scholarly journals Randomised double blind study of hypotonic oral rehydration solution in diarrhoea

1997 ◽  
Vol 76 (3) ◽  
pp. 272-274 ◽  
Author(s):  
T. Rautanen ◽  
S. Kurki ◽  
T. Vesikari
Keyword(s):  
Oral Rehydration Solution ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Oral Rehydration ◽  
Rehydration Solution

Glucose vs Sucrose in Oral Rehydration Solutions for Infants and Young Children with Rotavirus-Associated Diarrhea

PEDIATRICS ◽  
1981 ◽  
Vol 67 (1) ◽  
pp. 79-83
Author(s):  
Robert E. Black ◽  
Michael H. Merson ◽  
Philip R. Taylor ◽  
Robert H. Yolken ◽  
Md. Yunus ◽  
...  
Keyword(s):  
Oral Fluid ◽  
Oral Rehydration Solution ◽  
Electrolyte Solutions ◽  
Double Blind ◽  
Oral Rehydration ◽  
Rehydration Solutions ◽  
Cause Of Failure ◽  
Rehydration Solution ◽  
Infants And Young Children ◽  
Weight For Age

The use of oral rehydration solutions containing essential electrolytes and either glucose or sucrose of equal osmolality was compared in a double-blind sequential trial of 784 children with rotavirus-associated diarrhea treated at a center in rural Bangladesh. The oral fluid failure rate was 11.5% for the sucrose-containing solution group and 7.3% for the glucose-containing group (P = NS). Vomiting was a significantly more common cause of failure for the group treated with sucrose-containing oral rehydration solution and was associated with an increased rate of intake of the sweeter sucrose-containing solution. The purging rate was not different for the two groups. The oral fluid failure rates for children in the most underweight category (<60% of expected weight for age) were not different from those for other groups, although, as assessed by purging rate and initial dehydration, the stool losses of members of this group constituted a greater proportion of their body weight. Glucose is the preferred carbohydrate for oral electrolyte solutions, although sucrose can be substituted with only minimum loss of efficacy.

scholarly journals Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938 and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1189 ◽  
Author(s):  
Maria Maragkoudaki ◽  
George Chouliaras ◽  
Antonia Moutafi ◽  
Athanasios Thomas ◽  
Archodoula Orfanakou ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Lactobacillus Reuteri ◽  
Oral Rehydration Solution ◽  
Statistical Significance ◽  
Acute Diarrhoea ◽  
Controlled Study ◽  
Double Blind ◽  
Oral Rehydration ◽  
Number Of Patients ◽  
Rehydration Solution

The efficacy of oral rehydration solution (ORS) enriched with Lactobacillus reuteri DSM 17938 and zinc in infants with acute gastroenteritis, is poorly defined. The aim of this double-blind, randomized, placebo-controlled study, was to assess the efficacy of an ORS enriched with Lactobacillus reuteri DSM 17938 and zinc (ORS+Lr&Z) in well-nourished, non-hospitalized infants with acute diarrhoea. Fifty one infants with acute diarrhoea were randomly assigned to receive either ORS+Lr&Z (28 infants, mean ± SD age 1.7 ± 0.7 years, 21 males), or standard ORS (ORS−Lr&Z; 23 infants, mean ± SD age 1.8 ± 0.7 years, 16 males). Stools volume and consistency were recorded pre- and posttreatment using the Amsterdam Infant Stool Scale and were compared between the two groups, as well as lost work/day care days, drug administration and need for hospitalization. Both groups showed reduction in the severity of diarrhoea on day two (p < 0.001) while, all outcomes showed a trend to be better in the ORS+Lr&Z group, without reaching statistical significance, probably due to the relatively small number of patients. No adverse effects were recorded. In conclusion, both ORS were effective in managing acute diarrhoea in well-nourished, non-hospitalized infants. ORS enriched with L. reuteri DSM 17938 and zinc was well tolerated with no adverse effects.

scholarly journals An oral electrolyte solution without glucose for oral rehydration indiarrhea with mild and moderate dehydration

1981 ◽  
Vol 21 (1-2) ◽  
pp. 35
Author(s):  
Rosyid R. A ◽  
Sutrisno D. S. ◽  
Harun Alrasyid ◽  
Untoro Untoro ◽  
Rien Armi U. ◽  
...  
Keyword(s):  
Electrolyte Solution ◽  
Rural Areas ◽  
Blind Study ◽  
Oral Glucose ◽  
Double Blind Study ◽  
Severe Dehydration ◽  
Double Blind ◽  
Oral Rehydration

For rural areas in Indonesia where glucose is not always available a trial has been done to prevent severe dehydration and death from diarrhea with an oral electrolyte solution without glucose.The efficacy of oral electrolyte solution without glucose was not different from oral glucose electrolyte solution in a double blind study on 60 children with mild and moderate dehydration due to diarrhea.Electrolyte solution without glucose can act as a substitute for glucose electrolyte solution in the therapy of mild and moderate dehydration due to diarrhea. 

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