Recent developments in syntheses of the post-secodine indole alkaloids. Part III: Rearranged alkaloid types

2011 ◽  
Vol 76 (12) ◽  
pp. 2023-2083 ◽  
Author(s):  
Josef Hájíček
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids ◽  
The Third ◽  
Recent Developments

The third part of a planned review on developments in the field of total and formal total synthesis of the post-secodine indole alkaloids focuses on types of rearranged alkaloids, i.e. on the skeletons with altered connectivities next to the indol(e)ine moiety, especially with a new bond to N-1. It reviews the synthesis of melodane, goniomitine, chippiine/dippinine, lirofoline and tronocarpine alkaloids, as well as alkaloids of secoschizozygane/vallesamidine, schizozygane and isoschizozygane type. It covers the literature from approximately 1991 up to May 2011. A review with 115 references.

A Review on Recent Developments in Syntheses of the post-Secodine Indole Alkaloids. Part II: Modified Alkaloid Types

2007 ◽  
Vol 72 (7) ◽  
pp. 821-898 ◽  
Author(s):  
Josef Hájíček
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids ◽  
Recent Developments ◽  
Lapidilectine B

The second part of the planned review on developments in the field of total and formal total synthesis of the post-secodine indole alkaloids concentrates on modified alkaloid types, i.e. those skeletons derived from primary types by formation of additional and/or rupture of existing bonds, while connectivities next to indol(e)ine moiety remain intact. It thus reviews the synthesis of alkaloids of quebrachamine/cleavamine type including VLB-bis-indoles, rhazinilam type, aspidofractinine/kopsane and kopsifoline type, as well as kopsijasminilam alkaloids, lapidilectine B and danuphylline. It covers the literature of from 1991-1992 up to approximately end 2006. A review with 174 references.

A Review on Recent Developments in Syntheses of the Post-Secodine Indole Alkaloids. Part I: The Primary Alkaloid Types

2004 ◽  
Vol 69 (9) ◽  
pp. 1681-1767 ◽  
Author(s):  
Josef Hájíček
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids ◽  
Recent Developments

This first part of a planned review on developments in the field of total and formal total synthesis of the post-secodine indole alkaloids concentrates on primary alkaloid types. It reviews the synthesis of secodine, aspidospermane, pseudoaspidospermane and ibogane alkaloids; andranginine is also included. It covers the literature from 1992-1993 up to approximately May 2004. A review with 179 references.

No fear of George Kingsley Zipf

10.1558/37291 ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 242-263
Author(s):  
Stefano Rastelli ◽  
Kook-Hee Gil
Keyword(s):  
Minimalist Program ◽  
Classroom Research ◽  
Language Design ◽  
Efficient Computation ◽  
Generative Linguistics ◽  
The Third ◽  
Factor Effect ◽  
Language Classroom ◽  
Recent Developments ◽  
Insight Into

This paper offers a new insight into GenSLA classroom research in light of recent developments in the Minimalist Program (MP). Recent research in GenSLA has shown how generative linguistics and acquisition studies can inform the language classroom, mostly focusing on what linguistic aspects of target properties should be integrated as a part of the classroom input. Based on insights from Chomsky’s ‘three factors for language design’ – which bring together the Faculty of Language, input and general principles of economy and efficient computation (the third factor effect) for language development – we put forward a theoretical rationale for how classroom research can offer a unique environment to test the learnability in L2 through the statistical enhancement of the input to which learners are exposed.

Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity

2021 ◽  
Author(s):  
Robert M. Hohlman ◽  
David H. Sherman
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Indole Alkaloids ◽  
Recent Advances

This review covers isolation, biological activity, an overview of total synthesis efforts and recent biosynthetic discoveries related to hapalindole-type indole alkaloids.

scholarly journals The chemistry of mavacurane alkaloids: a rich source of bis-indole alkaloids

2021 ◽  
Author(s):  
Audrey Mauger ◽  
Maxime Jarret ◽  
Cyrille Kouklovsky ◽  
Erwan Poupon ◽  
Laurent Evanno ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids ◽  
Rich Source ◽  
Monoterpene Indole Alkaloids

This review presents the chemistry of mavacuranes, a subfamily of the monoterpene indole alkaloids, from their isolation, biosynthesis, total synthesis to their tendency to assemble with other partners to form intricate bis-indole alkaloids.

Testing for Language Teachers

2020 ◽  
Author(s):  
Arthur Hughes ◽  
Jake Hughes
Keyword(s):  
Adaptive Testing ◽  
Language Teachers ◽  
Experienced Teachers ◽  
Automated Scoring ◽  
Testing Methods ◽  
The Third ◽  
Recent Developments ◽  
Extended Discussion ◽  
Straightforward Approach ◽  
Practical Recommendations

This book provides an accessible guide to concepts in language testing and the testing of specific skills and systems. It combines theory and practical recommendations to help teachers understand the principles of testing and how they can be applied, supporting them to write better tests. The third edition has been extensively revised and updated to reflect recent developments in the field, while retaining the straightforward approach that made the earlier editions essential reading for trainee and experienced teachers alike. It features new content on technology, including computer adaptive testing and the use of automated scoring for all skills. It also includes an extended discussion of language testers' responsibilities, new chapters on non-testing methods of assessment and a checklist to help teachers choose tests.

ChemInform Abstract: Total Synthesis of the Indole Alkaloids Henrycinol A (Ia) and B (Ib).

ChemInform ◽  
2014 ◽  
Vol 45 (51) ◽  
pp. no-no
Author(s):  
Kavirayani R. Prasad ◽  
John Eugene Nidhiry ◽  
Makuteswaran Sridharan
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids

scholarly journals Bioinspired Oxidative Cyclization of the Geissoschizine Skeleton for the Enantioselective Total Synthesis of Mavacuran Alkaloids

2019 ◽  
Author(s):  
Maxime Jarret ◽  
Victor Turpin ◽  
Aurélien Tap ◽  
Jean-Francois Gallard ◽  
Cyrille Kouklovsky ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Oxidative Coupling ◽  
Indole Alkaloids ◽  
Oxidative Cyclization ◽  
Total Syntheses ◽  
Enantioselective Total Synthesis ◽  
Biosynthetic Precursor ◽  
Monoterpene Indole Alkaloids ◽  
Coupling Approach

We report the enantioselective total syntheses of mavacurans alkaloids, (+)-taberdivarine H, (+)-16-hydoxymethyl-pleiocarpamine, (+)-16-epi-pleiocarpamine, and their postulated biosynthetic precursor 16-formyl-pleiocarpamine. This family of monoterpene indole alkaloids is a target of choice since some of its members are subunits of intricate bisindole alkaloids such as bipleiophylline. Inspired by the biosynthetic hypothesis, we explored an oxidative coupling approach from the geissoschizine framework to form the N1-C16 bond. Quaternization of the aliphatic nitrogen was key to achieve the oxidative coupling induced by KHMDS/I<sub>2 </sub>since<sub> </sub>it hides the nucleophilicity of the aliphatic nitrogen and locks the required cis conformation.

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