The Effect of Light on Tissue Repair

1993 ◽  
Vol 11 (1) ◽  
pp. 17-19 ◽  
Author(s):  
SR Young ◽  
M Dyson
Keyword(s):  
Pain Relief ◽  
Tissue Repair ◽  
Clinical Evidence ◽  
Light Therapy ◽  
Repair Process ◽  
Mechanisms Of Action ◽  
Weight Of Evidence ◽  
Underlying Mechanisms ◽  
Recent Laboratory ◽  
Effect Of Light

Electrotherapeutic modalities are widely used by physiotherapists to accelerate repair and reduce pain. It is important that the underlying mechanisms and effects that they produce are fully understood, together with any underlying adverse effects which may arise from their use. Light therapy is a relatively new addition to the physiotherapy arsenal and the mechanisms of action have not yet been fully identified. There is clinical evidence suggesting that it is effective in promoting tissue repair and pain relief. This, together with some recent laboratory evidence showing light to be effective in stimulating cells that are involved in the repair process to produce wound mediators, is described. The weight of evidence suggests that, if used correctly, light therapy can induce bioeffects which are beneficial to the patient.

Effects of Low-Power Light Therapy on the Tissue Repair Process of Chronic Wounds in Diabetic Feet

2018 ◽  
Vol 36 (6) ◽  
pp. 298-304 ◽  
Author(s):  
Joelita de Alencar Fonseca Santos ◽  
Mariana Barbosa Dias Campelo ◽  
Rauirys Alencar de Oliveira ◽  
Renata Amadei Nicolau ◽  
Verônica Elis Araújo Rezende ◽  
...  
Keyword(s):  
Low Power ◽  
Tissue Repair ◽  
Chronic Wounds ◽  
Light Therapy ◽  
Repair Process

scholarly journals Terapia a laser de baixa potência na cicatrização de feridas

2019 ◽  
Vol 13 (1) ◽  
pp. 216 ◽  
Author(s):  
Taline Bavaresco ◽  
Viviane Maria Osmarin ◽  
Ananda Ughini Bertoldo Pires ◽  
Vítor Monteiro Moraes ◽  
Amália De Fátima Lucena
Keyword(s):  
Low Power ◽  
Laser Therapy ◽  
Tissue Repair ◽  
Light Therapy ◽  
Repair Process ◽  
Patient Comfort ◽  
Virtual Library ◽  
Power Laser ◽  
Tratamiento Adyuvante ◽  
Research Designs

ABSTRACT Objective: to identify the action of low power laser therapy in wound healing. Method: this is a bibliographical study, of integrative review type, with search of articles published between 2004 and 2017, in the MEDLINE, LILACS and virtual library SciELO databases. After the articles were read, the data was extracted and analyzed, and presented in figure form. Results: 24 articles were selected, with different research designs. It has been found that low-power laser therapy promotes positive actions in oxygenation, cell growth and modulation due to irradiated light, which affects the metabolic processes and produces cellular and vascular biostimulants essential to the tissue repair process. Conclusion: it is concluded that low-power laser therapy is an adjuvant treatment that accelerates the tissue repair process and promotes patient comfort benefits. Descriptors: Laser therapy; Low Intensity Light Therapy; Healing; Review; Treatment Outcome; Wounds. RESUMOObjetivo identificar a ação da terapia a laser de baixa potência na cicatrização de feridas. Método: trata-se de um estudo bibliográfico, tipo revisão integrativa, com busca de artigos publicados entre 2004 a 2017, nas bases de dados MEDLINE, LILACS e biblioteca virtual SciELO. Efetuaram-se, após a leitura dos artigos, a extração e a análise dos dados, e apresentam-se em forma de figura. Resultados: selecionaram-se 24 artigos, com diferentes delineamentos de pesquisa. Verificou-se que a terapia a laser de baixa potência propicia ações positivas na oxigenação, crescimento e modulação celular devido à luz irradiada, que afeta os processos metabólicos e produz bioestimulantes celulares e vasculares essenciais ao processo de reparo tecidual. Conclusão: conclui-se que a terapia a laser de baixa potência é um tratamento adjuvante que acelera o processo de reparação tecidual e promove benefícios ao conforto dos pacientes. Descritores: Terapia a laser; Terapia a Luz de Baixa Intensidade; Cicatrização; Revisão; Resultado do Tratamento; Feridas.RESUMEN Objetivo: identificar la acción de la terapia láser de baja potencia en la cicatrización de las heridas. Método: se trata de un estudio bibliográfico, tipo revisión integrativa, con búsqueda de artículos publicados entre 2004 a 2017, en las bases de datos MEDLINE, LILACS y biblioteca virtual SciELO. Se realizaron, después de la lectura de los artículos, la extracción y el análisis de los datos, y se presentan en forma de figura. Resultados: se seleccionaron 24 artículos, con diferentes delineamientos de investigación. Se ha comprobado que la terapia láser de baja potencia propicia acciones positivas en la oxigenación, crecimiento y modulación celular debido a la luz irradiada, que afecta los procesos metabólicos y produce bioestimulantes celulares y vasculares esenciales al proceso de reparación del tejido. Conclusión: se concluye que la terapia láser de baja potencia es un tratamiento adyuvante que acelera el proceso de reparación tisular y promueve beneficios al bien estar de los pacientes. Descriptores: Terapia por Láser; Terapia por Luz de Baja Intensidad; Cicatrización de Herida; Revisión; Resultado del tratamento; Heridas y Lesiones.

Autophagy Modulators and Neuroinflammation

2020 ◽  
Vol 27 (6) ◽  
pp. 955-982 ◽  
Author(s):  
Kyoung Sang Cho ◽  
Jang Ho Lee ◽  
Jeiwon Cho ◽  
Guang-Ho Cha ◽  
Gyun Jee Song
Keyword(s):  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Mammalian Cells ◽  
Critical Role ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Scientific Interest ◽  
Therapeutic Tools ◽  
Underlying Mechanisms

Background: Neuroinflammation plays a critical role in the development and progression of various neurological disorders. Therefore, various studies have focused on the development of neuroinflammation inhibitors as potential therapeutic tools. Recently, the involvement of autophagy in the regulation of neuroinflammation has drawn substantial scientific interest, and a growing number of studies support the role of impaired autophagy in the pathogenesis of common neurodegenerative disorders. Objective: The purpose of this article is to review recent research on the role of autophagy in controlling neuroinflammation. We focus on studies employing both mammalian cells and animal models to evaluate the ability of different autophagic modulators to regulate neuroinflammation. Methods: We have mostly reviewed recent studies reporting anti-neuroinflammatory properties of autophagy. We also briefly discussed a few studies showing that autophagy modulators activate neuroinflammation in certain conditions. Results: Recent studies report neuroprotective as well as anti-neuroinflammatory effects of autophagic modulators. We discuss the possible underlying mechanisms of action of these drugs and their potential limitations as therapeutic agents against neurological disorders. Conclusion: Autophagy activators are promising compounds for the treatment of neurological disorders involving neuroinflammation.

scholarly journals Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair

2021 ◽  
Vol 22 (3) ◽  
pp. 1201
Author(s):  
Hsuan Peng ◽  
Kazuhiro Shindo ◽  
Renée R. Donahue ◽  
Ahmed Abdel-Latif
Keyword(s):  
Stem Cell ◽  
Immune Responses ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Current Knowledge ◽  
Cell Delivery ◽  
Cardiac Cell Therapy ◽  
Stem Cell Treatment

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

scholarly journals Vitamin K and D Supplementation and Bone Health in Chronic Kidney Disease—Apart or Together?

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 809
Author(s):  
Marta Ziemińska ◽  
Beata Sieklucka ◽  
Krystyna Pawlak
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin K ◽  
Bone Health ◽  
Clinical Evidence ◽  
Mechanisms Of Action ◽  
Preclinical Studies ◽  
Normal Bone ◽  
Combined Supplementation

Vitamin K (VK) and vitamin D (VD) deficiency/insufficiency is a common feature of chronic kidney disease (CKD), leading to impaired bone quality and a higher risk of fractures. CKD patients, with disturbances in VK and VD metabolism, do not have sufficient levels of these vitamins for maintaining normal bone formation and mineralization. So far, there has been no consensus on what serum VK and VD levels can be considered sufficient in this particular population. Moreover, there are no clear guidelines how supplementation of these vitamins should be carried out in the course of CKD. Based on the existing results of preclinical studies and clinical evidence, this review intends to discuss the effect of VK and VD on bone remodeling in CKD. Although the mechanisms of action and the effects of these vitamins on bone are distinct, we try to find evidence for synergy between them in relation to bone metabolism, to answer the question of whether combined supplementation of VK and VD will be more beneficial for bone health in the CKD population than administering each of these vitamins separately.

scholarly journals Antisettici e controllo della carica batterica nelle ulcere venose/Antiseptics and control of bacterial load in venous ulcers

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Giuseppe Nebbioso ◽  
Ciro Falasconi ◽  
Viviana Nebbioso ◽  
Francesco Petrella
Keyword(s):  
Tissue Repair ◽  
Chronic Wound ◽  
Early Stage ◽  
Bacterial Load ◽  
Repair Process ◽  
Local Infection ◽  
Bacterial Burden ◽  
Venous Ulcers ◽  
Systemic Antibiotic Therapy ◽  
And Control

L’insorgenza di infezione su una lesione cutanea cronica determina un arresto del processo di riparazione tessutale e impone l’instaurazione di una terapia antibiotica sistemica che, in una fase iniziale, sarà empirica e, dunque, non scevra di insuccessi. L’utilizzo di antimicrobici con ridotto potere citotossoco/istiolesivo può essere considerata, in molti casi, una valida alternativa per il controllo della carica batterica e dell’infezione locale. L’associazione di antimicrobici a base di poliesanide biguanide, betaina e cadexomero iodico, in molti casi, permette di controllare/ridurre la carica batterica e l’infezione locale fungendo da starter per la ripresa del processo di riparazione tessutale. The onset of infection on a skin ulcer (chronic wound) leads to a halt in the tissue repair process and requires a systemic antibiotic therapy which, at an early stage, will be empirical and, therefore, not free from setbacks. The use of antimicrobials with reduced cytotoxic/histiolesive power can be considered, in many cases, a valid alternative for bacterial burden and local infection control. The combination of antimicrobials based on polystyrene biguanide, betaine and iodine cadexomer, in many cases, allows to control/reduce the bacterial burden and local infection by acting as a starter for the resumption of the tissue repair process.

EMDR’s Neurobiological Mechanisms of Action: A Survey of 20 Years of Searching

2010 ◽  
Vol 4 (1) ◽  
pp. 22-42 ◽  
Author(s):  
Uri Bergmann
Keyword(s):  
Eye Movement ◽  
Mechanisms Of Action ◽  
Before And After ◽  
Underlying Mechanisms ◽  
Emdr Therapy

Historically, mechanisms of action have often been difficult to ascertain. Thus far, the definitive discovery of eye movement desensitization and reprocessing (EMDR)’s underlying mechanisms has been equally elusive. We review the neurobiological studies of EMDR, as well as the theoretically driven speculative models that have been posited to date. The speculative theoretically driven models are reviewed historically to illustrate their growth in neurobiological complexity and specificity. Alternatively, the neurobiological studies of EMDR are reviewed with regard to their object of investigation and categorized as follows: findings before and after EMDR therapy (neuroimaging and psychophysiological studies) and findings during the EMDR set (psychophysiological, neuroimaging, and qEEG studies).

P5374Genetic deletion of IL-22 increased cardiac rupture after myocardial infarction in mice

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Yamamoto ◽  
H Yasukawa ◽  
J Takahashi ◽  
S Nohara ◽  
T Sasak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Real Time ◽  
Real Time Pcr ◽  
Tissue Repair ◽  
Repair Process ◽  
Cardiac Rupture ◽  
Blue Dye ◽  
Border Area ◽  
Infarct Area

Abstract Background Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, which mainly targets epithelial cells and does not target immune cells. Recently, it has been reported that IL-22 play roles in tissue repair in the skin and the liver; however, role of IL-22 in the process of tissue repair after myocardial infarction (MI) is unknown. Here, we investigated the role of IL-22 in tissue repair process after MI. Methods and results First, we examined the expression of IL-22 and its receptor IL-22RA1 in the wild type (WT) mice by real-time PCR. The expression of IL-22 and IL-22RA1 in the hearts were significantly increased 3 days after MI (p<0.05). To clarify the role of IL-22 in the heart after MI, we produced MI model in the WT mice and IL-22 knockout (KO) mice. We found that the IL-22 KO mice had significantly higher mortality than the WT mice after MI (p<0.05). Approximately 80% of the IL-22 KO mice died with cardiac rupture after MI. The infarct size which was estimated by evans blue dye and triphenyltetrazolium chloride staining at 3 days after MI was comparable between the IL-22 KO mice and the WT mice. Next, we performed real time PCR and PCR array analysis for tissue fibrosis and repair genes. We found that alpha-smooth muscle actin (aSMA), NF-kB, TNF-a and MMP13 (also known as collagenase-3) were significantly increased in the infarct area of IL-22 KO mice compared to WT mice. Immunostaining showed that the myofibroblast marker aSMA positive cells in the border area after MI were markedly higher in the IL-22 KO mice compared with the WT mice (p<0.05). Approximately 70% of cardiac rupture after MI in the IL-22 KO mice were occurred in the infarct area adjacent to the border area. Furthermore, we found aSMA positive cells and MMP13 positive cells around the ruptured site of the heart. Conclusion Thus, IL-22 KO mice exhibit high mortality and increased cardiac rupture after MI. And expression of aSMA and MMP13 were highly expressed in the ruptured site after MI in the IL-22 KO mice. These results suggest that IL-22 may play an important role in the tissue repair process after MI.

scholarly journals Mechanisms of Action of Human Mesenchymal Stem Cells in Tissue Repair Regeneration and their Implications

2017 ◽  
Vol 53 (02) ◽  
pp. 104-120 ◽  
Author(s):  
Manisha Singh ◽  
Suchi Gupta ◽  
Sonali Rawat ◽  
Swati Midha ◽  
Krishan Gopal Jain ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Human Mesenchymal Stem Cells ◽  
Mechanisms Of Action ◽  
Maximum Output ◽  
Cell Replacement Therapy ◽  
Tissue Repair And Regeneration

ABSTRACTCell replacement therapy holds a promising future in the treatment of degenerative diseases related to neuronal, cardiac and bone tissues. In such kind of diseases, there is a progressive loss of specific types of cells. Currently the most upcoming and trusted cell candidate is Mesenchymal Stem Cells (MSCs) as these cells are easy to isolate from the tissue, easy to maintain and expand and no ethical concerns are linked. MSCs can be obtained from a number of sources like bone marrow, umbilical cord blood, umbilical cord, dental pulp, adipose tissues, etc. MSCs help in tissue repair and regeneration by various mechanisms of action like cell differentiation, immunomodulation, paracrine effect, etc. The future of regenerative medicine lies in tissue engineering and exploiting various properties to yield maximum output. In the current review article, we have targeted the repair and regeneration mechanisms of MSCs in neurodegenerative diseases, cardiac diseases and those related to bones. Yet there is a lot to understand, discover and then understand again about the molecular mechanisms of MSCs and then applying this knowledge in developing the therapy to get maximum repair and regeneration of concerned tissue and in turn the recovery of the patient.

Distinct anti-inflammatory properties of alpha1-antitrypsin and corticosteroids reveal unique underlying mechanisms of action

2020 ◽  
Vol 356 ◽  
pp. 104177
Author(s):  
Ronen Schuster ◽  
Noa Motola-Kalay ◽  
Boris M. Baranovski ◽  
Liliana Bar ◽  
Naveh Tov ◽  
...  
Keyword(s):  
Mechanisms Of Action ◽  
Alpha1 Antitrypsin ◽  
Anti Inflammatory ◽  
Underlying Mechanisms
Sign in / Sign up

Export Citation Format

Share Document