scholarly journals Optimizing Subjective Cognitive Decline to Detect Early Cognitive Dysfunction

2021 ◽  
Vol 80 (3) ◽  
pp. 1185-1196
Author(s):  
Silvia Chapman ◽  
Preeti Sunderaraman ◽  
Jillian L. Joyce ◽  
Martina Azar ◽  
Leigh E. Colvin ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cognitive Dysfunction ◽  
Associative Memory ◽  
Short Term Memory ◽  
Subjective Cognitive Decline ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Preclinical Ad ◽  
List Learning

Background: The utility of subjective cognitive decline (SCD) as an indicator of preclinical AD is overshadowed by its inconsistent association with objective cognition. Objective: This study examines if manipulations of SCD measurement affect its association with early cognitive dysfunction characteristic of preclinical AD. Methods: Cognitively healthy older adults (n = 110) completed SCD questionnaires that elicited complaints in general, compared to 5 years ago (retrospective SCD) and compared to their peers (age-anchored SCD) in binary and Likert scales. Outcome cognitive tasks included an associative memory task (Face-Name Test), a visual short-term memory binding task (STMB test), and a clinical neuropsychological list learning test (Selective Reminder Test). Results: SCD complaints, when compared to age-matched peers (age-anchored SCD) were endorsed less frequently than complaints compared to 5 years ago (retrospective SCD) (p < 0.01). In demographically adjusted regressions, age-anchored ordinal-rated SCD was associated with short term memory binding (β= –0.22, p = 0.040, CI = –0.45, –0.01), associative memory (β= –0.26, p = 0.018, CI = –0.45, –0.06), and list learning (β= –0.31, p = 0.002, CI = –0.51, –0.12). Retrospective and general ordinal-rated SCD was associated with associative memory (β= –0.25, p = 0.012, CI = –0.44, –0.06; β= –0.29, p = 0.003, CI = –0.47, –0.10) and list learning only (β= –0.25, p = 0.014, CI = –0.45, –0.05; β= –0.28, p = 0.004, CI = –0.48, –0.09). Conclusion: Ordinal age-anchored SCD appears better suited than other SCD measurements to detect early cognitive dysfunction characteristic of preclinical AD.

P2-337: THE SHORT-TERM MEMORY BINDING TEST DIFFERENTIATES ELDERLY WITH SUBJECTIVE COGNITIVE DECLINE FROM HEALTHY CONTROLS IN A BRAZILIAN COHORT

2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P813-P813
Author(s):  
Adalberto Studart Neto ◽  
Natalia Cristina Moraes ◽  
Mario Amore Cecchini ◽  
Jacy Bezerra Parmera ◽  
Raphael Ribeiro Spera ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Short Term Memory ◽  
Subjective Cognitive Decline ◽  
Healthy Controls ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Brazilian Cohort

scholarly journals Visual short-term memory binding deficits in Alzheimer's disease: a reply to Parra's commentary.

Cortex ◽  
2017 ◽  
Vol 88 ◽  
pp. 201-204 ◽  
Author(s):  
Yuying Liang ◽  
Yoni Pertzov ◽  
Jennifer M. Nicholas ◽  
Susie M.D. Henley ◽  
Sebastian Crutch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding

scholarly journals Short-term memory binding deficits in Alzheimer's disease

Brain ◽  
2008 ◽  
Vol 132 (4) ◽  
pp. 1057-1066 ◽  
Author(s):  
M. A. Parra ◽  
S. Abrahams ◽  
K. Fabi ◽  
R. Logie ◽  
S. Luzzi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

Impact of intrathecal cell therapy with autologous stromal cells on short‐term memory binding in early Alzheimer’s disease: One‐year follow‐up assessment

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Sara Fernández Guinea ◽  
Mercedes Zurita ◽  
Jorge Mucientes ◽  
Estefanía García ◽  
Javier González Marqués ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Therapy ◽  
Stromal Cells ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding ◽  
Early Alzheimer’S Disease ◽  
One Year

scholarly journals Visual Short-term Memory Impairments in Presymptomatic Familial Alzheimer’s Disease: a Longitudinal Observational Study

2020 ◽  
Author(s):  
Ivanna M. Pavisic ◽  
Jennifer M. Nicholas ◽  
Yoni Pertzov ◽  
Antoinette O'Connor ◽  
Yuying Liang ◽  
...  
Keyword(s):  
Symptom Onset ◽  
Short Term Memory ◽  
Memory Load ◽  
Load Condition ◽  
Healthy Controls ◽  
Short Term ◽  
Cross Sectional ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Preclinical Ad

Abstract Background: Cross-sectional studies in presymptomatic familial Alzheimer’s disease (FAD), have associated binding deficits with preclinical AD. How impairments in visual-short term memory (VSTM) relate to longitudinal change and proximity to expected symptom onset (EYO) is less characterized.Methods: Thirty-two FAD mutation carriers (23 presymptomatic; 9 symptomatic) carrying a mutation in either presenilin 1 or amyloid precursor protein genes and 67 healthy controls were included in an extension VSTM cross-sectional study. Forty-eight participants (23 presymptomatic carriers, 6 symptomatic and 19 healthy controls) who had at least two annual visits (median= 3), were included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Results: While cross-sectionally only symptomatic carriers (N=9) showed significant impairments in VSTM performance, longitudinally, presymptomatic carriers within 8.5 years of estimated symptom onset (mean=5.8 years ±SD [1.8], N=11) showed a faster rate of decline in localisation performance in long-delay conditions (4s) compared to controls: increase/year in localisation error was 6.9% greater in the high-memory load condition (p=0.008) and 7.0% greater for the low-memory load condition (p=0.043). Change in this metric preceded presymptomatic changes in traditional measures of verbal episodic memory. Symptomatic carriers had 15% faster reduction in identification performance per year compared to controls (p=0.036) and some evidence of faster increase in localisation error (6.5% increase/year; p=0.066). The earliest significant difference in VSTM performance between FAD mutation carriers (presymptomatic and symptomatic) and controls was in localisation performance, six years prior to estimated symptom onset (p=0.024). Conclusions: This longitudinal study of FAD, suggests changes in VSTM resolution, which measure precision and thus quality of recall of the memory presentation, may be sensitive markers for tracking and predicting cognitive decline in preclinical AD.

Age differences in short-term memory binding are related to working memory performance across the lifespan.

2014 ◽  
Vol 29 (1) ◽  
pp. 140-149 ◽  
Author(s):  
Yana Fandakova ◽  
Myriam C. Sander ◽  
Markus Werkle-Bergner ◽  
Yee Lee Shing
Keyword(s):  
Working Memory ◽  
Age Differences ◽  
Short Term Memory ◽  
Memory Performance ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

scholarly journals Association of Olfactory Impairment and Postoperative Cognitive Dysfunction in Elderly Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Yang Lan ◽  
Zhi-jian You ◽  
Ruiming Du ◽  
Le-si Chen ◽  
Jia-xuan Wu
Keyword(s):  
Cognitive Function ◽  
Abdominal Surgery ◽  
Elderly Patients ◽  
General Anesthesia ◽  
Cognitive Dysfunction ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Olfactory Impairment ◽  
Surgical Group

ObjectiveTo investigate the impact of anesthesia on the change of olfactory function and cognitive function in elderly patients who undergo abdominal surgery.MethodsA total of 30 elderly patients who underwent abdominal surgery were recruited as the research subjects. The Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test was used to test the olfactory function and the Mini-mental State Examination (MMSE), Hopkins Verbal Learning Test – Revised (HVLT-R), Trail Making Test (TMT), Stroop Color Word Test (SCWT), Digit-Symbol Coding Test (DSCT), and Verbal Fluency Test (VFT) were used to assess their cognitive function before general anesthesia, and on the 3rd and 7th day post-anesthesia. The serum level of IL-1β, IL-6, and TNF-α were measured before anesthesia and at 0, 12, and 24 h post-anesthesia. In total, 30 healthy volunteers who did not undergo anesthesia were used as the control group. The test results of all subjects were recorded and their correlations were analyzed.ResultsOn the 3rd and 7th day post-anesthesia, the olfactory recognition threshold of patients in the surgical group was lower than that of control group with significant difference (P &lt; 0.05). On the 3rd and 7th postoperative day, the patient’s short-term memory and delayed memory, attention and processing speed were decreased (P &lt; 0.05). On the 7th day post-anesthesia, delayed memory and processing ability were still decreased (P &lt; 0.05). In the surgical group, Spearman correlation analysis showed that the difference of olfactory recognition score on the 3rd and 7th day post-anesthesia was positively correlated with short-term memory and delayed memory of cognitive function. Compared with pre-anesthesia, the serum levels of IL-1β, IL-6, and TNF-α in the surgical group were significantly increased at each time point after anesthesia.ConclusionAbdominal surgery with general anesthesia in elderly patients may increase the level of serum inflammatory factors, induce olfactory impairment, particularly the decline of olfactory identification threshold and cause cognitive dysfunction with declined short-term memory, delayed memory and attention. There was a positive correlation between olfactory impairment and cognitive dysfunction after general anesthesia. Therefore, olfactory impairment could be an early indicator to guide early intervention for postoperative cognitive dysfunction.

Verbal short-term memory as an articulatory system: Evidence from an alternative paradigm

2002 ◽  
Vol 55 (1) ◽  
pp. 195-223 ◽  
Author(s):  
Him Cheung ◽  
Lana Wooltorton
Keyword(s):  
Short Term Memory ◽  
Inhibitory Effect ◽  
Auditory Memory ◽  
Word Target ◽  
Short Term ◽  
Term Memory ◽  
Immediate Serial Recall ◽  
Final Item ◽  
List Learning ◽  
Span Tasks

In a series of seven experiments, the role of articulatory rehearsal in verbal short-term memory was examined via a shadowing-plus-recall paradigm. In this paradigm, subjects shadowed a word target presented closely after an auditory memory list before they recalled the list. The phonological relationship between the shadowing target and the final item on the memory list was manipulated. Experiments 1 and 2 demonstrated that targets sounding similar to the list-final memory item generally took longer to shadow than unrelated targets. This inhibitory effect of phonological relatedness was more pronounced with tense- than lax-vowel pseudoword recall lists. The interaction between vowel tenseness and phonological relatedness was replicated in Experiment 3 using shorter lists of real words. In Experiment 4, concurrent articulation was applied during list learning to block rehearsal; consequently, neither the phonological relatedness effect nor its interaction with vowel tenseness emerged. Experiments 5 and 6 manipulated the occurrence frequencies and lexicality of the recall items, respectively, instead of vowel tenseness. Unlike vowel tenseness, these non-articulatory memory factors failed to interact with the phonological relatedness effect. Experiment 7 orthogonally manipulated the vowel tenseness and frequencies of the recall items; slowing in shadowing times due to phonological relatedness was modulated by vowel tenseness but not frequency. Taken together, these results suggest that under the present paradigm, the modifying effect of vowel tenseness on the magnitude of slowing in shadowing due to phonological relatedness is indicative of a prominent articulatory component in verbal short-term retention. The shadowing-plus-recall approach avoids confounding overt recall into internal memory processing, which is an inherent problem of the traditional immediate serial recall and span tasks.

P2-317: WHEN IS SHORT-TERM MEMORY BINDING SELECTIVELY IMPAIRED IN MILD COGNITIVE IMPAIRMENT?

2016 ◽  
Vol 12 ◽  
pp. P761-P761 ◽  
Author(s):  
Mario Alfredo Parra ◽  
Sara Fernandez Guinea ◽  
Lidia Sanchez ◽  
Beatriz Suarez ◽  
Anna Frank ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

Deficits in visual short-term memory binding in children at risk of non-verbal learning disabilities

2015 ◽  
Vol 45-46 ◽  
pp. 365-372 ◽  
Author(s):  
Ricardo Basso Garcia ◽  
Irene C. Mammarella ◽  
Arianna Pancera ◽  
Cesar Galera ◽  
Cesare Cornoldi
Keyword(s):  
At Risk ◽  
Learning Disabilities ◽  
Short Term Memory ◽  
Verbal Learning ◽  
Children At Risk ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding
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