scholarly journals Serum concentrations of soluble interleukin 2 receptor in patients with rheumatoid arthritis: effect of second line drugs.

1993 ◽  
Vol 52 (1) ◽  
pp. 58-60 ◽  
Author(s):  
A Crilly ◽  
R Madhok ◽  
J Watson ◽  
H A Capell
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 2 ◽  
Second Line ◽  
Serum Concentrations ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

Elevated soluble interleukin-2 receptor levels in the sera and synovial fluids of patients with rheumatoid arthritis

1988 ◽  
Vol 31 (7) ◽  
pp. 844-849 ◽  
Author(s):  
E. C. Keystone ◽  
K. M. Snow ◽  
C. Bombardier ◽  
Chi-Hsing Chang ◽  
D. L. Nelson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
Synovial Fluids ◽  
Soluble Interleukin 2 Receptor

Impaired Erythropoietin Responsiveness in Anaemic Rheumatoid Arthritis Patients: Potential Relation to Immune Mechanisms

1994 ◽  
Vol 86 (5) ◽  
pp. 633-638 ◽  
Author(s):  
Felix Stockenhuber ◽  
Michaela Keil ◽  
Christian Wurnig ◽  
Robert W. Kurz ◽  
Michael Gottsauner-Wolf ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Interleukin 2 ◽  
Inverse Correlation ◽  
Tumour Necrosis Factor Α ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor ◽  
Factor Α ◽  
Necrosis Factor

1. Serum levels of erythropoietin and the immune parameters tumour necrosis factor-α, soluble interleukin-2 receptor, interleukin-2, interleukin-6 and interferon-γ were measured in patients with rheumatoid arthritis. 2. Out of 69 patients, 44 had anaemia with serum haemoglobin concentrations of 10.8 (SD 1.2) g/dl. In these patients erythropoietin levels were significantly higher than in non-anaemic patients [51.97 (SD 23.9) versus 26.06 (SD 11.9) m-units/ml; P < 0.0001; control patients: 18.1 (SD 13.8) m-units/ml]. Mean soluble interleukin-2 receptor activity was elevated in all patients with rheumatoid arthritis [1324 (SD 715) units/ml; control patients: 480 (SD 75) units/ml; P < 0.001] and was significantly higher in the anaemic group than in the non-anaemic group [1562 (SD 662) versus 696 (SD 402) units/ml; P < 0.0001]. The serum activity of soluble interleukin-2 receptor showed an inverse correlation with haemoglobin (r = 0.79; P < 0.0001) and a positive correlation with erythropoietin (r = 0.70, P < 0.0001). 3. Elevated serum tumour necrosis factor-α levels were found in 19 anaemic patients [20.6 (SD 9.1) pg/ml]. Concentrations of tumour necrosis factor-α in serum showed an inverse correlation with haemoglobin (r = 0.57, P < 0.001) and a positive correlation with erythropoietin (r = 0.46, P < 0.05). Interleukin-6 was detected in seven anaemic patients [21 (SD 14) pg/ml] and interleukin-2 activity in three anaemic patients (12, 16 and 14 units/ml, respectively). Interferon-γ was not detected in any of the patients investigated. 4. The present study supports the concept that in patients with rheumatoid arthritis the responsiveness to erythropoietin is impaired. Immune mechanisms may be operative and point to a pivotal role for tumour necrosis factor-α.

scholarly journals Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity.

Gut ◽  
1990 ◽  
Vol 31 (9) ◽  
pp. 1033-1036 ◽  
Author(s):  
J E Crabtree ◽  
L D Juby ◽  
R V Heatley ◽  
A J Lobo ◽  
D W Bullimore ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Interleukin 2 ◽  
Serum Concentrations ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor
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