Comparison of Penetratin and Other Homeodomain-Derived Cell-Penetrating Peptides:  Interaction in a Membrane-Mimicking Environment and Cellular Uptake Efficiency†

Biochemistry ◽  
2006 ◽  
Vol 45 (5) ◽  
pp. 1408-1420 ◽  
Author(s):  
Stéphane Balayssac ◽  
Fabienne Burlina ◽  
Odile Convert ◽  
Gérard Bolbach ◽  
Gérard Chassaing ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Uptake Efficiency ◽  
Cell Penetrating ◽  
Cellular Uptake Efficiency

siRNA versus pharmacological inhibition of endocytic pathways for studying cellular uptake of cell penetrating peptides and other drug delivery vectors

2010 ◽  
Vol 15 (23-24) ◽  
pp. 1103-1103
Author(s):  
Monerah H. Al-Soraj ◽  
Catherine L. Watkins ◽  
Dries Vercauteren ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Pharmacological Inhibition ◽  
Cell Penetrating ◽  
Endocytic Pathways

scholarly journals Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and the Contribution of Membrane-Associated Proteoglycans

2015 ◽  
Vol 27 (155) ◽  
pp. 81-88 ◽  
Author(s):  
Ikuhiko Nakase ◽  
Yoshimasa Kawaguchi ◽  
Motoyoshi Nomizu ◽  
Shiroh Futaki
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals A comparison of acyl-moieties for noncovalent functionalization of PLGA and PEG-PLGA nanoparticles with a cell-penetrating peptide

RSC Advances ◽  
2021 ◽  
Vol 11 (57) ◽  
pp. 36116-36124
Author(s):  
Omar Paulino da Silva Filho ◽  
Muhanad Ali ◽  
Rike Nabbefeld ◽  
Daniel Primavessy ◽  
Petra H. Bovee-Geurts ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Plga Nanoparticles ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Noncovalent Functionalization ◽  
Cell Penetrating ◽  
A Cell

Noncovalent functionalization with acylated cell-penetrating peptides achieves an efficient cellular uptake of PLGA and PEG-PLGA nanoparticles.

scholarly journals Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Gisela Lättig-Tünnemann ◽  
Manuel Prinz ◽  
Daniel Hoffmann ◽  
Joachim Behlke ◽  
Caroline Palm-Apergi ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

Machine-Learning-Based Prediction of Cell-Penetrating Peptides and Their Uptake Efficiency with Improved Accuracy

2018 ◽  
Vol 17 (8) ◽  
pp. 2715-2726 ◽  
Author(s):  
Balachandran Manavalan ◽  
Sathiyamoorthy Subramaniyam ◽  
Tae Hwan Shin ◽  
Myeong Ok Kim ◽  
Gwang Lee
Keyword(s):  
Machine Learning ◽  
Cell Penetrating Peptides ◽  
Uptake Efficiency ◽  
Cell Penetrating ◽  
Improved Accuracy

scholarly journals The morphology and surface charge-dependent cellular uptake efficiency of upconversion nanostructures revealed by single-particle optical microscopy

2018 ◽  
Vol 9 (23) ◽  
pp. 5260-5269 ◽  
Author(s):  
Di Zhang ◽  
Lin Wei ◽  
Meile Zhong ◽  
Lehui Xiao ◽  
Hung-Wing Li ◽  
...  
Keyword(s):  
Surface Charge ◽  
Optical Microscopy ◽  
Cellular Uptake ◽  
Single Particle ◽  
Cellular Internalization ◽  
Uptake Efficiency ◽  
Size And Shape ◽  
Internalization Process ◽  
Cellular Uptake Efficiency

The cellular uptake efficiency of nanostructures has been demonstrated to be highly dependent on the surface charge, size and shape although the cellular internalization process is still far from being well-understood.

scholarly journals Internalization mechanisms of cell-penetrating peptides

2020 ◽  
Vol 11 ◽  
pp. 101-123 ◽  
Author(s):  
Ivana Ruseska ◽  
Andreas Zimmer
Keyword(s):  
Cellular Uptake ◽  
Cell Types ◽  
Cell Penetrating Peptides ◽  
Uptake Mechanism ◽  
Black And White ◽  
Cell Penetrating ◽  
Basic Peptides ◽  
Different Cell Types ◽  
Immense Potential

In today’s modern era of medicine, macromolecular compounds such as proteins, peptides and nucleic acids are dethroning small molecules as leading therapeutics. Given their immense potential, they are highly sought after. However, their application is limited mostly due to their poor in vivo stability, limited cellular uptake and insufficient target specificity. Cell-penetrating peptides (CPPs) represent a major breakthrough for the transport of macromolecules. They have been shown to successfully deliver proteins, peptides, siRNAs and pDNA in different cell types. In general, CPPs are basic peptides with a positive charge at physiological pH. They are able to translocate membranes and gain entry to the cell interior. Nevertheless, the mechanism they use to enter cells still remains an unsolved piece of the puzzle. Endocytosis and direct penetration have been suggested as the two major mechanisms used for internalization, however, it is not all black and white in the nanoworld. Studies have shown that several CPPs are able to induce and shift between different uptake mechanisms depending on their concentration, cargo or the cell line used. This review will focus on the major internalization pathways CPPs exploit, their characteristics and regulation, as well as some of the factors that influence the cellular uptake mechanism.

Membrane Microdomain Structures of Liposomes and Their Contribution to the Cellular Uptake Efficiency into HeLa Cells

2016 ◽  
Vol 13 (2) ◽  
pp. 369-378 ◽  
Author(s):  
Yoshinori Onuki ◽  
Yasuko Obata ◽  
Kumi Kawano ◽  
Hiromu Sano ◽  
Reina Matsumoto ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Hela Cells ◽  
Uptake Efficiency ◽  
Membrane Microdomain ◽  
Cellular Uptake Efficiency

scholarly journals Biocompatible carbon-doped MoSe2 nanoparticles as a highly efficient targeted agent for human renal cell carcinoma

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11567-11575 ◽  
Author(s):  
Li Gao ◽  
Yi-zeng Fan ◽  
Tao-hong Zhang ◽  
Hui-qiu Xu ◽  
Xian-ling Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cellular Uptake ◽  
Renal Cell ◽  
Human Renal Cell Carcinoma ◽  
Carbon Doped ◽  
Uptake Efficiency ◽  
High Viability ◽  
Targeted Agent ◽  
Cellular Uptake Efficiency

HK-2 cells have weak cellular uptake efficiency leading to high viability with carbon-doped MoSe2 nanoparticles.

scholarly journals Cellular uptake and membrane-destabilising properties of α-peptide/β-peptoid chimeras: lessons for the design of new cell-penetrating peptides

2008 ◽  
Vol 1778 (11) ◽  
pp. 2487-2495 ◽  
Author(s):  
Camilla Foged ◽  
Henrik Franzyk ◽  
Shervin Bahrami ◽  
Sven Frokjaer ◽  
Jerzy W. Jaroszewski ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating
Sign in / Sign up

Export Citation Format

Share Document