Did ‘the Princess on the Pea— Suffer from Fibromyalgia Syndrome?

2007 ◽  
Vol 25 (4) ◽  
pp. 184-197 ◽  
Author(s):  
Thomas Lundeberg ◽  
Iréne Lund
Keyword(s):  
Cognitive Dysfunction ◽  
Sleep Disturbances ◽  
Fibromyalgia Syndrome ◽  
Short Term Memory ◽  
Treatment Strategies ◽  
Specific Effect ◽  
Pain Syndrome ◽  
Individual Variability ◽  
Specific Effects ◽  
Systematic Effects

Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterised by central sensitisation resulting in hypersentivity of the skin and deeper tissues as well as fatigue. Possibly the princess in Hans Christian Andersen's ‘The Princess and the Pea’ suffered from FMS since chronic sleep disturbances are typical in FMS. These sleep disturbances have been attributed to a dysfunction in the systems regulating sleep and wakefulness resulting in loss of deep sleep. In addition, many patients with FMS experience cognitive dysfunction, characterised by impaired concentration and short term memory consolidation, a complaint also commonly reported in other sleep disorders. In recent reviews evaluating the efficacy of acupuncture in FMS it has been concluded that acupuncture has no specific effect. A prerequisite for this conclusion is that all the major symptoms in the syndrome have been assessed. However, previous studies have generally focused on the pain alleviating effect of acupuncture in FMS. We have observed that not only pain but also sleep and cognitive dysfunction may be ameliorated in response to acupuncture, suggesting that these variables should be taken into account when evaluating the effects of acupuncture in FMS. Furthermore, the results demonstrated great individual variability apart from the systematic effects related to the group, indicating that individually performed treatment strategies are required. Our suggestion is supported by experimental and clinical studies showing that acupuncture may affect in somnia and alertness, and that there may be neurophysiologic bases for these specific effects.

Investigation of ACE rs4646994, MTHFR rs1801133 and VDR rs2228570 Genotypes in Jordanian Patients with Fibromyalgia Syndrome

2020 ◽  
Vol 21 ◽  
Author(s):  
Raida Khalil ◽  
Wajdy J. Al-Awaida ◽  
Hamzeh J. Al-Ameer ◽  
Yazun Jarrar ◽  
Amer Imraish ◽  
...  
Keyword(s):  
Sleep Disturbances ◽  
Fibromyalgia Syndrome ◽  
Methylenetetrahydrofolate Reductase ◽  
Pain Tolerance ◽  
The Body ◽  
Restless Leg Syndrome ◽  
Jordanian Arabic ◽  
Clinical Investigations ◽  
Polymerase Chain ◽  
Larger Sample

Background: Fibromyalgia syndrome (FMS) is a chronic disease characterized by widespread body pain, weakness in certain parts of the body (critical points), low pain tolerance, sleep disturbances, and fatigue. This syndrome is considered rare in Jordan. Objectives: The research aimed to find out the association of the angiotensin converting enzyme, methylenetetrahydrofolate reductase, and vitamin D receptor (ACE, MHFTR, and VDR, respectively) genotypes with FMS among Jordanian patients. Methods: This work included 22 FM patients and 22 healthy individuals of Jordanian Arabic origin. The ACE rs4646994, MTHFR rs1801133, and VDR rs2228570 genotypes were determined using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism. Results: No associations between ACE rs4646994, MTHFR rs1801133, and VDR rs2228570 with the vulnerability of a person for the development of FMS were found. However, we found an association between the ACE rs4646994 genotype and restless leg among FM patients. Conclusion: Based on result from this study, it appears that the ACE rs4646994 genotype is associated with restless leg among FMS patients of Jordanian origin. Further clinical investigations with larger sample sizes are required to confirm these findings and to understand the molecular mechanism of ACE rs4646994 genetic variant in the restless leg syndrome among FM patients.

scholarly journals Optimizing Subjective Cognitive Decline to Detect Early Cognitive Dysfunction

2021 ◽  
Vol 80 (3) ◽  
pp. 1185-1196
Author(s):  
Silvia Chapman ◽  
Preeti Sunderaraman ◽  
Jillian L. Joyce ◽  
Martina Azar ◽  
Leigh E. Colvin ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cognitive Dysfunction ◽  
Associative Memory ◽  
Short Term Memory ◽  
Subjective Cognitive Decline ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Preclinical Ad ◽  
List Learning

Background: The utility of subjective cognitive decline (SCD) as an indicator of preclinical AD is overshadowed by its inconsistent association with objective cognition. Objective: This study examines if manipulations of SCD measurement affect its association with early cognitive dysfunction characteristic of preclinical AD. Methods: Cognitively healthy older adults (n = 110) completed SCD questionnaires that elicited complaints in general, compared to 5 years ago (retrospective SCD) and compared to their peers (age-anchored SCD) in binary and Likert scales. Outcome cognitive tasks included an associative memory task (Face-Name Test), a visual short-term memory binding task (STMB test), and a clinical neuropsychological list learning test (Selective Reminder Test). Results: SCD complaints, when compared to age-matched peers (age-anchored SCD) were endorsed less frequently than complaints compared to 5 years ago (retrospective SCD) (p < 0.01). In demographically adjusted regressions, age-anchored ordinal-rated SCD was associated with short term memory binding (β= –0.22, p = 0.040, CI = –0.45, –0.01), associative memory (β= –0.26, p = 0.018, CI = –0.45, –0.06), and list learning (β= –0.31, p = 0.002, CI = –0.51, –0.12). Retrospective and general ordinal-rated SCD was associated with associative memory (β= –0.25, p = 0.012, CI = –0.44, –0.06; β= –0.29, p = 0.003, CI = –0.47, –0.10) and list learning only (β= –0.25, p = 0.014, CI = –0.45, –0.05; β= –0.28, p = 0.004, CI = –0.48, –0.09). Conclusion: Ordinal age-anchored SCD appears better suited than other SCD measurements to detect early cognitive dysfunction characteristic of preclinical AD.

Location-specific effects of attention during visual short-term memory maintenance.

2014 ◽  
Vol 40 (3) ◽  
pp. 1103-1116 ◽  
Author(s):  
Michi Matsukura ◽  
Joshua D. Cosman ◽  
Zachary J. J. Roper ◽  
Daniel B. Vatterott ◽  
Shaun P. Vecera
Keyword(s):  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Specific Effects

scholarly journals Common and specific effects of the two major forms of prolactin in the rat testis

2007 ◽  
Vol 293 (6) ◽  
pp. E1795-E1803 ◽  
Author(s):  
Valencia L. Williams ◽  
Ariel DeGuzman ◽  
Hong Dang ◽  
Mitsumori Kawaminami ◽  
Timothy W. C. Ho ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Fas Ligand ◽  
Regulatory Protein ◽  
Specific Effect ◽  
Serum Testosterone ◽  
Hydroxysteroid Dehydrogenase ◽  
Luteinizing Hormone Receptor ◽  
Male Rats ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Specific Effects

Prolactin (PRL) has both stimulatory and inhibitory effects on testicular function, a finding we hypothesized may be related in some part to the form of the hormone present or administered. In the analysis of the pituitary secretion profiles of early pubescent vs. mature male rats, we found PRL released from early pubescent pituitaries had about twice the degree of phosphorylation. Treatment of mature males with either unmodified PRL (U-PRL) or phosphorylated PRL (via the molecular mimic S179D PRL) for a period of 4 wk (circulating level of ∼50 ng/ml) showed serum testosterone decreased by ∼35% only by treatment with the phospho-mimic S179D PRL. Given the specificity of this effect, it was initially surprising that both forms of PRL decreased testicular expression of 3β-hydroxysteroid dehydrogenase and steroidogenic acute regulatory protein. Both forms also increased expression of the luteinizing hormone receptor, but only S179D PRL increased the ratio of short to long PRL receptors. Endogenous PRL and luteinizing hormone levels were unchanged in all groups in this time frame, suggesting that effects on steroidogenic gene expression were directly on the testis. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling analysis combined with staining for 3β-hydroxysteroid dehydrogenase and morphometric analysis showed that S179D PRL, but not U-PRL, increased apoptosis of Leydig cells, a finding supported by increased staining for Fas and Fas ligand in the testicular interstitium, providing an explanation for the specific effect on testosterone. S179D PRL, but not U-PRL, also increased apoptosis of primary spermatogonia, and U-PRL, but not S179D PRL, decreased apoptosis of elongating spermatids. Thus, in mature males, hyperprolactinemic levels of both forms of PRL have common effects on steroidogenic proteins, but specific effects on the apoptosis of Leydig and germ cells.

Health-Related Physical Fitness in Women with Fibromyalgia Syndrome or Myofascial Pain Syndrome

2008 ◽  
Vol 16 (4) ◽  
pp. 258-265 ◽  
Author(s):  
Neslihan Alkan PT ◽  
Arzu Daskapan ◽  
Emine Handan Tuzun ◽  
Mahmut Nafiz Akman
Keyword(s):  
Physical Fitness ◽  
Fibromyalgia Syndrome ◽  
Myofascial Pain ◽  
Pain Syndrome ◽  
Myofascial Pain Syndrome ◽  
Health Related

scholarly journals Does propofol ameliorate occurrence of postoperative cognitive dysfunction after general anaesthesia? A protocol of systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Xi Zhao ◽  
Ze-qing Huang
Keyword(s):  
Systematic Review ◽  
Cognitive Dysfunction ◽  
Short Term Memory ◽  
Meta Analysis ◽  
Postoperative Cognitive Dysfunction ◽  
Biomedical Literature ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
China National Knowledge Infrastructure

Abstract Background Postoperative cognitive dysfunction (POCD) is a common condition after general anesthesia (GA). Previous studies have reported that propofol can ameliorate the occurrence of such disorder. However, its results are still inconsistent. Therefore, this systematic review will assess the efficacy and safety of propofol on POCD after GA. Methods Literature sources will be sought from inception to the present in Cochrane Library, MEDLINE, EMBASE, PsycINFO, Web of Science, Scopus, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure for randomized controlled trials (RCTs) assessing the administration of propofol on POCD after GA. All searches will be carried out without limitations to language and publication status. Outcomes comprise of cognitive impairments changes, impairments in short-term memory, concentration, language comprehension, social integration, quality of life, and adverse events. Cochrane risk of bias tool will be utilized to assess study quality. We will evaluate the quality of evidence for each outcome using Grading of Recommendations Assessment, Development and Evaluation approach. A narrative synthesis or a meta-analysis will be undertaken as appropriate. Discussion This study will systematically and comprehensively search literature and integrate evidence on the efficacy and safety of propofol on POCD after GA. Our findings will be of interest to clinicians and health-related policy makers. Systematic review registration PROSPERO CRD42020164096

scholarly journals Physical therapy modalities for treating fibromyalgia

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2030 ◽  
Author(s):  
Fernanda Mendonça Araújo ◽  
Josimari Melo DeSantana
Keyword(s):  
Physical Therapy ◽  
Cognitive Dysfunction ◽  
Musculoskeletal Pain ◽  
Sleep Disturbances ◽  
Physical Therapy Modalities ◽  
Alternative Therapies ◽  
Chronic Musculoskeletal Pain ◽  
Gastrointestinal Disorders ◽  
Psychosomatic Symptoms ◽  
Anxiety Depression

Fibromyalgia is a syndrome characterized by generalized chronic musculoskeletal pain, hyperalgesia in specific points, and psychosomatic symptoms, such as fatigue, sleep disturbances (waking unrefreshed), anxiety, depression, cognitive dysfunction, headache, and gastrointestinal disorders. Investigations with non-pharmacological therapies, focused on physical therapy, have increased in recent years as alternative therapies for the treatment of fibromyalgia. The purpose of this review is to summarize the main physical therapy modalities used to treat fibromyalgia.

Benign disease of the vulva

2020 ◽  
pp. 627-636
Author(s):  
Rosalind Simpson ◽  
David Nunns
Keyword(s):  
Health Professionals ◽  
Complex Disease ◽  
Treatment Strategies ◽  
Pain Syndrome ◽  
Skin Condition ◽  
Knowledge And Skills ◽  
Level Of Functioning ◽  
Individualized Management ◽  
Vulval Disease ◽  
Careful Assessment

This chapter aims to enhance knowledge and skills in patient assessment, vulval examination, and treatment of vulval disease, specifically dermatological conditions and vulval pain. The prompt identification and treatment of vulval conditions can reduce anxiety, alleviate symptoms, and preserve an acceptable level of functioning for patients. Often simple measures can benefit the patient (e.g. use of emollients), but many have complex disease and can present with more than one condition so careful assessment and individualized management is essential. Combining treatment strategies is sometimes needed. Vulvodynia is not a skin condition but a chronic pain syndrome and is also covered in this chapter. It is important that health professionals work within their own competencies. Patients with complicated, rare, and treatment-refractory disease should be referred on to a vulval service for a multidisciplinary opinion.

Sign in / Sign up

Export Citation Format

Share Document