit ◽  
Asset Turnover ◽  
Turn Over

Laporan keuangan tahunan suatu koperasi dapat memberikan informasi sehubungan dengan kondisi keuangan dan hasil yang telah dicapai koperasi tersebut. Untuk mengetahui dan menilai kinerja koperasi dalam proses mencapai tujuannya diperlukan metode pengukuran terhadap kinerja keuangan koperasi itu sendiri. Penelitian ini dilakukan dengan tujuan untuk mengetahui kinerja keuangan Koperasi Dosen dan Karyawan (KDK) Sekolah Tinggi Ilmu Ekonomi Indragiri (STIE-I) Rengat selama periode 2014 – 2018. Analisis yang digunakan dalam mengukur kinerja keuangan Koperasi Dosen dan Karyawan STIE Indragiri dengan menggunakan sistem Du-Pont. Analisis dengan sistem Du-Pont memfokuskan pengukuran pada Return on Invesment (ROI) yang merupakan integrasi dari pengukuran Net Profit Margin dan Asset Turnover. Data yang digunakan dalam penelitian ini adalah data laporan keuangan yang berupa neraca dan laporan laba/rugi periode tahun 2014 sampai dengan 2018. Hasil analisis yang dilakukan menunjukkan Total Aktiva, Modal, Pendapatan dan Laba Bersih cenderung mengalami peningkatan dan pertumbuhan yang positif (surplus) kecuali pada sisi laba bersih, dimana laba bersih pada akhir periode 2016 tidak mengalami pertumbuhan. Indeks pertumbuhan NPM tertinggi diperoleh pada periode 2015 dan 2018 yaitu sebesar 1,25 dan indek pertumbuhan NPM terendah terjadi pada periode 2016 yaitu sebesar 0.37. Total Asset Turn Over (TATO), atau perputaran total aktiva tertinggi terjadi pada periode 2016 dengan Indeks sebesar 1 dan terendah pada periode 2015 sebesar 0,50. Return On Invesment (ROI) indeks pertumbuhan tertinggi terjadi di periode tahun 2018 yaitu pada angka indeks 1,10 dan terendah tahun 2016 yaitu pada indeks sebesar 0,39. Dilihat dari pertumbuhannya hal ini mengindikasikan bahwa manajemen KDK-STIE Indragiri sudah mampu memberikan kinerja yang baik

PENGARUH RASIO KEUANGAN TERHADAP PENCAPAIAN LABA PERUSAHAAN KELOMPOK INDUSTRI MAKANAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Akhmad Sodiqin
Keyword(s):  
Stock Exchange ◽  
Fixed Effect ◽  
Current Ratio ◽  
Return On Equity ◽  
Leverage Ratio ◽  
Food Industries ◽  
Equity Ratio ◽  
Turn Over

The aims of this research are to know influence of finacial ratios which consisted of Current ratio, Debt equity ratio, Leverage ratio, Inventory turn over, and total assets turn over to return on equity simultanously and to know influence of finacial ratios which consisted of Current ratio, Debt equity ratio, Leverage ratio, Inventory turn over, and total assets turn over to return on equity partially. Data was analyzed used fixed effect model.Data which collected for 3 years from 2011 until 2013 comes 8 firms in food industries listed in Indonesian Stock Exchange (IDX). Based on data analyzed was known that finacial ratios which consisted of Current ratio, Debt equity ratio, Leverage ratio, Inventory turn over, and total assets turn over to didn’t influence to return on equity simultanously and finacial ratios which consisted of Current ratio, Leverage ratio, Inventory turn over, and total assets turn over didn’t inluence to return on equity partially but debt equity ratio influence significantly to return on equity.

PENGARUH MODAL KERJA TERHADAP PROFITABILITAS PERUSAHAAN LQ-45 YANG TERDAFTAR DI BURSA EFEK INDONESIA

2008 ◽  
Author(s):  
Raja Adri Satriawan Surya ◽  
Kirmizi Kirmizi ◽  
Tita Ratna Juwita R. Ratna Juwita R.
Keyword(s):  
Significant Influence ◽  
Sampling Method ◽  
T Test ◽  
Working Capital ◽  
F Test ◽  
Purposive Sampling ◽  
Inventory Turnover ◽  
Turn Over

The purpose of this research is to test the effect of working capital (cash turn over, inventory turnover and receivable turnover) towards profitability at LQ-45 companies listed at Bursa Efek Indonesia. The population of this research are all LQ-45 companies listed in Bursa Efek Indonesia (BEI). The samples are 19 LQ-45 companies listed in BEI during the year 2004 - 2006. The samples are chosen by using purposive sampling method. The data are analysed with partial test (T-test) and simultant test (F-test) by means of SPSS Ver 13.0. The results show that cash turn over, inventory turnover, and receivable turnover simultaneously have significant influence towards profitability. Partially cash turn over, inventory turnover, and receivable turnover have also significant influence to profitability.

Excitotoxicity as a Target Against Neurodegenerative Processes

2020 ◽  
Vol 26 (12) ◽  
pp. 1251-1262 ◽  
Author(s):  
Octavio Binvignat ◽  
Jordi Olloquequi
Keyword(s):  
Neurodegenerative Diseases ◽  
Effective Treatment ◽  
Molecular Mechanisms ◽  
Prolonged Exposure ◽  
Mitochondrial Dysfunctions ◽  
Beneficial Effects ◽  
Clinical Investigations ◽  
Turn Over ◽  
Excitotoxic Cell Death ◽  
Lateral Sclerosis

: The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population. Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury and death of neurons due to excessive or prolonged exposure to excitatory amino acids, has been shown to play a pivotal role. The increased release and/or decreased uptake of glutamate results in dysregulation of neuronal calcium homeostasis, leading to oxidative stress, mitochondrial dysfunctions, disturbances in protein turn-over and neuroinflammation. : Despite the anti-excitotoxic drug memantine has shown modest beneficial effects in some patients with dementia, to date, there is no effective treatment capable of halting or curing neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington’s disease or amyotrophic lateral sclerosis. This has led to a growing body of research focusing on understanding the mechanisms associated with the excitotoxic insult and on uncovering potential therapeutic strategies targeting these mechanisms. : In the present review, we examine the molecular mechanisms related to excitotoxic cell death. Moreover, we provide a comprehensive and updated state of the art of preclinical and clinical investigations targeting excitotoxic- related mechanisms in order to provide an effective treatment against neurodegeneration.

The London Hospital

BMJ ◽  
1866 ◽  
Vol 1 (272) ◽  
pp. 273-274
Keyword(s):  
London Hospital
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