Modulation of the cellular uptake efficiency and the intracellular localization of conjugated Trojan peptides

2007 ◽  
Author(s):  
Fabienne Burlina ◽  
Baptiste Aussedat ◽  
Soline Aubry ◽  
Diane Delaroche ◽  
Edmond Dupont ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Intracellular Localization ◽  
Uptake Efficiency ◽  
Cellular Uptake Efficiency

scholarly journals The morphology and surface charge-dependent cellular uptake efficiency of upconversion nanostructures revealed by single-particle optical microscopy

2018 ◽  
Vol 9 (23) ◽  
pp. 5260-5269 ◽  
Author(s):  
Di Zhang ◽  
Lin Wei ◽  
Meile Zhong ◽  
Lehui Xiao ◽  
Hung-Wing Li ◽  
...  
Keyword(s):  
Surface Charge ◽  
Optical Microscopy ◽  
Cellular Uptake ◽  
Single Particle ◽  
Cellular Internalization ◽  
Uptake Efficiency ◽  
Size And Shape ◽  
Internalization Process ◽  
Cellular Uptake Efficiency

The cellular uptake efficiency of nanostructures has been demonstrated to be highly dependent on the surface charge, size and shape although the cellular internalization process is still far from being well-understood.

Membrane Microdomain Structures of Liposomes and Their Contribution to the Cellular Uptake Efficiency into HeLa Cells

2016 ◽  
Vol 13 (2) ◽  
pp. 369-378 ◽  
Author(s):  
Yoshinori Onuki ◽  
Yasuko Obata ◽  
Kumi Kawano ◽  
Hiromu Sano ◽  
Reina Matsumoto ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Hela Cells ◽  
Uptake Efficiency ◽  
Membrane Microdomain ◽  
Cellular Uptake Efficiency

scholarly journals Biocompatible carbon-doped MoSe2 nanoparticles as a highly efficient targeted agent for human renal cell carcinoma

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11567-11575 ◽  
Author(s):  
Li Gao ◽  
Yi-zeng Fan ◽  
Tao-hong Zhang ◽  
Hui-qiu Xu ◽  
Xian-ling Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cellular Uptake ◽  
Renal Cell ◽  
Human Renal Cell Carcinoma ◽  
Carbon Doped ◽  
Uptake Efficiency ◽  
High Viability ◽  
Targeted Agent ◽  
Cellular Uptake Efficiency

HK-2 cells have weak cellular uptake efficiency leading to high viability with carbon-doped MoSe2 nanoparticles.

Comparison of Penetratin and Other Homeodomain-Derived Cell-Penetrating Peptides:  Interaction in a Membrane-Mimicking Environment and Cellular Uptake Efficiency†

Biochemistry ◽  
2006 ◽  
Vol 45 (5) ◽  
pp. 1408-1420 ◽  
Author(s):  
Stéphane Balayssac ◽  
Fabienne Burlina ◽  
Odile Convert ◽  
Gérard Bolbach ◽  
Gérard Chassaing ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Uptake Efficiency ◽  
Cell Penetrating ◽  
Cellular Uptake Efficiency

Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake

2014 ◽  
Vol 2 (30) ◽  
pp. 4929-4934 ◽  
Author(s):  
Yannan Yang ◽  
Surajit Karmakar ◽  
Jun Zhang ◽  
Meihua Yu ◽  
Neena Mitter ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Uptake Efficiency ◽  
Cellular Uptake Efficiency

SBA-15 rods with 80–200 nm in length and 18 ± 8 nm in width have been prepared, showing enhanced cellular uptake efficiency.

The evaluation of cellular uptake efficiency and tumor-targeting ability of MPEG–PDLLA micelles: effect of particle size

RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 13698-13709 ◽  
Author(s):  
Ying Hao ◽  
YiXing Huang ◽  
YunQi He ◽  
JinRong Peng ◽  
LiJuan Chen ◽  
...  
Keyword(s):  
Particle Size ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Particle Sizes ◽  
Uptake Efficiency ◽  
Effect Of Particle Size ◽  
Targeting Ability ◽  
Cellular Uptake Efficiency

The study reported herein describes the cellular uptake efficiency and tumor-targeting ability of MPEG–PDLLA micelles with two different particle sizes.

scholarly journals Transdermal Penetrating Peptide Conjugated Liposomes as Drug Delivery Carrier Comprising Macromolecules

2021 ◽  
Vol 12 (5) ◽  
pp. 414-419
Author(s):  
Hyung Jun Lim, Jinseo Lee, Su In Park, Soo Hyeon Heo, Beom-Jin Lee, Moon Sam Shin
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Zeta Potential ◽  
Cellular Uptake ◽  
Rhodamine B ◽  
Skin Permeation ◽  
Molar Ratio ◽  
Active Materials ◽  
Uptake Efficiency ◽  
Cellular Uptake Efficiency

: The aim of the study was to investigate a system using liposomes and cell penetrating peptides (CPP) for optimal transdermal delivery of macromolecules. Typical DOPE liposomes were prepared with lipid mixture (DOPE:PC:Chol = 1.5:1.5:2.0, molar ratio) and active materials (Rhodamine B; MW ~480 and Dextran-RITC; MW ~10,000).  CPP-conjugated DOPE liposomescontaining active materials were prepared by conjugating the peptide to DOPE liposomes (DOPE:PC:Chol:DSPE-PEG-Mal = 1.5:1.1:2.0:0.2 or 0.4, molar ratio). Physical properties of both liposomes were evaluated, including particle size and zeta potential. The particle sizes of typical liposome and CPP-DOPE liposome were approximately 100 nm, and the zeta potential values of both liposomes were approximately -25mV and over +11mV respectively. Moreover, cellular uptake efficiency was assessed by flow cytometry (FACS). CPP-conjugated liposomes resulted higher cellular uptake efficiency compared to typical DOPE liposomes, showing higher fluorescent intensity in CPP-DOPE liposomes. In confocal laser scanning microscope (CLSM) studies, both cellular uptake and skin permeation were visually estimated. In the case of Rhodamine B, having a relatively small molecular weight,absorption into the cell was successful, and showed the highest rate of cellular uptake with CPP-DOPE liposomes. Dextran-RITC, a macromolecule with a relatively bigger molecular weight, showed similar results to Rhodamine B. In terms of skin permeation, CPP-DOPE liposomes containing Rhodamine B showed noticeable skin absorption after 4 and 18 hours, and the permeation range was wider and thicker than that with typical liposomes. For Dextran-RITC, with typical DOPE liposome, it was hardly permeable through the skin, but with CPP-DOPE liposomes, on the other hand, the skin permeations after 4 and 18 hours were remarkable. The improved cellular uptake and skin permeation of the CPP-conjugated liposomes are due to the cationic arginine-rich peptide. In vivo studies also proved that the CPP-conjugated liposomes are superior in depigmentation and anti-wrinkle studies than typical liposomes. These results demonstrate that the CPP-conjugated liposomes could also be effective for transdermal drug delivery of antioxidant and anti-aging therapeutics.

Sign in / Sign up

Export Citation Format

Share Document