scholarly journals Serum eosinophilic cationic protein may predict clinical course of wheezing in young children

1998 ◽  
Vol 78 (5) ◽  
pp. 448-452 ◽  
Author(s):  
J R Villa ◽  
G Garcia ◽  
S Rueda ◽  
A Nogales
Keyword(s):  
Young Children ◽  
Clinical Course ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein

scholarly journals To Evaluate Serum Eosinophil Cationic Protein and Total IgE Concomitantly May Predict the Persistence of Wheezing in Young Children

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Esengül Keleş ◽  
Hamza Yazgan ◽  
Arzu Gebeşçe
Keyword(s):  
Relative Risk ◽  
Young Children ◽  
Predictive Value ◽  
Eosinophil Cationic Protein ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Total Ige ◽  
Significant Difference ◽  
Group 1

Background. We investigated the predictive value and the relative risk of the evaluation of serum eosinophilic cationic protein (sECP) and total IgE levels concomitantly in relation to the persistence of wheezing in young children. Methods. The study was conducted prospectively between January 2007 and December 2010. A hundred and eight children, aged between three months and four years, with three or more episodes of wheezing, were studied to evaluate the role of eosinophil inflammation and its relation to persistence of wheezing two years later. Results. A statistically significant difference in terms of total IgE and sECP values was observed between the groups (P<0.05). When measurement of IgE and sECP was assessed concomitantly, the sensitivity was found to be 92.68%, the negative predictive value was found to be 71.43%, accuracy rate was found to be 84.26%, and the relative risk was found to be 3.06 in group 1. Conclusions. In this study, we aimed to emphasize the importance of the assessment of sECP and total IgE concomitantly, as being two noninvasive and easily applicable tests, useful in predicting persistent wheezing in early childhood.

Eosinophilic Cationic Protein in Chronic Eosinophilic Pneumonia and Eosinophilic Granuloma

CHEST Journal ◽  
1994 ◽  
Vol 106 (5) ◽  
pp. 1481-1486 ◽  
Author(s):  
Noriharu Shijubo ◽  
Katsunori Shigehara ◽  
Michio Hirasawa ◽  
Manabu Inuzuka ◽  
Shosaku Abe
Keyword(s):  
Eosinophilic Granuloma ◽  
Eosinophilic Pneumonia ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Chronic Eosinophilic Pneumonia

Eosinophilic cationic protein (ECP) in the clinical work-up of chronic cough

2021 ◽  
Author(s):  
Mara DE AMICI ◽  
Davide PILONI ◽  
Claudio TIRELLI ◽  
Francesca MARIANI ◽  
Giulia ACCORDINO ◽  
...  
Keyword(s):  
Chronic Cough ◽  
Clinical Work ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Work Up

Acute Bronchiolitis: A Study of 207 Cases

1962 ◽  
Vol 1 (2) ◽  
pp. 75-81
Author(s):  
Bruce D. Ackerman
Keyword(s):  
Young Children ◽  
Physical Examination ◽  
Clinical Course ◽  
Clinical Syndrome ◽  
Viral Agent ◽  
Acute Bronchiolitis ◽  
Respiratory Difficulty ◽  
Respiratory Embarrassment ◽  
Infants And Young Children

Acute bronchiolitis is an important clinical syndrome seen in infants and young children. It is most common in infants between the ages of two and seven months. The disease is characterized by recurrent epidemics during which a large number of cases are seen over a period of one to two months. The presenting history is usually dominated by the symptom of cough. Physical examination reveals an acutely ill infant with a characteristic cough, labored respirations, an emphysematous chest, and high-pitched expiratory wheezes. The clinical course is typically characterized by severe respiratory difficulty for one to two days followed by sudden improvement. Respiratory embarrassment is sometimes extreme and on rare occasions fatal. The etiology most often appears to be infection with a viral agent.

scholarly journals Serum Eosinophilic cationic protein (ECP) as an effective biological marker to monitor therapy in bronchial asthma patients.

2011 ◽  
Vol 5 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Afroza Begum ◽  
Humayun Sattar ◽  
Abu Naser Ibne Sattar ◽  
Md. Ruhul Amin Miah ◽  
Ahmed Abu Saleh
Keyword(s):  
Bronchial Asthma ◽  
Persistent Asthma ◽  
Biological Marker ◽  
Forced Expiratory Volume ◽  
Asthma Therapy ◽  
Eosinophilic Cationic Protein ◽  
Cationic Protein ◽  
Before And After ◽  
Asthma Patients

Clinically diagnosed bronchial asthma patients comprising of new cases, on therapy or follow up were enrolled for this study to see if the new biological marker Eosinophilic cationic protein (ECP) can be used as a more precise marker to monitor therapy than the presently used conventional ones like FEV1% predicted, PEFR, and Circulating eosinophil (C.E) count. Out of 70 bronchial asthma patients, 30 intermittent, 4 mild persistent, 24 moderate persistent and 12 severe persistent asthma patients were included, while 45 cases were enrolled for follow up. Serum level of eosinophil granular protein, Eosinophilic cationic protein (ECP) was measured in relation to changes in their forced expiratory volume in 1st second (FEV1% predicted) and Circulating Eosinophil count (%) before and after therapy in 45 follow up patients on asthma therapy. In this study, it was observed that C.E count (%) and FEV1% predicted were not decreased significantly and serum eosinophilic cationic protein (ECP) decreased significantly (p<0.001) after asthma therapy. Thus, serum ECP level can be used as a biological marker than other conventionally used marker (FEV1, C.E count) to monitor therapeutic efficacy in bronchial asthma patients.DOI: http://dx.doi.org/10.3329/bjmm.v5i1.15813 Bangladesh J Med Microbiol 2011; 05 (01): 3-7

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